-
1
-
-
21144450049
-
ATP hydrolysis-dependent disassembly of the 26S proteasome is part of the catalytic cycle
-
Babbitt, S. E., Kiss, A., Deffenbaugh, A. E., Chang, Y. H., Bailly, E., Erdjument-Bromage, H., et al. (2005). ATP hydrolysis-dependent disassembly of the 26S proteasome is part of the catalytic cycle. Cell 121, 553-565. doi: 10.1016/j.cell.2005.03.028
-
(2005)
Cell
, vol.121
, pp. 553-565
-
-
Babbitt, S.E.1
Kiss, A.2
Deffenbaugh, A.E.3
Chang, Y.H.4
Bailly, E.5
Erdjument-Bromage, H.6
-
2
-
-
84867818118
-
A proteasome inhibitor-stimulated Nrf1 protein-dependent compensatory increase in proteasome subunit gene expression reduces polycomb group protein level
-
Balasubramanian, S., Kanade, S., Han, B., and Eckert, R. L. (2012). A proteasome inhibitor-stimulated Nrf1 protein-dependent compensatory increase in proteasome subunit gene expression reduces polycomb group protein level.J. Biol. Chem. 287, 36179-36189. doi: 10.1074/jbc.M112.359281
-
(2012)
J. Biol. Chem
, vol.287
, pp. 36179-36189
-
-
Balasubramanian, S.1
Kanade, S.2
Han, B.3
Eckert, R.L.4
-
3
-
-
38049016914
-
Low-level caloric restriction rescues proteasome activity and Hsc70 level in liver of aged rats
-
Bonelli, M. A., Desenzani, S., Cavallini, G., Donati, A., Romani, A. A., Bergamini, E., et al. (2008). Low-level caloric restriction rescues proteasome activity and Hsc70 level in liver of aged rats. Biogerontology 9, 1-10. doi: 10.1007/s10522-007-9111-9
-
(2008)
Biogerontology
, vol.9
, pp. 1-10
-
-
Bonelli, M.A.1
Desenzani, S.2
Cavallini, G.3
Donati, A.4
Romani, A.A.5
Bergamini, E.6
-
4
-
-
0037041420
-
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
-
Bucciantini, M., Giannoni, E., Chiti, F., Baroni, F., Formigli, L., Zurdo, J., et al. (2002). Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. Nature 416, 507-511. doi: 10.1038/416507a
-
(2002)
Nature
, vol.416
, pp. 507-511
-
-
Bucciantini, M.1
Giannoni, E.2
Chiti, F.3
Baroni, F.4
Formigli, L.5
Zurdo, J.6
-
5
-
-
70449719261
-
The roles of ubiquitin and 26S proteasome in human obesity
-
Chang, T. L., Chang, C. J., Lee, W. Y., Lin, M. N., Huang, Y. W., and Fan, K. (2009). The roles of ubiquitin and 26S proteasome in human obesity. Metabolism 58, 1643-1648. doi: 10.1016/j.metabol.2009.05.020
-
(2009)
Metabolism
, vol.58
, pp. 1643-1648
-
-
Chang, T.L.1
Chang, C.J.2
Lee, W.Y.3
Lin, M.N.4
Huang, Y.W.5
Fan, K.6
-
6
-
-
0033792614
-
Fibroblast cultures from healthy centenarians have an active proteasome
-
Chondrogianni, N., Petropoulos, I., Franceschi, C., Friguet, B., and Gonos, E. S. (2000). Fibroblast cultures from healthy centenarians have an active proteasome. Exp. Gerontol. 35, 721-728. doi: 10.1016/S0531-5565(00)00137-6
-
(2000)
Exp. Gerontol
, vol.35
, pp. 721-728
-
-
Chondrogianni, N.1
Petropoulos, I.2
Franceschi, C.3
Friguet, B.4
Gonos, E.S.5
-
7
-
-
84871750894
-
mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesis
-
Chou, S. D., Prince, T., Gong, J., and Calderwood, S. K. (2012). mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesis. PLoS ONE 7:e39679. doi: 10.1371/journal.pone.0039679
-
(2012)
PLoS ONE
, vol.7
-
-
Chou, S.D.1
Prince, T.2
Gong, J.3
Calderwood, S.K.4
-
8
-
-
0034659505
-
Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes
-
Cuesta, R., Laroia, G., and Schneider, R. J. (2000). Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes. Genes Dev. 14, 1460-1470. doi: 10.1101/gad.14.12.1460
-
(2000)
Genes Dev
, vol.14
, pp. 1460-1470
-
-
Cuesta, R.1
Laroia, G.2
Schneider, R.J.3
-
9
-
-
80053578494
-
Proteasome alterations during adipose differentiation and aging: Links to impaired adipocyte differentiation and development of oxidative stress
-
Dasuri, K., Zhang, L., Ebenezer, P., Fernandez-Kim, S. O., Bruce-Keller, A. J., Szweda, L. I., et al. (2011). Proteasome alterations during adipose differentiation and aging: links to impaired adipocyte differentiation and development of oxidative stress. Free Radic. Biol. Med. 51, 1727-1735. doi: 10.1016/j.freeradbiomed.2011.08.001
-
(2011)
Free Radic. Biol. Med
, vol.51
, pp. 1727-1735
-
-
Dasuri, K.1
Zhang, L.2
Ebenezer, P.3
Fernandez-Kim, S.O.4
Bruce-Keller, A.J.5
Szweda, L.I.6
-
10
-
-
77956795163
-
Widespread protein aggregation as an inherent part of aging in C. Elegans
-
David, D. C., Ollikainen, N., Trinidad, J. C., Cary, M. P., Burlingame, A. L., and Kenyon, C. (2010). Widespread protein aggregation as an inherent part of aging in C. elegans. PLoS Biol. 8:e1000450. doi: 10.1371/journal.pbio.1000450
-
(2010)
PLoS Biol
, vol.8
-
-
David, D.C.1
Ollikainen, N.2
Trinidad, J.C.3
Cary, M.P.4
Burlingame, A.L.5
Kenyon, C.6
-
11
-
-
84857628620
-
-
Univeristy of Tokyo (Accessed November 5, 2002)
-
De Hoon, M. (2002). Cluster 3.0 Manual. Available Online at:http://bonsai.hgc.jp/~mdehoon/software/cluster/manual/Contents.html#Contents: Univeristy of Tokyo (Accessed November 5, 2002).
-
(2002)
Cluster 3.0 Manual
-
-
De Hoon, M.1
-
12
-
-
34249085552
-
Proteasomes: Machines for all reasons
-
Demartino, G. N., and Gillette, T. G. (2007). Proteasomes: machines for all reasons. Cell 129, 659-662. doi: 10.1016/j.cell.2007.05.007
-
(2007)
Cell
, vol.129
, pp. 659-662
-
-
Demartino, G.N.1
Gillette, T.G.2
-
13
-
-
33845874433
-
Brain CHIP: Removing the culprits in neurodegenerative disease
-
Dickey, C. A., Patterson, C., Dickson, D., and Petrucelli, L. (2007). Brain CHIP: removing the culprits in neurodegenerative disease. Trends Mol. Med. 13, 32-38. doi: 10.1016/j.molmed.2006.11.003
-
(2007)
Trends Mol. Med
, vol.13
, pp. 32-38
-
-
Dickey, C.A.1
Patterson, C.2
Dickson, D.3
Petrucelli, L.4
-
14
-
-
84890100345
-
Oxidative damage and amyloid-beta metabolism in brain regions of the longest-lived rodents
-
Edrey, Y. H., Oddo, S., Cornelius, C., Caccamo, A., Calabrese, V., and Buffenstein, R. (2014). Oxidative damage and amyloid-beta metabolism in brain regions of the longest-lived rodents. J. Neurosci. Res. 92, 195-205. doi: 10.1002/jnr.23320
-
(2014)
J. Neurosci. Res
, vol.92
, pp. 195-205
-
-
Edrey, Y.H.1
Oddo, S.2
Cornelius, C.3
Caccamo, A.4
Calabrese, V.5
Buffenstein, R.6
-
15
-
-
27644576445
-
Characterization of the proteasome using native gel electrophoresis
-
Elasser, S., Schmidt, M., and Finley, D. (2005). Characterization of the proteasome using native gel electrophoresis.Meth. Enzymol. 398, 353-363. doi: 10.1016/S0076-6879(05)98029-4
-
(2005)
Meth. Enzymol
, vol.398
, pp. 353-363
-
-
Elasser, S.1
Schmidt, M.2
Finley, D.3
-
16
-
-
16344363800
-
Altered proteasome structure, function, and oxidation in aged muscle
-
Ferrington, D. A., Husom, A. D., and Thompson, L. V. (2005). Altered proteasome structure, function, and oxidation in aged muscle. FASEB J. 19, 644-646. doi: 10.1096/fj.04-2578fje
-
(2005)
FASEB J
, vol.19
, pp. 644-646
-
-
Ferrington, D.A.1
Husom, A.D.2
Thompson, L.V.3
-
17
-
-
84896834460
-
Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome
-
Fok, W. C., Chen, Y., Bokov, A., Zhang, Y., Salmon, A. B., Diaz, V., et al. (2014). Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome. PLoS ONE 9:e83988. doi: 10.1371/journal.pone.0083988
-
(2014)
PLoS ONE
, vol.9
-
-
Fok, W.C.1
Chen, Y.2
Bokov, A.3
Zhang, Y.4
Salmon, A.B.5
Diaz, V.6
-
18
-
-
70450220221
-
The small heat shock protein HSP25 protects astrocytes against stress induced by proteasomal inhibition
-
Goldbaum, O., Riedel, M., Stahnke, T., and Richter-Landsberg, C. (2009). The small heat shock protein HSP25 protects astrocytes against stress induced by proteasomal inhibition. Glia 57, 1566-1577. doi: 10.1002/glia.20870
-
(2009)
Glia
, vol.57
, pp. 1566-1577
-
-
Goldbaum, O.1
Riedel, M.2
Stahnke, T.3
Richter-Landsberg, C.4
-
19
-
-
33646512636
-
Proteasome inhibition by MG-132 induces apoptotic cell death and mitochondrial dysfunction in cultured rat brain oligodendrocytes but not in astrocytes
-
Goldbaum, O., Vollmer, G., and Richter-Landsberg, C. (2006). Proteasome inhibition by MG-132 induces apoptotic cell death and mitochondrial dysfunction in cultured rat brain oligodendrocytes but not in astrocytes. Glia 53, 891-901. doi: 10.1002/glia.20348
-
(2006)
Glia
, vol.53
, pp. 891-901
-
-
Goldbaum, O.1
Vollmer, G.2
Richter-Landsberg, C.3
-
20
-
-
79959534486
-
Oxidative protein damage and the proteasome
-
Grimm, S., Hohn, A., and Grune, T. (2012). Oxidative protein damage and the proteasome. Amino Acids 42, 23-38. doi: 10.1007/s00726-010-0646-8
-
(2012)
Amino Acids
, vol.42
, pp. 23-38
-
-
Grimm, S.1
Hohn, A.2
Grune, T.3
-
21
-
-
80052265819
-
HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress
-
Grune, T., Catalgol, B., Licht, A., Ermak, G., Pickering, A. M., Ngo, J. K., et al. (2011). HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress. Free Radic. Biol. Med. 51, 1355-1364. doi: 10.1016/j.freeradbiomed.2011.06.015
-
(2011)
Free Radic. Biol. Med
, vol.51
, pp. 1355-1364
-
-
Grune, T.1
Catalgol, B.2
Licht, A.3
Ermak, G.4
Pickering, A.M.5
Ngo, J.K.6
-
22
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., et al. (2009). Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460, 392-395. doi: 10.1038/nature08221
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
Nelson, J.F.4
Astle, C.M.5
Flurkey, K.6
-
23
-
-
84892421283
-
eRapa restores a normal life span in a FAP mouse model
-
Hasty, P., Livi, C. B., Dodds, S. G., Jones, D., Strong, R., Javors, M., et al. (2014). eRapa restores a normal life span in a FAP mouse model. Cancer Prev. Res. 7, 169-178. doi: 10.1158/1940-6207.CAPR-13-0299
-
(2014)
Cancer Prev. Res
, vol.7
, pp. 169-178
-
-
Hasty, P.1
Livi, C.B.2
Dodds, S.G.3
Jones, D.4
Strong, R.5
Javors, M.6
-
24
-
-
0034644608
-
Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells
-
Haynes, M. P., Sinha, D., Russell, K. S., Collinge, M., Fulton, D., Morales-Ruiz, M., et al. (2000). Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells. Circ. Res. 87, 677-682. doi: 10.1161/01.RES.87.8.677
-
(2000)
Circ. Res
, vol.87
, pp. 677-682
-
-
Haynes, M.P.1
Sinha, D.2
Russell, K.S.3
Collinge, M.4
Fulton, D.5
Morales-Ruiz, M.6
-
25
-
-
80053445278
-
Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae
-
Kruegel, U., Robison, B., Dange, T., Kahlert, G., Delaney, J. R., Kotireddy, S., et al. (2011). Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae. PLoS Genet. 7:e1002253. doi: 10.1371/journal.pgen.1002253
-
(2011)
PLoS Genet
, vol.7
-
-
Kruegel, U.1
Robison, B.2
Dange, T.3
Kahlert, G.4
Delaney, J.R.5
Kotireddy, S.6
-
26
-
-
84894225988
-
Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)
-
Lamming, D. W., Demirkan, G., Boylan, J. M., Mihaylova, M. M., Peng, T., Ferreira, J., et al. (2014). Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2). FASEB J. 28, 300-315. doi: 10.1096/fj.13-237743
-
(2014)
FASEB J
, vol.28
, pp. 300-315
-
-
Lamming, D.W.1
Demirkan, G.2
Boylan, J.M.3
Mihaylova, M.M.4
Peng, T.5
Ferreira, J.6
-
27
-
-
84880507764
-
Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive
-
Lamming, D. W., Ye, L., Astle, C. M., Baur, J. A., Sabatini, D. M., and Harrison, D. E. (2013). Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive. Aging Cell12, 712-718. doi: 10.1111/acel.12097
-
(2013)
Aging Cell
, vol.12
, pp. 712-718
-
-
Lamming, D.W.1
Ye, L.2
Astle, C.M.3
Baur, J.A.4
Sabatini, D.M.5
Harrison, D.E.6
-
28
-
-
33749069075
-
ATP Binding and ATP hydrolysis play distinct roles in the function of 26S Proteasome
-
Liu, C.-W., Li, X., Thompson, D., Wooding, K., Chang, T.-I., Tang, Z., et al. (2006). ATP Binding and ATP hydrolysis play distinct roles in the function of 26S Proteasome. Mol. Cell 24, 39-50. doi: 10.1016/j.molcel.2006.08.025
-
(2006)
Mol. Cell
, vol.24
, pp. 39-50
-
-
Liu, C.-W.1
Li, X.2
Thompson, D.3
Wooding, K.4
Chang, T.-I.5
Tang, Z.6
-
29
-
-
77952393003
-
Mechanisms governing the control of mRNA translation
-
Livingstone, M., Atas, E., Meller, A., and Sonenberg, N. (2010). Mechanisms governing the control of mRNA translation. Phys. Biol. 7:021001. doi: 10.1088/1478-3975/7/2/021001
-
(2010)
Phys. Biol
, vol.7
-
-
Livingstone, M.1
Atas, E.2
Meller, A.3
Sonenberg, N.4
-
30
-
-
33745154534
-
Autophagic defects in aging - Looking for an emergency exit?
-
Massey, A. C., Kiffin, R., and Cuervo, A. M. (2006). Autophagic defects in aging - Looking for an emergency exit?Cell Cycle 5, 1292-1296. doi: 10.4161/cc.5.12.2865
-
(2006)
Cell Cycle
, vol.5
, pp. 1292-1296
-
-
Massey, A.C.1
Kiffin, R.2
Cuervo, A.M.3
-
31
-
-
0031841818
-
Heat shock response and protein degradation: Regulation of HSF2 by the ubiquitin-proteasome pathway
-
Mathew, A., Mathur, S. K., and Morimoto, R. I. (1998). Heat shock response and protein degradation: regulation of HSF2 by the ubiquitin-proteasome pathway. Mol. Cell Biol. 18, 5091-5098.
-
(1998)
Mol. Cell Biol
, vol.18
, pp. 5091-5098
-
-
Mathew, A.1
Mathur, S.K.2
Morimoto, R.I.3
-
32
-
-
79951794971
-
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
-
Miller, R. A., Harrison, D. E., Astle, C. M., Baur, J. A., Boyd, A. R., De Cabo, R., et al. (2011). Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J. Gerontol. A Biol. Sci. Med. Sci. 66, 191-201. doi: 10.1093/gerona/glq178
-
(2011)
J. Gerontol. A Biol. Sci. Med. Sci
, vol.66
, pp. 191-201
-
-
Miller, R.A.1
Harrison, D.E.2
Astle, C.M.3
Baur, J.A.4
Boyd, A.R.5
De Cabo, R.6
-
33
-
-
84901403995
-
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction
-
Miller, R. A., Harrison, D. E., Astle, C. M., Fernandez, E., Flurkey, K., Han, M., et al. (2014). Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell13, 468-477. doi: 10.1111/acel.12194
-
(2014)
Aging Cell
, vol.13
, pp. 468-477
-
-
Miller, R.A.1
Harrison, D.E.2
Astle, C.M.3
Fernandez, E.4
Flurkey, K.5
Han, M.6
-
34
-
-
84903362402
-
Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology
-
Orr, M. E., Salinas, A., Buffenstein, R., and Oddo, S. (2014). Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology. Neurobiol. Aging 35, 1233-1242. doi: 10.1016/j.neurobiolaging.2013.12.006
-
(2014)
Neurobiol. Aging
, vol.35
, pp. 1233-1242
-
-
Orr, M.E.1
Salinas, A.2
Buffenstein, R.3
Oddo, S.4
-
35
-
-
84879105829
-
Rapamycin allosterically inhibits the proteasome
-
Osmulski, P. A., and Gaczynska, M. (2013). Rapamycin allosterically inhibits the proteasome. Mol. Pharmacol. 84, 104-113. doi: 10.1124/mol.112.083873
-
(2013)
Mol. Pharmacol
, vol.84
, pp. 104-113
-
-
Osmulski, P.A.1
Gaczynska, M.2
-
36
-
-
84874678862
-
Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease
-
Pierce, A., Podlutskaya, N., Halloran, J. J., Hussong, S. A., Lin, P. Y., Burbank, R., et al. (2013). Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease. J. Neurochem. 124, 880-893. doi: 10.1111/jnc.12080
-
(2013)
J. Neurochem
, vol.124
, pp. 880-893
-
-
Pierce, A.1
Podlutskaya, N.2
Halloran, J.J.3
Hussong, S.A.4
Lin, P.Y.5
Burbank, R.6
-
37
-
-
78049280231
-
A Novel mouse model of enhanced proteostasis: Full-length human heat shock factor 1 transgenic mice
-
Pierce, A., Wei, R., Halade, D., Yoo, S. E., Ran, Q., and Richardson, A. (2010). A Novel mouse model of enhanced proteostasis: full-length human heat shock factor 1 transgenic mice. Biochem. Biophys. Res. Commun. 402, 59-65. doi: 10.1016/j.bbrc.2010.09.111
-
(2010)
Biochem. Biophys. Res. Commun
, vol.402
, pp. 59-65
-
-
Pierce, A.1
Wei, R.2
Halade, D.3
Yoo, S.E.4
Ran, Q.5
Richardson, A.6
-
38
-
-
84893092734
-
The pros and the cons of mTOR inhibitors in kidney transplantation
-
Ponticelli, C. (2014). The pros and the cons of mTOR inhibitors in kidney transplantation. Exp. Rev. Clin. Immunol. 10, 295-305. doi: 10.1586/1744666X.2014.872562
-
(2014)
Exp. Rev. Clin. Immunol
, vol.10
, pp. 295-305
-
-
Ponticelli, C.1
-
39
-
-
77950366349
-
Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells
-
Radhakrishnan, S. K., Lee, C. S., Young, P., Beskow, A., Chan, J. Y., and Deshaies, R. J. (2010). Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells. Mol. Cell 38, 17-28. doi: 10.1016/j.molcel.2010.02.029
-
(2010)
Mol. Cell
, vol.38
, pp. 17-28
-
-
Radhakrishnan, S.K.1
Lee, C.S.2
Young, P.3
Beskow, A.4
Chan, J.Y.5
Deshaies, R.J.6
-
40
-
-
84860431090
-
Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat
-
Rodriguez, K. A., Edrey, Y. H., Osmulski, P., Gaczynska, M., and Buffenstein, R. (2012). Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat. PLoS ONE 7:e35890. doi: 10.1371/journal.pone.0035890
-
(2012)
PLoS ONE
, vol.7
-
-
Rodriguez, K.A.1
Edrey, Y.H.2
Osmulski, P.3
Gaczynska, M.4
Buffenstein, R.5
-
41
-
-
77249166017
-
Molecular mechanisms of proteasome plasticity in aging
-
Rodriguez, K. A., Gaczynska, M., and Osmulski, P. A. (2010). Molecular mechanisms of proteasome plasticity in aging. Mech. Ageing Dev. 131, 144-155. doi: 10.1016/j.mad.2010.01.002
-
(2010)
Mech. Ageing Dev
, vol.131
, pp. 144-155
-
-
Rodriguez, K.A.1
Gaczynska, M.2
Osmulski, P.A.3
-
42
-
-
84907986019
-
A cytosolic protein factor from the naked mole-rat activates proteasomes of other species and protects these from inhibition
-
Rodriguez, K. A., Osmulski, P., Pierce, A., Weintraub, S. T., Gaczynska, M., and Buffenstein, R. (2014). A cytosolic protein factor from the naked mole-rat activates proteasomes of other species and protects these from inhibition.Biochim. Biophys. Acta. 1842, 2060-2072. doi: 10.1016/j.bbadis.2014.07.005
-
(2014)
Biochim. Biophys. Acta
, vol.1842
, pp. 2060-2072
-
-
Rodriguez, K.A.1
Osmulski, P.2
Pierce, A.3
Weintraub, S.T.4
Gaczynska, M.5
Buffenstein, R.6
-
43
-
-
3142514201
-
Protein aggregation and neurodegenerative disease
-
Ross, C. A., and Poirier, M. A. (2004). Protein aggregation and neurodegenerative disease. Nat. Med. 10(Suppl.). S10-S17. doi: 10.1038/nm1066
-
(2004)
Nat. Med
, vol.10
, pp. S10-S17
-
-
Ross, C.A.1
Poirier, M.A.2
-
44
-
-
79957684292
-
CHIP E3 ligase regulates mammalian senescence by modulating the levels of oxidized proteins
-
Sisoula, C., and Gonos, E. S. (2011). CHIP E3 ligase regulates mammalian senescence by modulating the levels of oxidized proteins. Mech. Ageing Dev. 132, 269-272. doi: 10.1016/j.mad.2011.04.003
-
(2011)
Mech. Ageing Dev
, vol.132
, pp. 269-272
-
-
Sisoula, C.1
Gonos, E.S.2
-
45
-
-
79951707743
-
ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycle
-
Smith, D. M., Fraga, H., Reis, C., Kafri, G., and Goldberg, A. L. (2011). ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycle. Cell 144, 526-538. doi: 10.1016/j.cell.2011.02.005
-
(2011)
Cell
, vol.144
, pp. 526-538
-
-
Smith, D.M.1
Fraga, H.2
Reis, C.3
Kafri, G.4
Goldberg, A.L.5
-
46
-
-
77956305343
-
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease
-
Spilman, P., Podlutskaya, N., Hart, M. J., Debnath, J., Gorostiza, O., Bredesen, D., et al. (2010). Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease.PLoS ONE 5:e9979. doi: 10.1371/journal.pone.0009979
-
(2010)
PLoS ONE
, vol.5
-
-
Spilman, P.1
Podlutskaya, N.2
Hart, M.J.3
Debnath, J.4
Gorostiza, O.5
Bredesen, D.6
-
47
-
-
23844438209
-
Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
-
Sun, S. Y., Rosenberg, L. M., Wang, X., Zhou, Z., Yue, P., Fu, H., et al. (2005). Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res. 65, 7052-7058. doi: 10.1158/0008-5472.CAN-05-0917
-
(2005)
Cancer Res
, vol.65
, pp. 7052-7058
-
-
Sun, S.Y.1
Rosenberg, L.M.2
Wang, X.3
Zhou, Z.4
Yue, P.5
Fu, H.6
-
48
-
-
0000085132
-
Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway
-
Sun, X. J., Goldberg, J. L., Qiao, L. Y., and Mitchell, J. J. (1999). Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway. Diabetes 48, 1359-1364. doi: 10.2337/diabetes.48.7.1359
-
(1999)
Diabetes
, vol.48
, pp. 1359-1364
-
-
Sun, X.J.1
Goldberg, J.L.2
Qiao, L.Y.3
Mitchell, J.J.4
-
49
-
-
77953467032
-
Characterization of the brain 26S Proteasome and its interacting proteins
-
Tai, H. C., Besche, H., Goldberg, A. L., and Schuman, E. M. (2010). Characterization of the brain 26S Proteasome and its interacting proteins. Front. Mol. Neurosci. 3:12. doi: 10.3389/fnmol.2010.00012
-
(2010)
Front. Mol. Neurosci
, vol.3
, pp. 12
-
-
Tai, H.C.1
Besche, H.2
Goldberg, A.L.3
Schuman, E.M.4
-
50
-
-
84860527756
-
A unifying model for mTORC1-mediated regulation of mRNA translation
-
Thoreen, C. C., Chantranupong, L., Keys, H. R., Wang, T., Gray, N. S., and Sabatini, D. M. (2012). A unifying model for mTORC1-mediated regulation of mRNA translation. Nature 485, 109-113. doi: 10.1038/nature11083
-
(2012)
Nature
, vol.485
, pp. 109-113
-
-
Thoreen, C.C.1
Chantranupong, L.2
Keys, H.R.3
Wang, T.4
Gray, N.S.5
Sabatini, D.M.6
-
51
-
-
84903958633
-
Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition
-
Umemura, A., Park, E. J., Taniguchi, K., Lee, J. H., Shalapour, S., Valasek, M. A., et al. (2014). Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. Cell Metab. 20, 133-144. doi: 10.1016/j.cmet.2014.05.001
-
(2014)
Cell Metab
, vol.20
, pp. 133-144
-
-
Umemura, A.1
Park, E.J.2
Taniguchi, K.3
Lee, J.H.4
Shalapour, S.5
Valasek, M.A.6
-
52
-
-
34548479261
-
Aging perturbs 26S proteasome assembly in Drosophila melanogaster
-
Vernace, V. A., Arnaud, L., Schmidt-Glenewinkel, T., and Figueiredo-Pereira, M. E. (2007). Aging perturbs 26S proteasome assembly in Drosophila melanogaster. FASEB J. 21, 2672-2682. doi: 10.1096/fj.06-6751com
-
(2007)
FASEB J
, vol.21
, pp. 2672-2682
-
-
Vernace, V.A.1
Arnaud, L.2
Schmidt-Glenewinkel, T.3
Figueiredo-Pereira, M.E.4
-
53
-
-
33947538050
-
Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism
-
Wan, X., Harkavy, B., Shen, N., Grohar, P., and Helman, L. J. (2007). Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene 26, 1932-1940. doi: 10.1038/sj.onc.1209990
-
(2007)
Oncogene
, vol.26
, pp. 1932-1940
-
-
Wan, X.1
Harkavy, B.2
Shen, N.3
Grohar, P.4
Helman, L.J.5
-
54
-
-
84864021710
-
Rapamycin slows aging in mice
-
Wilkinson, J. E., Burmeister, L., Brooks, S. V., Chan, C. C., Friedline, S., Harrison, D. E., et al. (2012). Rapamycin slows aging in mice. Aging Cell 11, 675-682. doi: 10.1111/j.1474-9726.2012.00832.x
-
(2012)
Aging Cell
, vol.11
, pp. 675-682
-
-
Wilkinson, J.E.1
Burmeister, L.2
Brooks, S.V.3
Chan, C.C.4
Friedline, S.5
Harrison, D.E.6
-
55
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger, S., Loewith, R., and Hall, M. N. (2006). TOR signaling in growth and metabolism. Cell 124, 471-484. doi: 10.1016/j.cell.2006.01.016
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
56
-
-
0034800371
-
Principal component analysis for clustering gene expression data
-
Yeung, K. Y., and Ruzzo, W. L. (2001). Principal component analysis for clustering gene expression data.Bioinformatics 17, 763-774. doi: 10.1093/bioinformatics/17.9.763
-
(2001)
Bioinformatics
, vol.17
, pp. 763-774
-
-
Yeung, K.Y.1
Ruzzo, W.L.2
-
57
-
-
33749573178
-
Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: Induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways
-
Yu, C., Friday, B. B., Lai, J. P., Yang, L., Sarkaria, J., Kay, N. E., et al. (2006). Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways. Mol. Cancer Ther. 5, 2378-2387. doi: 10.1158/1535-7163.MCT-06-0235
-
(2006)
Mol. Cancer Ther
, vol.5
, pp. 2378-2387
-
-
Yu, C.1
Friday, B.B.2
Lai, J.P.3
Yang, L.4
Sarkaria, J.5
Kay, N.E.6
-
58
-
-
84926672210
-
Rapamycin and dietary restriction induce metabolically distinctive changes in mouse liver
-
[Epub ahead of print]
-
Yu, Z., Wang, R., Fok, W. C., Coles, A., Salmon, A. B., and Perez, V. I. (2014). Rapamycin and dietary restriction induce metabolically distinctive changes in mouse liver. J. Gerontol. A Biol. Sci. Med. Sci. doi: 10.1093/gerona/glu053. [Epub ahead of print].
-
(2014)
J. Gerontol. A Biol. Sci. Med. Sci
-
-
Yu, Z.1
Wang, R.2
Fok, W.C.3
Coles, A.4
Salmon, A.B.5
Perez, V.I.6
-
59
-
-
84875539389
-
Proteasome inhibitor MG132 induces selective apoptosis in glioblastoma cells through inhibition of PI3K/Akt and NFkappaB pathways, mitochondrial dysfunction, and activation of p38-JNK1/2 signaling
-
Zanotto-Filho, A., Braganhol, E., Battastini, A. M., and Moreira, J. C. (2012). Proteasome inhibitor MG132 induces selective apoptosis in glioblastoma cells through inhibition of PI3K/Akt and NFkappaB pathways, mitochondrial dysfunction, and activation of p38-JNK1/2 signaling. Invest. New Drugs 30, 2252-2262. doi: 10.1007/s10637-012-9804-z
-
(2012)
Invest. New Drugs
, vol.30
, pp. 2252-2262
-
-
Zanotto-Filho, A.1
Braganhol, E.2
Battastini, A.M.3
Moreira, J.C.4
-
60
-
-
84896800569
-
Rapamycin extends life and health in C57BL/6 mice
-
Zhang, Y., Bokov, A., Gelfond, J., Soto, V., Ikeno, Y., Hubbard, G., et al. (2014a). Rapamycin extends life and health in C57BL/6 mice. J. Gerontol. A Biol. Sci. Med. Sci. 69, 119-130. doi: 10.1093/gerona/glt056
-
(2014)
J. Gerontol. A Biol. Sci. Med. Sci
, vol.69
, pp. 119-130
-
-
Zhang, Y.1
Bokov, A.2
Gelfond, J.3
Soto, V.4
Ikeno, Y.5
Hubbard, G.6
-
61
-
-
84906898355
-
Coordinated regulation of protein synthesis and degradation by mTORC1
-
Zhang, Y., Nicholatos, J., Dreier, J. R., Ricoult, S. J., Widenmaier, S. B., Hotamisligil, G. S., et al. (2014b). Coordinated regulation of protein synthesis and degradation by mTORC1. Nature 513, 440-443. doi: 10.1038/nature13492
-
(2014)
Nature
, vol.513
, pp. 440-443
-
-
Zhang, Y.1
Nicholatos, J.2
Dreier, J.R.3
Ricoult, S.J.4
Widenmaier, S.B.5
Hotamisligil, G.S.6
|