메뉴 건너뛰기




Volumn 42, Issue 11, 2012, Pages 2827-2833

STAT6-dependent and -independent mechanisms in Th2 polarization

Author keywords

IL 2 STAT5 signaling; IL 4 STAT6 signaling; MTOR signaling; Notch signaling; Th2 cell polarization; Wnt signaling

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 4; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; NOTCH RECEPTOR; STAT5 PROTEIN; STAT6 PROTEIN; TRANSCRIPTION FACTOR GATA 3; WNT PROTEIN;

EID: 84868143077     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201242433     Document Type: Article
Times cited : (132)

References (59)
  • 1
    • 77449090327 scopus 로고    scopus 로고
    • How diverse-CD4 effector T cells and their functions
    • Wan, Y. Y. and Flavell, R. A., How diverse-CD4 effector T cells and their functions. J. Mol. Cell Biol. 2009. 1: 20-36.
    • (2009) J. Mol. Cell Biol. , vol.1 , pp. 20-36
    • Wan, Y.Y.1    Flavell, R.A.2
  • 2
    • 77950261975 scopus 로고    scopus 로고
    • How are T(H)2-type immune responses initiated and amplified?
    • Paul, W. E. and Zhu, J., How are T(H)2-type immune responses initiated and amplified? Nat. Rev. Immunol. 2010. 10: 225-235.
    • (2010) Nat. Rev. Immunol , vol.10 , pp. 225-235
    • Paul, W.E.1    Zhu, J.2
  • 4
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
    • Kaplan, M. H., Schindler, U., Smiley, S. T. and Grusby, M. J., Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 1996. 4: 313-319.
    • (1996) Immunity , vol.4 , pp. 313-319
    • Kaplan, M.H.1    Schindler, U.2    Smiley, S.T.3    Grusby, M.J.4
  • 5
    • 4344647601 scopus 로고    scopus 로고
    • Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite
    • Min, B., Prout, M., Hu-Li, J., Zhu, J., Jankovic, D., Morgan, E. S., Urban, J. F., Jr. et al., Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. J. Exp. Med. 2004. 200: 507-517.
    • (2004) J. Exp. Med. , vol.200 , pp. 507-517
    • Min, B.1    Prout, M.2    Hu-Li, J.3    Zhu, J.4    Jankovic, D.5    Morgan, E.S.6    Urban Jr., J.F.7
  • 7
    • 48849102176 scopus 로고    scopus 로고
    • Mast cell production of IL-4 and TNF may be required for protective and pathological responses in gastrointestinal helminth infection
    • Ierna, M. X., Scales, H. E., Saunders, K. L. and Lawrence, C. E., Mast cell production of IL-4 and TNF may be required for protective and pathological responses in gastrointestinal helminth infection. Mucosal. Immunol. 2008. 1: 147-155.
    • (2008) Mucosal. Immunol. , vol.1 , pp. 147-155
    • Ierna, M.X.1    Scales, H.E.2    Saunders, K.L.3    Lawrence, C.E.4
  • 8
    • 33646407864 scopus 로고    scopus 로고
    • Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE
    • Gregory, G. D., Raju, S. S., Winandy, S. and Brown, M. A., Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE. J. Clin. Invest. 2006. 116: 1327-1336.
    • (2006) J. Clin. Invest. , vol.116 , pp. 1327-1336
    • Gregory, G.D.1    Raju, S.S.2    Winandy, S.3    Brown, M.A.4
  • 9
    • 0028177589 scopus 로고
    • CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3
    • Yoshimoto, T. and Paul, W. E., CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 1994. 179: 1285-1295.
    • (1994) J. Exp. Med. , vol.179 , pp. 1285-1295
    • Yoshimoto, T.1    Paul, W.E.2
  • 10
    • 0032715407 scopus 로고    scopus 로고
    • Stat6-dependent and -independent pathways for IL-4 production
    • Kaplan, M. H., Wurster, A. L., Smiley, S. T. and Grusby, M. J., Stat6-dependent and -independent pathways for IL-4 production. J. Immunol. 1999. 163: 6536-6540.
    • (1999) J. Immunol. , vol.163 , pp. 6536-6540
    • Kaplan, M.H.1    Wurster, A.L.2    Smiley, S.T.3    Grusby, M.J.4
  • 11
    • 65549114338 scopus 로고    scopus 로고
    • IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells
    • King, I. L. and Mohrs, M., IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells. J. Exp. Med. 2009. 206: 1001-1007.
    • (2009) J. Exp. Med. , vol.206 , pp. 1001-1007
    • King, I.L.1    Mohrs, M.2
  • 12
    • 0036153073 scopus 로고    scopus 로고
    • The IL-4 production capability of different strains of naive CD4(+) T cells controls the direction of the T(h) cell response
    • Yagi, R., Suzuki, W., Seki, N., Kohyama, M., Inoue, T., Arai, T. and Kubo, M., The IL-4 production capability of different strains of naive CD4(+) T cells controls the direction of the T(h) cell response. Int. Immunol. 2002. 14: 1-11.
    • (2002) Int. Immunol. , vol.14 , pp. 1-11
    • Yagi, R.1    Suzuki, W.2    Seki, N.3    Kohyama, M.4    Inoue, T.5    Arai, T.6    Kubo, M.7
  • 13
    • 79952985551 scopus 로고    scopus 로고
    • The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
    • Delgoffe, G. M., Pollizzi, K. N., Waickman, A. T., Heikamp, E., Meyers, D. J., Horton, M. R., Xiao, B. et al., The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat. Immunol. 2011. 12: 295-303.
    • (2011) Nat. Immunol. , vol.12 , pp. 295-303
    • Delgoffe, G.M.1    Pollizzi, K.N.2    Waickman, A.T.3    Heikamp, E.4    Meyers, D.J.5    Horton, M.R.6    Xiao, B.7
  • 15
    • 34447634411 scopus 로고    scopus 로고
    • Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch
    • Amsen, D., Antov, A., Jankovic, D., Sher, A., Radtke, F., Souabni, A., Busslinger, M. et al., Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity 2007. 27: 89-99.
    • (2007) Immunity , vol.27 , pp. 89-99
    • Amsen, D.1    Antov, A.2    Jankovic, D.3    Sher, A.4    Radtke, F.5    Souabni, A.6    Busslinger, M.7
  • 16
    • 69049088648 scopus 로고    scopus 로고
    • T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma
    • Yu, Q., Sharma, A., Oh, S. Y., Moon, H. G., Hossain, M. Z., Salay, T. M., Leeds, K. E. et al., T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma. Nat. Immunol. 2009. 10: 992-999.
    • (2009) Nat. Immunol. , vol.10 , pp. 992-999
    • Yu, Q.1    Sharma, A.2    Oh, S.Y.3    Moon, H.G.4    Hossain, M.Z.5    Salay, T.M.6    Leeds, K.E.7
  • 18
    • 0033973582 scopus 로고    scopus 로고
    • Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment
    • Ouyang, W., Lohning, M., Gao, Z., Assenmacher, M., Ranganath, S., Radbruch, A. and Murphy, K. M., Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity 2000. 12: 27-37.
    • (2000) Immunity , vol.12 , pp. 27-37
    • Ouyang, W.1    Lohning, M.2    Gao, Z.3    Assenmacher, M.4    Ranganath, S.5    Radbruch, A.6    Murphy, K.M.7
  • 19
    • 79955574671 scopus 로고    scopus 로고
    • Transcriptional regulation by STAT6
    • Goenka, S. and Kaplan, M. H., Transcriptional regulation by STAT6. Immunol. Res. 2011. 50: 87-96.
    • (2011) Immunol. Res. , vol.50 , pp. 87-96
    • Goenka, S.1    Kaplan, M.H.2
  • 21
    • 0035794217 scopus 로고    scopus 로고
    • DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites
    • Ehret, G. B., Reichenbach, P., Schindler, U., Horvath, C. M., Fritz, S., Nabholz, M. and Bucher, P., DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites. J. Biol. Chem. 2001. 276: 6675-6688.
    • (2001) J. Biol. Chem. , vol.276 , pp. 6675-6688
    • Ehret, G.B.1    Reichenbach, P.2    Schindler, U.3    Horvath, C.M.4    Fritz, S.5    Nabholz, M.6    Bucher, P.7
  • 22
    • 0034544564 scopus 로고    scopus 로고
    • IL-4-activated STAT-6 inhibits IFN-gamma-induced CD40 gene expression in macrophages/microglia
    • Nguyen, V. T. and Benveniste, E. N., IL-4-activated STAT-6 inhibits IFN-gamma-induced CD40 gene expression in macrophages/microglia. J. Immunol. 2000. 165: 6235-6243.
    • (2000) J. Immunol. , vol.165 , pp. 6235-6243
    • Nguyen, V.T.1    Benveniste, E.N.2
  • 23
    • 0030892382 scopus 로고    scopus 로고
    • Interleukin-4 suppression of tumor necrosis factor alpha-stimulated E-selectin gene transcription is mediated by STAT6 antagonism of NF-kappaB
    • Bennett, B. L., Cruz, R., Lacson, R. G. and Manning, A. M., Interleukin-4 suppression of tumor necrosis factor alpha-stimulated E-selectin gene transcription is mediated by STAT6 antagonism of NF-kappaB. J. Biol. Chem. 1997. 272: 10212-10219.
    • (1997) J. Biol. Chem. , vol.272 , pp. 10212-10219
    • Bennett, B.L.1    Cruz, R.2    Lacson, R.G.3    Manning, A.M.4
  • 24
    • 77953881949 scopus 로고    scopus 로고
    • Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming
    • Elo, L. L., Jarvenpaa, H., Tuomela, S., Raghav, S., Ahlfors, H., Laurila, K., Gupta, B. et al., Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming. Immunity 2010. 32: 852-862.
    • (2010) Immunity , vol.32 , pp. 852-862
    • Elo, L.L.1    Jarvenpaa, H.2    Tuomela, S.3    Raghav, S.4    Ahlfors, H.5    Laurila, K.6    Gupta, B.7
  • 25
  • 26
    • 0036568950 scopus 로고    scopus 로고
    • Cutting edge: identification of an alternative GATA-3 promoter directing tissue-specific gene expression in mouse and human
    • Asnagli, H., Afkarian, M. and Murphy, K. M., Cutting edge: identification of an alternative GATA-3 promoter directing tissue-specific gene expression in mouse and human. J. Immunol. 2002. 168: 4268-4271.
    • (2002) J. Immunol. , vol.168 , pp. 4268-4271
    • Asnagli, H.1    Afkarian, M.2    Murphy, K.M.3
  • 27
    • 59149092952 scopus 로고    scopus 로고
    • Transcriptional regulation of GATA3 in T helper cells by the integrated activities of transcription factors downstream of the interleukin-4 receptor and T cell receptor
    • Scheinman, E. J. and Avni, O., Transcriptional regulation of GATA3 in T helper cells by the integrated activities of transcription factors downstream of the interleukin-4 receptor and T cell receptor. J. Biol. Chem. 2009. 284: 3037-3048.
    • (2009) J. Biol. Chem. , vol.284 , pp. 3037-3048
    • Scheinman, E.J.1    Avni, O.2
  • 28
    • 0035884930 scopus 로고    scopus 로고
    • Activation of eotaxin-3/CCL26 gene expression in human dermal fibroblasts is mediated by STAT6
    • Hoeck, J. and Woisetschlager, M., Activation of eotaxin-3/CCL26 gene expression in human dermal fibroblasts is mediated by STAT6. J. Immunol. 2001. 167: 3216-3222.
    • (2001) J. Immunol. , vol.167 , pp. 3216-3222
    • Hoeck, J.1    Woisetschlager, M.2
  • 29
    • 0035313367 scopus 로고    scopus 로고
    • STAT6 mediates eotaxin-1 expression in IL-4 or TNF-alpha-induced fibroblasts
    • Hoeck, J. and Woisetschlager, M., STAT6 mediates eotaxin-1 expression in IL-4 or TNF-alpha-induced fibroblasts. J. Immunol. 2001. 166: 4507-4515.
    • (2001) J. Immunol. , vol.166 , pp. 4507-4515
    • Hoeck, J.1    Woisetschlager, M.2
  • 33
    • 0032482159 scopus 로고    scopus 로고
    • Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice
    • Akimoto, T., Numata, F., Tamura, M., Takata, Y., Higashida, N., Takashi, T., Takeda, K. et al., Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice. J. Exp. Med. 1998. 187: 1537-1542.
    • (1998) J. Exp. Med. , vol.187 , pp. 1537-1542
    • Akimoto, T.1    Numata, F.2    Tamura, M.3    Takata, Y.4    Higashida, N.5    Takashi, T.6    Takeda, K.7
  • 34
    • 15844374279 scopus 로고    scopus 로고
    • Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
    • Shimoda, K., van Deursen, J., Sangster, M. Y., Sarawar, S. R., Carson, R. T., Tripp, R. A., Chu, C. et al., Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 1996. 380: 630-633.
    • (1996) Nature , vol.380 , pp. 630-633
    • Shimoda, K.1    van Deursen, J.2    Sangster, M.Y.3    Sarawar, S.R.4    Carson, R.T.5    Tripp, R.A.6    Chu, C.7
  • 36
    • 53849139093 scopus 로고    scopus 로고
    • Interleukin-4, interleukin-13, signal transducer and activator of transcription factor 6, and allergic asthma
    • Kuperman, D. A. and Schleimer, R. P., Interleukin-4, interleukin-13, signal transducer and activator of transcription factor 6, and allergic asthma. Curr. Mol. Med. 2008. 8: 384-392.
    • (2008) Curr. Mol. Med. , vol.8 , pp. 384-392
    • Kuperman, D.A.1    Schleimer, R.P.2
  • 37
    • 77953917067 scopus 로고    scopus 로고
    • Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation
    • Wei, L., Vahedi, G., Sun, H. W., Watford, W. T., Takatori, H., Ramos, H. L., Takahashi, H. et al., Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation. Immunity 2010. 32: 840-851.
    • (2010) Immunity , vol.32 , pp. 840-851
    • Wei, L.1    Vahedi, G.2    Sun, H.W.3    Watford, W.T.4    Takatori, H.5    Ramos, H.L.6    Takahashi, H.7
  • 40
    • 77952584843 scopus 로고    scopus 로고
    • The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation
    • Chang, H. C., Sehra, S., Goswami, R., Yao, W., Yu, Q., Stritesky, G. L., Jabeen, R. et al., The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat. Immunol. 2010. 11: 527-534.
    • (2010) Nat. Immunol. , vol.11 , pp. 527-534
    • Chang, H.C.1    Sehra, S.2    Goswami, R.3    Yao, W.4    Yu, Q.5    Stritesky, G.L.6    Jabeen, R.7
  • 41
    • 84862665298 scopus 로고    scopus 로고
    • The symphony of the ninth: the development and function of Th9 cells
    • Jabeen, R. and Kaplan, M. H., The symphony of the ninth: the development and function of Th9 cells. Curr. Opin. Immunol. 2012. 24: 303-307.
    • (2012) Curr. Opin. Immunol. , vol.24 , pp. 303-307
    • Jabeen, R.1    Kaplan, M.H.2
  • 42
    • 0035742649 scopus 로고    scopus 로고
    • Upon prolonged allergen exposure IL-4 and IL-4Ralpha knockout mice produce specific IgE leading to anaphylaxis
    • Grunewald, S. M., Teufel, M., Erb, K., Nelde, A., Mohrs, M., Brombacher, F., Brocker, E. B. et al., Upon prolonged allergen exposure IL-4 and IL-4Ralpha knockout mice produce specific IgE leading to anaphylaxis. Int. Arch. Allergy Immunol. 2001. 125: 322-328.
    • (2001) Int. Arch. Allergy Immunol. , vol.125 , pp. 322-328
    • Grunewald, S.M.1    Teufel, M.2    Erb, K.3    Nelde, A.4    Mohrs, M.5    Brombacher, F.6    Brocker, E.B.7
  • 43
    • 58849099058 scopus 로고    scopus 로고
    • The different faces of Notch in T-helper-cell differentiation
    • Amsen, D., Antov, A. and Flavell, R. A., The different faces of Notch in T-helper-cell differentiation. Nat. Rev. Immunol. 2009. 9: 116-124.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 116-124
    • Amsen, D.1    Antov, A.2    Flavell, R.A.3
  • 44
    • 78650642332 scopus 로고    scopus 로고
    • Notch ligand delta-like 4 regulates development and pathogenesis of allergic airway responses by modulating IL-2 production and Th2 immunity
    • Jang, S., Schaller, M., Berlin, A. A. and Lukacs, N. W., Notch ligand delta-like 4 regulates development and pathogenesis of allergic airway responses by modulating IL-2 production and Th2 immunity. J. Immunol. 2010. 185: 5835-5844.
    • (2010) J. Immunol. , vol.185 , pp. 5835-5844
    • Jang, S.1    Schaller, M.2    Berlin, A.A.3    Lukacs, N.W.4
  • 45
    • 36549001590 scopus 로고    scopus 로고
    • Notch ligand delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines
    • Schaller, M. A., Neupane, R., Rudd, B. D., Kunkel, S. L., Kallal, L. E., Lincoln, P., Lowe, J. B. et al., Notch ligand delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines. J. Exp. Med. 2007. 204: 2925-2934.
    • (2007) J. Exp. Med. , vol.204 , pp. 2925-2934
    • Schaller, M.A.1    Neupane, R.2    Rudd, B.D.3    Kunkel, S.L.4    Kallal, L.E.5    Lincoln, P.6    Lowe, J.B.7
  • 47
    • 70350418625 scopus 로고    scopus 로고
    • mTOR signaling at a glance
    • Laplante, M. and Sabatini, D. M., mTOR signaling at a glance. J. Cell Sci. 2009. 122: 3589-3594.
    • (2009) J. Cell Sci. , vol.122 , pp. 3589-3594
    • Laplante, M.1    Sabatini, D.M.2
  • 48
    • 0036790814 scopus 로고    scopus 로고
    • Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation
    • Seki, Y., Hayashi, K., Matsumoto, A., Seki, N., Tsukada, J., Ransom, J., Naka, T. et al., Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. Proc. Natl. Acad. Sci. USA 2002. 99: 13003-13008.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 13003-13008
    • Seki, Y.1    Hayashi, K.2    Matsumoto, A.3    Seki, N.4    Tsukada, J.5    Ransom, J.6    Naka, T.7
  • 49
    • 77953897189 scopus 로고    scopus 로고
    • Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
    • Lee, K., Gudapati, P., Dragovic, S., Spencer, C., Joyce, S., Killeen, N., Magnuson, M. A. et al., Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity 2010. 32: 743-753.
    • (2010) Immunity , vol.32 , pp. 743-753
    • Lee, K.1    Gudapati, P.2    Dragovic, S.3    Spencer, C.4    Joyce, S.5    Killeen, N.6    Magnuson, M.A.7
  • 50
    • 0344064893 scopus 로고    scopus 로고
    • Stat5 activation plays a critical role in Th2 differentiation
    • Zhu, J., Cote-Sierra, J., Guo, L. and Paul, W. E., Stat5 activation plays a critical role in Th2 differentiation. Immunity 2003. 19: 739-748.
    • (2003) Immunity , vol.19 , pp. 739-748
    • Zhu, J.1    Cote-Sierra, J.2    Guo, L.3    Paul, W.E.4
  • 51
    • 14844344803 scopus 로고    scopus 로고
    • Indispensable role of Stat5a in Stat6-independent Th2 cell differentiation and allergic airway inflammation
    • Takatori, H., Nakajima, H., Hirose, K., Kagami, S., Tamachi, T., Suto, A., Suzuki, K. et al., Indispensable role of Stat5a in Stat6-independent Th2 cell differentiation and allergic airway inflammation. J. Immunol. 2005. 174: 3734-3740.
    • (2005) J. Immunol. , vol.174 , pp. 3734-3740
    • Takatori, H.1    Nakajima, H.2    Hirose, K.3    Kagami, S.4    Tamachi, T.5    Suto, A.6    Suzuki, K.7
  • 52
    • 69449106110 scopus 로고    scopus 로고
    • IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
    • Guo, L., Wei, G., Zhu, J., Liao, W., Leonard, W. J., Zhao, K. and Paul, W., IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc. Natl. Acad. Sci. USA 2009. 106: 13463-13468.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 13463-13468
    • Guo, L.1    Wei, G.2    Zhu, J.3    Liao, W.4    Leonard, W.J.5    Zhao, K.6    Paul, W.7
  • 53
    • 48749101937 scopus 로고    scopus 로고
    • WNT signalling in the immune system: WNT is spreading its wings
    • Staal, F. J., Luis, T. C. and Tiemessen, M. M., WNT signalling in the immune system: WNT is spreading its wings. Nat. Rev. Immunol. 2008. 8: 581-593.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 581-593
    • Staal, F.J.1    Luis, T.C.2    Tiemessen, M.M.3
  • 54
  • 55
  • 56
    • 75749152053 scopus 로고    scopus 로고
    • Global regulator SATB1 recruits beta-catenin and regulates T(H)2 differentiation in Wnt-dependent manner
    • Notani, D., Gottimukkala, K. P., Jayani, R. S., Limaye, A. S., Damle, M. V., Mehta, S., Purbey, P. K. et al., Global regulator SATB1 recruits beta-catenin and regulates T(H)2 differentiation in Wnt-dependent manner. PLoS Biol. 2010. 8: e1000296.
    • (2010) PLoS Biol. , vol.8
    • Notani, D.1    Gottimukkala, K.P.2    Jayani, R.S.3    Limaye, A.S.4    Damle, M.V.5    Mehta, S.6    Purbey, P.K.7
  • 57
    • 79955031250 scopus 로고    scopus 로고
    • T cell factor-1 negatively regulates expression of IL-17 family of cytokines and protects mice from experimental autoimmune encephalomyelitis
    • Yu, Q., Sharma, A., Ghosh, A. and Sen, J. M., T cell factor-1 negatively regulates expression of IL-17 family of cytokines and protects mice from experimental autoimmune encephalomyelitis. J. Immunol. 2011. 186: 3946-3952.
    • (2011) J. Immunol. , vol.186 , pp. 3946-3952
    • Yu, Q.1    Sharma, A.2    Ghosh, A.3    Sen, J.M.4
  • 58
    • 11244305618 scopus 로고    scopus 로고
    • WNT signalling and haematopoiesis: a WNT-WNT situation
    • Staal, F. J. and Clevers, H. C., WNT signalling and haematopoiesis: a WNT-WNT situation. Nat. Rev. Immunol. 2005. 5: 21-30.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 21-30
    • Staal, F.J.1    Clevers, H.C.2
  • 59
    • 78651400178 scopus 로고    scopus 로고
    • Inhibition of suppressive T cell factor 1 (TCF-1) isoforms in naive CD4+ T cells is mediated by IL-4/STAT6 signaling
    • Maier, E., Hebenstreit, D., Posselt, G., Hammerl, P., Duschl, A. and Horejs-Hoeck, J., Inhibition of suppressive T cell factor 1 (TCF-1) isoforms in naive CD4+ T cells is mediated by IL-4/STAT6 signaling. J. Biol. Chem. 2011. 286: 919-928.
    • (2011) J. Biol. Chem. , vol.286 , pp. 919-928
    • Maier, E.1    Hebenstreit, D.2    Posselt, G.3    Hammerl, P.4    Duschl, A.5    Horejs-Hoeck, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.