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Volumn 156, Issue , 2016, Pages 17-24

Apoptosis or senescence? Which exit route do epithelial cells and fibroblasts preferentially follow?

Author keywords

Apoptosis; Epithelial cell; Fibroblast; Senescence; Sudan black B

Indexed keywords

BETA GALACTOSIDASE;

EID: 84963631925     PISSN: 00476374     EISSN: 18726216     Source Type: Journal    
DOI: 10.1016/j.mad.2016.03.010     Document Type: Review
Times cited : (21)

References (124)
  • 1
    • 84881249955 scopus 로고    scopus 로고
    • Differences in protein changes between stress-induced premature senescence and replicative senescence states
    • Aan G.J., et al. Differences in protein changes between stress-induced premature senescence and replicative senescence states. Electrophoresis 2013, 34:2209-2217.
    • (2013) Electrophoresis , vol.34 , pp. 2209-2217
    • Aan, G.J.1
  • 2
    • 0344441890 scopus 로고    scopus 로고
    • A DNA damage checkpoint response in telomere-initiated senescence
    • Adda di Fagagna D.', et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 2003, 426:194-198.
    • (2003) Nature , vol.426 , pp. 194-198
    • Adda di Fagagna, D.'1
  • 3
    • 77957933902 scopus 로고    scopus 로고
    • Adult-type fibrosarcoma: a reevaluation of 163 putative cases diagnosed at a single institution over a 48-year period
    • Bahrami A., Folpe A.L. Adult-type fibrosarcoma: a reevaluation of 163 putative cases diagnosed at a single institution over a 48-year period. Am. J. Surg. Pathol. 2010, 34(10):1504-1513.
    • (2010) Am. J. Surg. Pathol. , vol.34 , Issue.10 , pp. 1504-1513
    • Bahrami, A.1    Folpe, A.L.2
  • 4
    • 36949005417 scopus 로고    scopus 로고
    • DNA damage signalling guards against activated oncogenes and tumour progression
    • Bartek J., et al. DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene 2007, 26:7773-7779.
    • (2007) Oncogene , vol.26 , pp. 7773-7779
    • Bartek, J.1
  • 5
    • 17244367849 scopus 로고    scopus 로고
    • DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    • Bartkova J., et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005, 434:864-870.
    • (2005) Nature , vol.434 , pp. 864-870
    • Bartkova, J.1
  • 6
    • 33845235459 scopus 로고    scopus 로고
    • Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
    • Bartkova J., et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 2006, 444:633-637.
    • (2006) Nature , vol.444 , pp. 633-637
    • Bartkova, J.1
  • 7
    • 1542781659 scopus 로고    scopus 로고
    • When cells get stressed: an integrative view of cellular senescence
    • Ben-Porath I., Weinberg R.A. When cells get stressed: an integrative view of cellular senescence. J. Clin. Invest. 2004, 113:8-13.
    • (2004) J. Clin. Invest. , vol.113 , pp. 8-13
    • Ben-Porath, I.1    Weinberg, R.A.2
  • 8
    • 40049094626 scopus 로고    scopus 로고
    • Impact of aging on the biology of breast cancer
    • Benz C.C. Impact of aging on the biology of breast cancer. Crit. Rev. Oncol. Hematol. 2008, 66:65-74.
    • (2008) Crit. Rev. Oncol. Hematol. , vol.66 , pp. 65-74
    • Benz, C.C.1
  • 9
    • 85077943934 scopus 로고    scopus 로고
    • Report differential oncogenic Ras signaling and senescence in tumor cells
    • Bihani T., et al. Report differential oncogenic Ras signaling and senescence in tumor cells. Cell Cycle 2004, 3:1201-1207.
    • (2004) Cell Cycle , vol.3 , pp. 1201-1207
    • Bihani, T.1
  • 10
    • 84947243777 scopus 로고    scopus 로고
    • DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease
    • Birch J., et al. DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease. Am. J. Physiol. Lung Cell. Mol. Physiol. 2015, 309:L1124-L1137.
    • (2015) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.309 , pp. L1124-L1137
    • Birch, J.1
  • 11
    • 60749125436 scopus 로고    scopus 로고
    • Epidermal homeostasis: a balancing act of stem cells in the skin
    • Blanpain C., Fuchs E. Epidermal homeostasis: a balancing act of stem cells in the skin. Nat. Rev. Mol. Cell Biol. 2009, 10:207-217.
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 207-217
    • Blanpain, C.1    Fuchs, E.2
  • 12
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into normal human cells
    • Bodnar A.G., et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998, 279:349-352.
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1
  • 13
    • 84925848840 scopus 로고    scopus 로고
    • Cell senescence: role in aging and age-related diseases
    • Campisi J., Robert L. Cell senescence: role in aging and age-related diseases. Interdiscip. Top. Gerontol. 2014, 39:45-61.
    • (2014) Interdiscip. Top. Gerontol. , vol.39 , pp. 45-61
    • Campisi, J.1    Robert, L.2
  • 14
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: when bad things happen to good cells
    • Campisi J., d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat. Rev. Mol. Cell Biol. 2007, 8:729-740.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 729-740
    • Campisi, J.1    d'Adda di Fagagna, F.2
  • 15
    • 84862886876 scopus 로고    scopus 로고
    • Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production
    • Capparelli C., et al. Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production. Cell Cycle 2012, 11:2285.
    • (2012) Cell Cycle , vol.11 , pp. 2285
    • Capparelli, C.1
  • 16
    • 65249100855 scopus 로고    scopus 로고
    • Stromagenesis during tumorigenesis: characterization of tumor-associated fibroblasts and stroma-derived 3D matrices
    • Castello-Cros R., Cukierman E. Stromagenesis during tumorigenesis: characterization of tumor-associated fibroblasts and stroma-derived 3D matrices. Methods Mol. Biol. 2009, 522:275-305.
    • (2009) Methods Mol. Biol. , vol.522 , pp. 275-305
    • Castello-Cros, R.1    Cukierman, E.2
  • 17
    • 38049059966 scopus 로고    scopus 로고
    • DNA damage, cellular senescence and organismal ageing: causal or correlative?
    • Chen J.-H., et al. DNA damage, cellular senescence and organismal ageing: causal or correlative?. Nucleic Acids Res. 2007, 35:7417-7428.
    • (2007) Nucleic Acids Res. , vol.35 , pp. 7417-7428
    • Chen, J.-H.1
  • 18
    • 0019982509 scopus 로고
    • Whole population cell kinetics of mouse duodenal jejunal, iieal, and colonic epithelia as determined by radioautography and flow cytometry
    • Cheng H., Bjerknes M. Whole population cell kinetics of mouse duodenal jejunal, iieal, and colonic epithelia as determined by radioautography and flow cytometry. Anat. Rec. 1982, 203:251-264.
    • (1982) Anat. Rec. , vol.203 , pp. 251-264
    • Cheng, H.1    Bjerknes, M.2
  • 19
    • 52449107748 scopus 로고    scopus 로고
    • Partial proteasome inhibition in human fibroblasts triggers accelerated M1 senescence or M2 crisis depending on p53 and Rb status
    • Chondrogianni N., et al. Partial proteasome inhibition in human fibroblasts triggers accelerated M1 senescence or M2 crisis depending on p53 and Rb status. Aging Cell 2008, 7:717-732.
    • (2008) Aging Cell , vol.7 , pp. 717-732
    • Chondrogianni, N.1
  • 20
    • 72949096792 scopus 로고    scopus 로고
    • Senescence in tumours: evidence from mice and humans. Nature reviews
    • Collado M., Serrano M. Senescence in tumours: evidence from mice and humans. Nature reviews. Cancer 2010, 10:51-57.
    • (2010) Cancer , vol.10 , pp. 51-57
    • Collado, M.1    Serrano, M.2
  • 21
    • 33644984490 scopus 로고    scopus 로고
    • A new description of cellular quiescence
    • Coller H.A., et al. A new description of cellular quiescence. PLoS Biol. 2006, 4:e83.
    • (2006) PLoS Biol. , vol.4 , pp. e83
    • Coller, H.A.1
  • 22
    • 77949881221 scopus 로고    scopus 로고
    • The senescence-associated secretory phenotype: the dark side of tumor suppression
    • Coppé J.-P., et al. The senescence-associated secretory phenotype: the dark side of tumor suppression. Ann. Rev. Path. Mech. Dis. 2010, 5:99-118.
    • (2010) Ann. Rev. Path. Mech. Dis. , vol.5 , pp. 99-118
    • Coppé, J.-P.1
  • 23
    • 84940666994 scopus 로고    scopus 로고
    • Programmed cell death in the skin
    • Costanzo A., et al. Programmed cell death in the skin. Int. J. Dev. Biol. 2015, 59(1-3):73-78.
    • (2015) Int. J. Dev. Biol. , vol.59 , Issue.1-3 , pp. 73-78
    • Costanzo, A.1
  • 24
    • 33845292259 scopus 로고    scopus 로고
    • A negative feedback signaling network underlies oncogene-induced senescence
    • Courtois-Cox S., et al. A negative feedback signaling network underlies oncogene-induced senescence. Cancer Cell 2006, 10:459-472.
    • (2006) Cancer Cell , vol.10 , pp. 459-472
    • Courtois-Cox, S.1
  • 25
    • 8444237425 scopus 로고    scopus 로고
    • Replicative senescence: a critical review
    • Cristofalo V.J., et al. Replicative senescence: a critical review. Mech. Ageing Dev. 2004, 125:827-848.
    • (2004) Mech. Ageing Dev. , vol.125 , pp. 827-848
    • Cristofalo, V.J.1
  • 26
    • 13844270572 scopus 로고    scopus 로고
    • Tissue repair contraction, and the myofibroblast
    • Desmouliere A., et al. Tissue repair contraction, and the myofibroblast. Wound Repair Regen. 2005, 13:7-12.
    • (2005) Wound Repair Regen. , vol.13 , pp. 7-12
    • Desmouliere, A.1
  • 27
    • 0029047362 scopus 로고
    • A biomarker that identifies senescent human cells in culture and in aging skin in vivo
    • Dimri G.P. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. U S A. 1995, 92:9363-9367.
    • (1995) Proc. Natl. Acad. Sci. U S A. , vol.92 , pp. 9363-9367
    • Dimri, G.P.1
  • 28
    • 17044395076 scopus 로고    scopus 로고
    • Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening
    • Duan J., et al. Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening. Int. J. Biochem. Cell Biol. 2005, 37:1407-1420.
    • (2005) Int. J. Biochem. Cell Biol. , vol.37 , pp. 1407-1420
    • Duan, J.1
  • 29
    • 43549120978 scopus 로고    scopus 로고
    • E2F-1 overexpression correlates with decreased proliferation and better prognosis in adenocarcinomas of Barrett oesophagus
    • Evangelou K., et al. E2F-1 overexpression correlates with decreased proliferation and better prognosis in adenocarcinomas of Barrett oesophagus. J. Clin. Pathol. 2008, 61(5):601-605.
    • (2008) J. Clin. Pathol. , vol.61 , Issue.5 , pp. 601-605
    • Evangelou, K.1
  • 30
    • 84905841925 scopus 로고    scopus 로고
    • E2F transcription factors and digestive system malignancies: how much do we know?
    • Evangelou K., et al. E2F transcription factors and digestive system malignancies: how much do we know?. World J. Gastroenterol. 2014, 20(29):10212-10216.
    • (2014) World J. Gastroenterol. , vol.20 , Issue.29 , pp. 10212-10216
    • Evangelou, K.1
  • 31
    • 41649108818 scopus 로고    scopus 로고
    • Drug-induced senescence bystander proliferation in prostate cancer cells in vitro and in vivo
    • Ewald J., et al. Drug-induced senescence bystander proliferation in prostate cancer cells in vitro and in vivo. Br. J. Cancer 2008, 98:1244-1249.
    • (2008) Br. J. Cancer , vol.98 , pp. 1244-1249
    • Ewald, J.1
  • 32
    • 0033965413 scopus 로고    scopus 로고
    • Cell senescence and human aging: where's the link?
    • Faragher R.G. Cell senescence and human aging: where's the link?. Biochem. Soc. Trans. 2000, 28:221-226.
    • (2000) Biochem. Soc. Trans. , vol.28 , pp. 221-226
    • Faragher, R.G.1
  • 33
    • 84877133556 scopus 로고    scopus 로고
    • Increased expression of senescence markers in cystic fibrosis airways
    • Fischer B.M., et al. Increased expression of senescence markers in cystic fibrosis airways. Am. J. Physiol. Lung Cell. Mol. Physiol. 2013, 304:L394-400.
    • (2013) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.304 , pp. L394-400
    • Fischer, B.M.1
  • 34
    • 77952105389 scopus 로고    scopus 로고
    • Inflammatory networks during cellular senescence: causes and consequences
    • Freund A., et al. Inflammatory networks during cellular senescence: causes and consequences. Trends Mol. Med 2010, 16:238-246.
    • (2010) Trends Mol. Med , vol.16 , pp. 238-246
    • Freund, A.1
  • 35
    • 84859372986 scopus 로고    scopus 로고
    • Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation
    • Fumagalli M., et al. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat. Cell Biol. 2012, 14:355-365.
    • (2012) Nat. Cell Biol. , vol.14 , pp. 355-365
    • Fumagalli, M.1
  • 36
    • 84255210700 scopus 로고    scopus 로고
    • Molecular definitions of cell death subroutines: recommendations of the nomenclature committee on cell death
    • Galluzzi L., et al. Molecular definitions of cell death subroutines: recommendations of the nomenclature committee on cell death. Cell Death Differ. 2012, 19:107-120.
    • (2012) Cell Death Differ. , vol.19 , pp. 107-120
    • Galluzzi, L.1
  • 37
    • 84939986310 scopus 로고    scopus 로고
    • Essential versus accessory aspects of cell death: recommendations of the NCCD
    • Galluzzi L., et al. Essential versus accessory aspects of cell death: recommendations of the NCCD. Cell Death Differ. 2015, 22(1):58-73.
    • (2015) Cell Death Differ. , vol.22 , Issue.1 , pp. 58-73
    • Galluzzi, L.1
  • 38
    • 84874967976 scopus 로고    scopus 로고
    • Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues
    • Georgakopoulou E., et al. Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues. Aging (Milano) 2013, 5:37.
    • (2013) Aging (Milano) , vol.5 , pp. 37
    • Georgakopoulou, E.1
  • 39
    • 84934434682 scopus 로고    scopus 로고
    • From molecules to matrix: construction and evaluation of molecularly defined bioscaffolds
    • Geutjes P.J., et al. From molecules to matrix: construction and evaluation of molecularly defined bioscaffolds. Adv. Exp. Med. Biol. 2006, 585:279-295.
    • (2006) Adv. Exp. Med. Biol. , vol.585 , pp. 279-295
    • Geutjes, P.J.1
  • 40
    • 1242320230 scopus 로고    scopus 로고
    • Ageing of human epidermis: the role of apoptosis Fas and telomerase
    • Gilhar A., et al. Ageing of human epidermis: the role of apoptosis Fas and telomerase. Br. J. Dermatol. 2004, 150:56-63.
    • (2004) Br. J. Dermatol. , vol.150 , pp. 56-63
    • Gilhar, A.1
  • 41
    • 78649629320 scopus 로고    scopus 로고
    • Oncogene-induced senescence: the bright and dark side of the response
    • Gorgoulis V.G., Halazonetis T.D. Oncogene-induced senescence: the bright and dark side of the response. Curr. Opin Cell Biol. 2010, 22(6):816-827.
    • (2010) Curr. Opin Cell Biol. , vol.22 , Issue.6 , pp. 816-827
    • Gorgoulis, V.G.1    Halazonetis, T.D.2
  • 42
    • 0036773376 scopus 로고    scopus 로고
    • Transcription factor E2F-1 acts as a growth-promoting factor and is associated with adverse prognosis in non-small cell lung carcinomas
    • Gorgoulis V.G., et al. Transcription factor E2F-1 acts as a growth-promoting factor and is associated with adverse prognosis in non-small cell lung carcinomas. J. Pathol. 2002, 198(2):142-156.
    • (2002) J. Pathol. , vol.198 , Issue.2 , pp. 142-156
    • Gorgoulis, V.G.1
  • 43
    • 17244366865 scopus 로고    scopus 로고
    • Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
    • Gorgoulis V.G., et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 2005, 434:907-913.
    • (2005) Nature , vol.434 , pp. 907-913
    • Gorgoulis, V.G.1
  • 44
    • 59649119553 scopus 로고    scopus 로고
    • Senescent keratinocytes die by autophagic programmed cell death
    • Gosselin K., et al. Senescent keratinocytes die by autophagic programmed cell death. Am. J. Pathol. 2009, 174:423-435.
    • (2009) Am. J. Pathol. , vol.174 , pp. 423-435
    • Gosselin, K.1
  • 45
    • 84945296001 scopus 로고    scopus 로고
    • Aging-related inflammation in osteoarthritis
    • Greene M.A., Loeser R.F. Aging-related inflammation in osteoarthritis. Osteoarthritis Cartilage 2015, 23:1966-1971.
    • (2015) Osteoarthritis Cartilage , vol.23 , pp. 1966-1971
    • Greene, M.A.1    Loeser, R.F.2
  • 46
    • 84878764042 scopus 로고    scopus 로고
    • Mechanics of epithelial tissue homeostasis and morphogenesis
    • Guillot C., Lecuit T. Mechanics of epithelial tissue homeostasis and morphogenesis. Science 2013, 340:1185-1189.
    • (2013) Science , vol.340 , pp. 1185-1189
    • Guillot, C.1    Lecuit, T.2
  • 47
    • 40449120350 scopus 로고    scopus 로고
    • An oncogene-induced DNA damage model for cancer development
    • Halazonetis T.D., et al. An oncogene-induced DNA damage model for cancer development. Science 2008, 319(5868):1352-1355.
    • (2008) Science , vol.319 , Issue.5868 , pp. 1352-1355
    • Halazonetis, T.D.1
  • 48
    • 0028589378 scopus 로고
    • Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis
    • Hall P.A., et al. Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis. J. Cell Sci. 1994, 107:3569-3577.
    • (1994) J. Cell Sci. , vol.107 , pp. 3569-3577
    • Hall, P.A.1
  • 49
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley C.B., et al. Telomeres shorten during ageing of human fibroblasts. Nature 1990, 345(6274):458-460.
    • (1990) Nature , vol.345 , Issue.6274 , pp. 458-460
    • Harley, C.B.1
  • 50
    • 77955516632 scopus 로고    scopus 로고
    • Cellular senescence predicts treatment outcome in metastasised colorectal cancer
    • Haugstetter A., et al. Cellular senescence predicts treatment outcome in metastasised colorectal cancer. Br. J. Cancer 2010, 103:505-509.
    • (2010) Br. J. Cancer , vol.103 , pp. 505-509
    • Haugstetter, A.1
  • 51
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick L., Moorhead P.S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 1961, 25:585-621.
    • (1961) Exp. Cell Res. , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 52
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid cell strains
    • Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 1965, 37:614-636.
    • (1965) Exp. Cell Res. , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 53
    • 33646468643 scopus 로고    scopus 로고
    • Apoptotic cell removal in development and tissue homeostasis
    • Henson P.M., Hume D.A. Apoptotic cell removal in development and tissue homeostasis. Trend. Immunol. 2006, 27:244-250.
    • (2006) Trend. Immunol. , vol.27 , pp. 244-250
    • Henson, P.M.1    Hume, D.A.2
  • 54
    • 0037038681 scopus 로고    scopus 로고
    • P16 (INK4a) inactivation is not required to immortalize human mammary epithelial cells
    • Herbert B.-S., et al. p16 (INK4a) inactivation is not required to immortalize human mammary epithelial cells. Oncogene 2002, 21:7897-7900.
    • (2002) Oncogene , vol.21 , pp. 7897-7900
    • Herbert, B.-S.1
  • 55
    • 2442511752 scopus 로고    scopus 로고
    • Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16 INK4a
    • Herbig U., et al. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16 INK4a. Mol. Cell 2004, 14:501-513.
    • (2004) Mol. Cell , vol.14 , pp. 501-513
    • Herbig, U.1
  • 56
    • 33644692330 scopus 로고    scopus 로고
    • Cellular senescence in aging primates
    • Herbig U., et al. Cellular senescence in aging primates. Science 2006, 311:1257.
    • (2006) Science , vol.311 , pp. 1257
    • Herbig, U.1
  • 57
    • 84859352385 scopus 로고    scopus 로고
    • Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence
    • Hewitt G., et al. Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence. Nat. Commun. 2012, 3:708.
    • (2012) Nat. Commun. , vol.3 , pp. 708
    • Hewitt, G.1
  • 58
    • 0142027011 scopus 로고    scopus 로고
    • Mechanisms of force generation and transmission by myofibroblasts
    • Hinz B., Gabbiani G. Mechanisms of force generation and transmission by myofibroblasts. Curr. Opin. Biotechnol. 2003, 14:538-546.
    • (2003) Curr. Opin. Biotechnol. , vol.14 , pp. 538-546
    • Hinz, B.1    Gabbiani, G.2
  • 59
    • 1842789989 scopus 로고    scopus 로고
    • Mechanisms of cellular senescence in human and mouse cells
    • Itahana K., et al. Mechanisms of cellular senescence in human and mouse cells. Biogerontology 2004, 5:1-10.
    • (2004) Biogerontology , vol.5 , pp. 1-10
    • Itahana, K.1
  • 60
    • 33846090789 scopus 로고    scopus 로고
    • Accumulation of senescent cells in mitotic tissue of aging primates
    • Jeyapalan J.C., et al. Accumulation of senescent cells in mitotic tissue of aging primates. Mech. Ageing Dev. 2007, 128:36-44.
    • (2007) Mech. Ageing Dev. , vol.128 , pp. 36-44
    • Jeyapalan, J.C.1
  • 61
    • 77954243065 scopus 로고    scopus 로고
    • The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
    • Jun J.I., Lau L.F. The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat. Cell Biol. 2010, 12:676-685.
    • (2010) Nat. Cell Biol. , vol.12 , pp. 676-685
    • Jun, J.I.1    Lau, L.F.2
  • 62
    • 84869186918 scopus 로고    scopus 로고
    • Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response
    • Jurk D., et al. Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response. Aging Cell 2012, 11:996-1004.
    • (2012) Aging Cell , vol.11 , pp. 996-1004
    • Jurk, D.1
  • 63
    • 81855169964 scopus 로고    scopus 로고
    • Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
    • Kang T.W., et al. Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature 2011, 479:547-551.
    • (2011) Nature , vol.479 , pp. 547-551
    • Kang, T.W.1
  • 66
    • 0032487675 scopus 로고    scopus 로고
    • Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
    • Kiyono T., et al. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 1998, 396:84-88.
    • (1998) Nature , vol.396 , pp. 84-88
    • Kiyono, T.1
  • 67
    • 33845418951 scopus 로고    scopus 로고
    • Senescence, wound healing and cancer: the PAI-1 connection
    • Kortlever R.M., Bernards R. Senescence, wound healing and cancer: the PAI-1 connection. Cell Cycle 2006, 5(23):2697-2703.
    • (2006) Cell Cycle , vol.5 , Issue.23 , pp. 2697-2703
    • Kortlever, R.M.1    Bernards, R.2
  • 68
    • 0035834121 scopus 로고    scopus 로고
    • Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging
    • Krtolica A., et al. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:12072-12077.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 12072-12077
    • Krtolica, A.1
  • 69
    • 78349257844 scopus 로고    scopus 로고
    • The essence of senescence
    • Kuilman T., et al. The essence of senescence. Genes Dev. 2010, 24:2463-2479.
    • (2010) Genes Dev. , vol.24 , pp. 2463-2479
    • Kuilman, T.1
  • 70
    • 77951687669 scopus 로고    scopus 로고
    • Senescent fibroblasts promote neoplastic transformation of partially transformed ovarian epithelial cells in a three-dimensional model of early stage ovarian cancer
    • (IN3)
    • Lawrenson K., et al. Senescent fibroblasts promote neoplastic transformation of partially transformed ovarian epithelial cells in a three-dimensional model of early stage ovarian cancer. Neoplasia 2010, 12:317. (IN3).
    • (2010) Neoplasia , vol.12 , pp. 317
    • Lawrenson, K.1
  • 71
    • 78149378853 scopus 로고    scopus 로고
    • Quiescent fibroblasts exhibit high metabolic activity
    • Lemons J.M.S., et al. Quiescent fibroblasts exhibit high metabolic activity. PLoS Biol. 2010, 8:e1000514.
    • (2010) PLoS Biol. , vol.8 , pp. e1000514
    • Lemons, J.M.S.1
  • 72
    • 36348944160 scopus 로고    scopus 로고
    • Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior
    • Liontos M., et al. Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior. Cancer Res. 2007, 67:10899-10909.
    • (2007) Cancer Res. , vol.67 , pp. 10899-10909
    • Liontos, M.1
  • 73
    • 67650003349 scopus 로고    scopus 로고
    • Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas
    • Liontos M., et al. Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas. Am. J. Pathol. 2009, 175:376-391.
    • (2009) Am. J. Pathol. , vol.175 , pp. 376-391
    • Liontos, M.1
  • 74
    • 27644456289 scopus 로고    scopus 로고
    • Death penalty for keratinocytes: apoptosis versus cornification
    • Lippens S., et al. Death penalty for keratinocytes: apoptosis versus cornification. Cell Death Differ. 2005, 12:1497-1508.
    • (2005) Cell Death Differ. , vol.12 , pp. 1497-1508
    • Lippens, S.1
  • 75
    • 19644367664 scopus 로고    scopus 로고
    • Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering
    • Lutolf M.P., Hubbell J.A. Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat. Biotechnol. 2005, 23:47-55.
    • (2005) Nat. Biotechnol. , vol.23 , pp. 47-55
    • Lutolf, M.P.1    Hubbell, J.A.2
  • 76
    • 84894565195 scopus 로고    scopus 로고
    • Self-consumption: the interplay of autophagy and apoptosis
    • Mariño G., et al. Self-consumption: the interplay of autophagy and apoptosis. Nat. Rev. Mol. Cell Biol. 2014, 15:81-94.
    • (2014) Nat. Rev. Mol. Cell Biol. , vol.15 , pp. 81-94
    • Mariño, G.1
  • 77
    • 84919798290 scopus 로고    scopus 로고
    • Long-term quiescent fibroblast cells transit into senescence
    • Marthandan S., et al. Long-term quiescent fibroblast cells transit into senescence. PLoS One 2014, 9:e115597.
    • (2014) PLoS One , vol.9 , pp. e115597
    • Marthandan, S.1
  • 79
    • 0030921323 scopus 로고    scopus 로고
    • Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease
    • McShea A., et al. Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease. Am. J Pathol. 1997, 150:1933-1939.
    • (1997) Am. J Pathol. , vol.150 , pp. 1933-1939
    • McShea, A.1
  • 80
    • 79955047394 scopus 로고    scopus 로고
    • Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells
    • Minagawa S., et al. Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 2011, 300:L391-L401.
    • (2011) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.300 , pp. L391-L401
    • Minagawa, S.1
  • 81
    • 84904702784 scopus 로고    scopus 로고
    • Cellular senescence: from physiology to pathology
    • Muñoz-Espín D., Serrano M. Cellular senescence: from physiology to pathology. Nat. Rev. Mol. Cell Biol. 2014, 15:482-496.
    • (2014) Nat. Rev. Mol. Cell Biol. , vol.15 , pp. 482-496
    • Muñoz-Espín, D.1    Serrano, M.2
  • 82
    • 84889600900 scopus 로고    scopus 로고
    • Programmed cell senescence during mammalian embryonic development
    • Muñoz-Espín D., et al. Programmed cell senescence during mammalian embryonic development. Cell 2013, 155:1104-1118.
    • (2013) Cell , vol.155 , pp. 1104-1118
    • Muñoz-Espín, D.1
  • 83
    • 0035858987 scopus 로고    scopus 로고
    • Human fibroblast replicative senescence can occur in the absence of extensive cell division and short telomeres
    • Munro J., et al. Human fibroblast replicative senescence can occur in the absence of extensive cell division and short telomeres. Oncogene 2001, 20(27):3541-3552.
    • (2001) Oncogene , vol.20 , Issue.27 , pp. 3541-3552
    • Munro, J.1
  • 84
    • 50149097809 scopus 로고    scopus 로고
    • A complex barcode underlies the heterogeneous response of p53 to stress
    • Murray-Zmijewski F., et al. A complex barcode underlies the heterogeneous response of p53 to stress. Nat. Rev. Mol. Cell Biol. 2008, 9:702-712.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 702-712
    • Murray-Zmijewski, F.1
  • 85
    • 77951976271 scopus 로고    scopus 로고
    • Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells
    • Nakamura A.J., et al. Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells. Aging 2009, 4:212-218.
    • (2009) Aging , vol.4 , pp. 212-218
    • Nakamura, A.J.1
  • 86
    • 77649175453 scopus 로고    scopus 로고
    • Genomic instability-an evolving hallmark of cancer
    • Negrini S., et al. Genomic instability-an evolving hallmark of cancer. Nat. Rev. Mol. Cell Biol. 2010, 11(3):220-228.
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , Issue.3 , pp. 220-228
    • Negrini, S.1
  • 87
    • 84904990966 scopus 로고    scopus 로고
    • Inside and out: the activities of senescence in cancer
    • Pérez-Mancera P.A., et al. Inside and out: the activities of senescence in cancer. Nat. Rev. Cancer 2014, 14:547-558.
    • (2014) Nat. Rev. Cancer , vol.14 , pp. 547-558
    • Pérez-Mancera, P.A.1
  • 88
    • 79960871658 scopus 로고    scopus 로고
    • Human lung fibroblasts prematurely senescent after exposure to ionizing radiation enhance the growth of malignant lung epithelial cells in vitro and in vivo
    • Papadopoulou A., Kletsas D. Human lung fibroblasts prematurely senescent after exposure to ionizing radiation enhance the growth of malignant lung epithelial cells in vitro and in vivo. Int. J. Oncol. 2011, 39(4):989-999.
    • (2011) Int. J. Oncol. , vol.39 , Issue.4 , pp. 989-999
    • Papadopoulou, A.1    Kletsas, D.2
  • 89
    • 21244445454 scopus 로고    scopus 로고
    • Comparison of replicative senescence and stress-induced premature senescence combining differential display and low-density DNA arrays
    • Pascal T., et al. Comparison of replicative senescence and stress-induced premature senescence combining differential display and low-density DNA arrays. FEBS Lett. 2005, 579:3651-3659.
    • (2005) FEBS Lett. , vol.579 , pp. 3651-3659
    • Pascal, T.1
  • 90
    • 38049057905 scopus 로고    scopus 로고
    • DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?
    • Passos J.F., et al. DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?. Nucleic Acids Res. 2007, 35:7505-7513.
    • (2007) Nucleic Acids Res. , vol.35 , pp. 7505-7513
    • Passos, J.F.1
  • 91
    • 84963492280 scopus 로고    scopus 로고
    • The assessment of angiogenesis and fibroblastic stromagenesis in hyperplastic and pre-invasive breast lesions
    • Pavlakis K., et al. The assessment of angiogenesis and fibroblastic stromagenesis in hyperplastic and pre-invasive breast lesions. BMC Cancer 2008, 2:8-88.
    • (2008) BMC Cancer , vol.2 , pp. 8-88
    • Pavlakis, K.1
  • 92
    • 0033011356 scopus 로고    scopus 로고
    • Cellular proliferation potential during aging and caloric restriction in rhesus monkeys (Macaca mulatta)
    • Pendergrass W.R., et al. Cellular proliferation potential during aging and caloric restriction in rhesus monkeys (Macaca mulatta). J. Cell Physiol. 1999, 180:123-130.
    • (1999) J. Cell Physiol. , vol.180 , pp. 123-130
    • Pendergrass, W.R.1
  • 93
    • 79952563157 scopus 로고    scopus 로고
    • Senescent mesenchymal cells accumulate in human fibrosis by a telomere-independent mechanism and ameliorate fibrosis through matrix metalloproteinases
    • Pitiyage G.N., et al. Senescent mesenchymal cells accumulate in human fibrosis by a telomere-independent mechanism and ameliorate fibrosis through matrix metalloproteinases. J. Pathol. 2011, 223:604-617.
    • (2011) J. Pathol. , vol.223 , pp. 604-617
    • Pitiyage, G.N.1
  • 94
    • 0042734423 scopus 로고    scopus 로고
    • The role of chondrocyte senescence in osteoarthritis
    • Price J.S., et al. The role of chondrocyte senescence in osteoarthritis. Aging Cell 2002, 1:57-65.
    • (2002) Aging Cell , vol.1 , pp. 57-65
    • Price, J.S.1
  • 95
    • 42549152045 scopus 로고    scopus 로고
    • No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas
    • Qiu W., et al. No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas. Nat. Genet 2008, 40:650-655.
    • (2008) Nat. Genet , vol.40 , pp. 650-655
    • Qiu, W.1
  • 96
    • 84922736742 scopus 로고    scopus 로고
    • Cancer-type-specific crosstalk between autophagy: necroptosis and apoptosis as a pharmacological target
    • Radogna F., et al. Cancer-type-specific crosstalk between autophagy: necroptosis and apoptosis as a pharmacological target. Biochem. Pharmacol. 2015, 94:1-11.
    • (2015) Biochem. Pharmacol. , vol.94 , pp. 1-11
    • Radogna, F.1
  • 97
    • 75149116221 scopus 로고    scopus 로고
    • Fibroblasts in three dimensional matrices: cell migration and matrix remodeling
    • Rhee S. Fibroblasts in three dimensional matrices: cell migration and matrix remodeling. Exp. Mol. Med. 2009, 41:858-865.
    • (2009) Exp. Mol. Med. , vol.41 , pp. 858-865
    • Rhee, S.1
  • 98
    • 30044440857 scopus 로고    scopus 로고
    • Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress
    • Rodriguez R., Meuth M. Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress. Mol. Biol. Cell 2006, 17:402-412.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 402-412
    • Rodriguez, R.1    Meuth, M.2
  • 99
    • 0035252089 scopus 로고    scopus 로고
    • Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
    • Romanov S.R., et al. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature 2001, 409:633-637.
    • (2001) Nature , vol.409 , pp. 633-637
    • Romanov, S.R.1
  • 100
    • 0035736138 scopus 로고    scopus 로고
    • If not apoptosis, then what?: Treatment-induced senescence and mitotic catastrophe in tumor cells
    • Roninson I.B., et al. If not apoptosis, then what?: Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist. Update 2001, 4:303-313.
    • (2001) Drug Resist. Update , vol.4 , pp. 303-313
    • Roninson, I.B.1
  • 101
    • 0038277105 scopus 로고    scopus 로고
    • Tumor cell senescence in cancer treatment
    • Roninson I.B. Tumor cell senescence in cancer treatment. Cancer Res. 2003, 63:2705-2715.
    • (2003) Cancer Res. , vol.63 , pp. 2705-2715
    • Roninson, I.B.1
  • 102
    • 84865409542 scopus 로고    scopus 로고
    • Irinotecan induces senescence and apoptosis in colonic cells in vitro
    • Rudolf E., et al. Irinotecan induces senescence and apoptosis in colonic cells in vitro. Toxicol. Lett. 2012, 214:1-8.
    • (2012) Toxicol. Lett. , vol.214 , pp. 1-8
    • Rudolf, E.1
  • 103
  • 104
    • 0034713329 scopus 로고    scopus 로고
    • Is beta-galactosidase staining a marker of senescence in vitro and in vivo?
    • Severino J., et al. Is beta-galactosidase staining a marker of senescence in vitro and in vivo?. Exp. Cell Res. 2000, 257:162-171.
    • (2000) Exp. Cell Res. , vol.257 , pp. 162-171
    • Severino, J.1
  • 105
    • 84865326113 scopus 로고    scopus 로고
    • The canonical NF-(B pathway differentially protects normal and human tumor cells from ROS-induced DNA damage
    • Sfikas A., et al. The canonical NF-(B pathway differentially protects normal and human tumor cells from ROS-induced DNA damage. Cell. Signal. 2012, 24:2007-2023.
    • (2012) Cell. Signal. , vol.24 , pp. 2007-2023
    • Sfikas, A.1
  • 106
    • 2342570379 scopus 로고    scopus 로고
    • Hallmarks of senescence in carcinogenesis and cancer therapy
    • Shay J.W., Roninson I.B. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 2004, 23:2919-2933.
    • (2004) Oncogene , vol.23 , pp. 2919-2933
    • Shay, J.W.1    Roninson, I.B.2
  • 107
    • 19844382620 scopus 로고    scopus 로고
    • Senescence and immortalization: role of telomeres and telomerase
    • Shay J.W., Wright W.E. Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis 2005, 26:867-874.
    • (2005) Carcinogenesis , vol.26 , pp. 867-874
    • Shay, J.W.1    Wright, W.E.2
  • 108
    • 77955845914 scopus 로고    scopus 로고
    • Telomeres and telomerase in normal and cancer stem cells
    • Shay J.W., Wright W.E. Telomeres and telomerase in normal and cancer stem cells. FEBS Lett. 2010, 584(17):3819-3825.
    • (2010) FEBS Lett. , vol.584 , Issue.17 , pp. 3819-3825
    • Shay, J.W.1    Wright, W.E.2
  • 109
    • 84866026484 scopus 로고    scopus 로고
    • Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory Bowel disease
    • Sohn J.J., et al. Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory Bowel disease. PLoS One 2012, 7:e44156.
    • (2012) PLoS One , vol.7 , pp. e44156
    • Sohn, J.J.1
  • 110
    • 84931434236 scopus 로고    scopus 로고
    • Giant cell fibroma of tongue: understanding the nature of an unusual histopathological entity
    • ID:864512
    • Sonalika W.G., et al. Giant cell fibroma of tongue: understanding the nature of an unusual histopathological entity. Case Rep. Dent. 2014, 2014:1-4. ID:864512.
    • (2014) Case Rep. Dent. , vol.2014 , pp. 1-4
    • Sonalika, W.G.1
  • 111
    • 16244383882 scopus 로고    scopus 로고
    • Distinct ROS and biochemical profiles in cells undergoing DNA damage-induced senescence and apoptosis
    • Song Y.S., et al. Distinct ROS and biochemical profiles in cells undergoing DNA damage-induced senescence and apoptosis. Mech. Ageing Dev. 2005, 126:580-590.
    • (2005) Mech. Ageing Dev. , vol.126 , pp. 580-590
    • Song, Y.S.1
  • 112
    • 0028943734 scopus 로고
    • Apoptosis in the pathogenesis and treatment of disease
    • Thompson C.B. Apoptosis in the pathogenesis and treatment of disease. Science 1995, 267:1456-1462.
    • (1995) Science , vol.267 , pp. 1456-1462
    • Thompson, C.B.1
  • 113
    • 0036710468 scopus 로고    scopus 로고
    • Stress-induced premature senescence and tissue ageing
    • Toussaint O., et al. Stress-induced premature senescence and tissue ageing. Biochem. Pharmacol. 2002, 64:1007-1009.
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 1007-1009
    • Toussaint, O.1
  • 114
    • 84868646775 scopus 로고    scopus 로고
    • Cellular senescence as a possible mechanism for halting progression of keloid lesions
    • Varmeh S., et al. Cellular senescence as a possible mechanism for halting progression of keloid lesions. Genes Cancer 2011, 2:1061-1066.
    • (2011) Genes Cancer , vol.2 , pp. 1061-1066
    • Varmeh, S.1
  • 115
    • 0035130153 scopus 로고    scopus 로고
    • Differential expression of thymosin β-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosis
    • Vasile E., et al. Differential expression of thymosin β-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosis. FASEB J. 2001, 15:458-466.
    • (2001) FASEB J. , vol.15 , pp. 458-466
    • Vasile, E.1
  • 116
    • 84864020954 scopus 로고    scopus 로고
    • The number of p16INK4a positive cells in human skin reflects biological age
    • Waaijer M.E., et al. The number of p16INK4a positive cells in human skin reflects biological age. Aging Cell 2012, 11:722-725.
    • (2012) Aging Cell , vol.11 , pp. 722-725
    • Waaijer, M.E.1
  • 117
    • 66149167336 scopus 로고    scopus 로고
    • DNA damage response and cellular senescence in tissues of aging mice
    • Wang C., et al. DNA damage response and cellular senescence in tissues of aging mice. Aging Cell 2009, 8:311-323.
    • (2009) Aging Cell , vol.8 , pp. 311-323
    • Wang, C.1
  • 118
    • 84863667325 scopus 로고    scopus 로고
    • Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence
    • Wang J.C., Bennett M. Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence. Circ. Res. 2012, 111(2):245-259.
    • (2012) Circ. Res. , vol.111 , Issue.2 , pp. 245-259
    • Wang, J.C.1    Bennett, M.2
  • 119
    • 84912573043 scopus 로고    scopus 로고
    • Protective effects of verapamil against H2O2-induced apoptosis in human lens epithelial cells
    • Wang Z., et al. Protective effects of verapamil against H2O2-induced apoptosis in human lens epithelial cells. Biomol. Ther. 2014, 22:553-557.
    • (2014) Biomol. Ther. , vol.22 , pp. 553-557
    • Wang, Z.1
  • 120
    • 33846937033 scopus 로고    scopus 로고
    • Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
    • Xue W., et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 2007, 445:656-660.
    • (2007) Nature , vol.445 , pp. 656-660
    • Xue, W.1
  • 121
    • 34248184169 scopus 로고    scopus 로고
    • Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells
    • Yaar M., et al. Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells. Breast Cancer Res. 2007, 9:R13.
    • (2007) Breast Cancer Res. , vol.9 , pp. R13
    • Yaar, M.1
  • 122
    • 33750798741 scopus 로고    scopus 로고
    • The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis
    • Yang G., et al. The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:16472-16477.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 16472-16477
    • Yang, G.1
  • 123
    • 3242682558 scopus 로고    scopus 로고
    • Distinct expression patterns of the transcription factor E2F-1 in relation to tumour growth parameters in common human carcinomas
    • Zacharatos P., et al. Distinct expression patterns of the transcription factor E2F-1 in relation to tumour growth parameters in common human carcinomas. J. Pathol. 2004, 203(3):744-753.
    • (2004) J. Pathol. , vol.203 , Issue.3 , pp. 744-753
    • Zacharatos, P.1
  • 124
    • 84901288438 scopus 로고    scopus 로고
    • The role of senescent cells in ageing
    • van Deursen J.M. The role of senescent cells in ageing. Nature 2014, 509:439-446.
    • (2014) Nature , vol.509 , pp. 439-446
    • van Deursen, J.M.1


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