-
1
-
-
84881249955
-
Differences in protein changes between stress-induced premature senescence and replicative senescence states
-
Aan G.J., et al. Differences in protein changes between stress-induced premature senescence and replicative senescence states. Electrophoresis 2013, 34:2209-2217.
-
(2013)
Electrophoresis
, vol.34
, pp. 2209-2217
-
-
Aan, G.J.1
-
2
-
-
0344441890
-
A DNA damage checkpoint response in telomere-initiated senescence
-
Adda di Fagagna D.', et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 2003, 426:194-198.
-
(2003)
Nature
, vol.426
, pp. 194-198
-
-
Adda di Fagagna, D.'1
-
3
-
-
77957933902
-
Adult-type fibrosarcoma: a reevaluation of 163 putative cases diagnosed at a single institution over a 48-year period
-
Bahrami A., Folpe A.L. Adult-type fibrosarcoma: a reevaluation of 163 putative cases diagnosed at a single institution over a 48-year period. Am. J. Surg. Pathol. 2010, 34(10):1504-1513.
-
(2010)
Am. J. Surg. Pathol.
, vol.34
, Issue.10
, pp. 1504-1513
-
-
Bahrami, A.1
Folpe, A.L.2
-
4
-
-
36949005417
-
DNA damage signalling guards against activated oncogenes and tumour progression
-
Bartek J., et al. DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene 2007, 26:7773-7779.
-
(2007)
Oncogene
, vol.26
, pp. 7773-7779
-
-
Bartek, J.1
-
5
-
-
17244367849
-
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
-
Bartkova J., et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005, 434:864-870.
-
(2005)
Nature
, vol.434
, pp. 864-870
-
-
Bartkova, J.1
-
6
-
-
33845235459
-
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
-
Bartkova J., et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 2006, 444:633-637.
-
(2006)
Nature
, vol.444
, pp. 633-637
-
-
Bartkova, J.1
-
7
-
-
1542781659
-
When cells get stressed: an integrative view of cellular senescence
-
Ben-Porath I., Weinberg R.A. When cells get stressed: an integrative view of cellular senescence. J. Clin. Invest. 2004, 113:8-13.
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 8-13
-
-
Ben-Porath, I.1
Weinberg, R.A.2
-
8
-
-
40049094626
-
Impact of aging on the biology of breast cancer
-
Benz C.C. Impact of aging on the biology of breast cancer. Crit. Rev. Oncol. Hematol. 2008, 66:65-74.
-
(2008)
Crit. Rev. Oncol. Hematol.
, vol.66
, pp. 65-74
-
-
Benz, C.C.1
-
9
-
-
85077943934
-
Report differential oncogenic Ras signaling and senescence in tumor cells
-
Bihani T., et al. Report differential oncogenic Ras signaling and senescence in tumor cells. Cell Cycle 2004, 3:1201-1207.
-
(2004)
Cell Cycle
, vol.3
, pp. 1201-1207
-
-
Bihani, T.1
-
10
-
-
84947243777
-
DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease
-
Birch J., et al. DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease. Am. J. Physiol. Lung Cell. Mol. Physiol. 2015, 309:L1124-L1137.
-
(2015)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.309
, pp. L1124-L1137
-
-
Birch, J.1
-
11
-
-
60749125436
-
Epidermal homeostasis: a balancing act of stem cells in the skin
-
Blanpain C., Fuchs E. Epidermal homeostasis: a balancing act of stem cells in the skin. Nat. Rev. Mol. Cell Biol. 2009, 10:207-217.
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 207-217
-
-
Blanpain, C.1
Fuchs, E.2
-
12
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar A.G., et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998, 279:349-352.
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
-
13
-
-
84925848840
-
Cell senescence: role in aging and age-related diseases
-
Campisi J., Robert L. Cell senescence: role in aging and age-related diseases. Interdiscip. Top. Gerontol. 2014, 39:45-61.
-
(2014)
Interdiscip. Top. Gerontol.
, vol.39
, pp. 45-61
-
-
Campisi, J.1
Robert, L.2
-
14
-
-
34548186667
-
Cellular senescence: when bad things happen to good cells
-
Campisi J., d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat. Rev. Mol. Cell Biol. 2007, 8:729-740.
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 729-740
-
-
Campisi, J.1
d'Adda di Fagagna, F.2
-
15
-
-
84862886876
-
Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production
-
Capparelli C., et al. Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production. Cell Cycle 2012, 11:2285.
-
(2012)
Cell Cycle
, vol.11
, pp. 2285
-
-
Capparelli, C.1
-
16
-
-
65249100855
-
Stromagenesis during tumorigenesis: characterization of tumor-associated fibroblasts and stroma-derived 3D matrices
-
Castello-Cros R., Cukierman E. Stromagenesis during tumorigenesis: characterization of tumor-associated fibroblasts and stroma-derived 3D matrices. Methods Mol. Biol. 2009, 522:275-305.
-
(2009)
Methods Mol. Biol.
, vol.522
, pp. 275-305
-
-
Castello-Cros, R.1
Cukierman, E.2
-
17
-
-
38049059966
-
DNA damage, cellular senescence and organismal ageing: causal or correlative?
-
Chen J.-H., et al. DNA damage, cellular senescence and organismal ageing: causal or correlative?. Nucleic Acids Res. 2007, 35:7417-7428.
-
(2007)
Nucleic Acids Res.
, vol.35
, pp. 7417-7428
-
-
Chen, J.-H.1
-
18
-
-
0019982509
-
Whole population cell kinetics of mouse duodenal jejunal, iieal, and colonic epithelia as determined by radioautography and flow cytometry
-
Cheng H., Bjerknes M. Whole population cell kinetics of mouse duodenal jejunal, iieal, and colonic epithelia as determined by radioautography and flow cytometry. Anat. Rec. 1982, 203:251-264.
-
(1982)
Anat. Rec.
, vol.203
, pp. 251-264
-
-
Cheng, H.1
Bjerknes, M.2
-
19
-
-
52449107748
-
Partial proteasome inhibition in human fibroblasts triggers accelerated M1 senescence or M2 crisis depending on p53 and Rb status
-
Chondrogianni N., et al. Partial proteasome inhibition in human fibroblasts triggers accelerated M1 senescence or M2 crisis depending on p53 and Rb status. Aging Cell 2008, 7:717-732.
-
(2008)
Aging Cell
, vol.7
, pp. 717-732
-
-
Chondrogianni, N.1
-
20
-
-
72949096792
-
Senescence in tumours: evidence from mice and humans. Nature reviews
-
Collado M., Serrano M. Senescence in tumours: evidence from mice and humans. Nature reviews. Cancer 2010, 10:51-57.
-
(2010)
Cancer
, vol.10
, pp. 51-57
-
-
Collado, M.1
Serrano, M.2
-
21
-
-
33644984490
-
A new description of cellular quiescence
-
Coller H.A., et al. A new description of cellular quiescence. PLoS Biol. 2006, 4:e83.
-
(2006)
PLoS Biol.
, vol.4
, pp. e83
-
-
Coller, H.A.1
-
22
-
-
77949881221
-
The senescence-associated secretory phenotype: the dark side of tumor suppression
-
Coppé J.-P., et al. The senescence-associated secretory phenotype: the dark side of tumor suppression. Ann. Rev. Path. Mech. Dis. 2010, 5:99-118.
-
(2010)
Ann. Rev. Path. Mech. Dis.
, vol.5
, pp. 99-118
-
-
Coppé, J.-P.1
-
23
-
-
84940666994
-
Programmed cell death in the skin
-
Costanzo A., et al. Programmed cell death in the skin. Int. J. Dev. Biol. 2015, 59(1-3):73-78.
-
(2015)
Int. J. Dev. Biol.
, vol.59
, Issue.1-3
, pp. 73-78
-
-
Costanzo, A.1
-
24
-
-
33845292259
-
A negative feedback signaling network underlies oncogene-induced senescence
-
Courtois-Cox S., et al. A negative feedback signaling network underlies oncogene-induced senescence. Cancer Cell 2006, 10:459-472.
-
(2006)
Cancer Cell
, vol.10
, pp. 459-472
-
-
Courtois-Cox, S.1
-
25
-
-
8444237425
-
Replicative senescence: a critical review
-
Cristofalo V.J., et al. Replicative senescence: a critical review. Mech. Ageing Dev. 2004, 125:827-848.
-
(2004)
Mech. Ageing Dev.
, vol.125
, pp. 827-848
-
-
Cristofalo, V.J.1
-
26
-
-
13844270572
-
Tissue repair contraction, and the myofibroblast
-
Desmouliere A., et al. Tissue repair contraction, and the myofibroblast. Wound Repair Regen. 2005, 13:7-12.
-
(2005)
Wound Repair Regen.
, vol.13
, pp. 7-12
-
-
Desmouliere, A.1
-
27
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
Dimri G.P. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. U S A. 1995, 92:9363-9367.
-
(1995)
Proc. Natl. Acad. Sci. U S A.
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
-
28
-
-
17044395076
-
Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening
-
Duan J., et al. Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening. Int. J. Biochem. Cell Biol. 2005, 37:1407-1420.
-
(2005)
Int. J. Biochem. Cell Biol.
, vol.37
, pp. 1407-1420
-
-
Duan, J.1
-
29
-
-
43549120978
-
E2F-1 overexpression correlates with decreased proliferation and better prognosis in adenocarcinomas of Barrett oesophagus
-
Evangelou K., et al. E2F-1 overexpression correlates with decreased proliferation and better prognosis in adenocarcinomas of Barrett oesophagus. J. Clin. Pathol. 2008, 61(5):601-605.
-
(2008)
J. Clin. Pathol.
, vol.61
, Issue.5
, pp. 601-605
-
-
Evangelou, K.1
-
30
-
-
84905841925
-
E2F transcription factors and digestive system malignancies: how much do we know?
-
Evangelou K., et al. E2F transcription factors and digestive system malignancies: how much do we know?. World J. Gastroenterol. 2014, 20(29):10212-10216.
-
(2014)
World J. Gastroenterol.
, vol.20
, Issue.29
, pp. 10212-10216
-
-
Evangelou, K.1
-
31
-
-
41649108818
-
Drug-induced senescence bystander proliferation in prostate cancer cells in vitro and in vivo
-
Ewald J., et al. Drug-induced senescence bystander proliferation in prostate cancer cells in vitro and in vivo. Br. J. Cancer 2008, 98:1244-1249.
-
(2008)
Br. J. Cancer
, vol.98
, pp. 1244-1249
-
-
Ewald, J.1
-
32
-
-
0033965413
-
Cell senescence and human aging: where's the link?
-
Faragher R.G. Cell senescence and human aging: where's the link?. Biochem. Soc. Trans. 2000, 28:221-226.
-
(2000)
Biochem. Soc. Trans.
, vol.28
, pp. 221-226
-
-
Faragher, R.G.1
-
33
-
-
84877133556
-
Increased expression of senescence markers in cystic fibrosis airways
-
Fischer B.M., et al. Increased expression of senescence markers in cystic fibrosis airways. Am. J. Physiol. Lung Cell. Mol. Physiol. 2013, 304:L394-400.
-
(2013)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.304
, pp. L394-400
-
-
Fischer, B.M.1
-
34
-
-
77952105389
-
Inflammatory networks during cellular senescence: causes and consequences
-
Freund A., et al. Inflammatory networks during cellular senescence: causes and consequences. Trends Mol. Med 2010, 16:238-246.
-
(2010)
Trends Mol. Med
, vol.16
, pp. 238-246
-
-
Freund, A.1
-
35
-
-
84859372986
-
Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation
-
Fumagalli M., et al. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat. Cell Biol. 2012, 14:355-365.
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 355-365
-
-
Fumagalli, M.1
-
36
-
-
84255210700
-
Molecular definitions of cell death subroutines: recommendations of the nomenclature committee on cell death
-
Galluzzi L., et al. Molecular definitions of cell death subroutines: recommendations of the nomenclature committee on cell death. Cell Death Differ. 2012, 19:107-120.
-
(2012)
Cell Death Differ.
, vol.19
, pp. 107-120
-
-
Galluzzi, L.1
-
37
-
-
84939986310
-
Essential versus accessory aspects of cell death: recommendations of the NCCD
-
Galluzzi L., et al. Essential versus accessory aspects of cell death: recommendations of the NCCD. Cell Death Differ. 2015, 22(1):58-73.
-
(2015)
Cell Death Differ.
, vol.22
, Issue.1
, pp. 58-73
-
-
Galluzzi, L.1
-
38
-
-
84874967976
-
Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues
-
Georgakopoulou E., et al. Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues. Aging (Milano) 2013, 5:37.
-
(2013)
Aging (Milano)
, vol.5
, pp. 37
-
-
Georgakopoulou, E.1
-
39
-
-
84934434682
-
From molecules to matrix: construction and evaluation of molecularly defined bioscaffolds
-
Geutjes P.J., et al. From molecules to matrix: construction and evaluation of molecularly defined bioscaffolds. Adv. Exp. Med. Biol. 2006, 585:279-295.
-
(2006)
Adv. Exp. Med. Biol.
, vol.585
, pp. 279-295
-
-
Geutjes, P.J.1
-
40
-
-
1242320230
-
Ageing of human epidermis: the role of apoptosis Fas and telomerase
-
Gilhar A., et al. Ageing of human epidermis: the role of apoptosis Fas and telomerase. Br. J. Dermatol. 2004, 150:56-63.
-
(2004)
Br. J. Dermatol.
, vol.150
, pp. 56-63
-
-
Gilhar, A.1
-
41
-
-
78649629320
-
Oncogene-induced senescence: the bright and dark side of the response
-
Gorgoulis V.G., Halazonetis T.D. Oncogene-induced senescence: the bright and dark side of the response. Curr. Opin Cell Biol. 2010, 22(6):816-827.
-
(2010)
Curr. Opin Cell Biol.
, vol.22
, Issue.6
, pp. 816-827
-
-
Gorgoulis, V.G.1
Halazonetis, T.D.2
-
42
-
-
0036773376
-
Transcription factor E2F-1 acts as a growth-promoting factor and is associated with adverse prognosis in non-small cell lung carcinomas
-
Gorgoulis V.G., et al. Transcription factor E2F-1 acts as a growth-promoting factor and is associated with adverse prognosis in non-small cell lung carcinomas. J. Pathol. 2002, 198(2):142-156.
-
(2002)
J. Pathol.
, vol.198
, Issue.2
, pp. 142-156
-
-
Gorgoulis, V.G.1
-
43
-
-
17244366865
-
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
-
Gorgoulis V.G., et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 2005, 434:907-913.
-
(2005)
Nature
, vol.434
, pp. 907-913
-
-
Gorgoulis, V.G.1
-
44
-
-
59649119553
-
Senescent keratinocytes die by autophagic programmed cell death
-
Gosselin K., et al. Senescent keratinocytes die by autophagic programmed cell death. Am. J. Pathol. 2009, 174:423-435.
-
(2009)
Am. J. Pathol.
, vol.174
, pp. 423-435
-
-
Gosselin, K.1
-
45
-
-
84945296001
-
Aging-related inflammation in osteoarthritis
-
Greene M.A., Loeser R.F. Aging-related inflammation in osteoarthritis. Osteoarthritis Cartilage 2015, 23:1966-1971.
-
(2015)
Osteoarthritis Cartilage
, vol.23
, pp. 1966-1971
-
-
Greene, M.A.1
Loeser, R.F.2
-
46
-
-
84878764042
-
Mechanics of epithelial tissue homeostasis and morphogenesis
-
Guillot C., Lecuit T. Mechanics of epithelial tissue homeostasis and morphogenesis. Science 2013, 340:1185-1189.
-
(2013)
Science
, vol.340
, pp. 1185-1189
-
-
Guillot, C.1
Lecuit, T.2
-
47
-
-
40449120350
-
An oncogene-induced DNA damage model for cancer development
-
Halazonetis T.D., et al. An oncogene-induced DNA damage model for cancer development. Science 2008, 319(5868):1352-1355.
-
(2008)
Science
, vol.319
, Issue.5868
, pp. 1352-1355
-
-
Halazonetis, T.D.1
-
48
-
-
0028589378
-
Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis
-
Hall P.A., et al. Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis. J. Cell Sci. 1994, 107:3569-3577.
-
(1994)
J. Cell Sci.
, vol.107
, pp. 3569-3577
-
-
Hall, P.A.1
-
49
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley C.B., et al. Telomeres shorten during ageing of human fibroblasts. Nature 1990, 345(6274):458-460.
-
(1990)
Nature
, vol.345
, Issue.6274
, pp. 458-460
-
-
Harley, C.B.1
-
50
-
-
77955516632
-
Cellular senescence predicts treatment outcome in metastasised colorectal cancer
-
Haugstetter A., et al. Cellular senescence predicts treatment outcome in metastasised colorectal cancer. Br. J. Cancer 2010, 103:505-509.
-
(2010)
Br. J. Cancer
, vol.103
, pp. 505-509
-
-
Haugstetter, A.1
-
51
-
-
0344622606
-
The serial cultivation of human diploid cell strains
-
Hayflick L., Moorhead P.S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 1961, 25:585-621.
-
(1961)
Exp. Cell Res.
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.S.2
-
52
-
-
50549218525
-
The limited in vitro lifetime of human diploid cell strains
-
Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 1965, 37:614-636.
-
(1965)
Exp. Cell Res.
, vol.37
, pp. 614-636
-
-
Hayflick, L.1
-
53
-
-
33646468643
-
Apoptotic cell removal in development and tissue homeostasis
-
Henson P.M., Hume D.A. Apoptotic cell removal in development and tissue homeostasis. Trend. Immunol. 2006, 27:244-250.
-
(2006)
Trend. Immunol.
, vol.27
, pp. 244-250
-
-
Henson, P.M.1
Hume, D.A.2
-
54
-
-
0037038681
-
P16 (INK4a) inactivation is not required to immortalize human mammary epithelial cells
-
Herbert B.-S., et al. p16 (INK4a) inactivation is not required to immortalize human mammary epithelial cells. Oncogene 2002, 21:7897-7900.
-
(2002)
Oncogene
, vol.21
, pp. 7897-7900
-
-
Herbert, B.-S.1
-
55
-
-
2442511752
-
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16 INK4a
-
Herbig U., et al. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16 INK4a. Mol. Cell 2004, 14:501-513.
-
(2004)
Mol. Cell
, vol.14
, pp. 501-513
-
-
Herbig, U.1
-
56
-
-
33644692330
-
Cellular senescence in aging primates
-
Herbig U., et al. Cellular senescence in aging primates. Science 2006, 311:1257.
-
(2006)
Science
, vol.311
, pp. 1257
-
-
Herbig, U.1
-
57
-
-
84859352385
-
Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence
-
Hewitt G., et al. Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence. Nat. Commun. 2012, 3:708.
-
(2012)
Nat. Commun.
, vol.3
, pp. 708
-
-
Hewitt, G.1
-
58
-
-
0142027011
-
Mechanisms of force generation and transmission by myofibroblasts
-
Hinz B., Gabbiani G. Mechanisms of force generation and transmission by myofibroblasts. Curr. Opin. Biotechnol. 2003, 14:538-546.
-
(2003)
Curr. Opin. Biotechnol.
, vol.14
, pp. 538-546
-
-
Hinz, B.1
Gabbiani, G.2
-
59
-
-
1842789989
-
Mechanisms of cellular senescence in human and mouse cells
-
Itahana K., et al. Mechanisms of cellular senescence in human and mouse cells. Biogerontology 2004, 5:1-10.
-
(2004)
Biogerontology
, vol.5
, pp. 1-10
-
-
Itahana, K.1
-
60
-
-
33846090789
-
Accumulation of senescent cells in mitotic tissue of aging primates
-
Jeyapalan J.C., et al. Accumulation of senescent cells in mitotic tissue of aging primates. Mech. Ageing Dev. 2007, 128:36-44.
-
(2007)
Mech. Ageing Dev.
, vol.128
, pp. 36-44
-
-
Jeyapalan, J.C.1
-
61
-
-
77954243065
-
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
-
Jun J.I., Lau L.F. The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat. Cell Biol. 2010, 12:676-685.
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 676-685
-
-
Jun, J.I.1
Lau, L.F.2
-
62
-
-
84869186918
-
Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response
-
Jurk D., et al. Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response. Aging Cell 2012, 11:996-1004.
-
(2012)
Aging Cell
, vol.11
, pp. 996-1004
-
-
Jurk, D.1
-
63
-
-
81855169964
-
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
-
Kang T.W., et al. Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature 2011, 479:547-551.
-
(2011)
Nature
, vol.479
, pp. 547-551
-
-
Kang, T.W.1
-
66
-
-
0032487675
-
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
-
Kiyono T., et al. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 1998, 396:84-88.
-
(1998)
Nature
, vol.396
, pp. 84-88
-
-
Kiyono, T.1
-
67
-
-
33845418951
-
Senescence, wound healing and cancer: the PAI-1 connection
-
Kortlever R.M., Bernards R. Senescence, wound healing and cancer: the PAI-1 connection. Cell Cycle 2006, 5(23):2697-2703.
-
(2006)
Cell Cycle
, vol.5
, Issue.23
, pp. 2697-2703
-
-
Kortlever, R.M.1
Bernards, R.2
-
68
-
-
0035834121
-
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging
-
Krtolica A., et al. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:12072-12077.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 12072-12077
-
-
Krtolica, A.1
-
69
-
-
78349257844
-
The essence of senescence
-
Kuilman T., et al. The essence of senescence. Genes Dev. 2010, 24:2463-2479.
-
(2010)
Genes Dev.
, vol.24
, pp. 2463-2479
-
-
Kuilman, T.1
-
70
-
-
77951687669
-
Senescent fibroblasts promote neoplastic transformation of partially transformed ovarian epithelial cells in a three-dimensional model of early stage ovarian cancer
-
(IN3)
-
Lawrenson K., et al. Senescent fibroblasts promote neoplastic transformation of partially transformed ovarian epithelial cells in a three-dimensional model of early stage ovarian cancer. Neoplasia 2010, 12:317. (IN3).
-
(2010)
Neoplasia
, vol.12
, pp. 317
-
-
Lawrenson, K.1
-
71
-
-
78149378853
-
Quiescent fibroblasts exhibit high metabolic activity
-
Lemons J.M.S., et al. Quiescent fibroblasts exhibit high metabolic activity. PLoS Biol. 2010, 8:e1000514.
-
(2010)
PLoS Biol.
, vol.8
, pp. e1000514
-
-
Lemons, J.M.S.1
-
72
-
-
36348944160
-
Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior
-
Liontos M., et al. Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior. Cancer Res. 2007, 67:10899-10909.
-
(2007)
Cancer Res.
, vol.67
, pp. 10899-10909
-
-
Liontos, M.1
-
73
-
-
67650003349
-
Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas
-
Liontos M., et al. Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas. Am. J. Pathol. 2009, 175:376-391.
-
(2009)
Am. J. Pathol.
, vol.175
, pp. 376-391
-
-
Liontos, M.1
-
74
-
-
27644456289
-
Death penalty for keratinocytes: apoptosis versus cornification
-
Lippens S., et al. Death penalty for keratinocytes: apoptosis versus cornification. Cell Death Differ. 2005, 12:1497-1508.
-
(2005)
Cell Death Differ.
, vol.12
, pp. 1497-1508
-
-
Lippens, S.1
-
75
-
-
19644367664
-
Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering
-
Lutolf M.P., Hubbell J.A. Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat. Biotechnol. 2005, 23:47-55.
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 47-55
-
-
Lutolf, M.P.1
Hubbell, J.A.2
-
76
-
-
84894565195
-
Self-consumption: the interplay of autophagy and apoptosis
-
Mariño G., et al. Self-consumption: the interplay of autophagy and apoptosis. Nat. Rev. Mol. Cell Biol. 2014, 15:81-94.
-
(2014)
Nat. Rev. Mol. Cell Biol.
, vol.15
, pp. 81-94
-
-
Mariño, G.1
-
77
-
-
84919798290
-
Long-term quiescent fibroblast cells transit into senescence
-
Marthandan S., et al. Long-term quiescent fibroblast cells transit into senescence. PLoS One 2014, 9:e115597.
-
(2014)
PLoS One
, vol.9
, pp. e115597
-
-
Marthandan, S.1
-
79
-
-
0030921323
-
Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease
-
McShea A., et al. Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease. Am. J Pathol. 1997, 150:1933-1939.
-
(1997)
Am. J Pathol.
, vol.150
, pp. 1933-1939
-
-
McShea, A.1
-
80
-
-
79955047394
-
Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells
-
Minagawa S., et al. Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 2011, 300:L391-L401.
-
(2011)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.300
, pp. L391-L401
-
-
Minagawa, S.1
-
81
-
-
84904702784
-
Cellular senescence: from physiology to pathology
-
Muñoz-Espín D., Serrano M. Cellular senescence: from physiology to pathology. Nat. Rev. Mol. Cell Biol. 2014, 15:482-496.
-
(2014)
Nat. Rev. Mol. Cell Biol.
, vol.15
, pp. 482-496
-
-
Muñoz-Espín, D.1
Serrano, M.2
-
82
-
-
84889600900
-
Programmed cell senescence during mammalian embryonic development
-
Muñoz-Espín D., et al. Programmed cell senescence during mammalian embryonic development. Cell 2013, 155:1104-1118.
-
(2013)
Cell
, vol.155
, pp. 1104-1118
-
-
Muñoz-Espín, D.1
-
83
-
-
0035858987
-
Human fibroblast replicative senescence can occur in the absence of extensive cell division and short telomeres
-
Munro J., et al. Human fibroblast replicative senescence can occur in the absence of extensive cell division and short telomeres. Oncogene 2001, 20(27):3541-3552.
-
(2001)
Oncogene
, vol.20
, Issue.27
, pp. 3541-3552
-
-
Munro, J.1
-
84
-
-
50149097809
-
A complex barcode underlies the heterogeneous response of p53 to stress
-
Murray-Zmijewski F., et al. A complex barcode underlies the heterogeneous response of p53 to stress. Nat. Rev. Mol. Cell Biol. 2008, 9:702-712.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 702-712
-
-
Murray-Zmijewski, F.1
-
85
-
-
77951976271
-
Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells
-
Nakamura A.J., et al. Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells. Aging 2009, 4:212-218.
-
(2009)
Aging
, vol.4
, pp. 212-218
-
-
Nakamura, A.J.1
-
86
-
-
77649175453
-
Genomic instability-an evolving hallmark of cancer
-
Negrini S., et al. Genomic instability-an evolving hallmark of cancer. Nat. Rev. Mol. Cell Biol. 2010, 11(3):220-228.
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, Issue.3
, pp. 220-228
-
-
Negrini, S.1
-
87
-
-
84904990966
-
Inside and out: the activities of senescence in cancer
-
Pérez-Mancera P.A., et al. Inside and out: the activities of senescence in cancer. Nat. Rev. Cancer 2014, 14:547-558.
-
(2014)
Nat. Rev. Cancer
, vol.14
, pp. 547-558
-
-
Pérez-Mancera, P.A.1
-
88
-
-
79960871658
-
Human lung fibroblasts prematurely senescent after exposure to ionizing radiation enhance the growth of malignant lung epithelial cells in vitro and in vivo
-
Papadopoulou A., Kletsas D. Human lung fibroblasts prematurely senescent after exposure to ionizing radiation enhance the growth of malignant lung epithelial cells in vitro and in vivo. Int. J. Oncol. 2011, 39(4):989-999.
-
(2011)
Int. J. Oncol.
, vol.39
, Issue.4
, pp. 989-999
-
-
Papadopoulou, A.1
Kletsas, D.2
-
89
-
-
21244445454
-
Comparison of replicative senescence and stress-induced premature senescence combining differential display and low-density DNA arrays
-
Pascal T., et al. Comparison of replicative senescence and stress-induced premature senescence combining differential display and low-density DNA arrays. FEBS Lett. 2005, 579:3651-3659.
-
(2005)
FEBS Lett.
, vol.579
, pp. 3651-3659
-
-
Pascal, T.1
-
90
-
-
38049057905
-
DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?
-
Passos J.F., et al. DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?. Nucleic Acids Res. 2007, 35:7505-7513.
-
(2007)
Nucleic Acids Res.
, vol.35
, pp. 7505-7513
-
-
Passos, J.F.1
-
91
-
-
84963492280
-
The assessment of angiogenesis and fibroblastic stromagenesis in hyperplastic and pre-invasive breast lesions
-
Pavlakis K., et al. The assessment of angiogenesis and fibroblastic stromagenesis in hyperplastic and pre-invasive breast lesions. BMC Cancer 2008, 2:8-88.
-
(2008)
BMC Cancer
, vol.2
, pp. 8-88
-
-
Pavlakis, K.1
-
92
-
-
0033011356
-
Cellular proliferation potential during aging and caloric restriction in rhesus monkeys (Macaca mulatta)
-
Pendergrass W.R., et al. Cellular proliferation potential during aging and caloric restriction in rhesus monkeys (Macaca mulatta). J. Cell Physiol. 1999, 180:123-130.
-
(1999)
J. Cell Physiol.
, vol.180
, pp. 123-130
-
-
Pendergrass, W.R.1
-
93
-
-
79952563157
-
Senescent mesenchymal cells accumulate in human fibrosis by a telomere-independent mechanism and ameliorate fibrosis through matrix metalloproteinases
-
Pitiyage G.N., et al. Senescent mesenchymal cells accumulate in human fibrosis by a telomere-independent mechanism and ameliorate fibrosis through matrix metalloproteinases. J. Pathol. 2011, 223:604-617.
-
(2011)
J. Pathol.
, vol.223
, pp. 604-617
-
-
Pitiyage, G.N.1
-
94
-
-
0042734423
-
The role of chondrocyte senescence in osteoarthritis
-
Price J.S., et al. The role of chondrocyte senescence in osteoarthritis. Aging Cell 2002, 1:57-65.
-
(2002)
Aging Cell
, vol.1
, pp. 57-65
-
-
Price, J.S.1
-
95
-
-
42549152045
-
No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas
-
Qiu W., et al. No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas. Nat. Genet 2008, 40:650-655.
-
(2008)
Nat. Genet
, vol.40
, pp. 650-655
-
-
Qiu, W.1
-
96
-
-
84922736742
-
Cancer-type-specific crosstalk between autophagy: necroptosis and apoptosis as a pharmacological target
-
Radogna F., et al. Cancer-type-specific crosstalk between autophagy: necroptosis and apoptosis as a pharmacological target. Biochem. Pharmacol. 2015, 94:1-11.
-
(2015)
Biochem. Pharmacol.
, vol.94
, pp. 1-11
-
-
Radogna, F.1
-
97
-
-
75149116221
-
Fibroblasts in three dimensional matrices: cell migration and matrix remodeling
-
Rhee S. Fibroblasts in three dimensional matrices: cell migration and matrix remodeling. Exp. Mol. Med. 2009, 41:858-865.
-
(2009)
Exp. Mol. Med.
, vol.41
, pp. 858-865
-
-
Rhee, S.1
-
98
-
-
30044440857
-
Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress
-
Rodriguez R., Meuth M. Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress. Mol. Biol. Cell 2006, 17:402-412.
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 402-412
-
-
Rodriguez, R.1
Meuth, M.2
-
99
-
-
0035252089
-
Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
-
Romanov S.R., et al. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature 2001, 409:633-637.
-
(2001)
Nature
, vol.409
, pp. 633-637
-
-
Romanov, S.R.1
-
100
-
-
0035736138
-
If not apoptosis, then what?: Treatment-induced senescence and mitotic catastrophe in tumor cells
-
Roninson I.B., et al. If not apoptosis, then what?: Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist. Update 2001, 4:303-313.
-
(2001)
Drug Resist. Update
, vol.4
, pp. 303-313
-
-
Roninson, I.B.1
-
101
-
-
0038277105
-
Tumor cell senescence in cancer treatment
-
Roninson I.B. Tumor cell senescence in cancer treatment. Cancer Res. 2003, 63:2705-2715.
-
(2003)
Cancer Res.
, vol.63
, pp. 2705-2715
-
-
Roninson, I.B.1
-
102
-
-
84865409542
-
Irinotecan induces senescence and apoptosis in colonic cells in vitro
-
Rudolf E., et al. Irinotecan induces senescence and apoptosis in colonic cells in vitro. Toxicol. Lett. 2012, 214:1-8.
-
(2012)
Toxicol. Lett.
, vol.214
, pp. 1-8
-
-
Rudolf, E.1
-
104
-
-
0034713329
-
Is beta-galactosidase staining a marker of senescence in vitro and in vivo?
-
Severino J., et al. Is beta-galactosidase staining a marker of senescence in vitro and in vivo?. Exp. Cell Res. 2000, 257:162-171.
-
(2000)
Exp. Cell Res.
, vol.257
, pp. 162-171
-
-
Severino, J.1
-
105
-
-
84865326113
-
The canonical NF-(B pathway differentially protects normal and human tumor cells from ROS-induced DNA damage
-
Sfikas A., et al. The canonical NF-(B pathway differentially protects normal and human tumor cells from ROS-induced DNA damage. Cell. Signal. 2012, 24:2007-2023.
-
(2012)
Cell. Signal.
, vol.24
, pp. 2007-2023
-
-
Sfikas, A.1
-
106
-
-
2342570379
-
Hallmarks of senescence in carcinogenesis and cancer therapy
-
Shay J.W., Roninson I.B. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 2004, 23:2919-2933.
-
(2004)
Oncogene
, vol.23
, pp. 2919-2933
-
-
Shay, J.W.1
Roninson, I.B.2
-
107
-
-
19844382620
-
Senescence and immortalization: role of telomeres and telomerase
-
Shay J.W., Wright W.E. Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis 2005, 26:867-874.
-
(2005)
Carcinogenesis
, vol.26
, pp. 867-874
-
-
Shay, J.W.1
Wright, W.E.2
-
108
-
-
77955845914
-
Telomeres and telomerase in normal and cancer stem cells
-
Shay J.W., Wright W.E. Telomeres and telomerase in normal and cancer stem cells. FEBS Lett. 2010, 584(17):3819-3825.
-
(2010)
FEBS Lett.
, vol.584
, Issue.17
, pp. 3819-3825
-
-
Shay, J.W.1
Wright, W.E.2
-
109
-
-
84866026484
-
Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory Bowel disease
-
Sohn J.J., et al. Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory Bowel disease. PLoS One 2012, 7:e44156.
-
(2012)
PLoS One
, vol.7
, pp. e44156
-
-
Sohn, J.J.1
-
110
-
-
84931434236
-
Giant cell fibroma of tongue: understanding the nature of an unusual histopathological entity
-
ID:864512
-
Sonalika W.G., et al. Giant cell fibroma of tongue: understanding the nature of an unusual histopathological entity. Case Rep. Dent. 2014, 2014:1-4. ID:864512.
-
(2014)
Case Rep. Dent.
, vol.2014
, pp. 1-4
-
-
Sonalika, W.G.1
-
111
-
-
16244383882
-
Distinct ROS and biochemical profiles in cells undergoing DNA damage-induced senescence and apoptosis
-
Song Y.S., et al. Distinct ROS and biochemical profiles in cells undergoing DNA damage-induced senescence and apoptosis. Mech. Ageing Dev. 2005, 126:580-590.
-
(2005)
Mech. Ageing Dev.
, vol.126
, pp. 580-590
-
-
Song, Y.S.1
-
112
-
-
0028943734
-
Apoptosis in the pathogenesis and treatment of disease
-
Thompson C.B. Apoptosis in the pathogenesis and treatment of disease. Science 1995, 267:1456-1462.
-
(1995)
Science
, vol.267
, pp. 1456-1462
-
-
Thompson, C.B.1
-
113
-
-
0036710468
-
Stress-induced premature senescence and tissue ageing
-
Toussaint O., et al. Stress-induced premature senescence and tissue ageing. Biochem. Pharmacol. 2002, 64:1007-1009.
-
(2002)
Biochem. Pharmacol.
, vol.64
, pp. 1007-1009
-
-
Toussaint, O.1
-
114
-
-
84868646775
-
Cellular senescence as a possible mechanism for halting progression of keloid lesions
-
Varmeh S., et al. Cellular senescence as a possible mechanism for halting progression of keloid lesions. Genes Cancer 2011, 2:1061-1066.
-
(2011)
Genes Cancer
, vol.2
, pp. 1061-1066
-
-
Varmeh, S.1
-
115
-
-
0035130153
-
Differential expression of thymosin β-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosis
-
Vasile E., et al. Differential expression of thymosin β-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosis. FASEB J. 2001, 15:458-466.
-
(2001)
FASEB J.
, vol.15
, pp. 458-466
-
-
Vasile, E.1
-
116
-
-
84864020954
-
The number of p16INK4a positive cells in human skin reflects biological age
-
Waaijer M.E., et al. The number of p16INK4a positive cells in human skin reflects biological age. Aging Cell 2012, 11:722-725.
-
(2012)
Aging Cell
, vol.11
, pp. 722-725
-
-
Waaijer, M.E.1
-
117
-
-
66149167336
-
DNA damage response and cellular senescence in tissues of aging mice
-
Wang C., et al. DNA damage response and cellular senescence in tissues of aging mice. Aging Cell 2009, 8:311-323.
-
(2009)
Aging Cell
, vol.8
, pp. 311-323
-
-
Wang, C.1
-
118
-
-
84863667325
-
Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence
-
Wang J.C., Bennett M. Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence. Circ. Res. 2012, 111(2):245-259.
-
(2012)
Circ. Res.
, vol.111
, Issue.2
, pp. 245-259
-
-
Wang, J.C.1
Bennett, M.2
-
119
-
-
84912573043
-
Protective effects of verapamil against H2O2-induced apoptosis in human lens epithelial cells
-
Wang Z., et al. Protective effects of verapamil against H2O2-induced apoptosis in human lens epithelial cells. Biomol. Ther. 2014, 22:553-557.
-
(2014)
Biomol. Ther.
, vol.22
, pp. 553-557
-
-
Wang, Z.1
-
120
-
-
33846937033
-
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
-
Xue W., et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 2007, 445:656-660.
-
(2007)
Nature
, vol.445
, pp. 656-660
-
-
Xue, W.1
-
121
-
-
34248184169
-
Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells
-
Yaar M., et al. Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells. Breast Cancer Res. 2007, 9:R13.
-
(2007)
Breast Cancer Res.
, vol.9
, pp. R13
-
-
Yaar, M.1
-
122
-
-
33750798741
-
The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis
-
Yang G., et al. The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:16472-16477.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 16472-16477
-
-
Yang, G.1
-
123
-
-
3242682558
-
Distinct expression patterns of the transcription factor E2F-1 in relation to tumour growth parameters in common human carcinomas
-
Zacharatos P., et al. Distinct expression patterns of the transcription factor E2F-1 in relation to tumour growth parameters in common human carcinomas. J. Pathol. 2004, 203(3):744-753.
-
(2004)
J. Pathol.
, vol.203
, Issue.3
, pp. 744-753
-
-
Zacharatos, P.1
-
124
-
-
84901288438
-
The role of senescent cells in ageing
-
van Deursen J.M. The role of senescent cells in ageing. Nature 2014, 509:439-446.
-
(2014)
Nature
, vol.509
, pp. 439-446
-
-
van Deursen, J.M.1
|