The sestrins interact with gator2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1

Cell Reports

Volumn 9, Issue 1, 2014, Pages 1-8

  Chantranupong, Lynne ^a,b,c   Wolfson, Rachel L ^a,b,c   Orozco, Jose M ^a,b,c   Saxton, Robert A ^a,b,c   Scaria, Sonia M ^a,b   Bar Peled, Liron ^a,b,c,e   Spooner, Eric ^a   Isasa, Marta ^d   Gygi, Steven P ^d   Sabatini, David M ^a,b,c  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c KOCH INSTITUTE FOR INTEGRATIVE CANCER RESEARCH   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; DNA; GATOR1; GATOR2; GROWTH FACTOR; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; LIPID; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PROTEIN; SESTRIN1; SESTRIN2; SESTRIN3; UNCLASSIFIED DRUG; HEAT SHOCK PROTEIN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; NUCLEAR PROTEIN; SESN1 PROTEIN, HUMAN; SESN2 PROTEIN, HUMAN; SESN3 PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

ARTICLE; CELL GROWTH; CELL STRESS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA FLANKING REGION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIPOGENESIS; LYSOSOME; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RNA TRANSLATION; GENETICS; HEK293 CELL LINE; METABOLISM; SIGNAL TRANSDUCTION;

AMINO ACIDS; HEAT-SHOCK PROTEINS; HEK293 CELLS; HUMANS; MULTIPROTEIN COMPLEXES; NUCLEAR PROTEINS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84907991157     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.09.014     Document Type: Article

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