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Volumn 6, Issue 5, 2016, Pages

Inhibition of the mechanistic target of rapamycin (mTOR)–Rapamycin and beyond

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; RAPAMYCIN; ANTINEOPLASTIC ANTIBIOTIC; IMMUNOSUPPRESSIVE AGENT; TARGET OF RAPAMYCIN KINASE;

EID: 84964995198     PISSN: None     EISSN: 21571422     Source Type: Journal    
DOI: 10.1101/cshperspect.a025924     Document Type: Article
Times cited : (124)

References (114)
  • 2
    • 84891693313 scopus 로고    scopus 로고
    • Remodeling of lipid metabolism by dietary restriction of essential amino acids
    • Anthony TG, Morrison CD, Gettys TW. 2013. Remodeling of lipid metabolism by dietary restriction of essential amino acids. Diabetes 62: 2635–2644.
    • (2013) Diabetes , vol.62 , pp. 2635-2644
    • Anthony, T.G.1    Morrison, C.D.2    Gettys, T.W.3
  • 4
    • 84903158167 scopus 로고    scopus 로고
    • Regulation of mTORC1 by amino acids
    • Bar-Peled L, Sabatini DM. 2014. Regulation of mTORC1 by amino acids. Trends Cell Biol 24: 400–406.
    • (2014) Trends Cell Biol , vol.24 , pp. 400-406
    • Bar-Peled, L.1    Sabatini, D.M.2
  • 6
    • 84881098989 scopus 로고    scopus 로고
    • Feature article: MTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology
    • Betz C, Stracka D, Prescianotto-Baschong C, Frieden M, Demaurex N, Hall MN. 2013. Feature article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology. Proc Natl Acad Sci 110: 12526–12534.
    • (2013) Proc Natl Acad Sci , vol.110 , pp. 12526-12534
    • Betz, C.1    Stracka, D.2    Prescianotto-Baschong, C.3    Frieden, M.4    Demaurex, N.5    Hall, M.N.6
  • 8
    • 31544454965 scopus 로고    scopus 로고
    • Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise
    • Blomstrand E, Eliasson J, Karlsson HK, Kohnke R. 2006. Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise. J Nutr 136: 269S–273S.
    • (2006) J Nutr , vol.136 , pp. 269S-273S
    • Blomstrand, E.1    Eliasson, J.2    Karlsson, H.K.3    Kohnke, R.4
  • 10
    • 79959776029 scopus 로고    scopus 로고
    • Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson–Gilford progeria syndrome cells
    • Cao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS. 2011. Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson–Gilford progeria syndrome cells. Sci Transl Med 3: 89ra58.
    • (2011) Sci Transl Med , vol.3
    • Cao, K.1    Graziotto, J.J.2    Blair, C.D.3    Mazzulli, J.R.4    Erdos, M.R.5    Krainc, D.6    Collins, F.S.7
  • 11
    • 84937542416 scopus 로고    scopus 로고
    • The roles of mTOR complexes in lipid metabolism
    • Caron A, Richard D, Laplante M. 2015. The roles of mTOR complexes in lipid metabolism. Annu Rev Nutr 35: 321–348.
    • (2015) Annu Rev Nutr , vol.35 , pp. 321-348
    • Caron, A.1    Richard, D.2    Laplante, M.3
  • 13
    • 84908424235 scopus 로고    scopus 로고
    • Pet dogs set to test anti-ageing drug
    • Check Hayden E. 2014. Pet dogs set to test anti-ageing drug. Nature 514: 546.
    • (2014) Nature , vol.514 , pp. 546
    • Check Hayden, E.1
  • 14
    • 75549090275 scopus 로고    scopus 로고
    • MTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
    • Chen C, Liu Y, Liu Y, Zheng P. 2009. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal 2: ra75.
    • (2009) Sci Signal , vol.2
    • Chen, C.1    Liu, Y.2    Liu, Y.3    Zheng, P.4
  • 18
    • 84895817036 scopus 로고    scopus 로고
    • Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver
    • Fok WC, Bokov A, Gelfond J, Yu Z, Zhang Y, Doderer M, Chen Y, Javors M, Wood WH III, Zhang Y, et al. 2014a. Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver. Aging Cell 13: 311–319.
    • (2014) Aging Cell , vol.13 , pp. 311-319
    • Fok, W.C.1    Bokov, A.2    Gelfond, J.3    Yu, Z.4    Zhang, Y.5    Doderer, M.6    Chen, Y.7    Javors, M.8    Wood, W.9    Zhang, Y.10
  • 20
    • 84925852614 scopus 로고    scopus 로고
    • Promoting health and longevity through diet: From model organisms to humans
    • Fontana L, Partridge L. 2015. Promoting health and longevity through diet: From model organisms to humans. Cell 161: 106–118.
    • (2015) Cell , vol.161 , pp. 106-118
    • Fontana, L.1    Partridge, L.2
  • 22
    • 58649092475 scopus 로고    scopus 로고
    • MTOR complex 2 (MTORC2) controls hydrophobic motif phosphorylation and activation of serum-and glucocorticoid-induced protein kinase 1 (SGK1)
    • Garcia-Martinez JM, Alessi DR. 2008. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum-and glucocorticoid-induced protein kinase 1 (SGK1). Biochem J 416: 375–385.
    • (2008) Biochem J , vol.416 , pp. 375-385
    • Garcia-Martinez, J.M.1    Alessi, D.R.2
  • 24
    • 84904409445 scopus 로고    scopus 로고
    • Inhibition of Akt/mTOR attenuates age-related changes in mesenchymal stem cells
    • Gharibi B, Farzadi S, Ghuman M, Hughes FJ. 2014. Inhibition of Akt/mTOR attenuates age-related changes in mesenchymal stem cells. Stem Cells 32: 2256–2266.
    • (2014) Stem Cells , vol.32 , pp. 2256-2266
    • Gharibi, B.1    Farzadi, S.2    Ghuman, M.3    Hughes, F.J.4
  • 26
    • 33751348056 scopus 로고    scopus 로고
    • Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKC-α, but not S6K1
    • Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM. 2006. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKC-α, but not S6K1. Dev Cell 11: 859–871.
    • (2006) Dev Cell , vol.11 , pp. 859-871
    • Guertin, D.A.1    Stevens, D.M.2    Thoreen, C.C.3    Burds, A.A.4    Kalaany, N.Y.5    Moffat, J.6    Brown, M.7    Fitzgerald, K.J.8    Sabatini, D.M.9
  • 27
    • 84869085771 scopus 로고    scopus 로고
    • Influence of long-term caloric restriction on myocardial and cardiomyocyte contractile function and autophagy in mice
    • Han X, Turdi S, Hu N, Guo R, Zhang Y, Ren J. 2012. Influence of long-term caloric restriction on myocardial and cardiomyocyte contractile function and autophagy in mice. J Nutr Biochem 23: 1592–1599.
    • (2012) J Nutr Biochem , vol.23 , pp. 1592-1599
    • Han, X.1    Turdi, S.2    Hu, N.3    Guo, R.4    Zhang, Y.5    Ren, J.6
  • 28
    • 33846423520 scopus 로고    scopus 로고
    • Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
    • Hansen M, Taubert S, Crawford D, Libina N, Lee SJ, Kenyon C. 2007. Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 6: 95–110.
    • (2007) Aging Cell , vol.6 , pp. 95-110
    • Hansen, M.1    Taubert, S.2    Crawford, D.3    Libina, N.4    Lee, S.J.5    Kenyon, C.6
  • 29
    • 40149105890 scopus 로고    scopus 로고
    • A role for autophagy in the extension of lifespan by dietary restriction in C. Elegans
    • Hansen M, Chandra A, Mitic LL, Onken B, Driscoll M, Kenyon C. 2008. A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet 4: e24.
    • (2008) Plos Genet , vol.4
    • Hansen, M.1    Chandra, A.2    Mitic, L.L.3    Onken, B.4    Driscoll, M.5    Kenyon, C.6
  • 30
    • 84908356915 scopus 로고    scopus 로고
    • The TSC complex is required for the benefits of dietary protein restriction on stress resistance in vivo
    • Harputlugil E, Hine C, Vargas D, Robertson L, Manning BD, Mitchell JR. 2014. The TSC complex is required for the benefits of dietary protein restriction on stress resistance in vivo. Cell Rep 8: 1160–1170.
    • (2014) Cell Rep , vol.8 , pp. 1160-1170
    • Harputlugil, E.1    Hine, C.2    Vargas, D.3    Robertson, L.4    Manning, B.D.5    Mitchell, J.R.6
  • 37
    • 44949215822 scopus 로고    scopus 로고
    • The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
    • Huang J, Dibble CC, Matsuzaki M, Manning BD. 2008. The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol 28: 4104–4115.
    • (2008) Mol Cell Biol , vol.28 , pp. 4104-4115
    • Huang, J.1    Dibble, C.C.2    Matsuzaki, M.3    Manning, B.D.4
  • 39
    • 47949104258 scopus 로고    scopus 로고
    • Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
    • Ikenoue T, Inoki K, Yang Q, Zhou X, Guan KL. 2008. Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. Embo J 27: 1919–1931.
    • (2008) Embo J , vol.27 , pp. 1919-1931
    • Ikenoue, T.1    Inoki, K.2    Yang, Q.3    Zhou, X.4    Guan, K.L.5
  • 40
    • 48149112155 scopus 로고    scopus 로고
    • Sirolimus is associated with new-onset diabetes in kidney transplant recipients
    • Johnston O, Rose CL, Webster AC, Gill JS. 2008. Sirolimus is associated with new-onset diabetes in kidney transplant recipients. J Am Soc Nephrol 19: 1411–1418.
    • (2008) J am Soc Nephrol , vol.19 , pp. 1411-1418
    • Johnston, O.1    Rose, C.L.2    Webster, A.C.3    Gill, J.S.4
  • 43
    • 3042648746 scopus 로고    scopus 로고
    • Regulation of lifespan in Drosophila by modulation of genes in the TORsignaling pathway
    • Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S. 2004. Regulation of lifespan in Drosophila by modulation of genes in the TORsignaling pathway. Curr Biol 14: 885–890.
    • (2004) Curr Biol , vol.14 , pp. 885-890
    • Kapahi, P.1    Zid, B.M.2    Harper, T.3    Koslover, D.4    Sapin, V.5    Benzer, S.6
  • 44
  • 45
    • 79551598347 scopus 로고    scopus 로고
    • AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
    • Kim J, Kundu M, Viollet B, Guan KL. 2011. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 13: 132–141.
    • (2011) Nat Cell Biol , vol.13 , pp. 132-141
    • Kim, J.1    Kundu, M.2    Viollet, B.3    Guan, K.L.4
  • 46
  • 50
    • 84964966254 scopus 로고    scopus 로고
    • Calorie restriction and TOR signaling converge on sirtuin-mediated lifespan extension in Saccharomyces cerevisiae
    • Lamming DW, Medvedik O, Kim KD, Sinclair DA. 2007. Calorie restriction and TOR signaling converge on sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. Age 29: 118–118.
    • (2007) Age , vol.29
    • Lamming, D.W.1    Medvedik, O.2    Kim, K.D.3    Sinclair, D.A.4
  • 52
    • 84874611570 scopus 로고    scopus 로고
    • Rapalogs and mTOR inhibitors as anti-aging therapeutics
    • Lamming DW, Ye L, Sabatini DM, Baur JA. 2013. Rapalogs and mTOR inhibitors as anti-aging therapeutics. J Clin Invest 123: 980–989.
    • (2013) J Clin Invest , vol.123 , pp. 980-989
    • Lamming, D.W.1    Ye, L.2    Sabatini, D.M.3    Baur, J.A.4
  • 57
    • 84898614114 scopus 로고    scopus 로고
    • MTORC2 phosphorylates protein kinase Cto regulate its stability and activity
    • Li X, Gao T. 2014. mTORC2 phosphorylates protein kinase Cto regulate its stability and activity. EMBORep 15: 191–198.
    • (2014) Emborep , vol.15 , pp. 191-198
    • Li, X.1    Gao, T.2
  • 58
    • 84855219620 scopus 로고    scopus 로고
    • Leucine nutrition in animals and humans:MTOR signaling and beyond
    • Li F, Yin Y, Tan B, Kong X, Wu G. 2011. Leucine nutrition in animals and humans:mTOR signaling and beyond. Amino Acids 41: 1185–1193.
    • (2011) Amino Acids , vol.41 , pp. 1185-1193
    • Li, F.1    Yin, Y.2    Tan, B.3    Kong, X.4    Wu, G.5
  • 59
    • 84858964150 scopus 로고    scopus 로고
    • Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (MTOR) inhibitors and characterization of their binding kinetics
    • Liu Q, Kirubakaran S, Hur W, Niepel M, Westover K, Thoreen CC, Wang J, Ni J, Patricelli MP, Vogel K, et al. 2012. Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics. J Biol Chem 287: 9742–9752.
    • (2012) J Biol Chem , vol.287 , pp. 9742-9752
    • Liu, Q.1    Kirubakaran, S.2    Hur, W.3    Niepel, M.4    Westover, K.5    Thoreen, C.C.6    Wang, J.7    Ni, J.8    Patricelli, M.P.9    Vogel, K.10
  • 60
    • 84904512846 scopus 로고    scopus 로고
    • Phosphorylation of Akt at the C-terminal tail triggers Akt activation
    • Liu P, Wang Z, Wei W. 2014a. Phosphorylation of Akt at the C-terminal tail triggers Akt activation. Cell Cycle 13: 2162–2164.
    • (2014) Cell Cycle , vol.13 , pp. 2162-2164
    • Liu, P.1    Wang, Z.2    Wei, W.3
  • 62
    • 21244456553 scopus 로고    scopus 로고
    • Rheb binding to mammalian target of rapamycin (MTOR) is regulated by amino acid sufficiency
    • Long X, Ortiz-Vega S, Lin Y, Avruch J. 2005. Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency. J Biol Chem 280: 23433–23436.
    • (2005) J Biol Chem , vol.280 , pp. 23433-23436
    • Long, X.1    Ortiz-Vega, S.2    Lin, Y.3    Avruch, J.4
  • 64
    • 84868143077 scopus 로고    scopus 로고
    • STAT6-dependent and-independent mechanisms in Th2 polarization
    • Maier E, Duschl A, Horejs-Hoeck J. 2012. STAT6-dependent and-independent mechanisms in Th2 polarization. Eur J Immunol 42: 2827–2833.
    • (2012) Eur J Immunol , vol.42 , pp. 2827-2833
    • Maier, E.1    Duschl, A.2    Horejs-Hoeck, J.3
  • 66
    • 57749196739 scopus 로고    scopus 로고
    • The lowmethionine content of vegan diets may make methionine restriction feasible as a life extension strategy
    • McCarty MF, Barroso-Aranda J, Contreras F. 2009. The lowmethionine content of vegan diets may make methionine restriction feasible as a life extension strategy. Med Hypotheses 72: 125–128.
    • (2009) Med Hypotheses , vol.72 , pp. 125-128
    • McCarty, M.F.1    Barroso-Aranda, J.2    Contreras, F.3
  • 73
    • 84925271824 scopus 로고    scopus 로고
    • MTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity
    • Mizunuma M, Neumann-Haefelin E, Moroz N, Li Y, Blackwell TK. 2014. mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity. Aging Cell 13: 869–878.
    • (2014) Aging Cell , vol.13 , pp. 869-878
    • Mizunuma, M.1    Neumann-Haefelin, E.2    Moroz, N.3    Li, Y.4    Blackwell, T.K.5
  • 74
    • 84893341852 scopus 로고    scopus 로고
    • Absence of leucine in an essential amino acid supplement reduces activation of mTORC1 signalling following resistance exercise in young females
    • Moberg M, Apro W, Ohlsson I, Ponten M, Villanueva A, Ekblom B, Blomstrand E. 2014. Absence of leucine in an essential amino acid supplement reduces activation of mTORC1 signalling following resistance exercise in young females. Appl Physiol Nutr Metab 39: 183–194.
    • (2014) Appl Physiol Nutr Metab , vol.39 , pp. 183-194
    • Moberg, M.1    Apro, W.2    Ohlsson, I.3    Ponten, M.4    Villanueva, A.5    Ekblom, B.6    Blomstrand, E.7
  • 80
    • 30944458446 scopus 로고    scopus 로고
    • Extension of chronological life span in yeast by decreased TOR pathway signaling
    • Powers RW III, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S. 2006. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev 20: 174–184.
    • (2006) Genes Dev , vol.20 , pp. 174-184
    • Powers, R.1    Kaeberlein, M.2    Caldwell, S.D.3    Kennedy, B.K.4    Fields, S.5
  • 81
    • 84896973434 scopus 로고    scopus 로고
    • Everolimus in advanced solid tumors: When to start, early or late?
    • Pusceddu S, Tessari A, Testa I, Procopio G. 2014. Everolimus in advanced solid tumors: When to start, early or late? Tumori 100: 2e–3e.
    • (2014) Tumori , vol.100 , pp. 2e-3e
    • Pusceddu, S.1    Tessari, A.2    Testa, I.3    Procopio, G.4
  • 84
    • 84860431090 scopus 로고    scopus 로고
    • Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat
    • Rodriguez KA, Edrey YH, Osmulski P, Gaczynska M, Buffenstein R. 2012. Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat. PLoS ONE 7: e35890.
    • (2012) Plos ONE , vol.7
    • Rodriguez, K.A.1    Edrey, Y.H.2    Osmulski, P.3    Gaczynska, M.4    Buffenstein, R.5
  • 86
    • 79953307234 scopus 로고    scopus 로고
    • Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size
    • Saci A, Cantley LCT, Carpenter CL. 2011. Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size. Mol Cell 42: 50–61.
    • (2011) Mol Cell , vol.42 , pp. 50-61
    • Saci, A.1    Cantley, L.2    Carpenter, C.L.3
  • 87
    • 77951768486 scopus 로고    scopus 로고
    • Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
    • Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. 2010. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141: 290–303.
    • (2010) Cell , vol.141 , pp. 290-303
    • Sancak, Y.1    Bar-Peled, L.2    Zoncu, R.3    Markhard, A.L.4    Nada, S.5    Sabatini, D.M.6
  • 88
    • 33745656396 scopus 로고    scopus 로고
    • Leucine activates pancreatic translational machinery in rats and mice through mTOR independently of CCK and insulin
    • Sans MD, Tashiro M, Vogel NL, Kimball SR, D’Alecy LG, Williams JA. 2006. Leucine activates pancreatic translational machinery in rats and mice through mTOR independently of CCK and insulin. J Nutr 136: 1792–1799.
    • (2006) J Nutr , vol.136 , pp. 1792-1799
    • Sans, M.D.1    Tashiro, M.2    Vogel, N.L.3    Kimball, S.R.4    D’Alecy, L.G.5    Williams, J.A.6
  • 91
    • 79551563247 scopus 로고    scopus 로고
    • Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1
    • Selman C, Partridge L, Withers DJ. 2011. Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1. PLoS ONE 6: e16144.
    • (2011) Plos ONE , vol.6
    • Selman, C.1    Partridge, L.2    Withers, D.J.3
  • 92
    • 84901651824 scopus 로고    scopus 로고
    • Rapamycin and mTOR: A serendipitous discovery and implications for breast cancer
    • Seto B. 2012. Rapamycin and mTOR: A serendipitous discovery and implications for breast cancer. Clin TransMed 1: 29.
    • (2012) Clin Transmed , vol.1 , pp. 29
    • Seto, B.1
  • 97
    • 33847199335 scopus 로고    scopus 로고
    • EIF4E function in somatic cells modulates ageing in Caenorhabditis elegans
    • Syntichaki P, Troulinaki K, Tavernarakis N. 2007. eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Nature 445: 922–926.
    • (2007) Nature , vol.445 , pp. 922-926
    • Syntichaki, P.1    Troulinaki, K.2    Tavernarakis, N.3
  • 98
    • 84962018940 scopus 로고    scopus 로고
    • Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling
    • Tao R, Xiong X, Liangpunsakul S, Dong XC. 2014. Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling. Diabetes 64: 1211–1223.
    • (2014) Diabetes , vol.64 , pp. 1211-1223
    • Tao, R.1    Xiong, X.2    Liangpunsakul, S.3    Dong, X.C.4
  • 103
    • 0016724057 scopus 로고
    • Rapamycin (AY-22,989), a new antifungal antibiotic. I: Taxonomy of the producing streptomycete and isolation of the active principle
    • Vezina C, Kudelski A, Sehgal SN. 1975. Rapamycin (AY-22,989), a new antifungal antibiotic. I: Taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot (Tokyo) 28: 721–726.
    • (1975) J Antibiot (Tokyo) , vol.28 , pp. 721-726
    • Vezina, C.1    Kudelski, A.2    Sehgal, S.N.3
  • 107
    • 79952374033 scopus 로고    scopus 로고
    • Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/ S6K1 and AMPK pathways
    • Xiao F, Huang Z, Li H, Yu J, Wang C, Chen S, Meng Q, Cheng Y, Gao X, Li J, et al. 2011. Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/ S6K1 and AMPK pathways. Diabetes 60: 746–756.
    • (2011) Diabetes , vol.60 , pp. 746-756
    • Xiao, F.1    Huang, Z.2    Li, H.3    Yu, J.4    Wang, C.5    Chen, S.6    Meng, Q.7    Cheng, Y.8    Gao, X.9    Li, J.10
  • 111
    • 51349095898 scopus 로고    scopus 로고
    • Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function
    • Zhang C, Cuervo AM. 2008. Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. Nat Med 14: 959–965.
    • (2008) Nat Med , vol.14 , pp. 959-965
    • Zhang, C.1    Cuervo, A.M.2
  • 114
    • 79952293503 scopus 로고    scopus 로고
    • Activation of mTORC2 by association with the ribosome
    • Zinzalla V, Stracka D, Oppliger W, Hall MN. 2011. Activation of mTORC2 by association with the ribosome. Cell 144: 757–768.
    • (2011) Cell , vol.144 , pp. 757-768
    • Zinzalla, V.1    Stracka, D.2    Oppliger, W.3    Hall, M.N.4


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