Inhibition of Akt/mTOR attenuates age-related changes in mesenchymal stem cells

Stem Cells

Volumn 32, Issue 8, 2014, Pages 2256-2266

  Gharibi, Borzo ^a   Farzadi, Samira ^a   Ghuman, Mandeep ^a   Hughes, Francis J ^a  

^a GUY S HOSPITAL   (United Kingdom)

Author keywords

Aging; Akt; Mammalian target of rapamycin; Mesenchymal stem cell; Rapamycin; Self renewal

Indexed keywords

ALKALINE PHOSPHATASE; MAMMALIAN TARGET OF RAPAMYCIN; OCTAMER TRANSCRIPTION FACTOR 4; OSTEOPONTIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR RUNX2; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

AGING; ARTICLE; BONE DEVELOPMENT; CELL CULTURE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CELL RENEWAL; CELL SIZE; CELL STRUCTURE; CLONOGENESIS; CONTROLLED STUDY; CYTOPLASM; DNA DAMAGE; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; MESENCHYMAL STEM CELL; PHENOTYPE; PROTEIN EXPRESSION; SENESCENCE; STEM CELL EXPANSION; ADULT; CELL AGING; COMET ASSAY; CYTOLOGY; FEMALE; FLOW CYTOMETRY; MALE; MESENCHYMAL STROMA CELL; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; YOUNG ADULT;

ADULT; BLOTTING, WESTERN; CELL AGING; CELL DIFFERENTIATION; COMET ASSAY; DNA DAMAGE; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; MESENCHYMAL STROMAL CELLS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOR SERINE-THREONINE KINASES; YOUNG ADULT;

EID: 84904409445     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1709     Document Type: Article

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