Elevated proteasome capacity extends replicative lifespan in saccharomyces cerevisiae

PLoS Genetics

Volumn 7, Issue 9, 2011, Pages

  Kruegel, Undine ^a   Robison, Brett ^b,c   Dange, Thomas ^a,e   Kahlert, Günther ^d   Delaney, Joe R ^b   Kotireddy, Soumya ^b   Tsuchiya, Mitsuhiro ^c   Tsuchiyama, Scott ^c   Murakami, Christopher J ^b   Schleit, Jennifer ^b   Sutphin, George ^b   Carr, Daniel ^b   Tar, Krisztina ^a   Dittmar, Gunnar ^d   Kaeberlein, Matt ^b   Kennedy, Brian K ^b,c   Schmidt, Marion ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^d MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^e DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

HUNTINGTIN; PROTEASOME; SIRTUIN 1; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RPN4; TRANSCRIPTION FACTOR YAP1; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE UBR2; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; RPN4 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; SILENT INFORMATION REGULATOR PROTEIN; SIR2 PROTEIN, S CEREVISIAE; SIRTUIN 2; TOR1 PROTEIN, S CEREVISIAE; UBR2 PROTEIN, S CEREVISIAE; YAP1 PROTEIN, S CEREVISIAE;

AGING; ARTICLE; CONTROLLED STUDY; DETOXIFICATION; DIET RESTRICTION; ENZYME REGULATION; EPISTASIS; GENE LOSS; LIFESPAN; LONGEVITY; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PROTEIN METABOLISM; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION REGULATION; UPREGULATION; DNA REPLICATION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; TRANSCRIPTION INITIATION;

HETEROCEPHALUS GLABER; RODENTIA; SACCHAROMYCES CEREVISIAE;

DNA REPLICATION; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; HUMANS; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEASOME ENDOPEPTIDASE COMPLEX; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUIN 2; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 80053445278     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002253     Document Type: Article

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