Effects of neuroglobin overexpression on acute brain injury and long-term outcomes after focal cerebral ischemia

Stroke

Volumn 39, Issue 6, 2008, Pages 1869-1874

  Wang, Xiaoying ^a   Liu, Jianxiang ^a   Zhu, Haihao ^a   Tejima, Emiri ^a   Tsuji, Kiyoshi ^a   Murata, Yoshihiro ^a   Atochin, Dmitriy N ^a   Huang, Paul L ^a   Zhang, Chenggang ^b   Lo, Eng H ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

Neuroglobin; Nuroprotection; Oxidative stress; Stroke

Indexed keywords

COMPLEMENTARY DNA; MALONALDEHYDE; MESSENGER RNA; NEUROGLOBIN; BIOLOGICAL MARKER; GLOBIN; NERVE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; COGNITION; CONTROLLED STUDY; GENE OVEREXPRESSION; GENE THERAPY; MOUSE; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; OUTCOMES RESEARCH; OXIDATIVE STRESS; PRIORITY JOURNAL; SENSORIMOTOR NEUROPATHY; TRANSGENIC MOUSE; ACUTE DISEASE; ANIMAL; CELL PROTECTION; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; METHODOLOGY; PATHOPHYSIOLOGY; TIME; UPREGULATION;

ACUTE DISEASE; ANIMALS; BIOLOGICAL MARKERS; BRAIN ISCHEMIA; CEREBRAL INFARCTION; CYTOPROTECTION; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GENE THERAPY; GLOBINS; MALONDIALDEHYDE; MICE; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; OXIDATIVE STRESS; RNA, MESSENGER; TIME; TIME FACTORS; UP-REGULATION;

EID: 46249131382     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.107.506022     Document Type: Article

References (33)

1. Awenius C, Hankeln T, Burmester T. Neuroglobins from the zebrafish Danio rerio and the pufferfish Tetraodon nigroviridis. Biochem Biophys Res Commun. 2001;287:418-421.
2. Zhang CG, Li L, Deng MY, Xie F, Wang CL, Zhou WQ, Wang HY, He FC. Coding region cDNA sequence cloning of rat neuroglobin gene, its polymorphism feature and tissue expression profile analysis [in Chinese]. Yi Chuan Xue Bao. 2001;28:997-1001.
3. Burmester T, Weich B, Reinhardt S, Hankeln T. A vertebrate globin expressed in the brain. Nature. 2000;407:520-523.
4. Burmester T, Hankeln T. Neuroglobin: a respiratory protein of the nervous system. News Physiol Sci. 2004;19:110-113.
5. Garry DJ, Mammen PP. Neuroprotection and the role of neuroglobin. Lancet. 2003;362:342-343.
6. Sun Y, Jin K, Mao XO, Zhu Y, Greenberg DA. Neuroglobin is up-regulated by and protects neurons from hypoxic-ischemic injury. Proc Natl Acad Sci U S A. 2001;98:15306-15311.
7. Sun Y, Jin K, Mao XO, Xie L, Peel A, Childs JT, Logvinova A, Wang X, Greenberg DA. Effect of aging on neuroglobin expression in rodent brain. Neurobiol Aging. 2005;26:275-278.
8. Mammen PP, Shelton JM, Goetsch SC, Williams SC, Richardson JA, Garry MG, Garry DJ. Neuroglobin, a novel member of the globin family, is expressed in focal regions of the brain. J Histochem Cytochem. 2002; 50:1591-1598.
9. Garry DJ, Kanatous SB, Mammen PP. Emerging roles for myoglobin in the heart. Trends Cardiovasc Med. 2003;13:111-116.
10. Marcinek DJ, Ciesielski WA, Conley KE, Schenkman KA. Oxygen regulation and limitation to cellular respiration in mouse skeletal muscle in vivo. Am J Physiol Heart Circ Physiol. 2003;285:H1900-H1908.
11. Vasil'ieva VO, Korobov VM, Velykyik. Role of myoglobin in supplying oxygen to tissues [in Ukranian]. Ukr Biokhim Zh. 1996;68:45-55.
12. Khan AA, Wang Y, Sun Y, Mao XO, Xie L, Miles E, Graboski J, Chen S, Ellerby LM, Jin K, Greenberg DA. Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia. Proc Natl Acad Sci U S A. 2006;103:17944-17948.
13. Asahi M, Wang X, Mori T, Sumii T, Jung JC, Moskowitz MA, Fini ME, Lo EH. Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood- brain barrier and white matter components after cerebral ischemia. J Neurosci. 2001;21:7724-7732.
14. Zhao BQ, Wang S, Kim HY, Storrie H, Rosen BR, Mooney DJ, Wang X, Lo EH. Role of matrix metalloproteinases in delayed cortical responses after stroke. Nat Med. 2006;12:441-445.
15. Tsuji K, Aoki T, Tejima E, Arai K, Lee SR, Atochin DN, Huang PL, Wang X, Montaner J, Lo EH. Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia. Stroke. 2005;36:1954-1959.
16. Asahi M, Sumii T, Fini ME, Itohara S, Lo EH. Matrix metalloproteinase 2 gene knockout has no effect on acute brain injury after focal ischemia. Neuroreport. 2001;12:3003-3007.
17. Asahi M, Asahi K, Jung JC, del Zoppo GJ, Fini ME, Lo EH. Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with bb-94. J Cereb Blood Flow Metab. 2000;20:1681-1689.
18. Wang X, Jung J, Asahi M, Chwang W, Russo L, Moskowitz MA, Dixon CE, Fini ME, Lo EH. Effects of matrix metalloproteinase-9 gene knock-out on morphological and motor outcomes after traumatic brain injury. J Neurosci. 2000;20:7037-7042.
19. Gibson CL, Bath PM, Murphy SP. G-CSF reduces infarct volume and improves functional outcome after transient focal cerebral ischemia in mice. J Cereb Blood Flow Metab. 2005;25:431-439.
20. Hattori K, Lee H, Hurn PD, Crain BJ, Traystman RJ, DeVries AC. Cognitive deficits after focal cerebral ischemia in mice. Stroke. 2000;31:1939 -1944.
21. Wakasugi K, Kitatsuji C, Morishima I. Possible neuroprotective mechanism of human neuroglobin. Ann N Y Acad Sci. 2005;1053:220 -230.
22. Herold S, Fago A. Reactions of peroxynitrite with globin proteins and their possible physiological role. Comp Biochem Physiol A Mol Integr Physiol. 2005;142:124-129.
23. Fago A, Mathews AJ, Dewilde S, Moens L, Brittain T. The reactions of neuroglobin with CO: evidence for two forms of the ferrous protein. J Inorg Biochem. 2006;100:1339-1343.
24. Brunori M, Giuffre A, Nienhaus K, Nienhaus GU, Scandurra FM, Vallone B. Neuroglobin, nitric oxide, and oxygen: functional pathways and conformational changes. Proc Natl Acad Sci U S A. 2005;102:8483- 8488.
25. Uno T, Ryu D, Tsutsumi H, Tomisugi Y, Ishikawa Y, Wilkinson AJ, Sato H, Hayashi T. Residues in the distal heme pocket of neuroglobin. Implications for the multiple ligand binding steps. J Biol Chem. 2004;279:5886 -5893.
26. Fago A, Hundahl C, Malte H, Weber RE. Functional properties of neuroglobin and cytoglobin. Insights into the ancestral physiological roles of globins. IUBMB Life. 2004;56:689-696.
27. Bunn HF, Poyton RO. Oxygen sensing and molecular adaptation to hypoxia. hysiol Rev. 1996;76:839-885.
28. Vanden Hoek TL, Becker LB, Shao Z, Li C, Schumacker PT. Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes. J Biol Chem. 1998;273:18092-18098.
29. Herold S, Fago A, Weber RE, Dewilde S, Moens L. Reactivity studies of the Fe(iii) and Fe(ii)NO forms of human neuroglobin reveal a potential role against oxidative stress. J Biol Chem. 2004;279:22841-22847.
30. Sims NR, Anderson MF. Mitochondrial contributions to tissue damage in stroke. Neurochem Int. 2002;40:511-526.
31. Saito A, Maier CM, Narasimhan P, Nishi T, Song YS, Yu F, Liu J, Lee YS, Nito C, Kamada H, Dodd RL, Hsieh LB, Hassid B, Kim EE, Gonzalez M, Chan PH. Oxidative stress and neuronal death/survival signaling in cerebral ischemia. Mol Neurobiol. 2005;31:105-116.
32. Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab. 2001;21:2-14.
33. Perez-Pinzon MA, Dave KR, Raval AP. Role of reactive oxygen species and protein kinase C in ischemic tolerance in the brain. Antioxid Redox Signal. 2005;7:1150-1157.