Aging-related inflammation in osteoarthritis

Osteoarthritis and Cartilage

Volumn 23, Issue 11, 2015, Pages 1966-1971

  Greene, M A ^a,b   Loeser, R F ^b  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Cartilage; Chondrocyte; Cytokines; Growth factors; Osteoarthritis; Senescence

Indexed keywords

C REACTIVE PROTEIN; CXCL13 CHEMOKINE; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 15; INTERLEUKIN 16; INTERLEUKIN 18; INTERLEUKIN 6; INTERLEUKIN 7; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 2; RANTES; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE;

AGING; CARTILAGE; CARTILAGE CELL; CCL5 GENE; CCL8 GENE; CXCL13 GENE; CYTOKINE PRODUCTION; DISEASE COURSE; DOWN REGULATION; GENDER; GENETICS; HIGH RISK PATIENT; HUMAN; IL 7 GENE; IL33 GENE; IL6 GENE; IMMUNOPATHOGENESIS; INFLAMMATION; INNATE IMMUNITY; JOINT; JOINT INJURY; KNEE MENISCUS; KNOCKOUT MOUSE; MORTALITY; NONHUMAN; OBESITY; OSTEOARTHRITIS; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SENESCENCE; SENESCENCE ASSOCIATED SECRETORY PHENOTYPE; SYNOVIUM; UPREGULATION; ANIMAL; ARTICULAR CARTILAGE; CELL AGING; CHONDROCYTE; METABOLISM; PATHOLOGY;

AGING; ANIMALS; CARTILAGE, ARTICULAR; CELL AGING; CHONDROCYTES; CYTOKINES; DISEASE PROGRESSION; HUMANS; INFLAMMATION; OSTEOARTHRITIS;

EID: 84945296001     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2015.01.008     Document Type: Review

References (63)

1. Anderson S.A., Loeser R.F. Why is osteoarthritis an age-related disease?. Best Pract Res Clin Rheumatol 2010, 24:15-26.
2. Prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation - United States, 2007-2009. MMWR Morb Mortal Wkly Rep 2010, 59:1261-1265.
3. Lopez-Otin C., Blasco M.A., Partridge L., Serrano M., Kroemer G. The hallmarks of aging. Cell 2013, 153:1194-1217.
4. Ershler W.B. Interleukin-6: a cytokine for gerontologists. J Am Geriatr Soc 1993, 41:176-181.
5. Strandberg T.E., Tilvis R.S. C-reactive protein, cardiovascular risk factors, and mortality in a prospective study in the elderly. Arterioscler Thromb Vasc Biol 2000, 20:1057-1060.
6. Bruunsgaard H. Effects of tumor necrosis factor-alpha and interleukin-6 in elderly populations. Eur Cytokine Netw 2002, 13:389-391.
7. Bruunsgaard H., Andersen-Ranberg K., Jeune B., Pedersen A.N., Skinhoj P., Pedersen B.K. A high plasma concentration of TNF-alpha is associated with dementia in centenarians. J Gerontol A Biol Sci Med Sci 1999, 54:M357-M364.
8. Singh T., Newman A.B. Inflammatory markers in population studies of aging. Ageing Res Rev 2011, 10:319-329.
9. Spector T.D., Hart D.J., Nandra D., Doyle D.V., Mackillop N., Gallimore J.R., et al. Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease. Arthritis Rheum 1997, 40:723-727.
10. Livshits G., Zhai G., Hart D.J., Kato B.S., Wang H., Williams F.M., et al. Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: the Chingford study. Arthritis Rheum 2009, 60:2037-2045.
11. Goekoop R.J., Kloppenburg M., Kroon H.M., Frolich M., Huizinga T.W., Westendorp R.G., et al. Low innate production of interleukin-1beta and interleukin-6 is associated with the absence of osteoarthritis in old age. Osteoarthritis Cartilage 2010, 18:942-947.
12. Stannus O.P., Jones G., Blizzard L., Cicuttini F.M., Ding C. Associations between serum levels of inflammatory markers and change in knee pain over 5 years in older adults: a prospective cohort study. Ann Rheum Dis 2013, 72:535-540.
13. Penninx B.W., Abbas H., Ambrosius W., Nicklas B.J., Davis C., Messier S.P., et al. Inflammatory markers and physical function among older adults with knee osteoarthritis. J Rheumatol 2004, 31:2027-2031.
14. Franceschi C., Bonafe M., Valensin S., Olivieri F., De Luca M., Ottaviani E., et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 2000, 908:244-254.
15. Vitale G., Salvioli S., Franceschi C. Oxidative stress and the ageing endocrine system. Nat Rev Endocrinol 2013, 9:228-240.
16. Olivieri F., Rippo M.R., Monsurro V., Salvioli S., Capri M., Procopio A.D., et al. MicroRNAs linking inflamm-aging, cellular senescence and cancer. Ageing Res Rev 2013, 12:1056-1068.
17. Calcada D., Vianello D., Giampieri E., Sala C., Castellani G., de Graaf A., et al. The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach. Mech Ageing Dev 2014, 136-137:138-147.
18. Morrisette-Thomas V., Cohen A.A., Fulop T., Riesco E., Legault V., Li Q., et al. Inflamm-aging does not simply reflect increases in pro-inflammatory markers. Mech Ageing Dev 2014, 139:49-57.
19. de Hooge A.S., van de Loo F.A., Bennink M.B., Arntz O.J., de Hooge P., van den Berg W.B. Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging. Osteoarthritis Cartilage 2005, 13:66-73.
20. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965, 37:614-636.
21. Campisi J. Cellular senescence: putting the paradoxes in perspective. Curr Opin Genet Dev 2011, 21:107-112.
22. Price J.S., Waters J.G., Darrah C., Pennington C., Edwards D.R., Donell S.T., et al. The role of chondrocyte senescence in osteoarthritis. Aging Cell 2002, 1:57-65.
23. Martin J.A., Buckwalter J.A. The role of chondrocyte senescence in the pathogenesis of osteoarthritis and in limiting cartilage repair. J Bone Joint Surg Am 2003, 85-A(Suppl 2):106-110.
24. Rose J., Soder S., Skhirtladze C., Schmitz N., Gebhard P.M., Sesselmann S., et al. DNA damage, discoordinated gene expression and cellular senescence in osteoarthritic chondrocytes. Osteoarthritis Cartilage 2012, 20:1020-1028.
25. Harbo M., Bendix L., Bay-Jensen A.C., Graakjaer J., Soe K., Andersen T.L., et al. The distribution pattern of critically short telomeres in human osteoarthritic knees. Arthritis Res Ther 2012, 14:R12.
26. Zhou H.W., Lou S.Q., Zhang K. Recovery of function in osteoarthritic chondrocytes induced by p16INK4a-specific siRNA in vitro. Rheumatology (Oxford) 2004, 43:555-568.
27. Aigner T., Hemmel M., Neureiter D., Gebhard P.M., Zeiler G., Kirchner T., et al. Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritis human articular knee cartilage: a study of proliferation, programmed cell death (apoptosis), and viability of chondrocytes in normal and osteoarthritic human knee cartilage. Arthritis Rheum 2001, 44:1304-1312.
28. Rodier F., Campisi J. Four faces of cellular senescence. J Cell Biol 2011, 192:547-556.
29. Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 2005, 120:513-522.
30. Coppe J.P., Patil C.K., Rodier F., Sun Y., Munoz D.P., Goldstein J., et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 2008, 6:2853-2868.
31. Freund A., Orjalo A.V., Desprez P.Y., Campisi J. Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med 2010, 16:238-246.
32. De Ceuninck F., Dassencourt L., Anract P. The inflammatory side of human chondrocytes unveiled by antibody microarrays. Biochem Biophys Res Commun 2004, 323:960-969.
33. Borzi R.M., Mazzetti I., Cattini L., Uguccioni M., Baggiolini M., Facchini A. Human chondrocytes express functional chemokine receptors and release matrix-degrading enzymes in response to C-X-C and C-C chemokines. Arthritis Rheum 2000, 43:1734-1741.
34. Long D., Blake S., Song X.Y., Lark M., Loeser R.F. Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13. Arthritis Res Ther 2008, 10:R23.
35. Sohn D.H., Sokolove J., Sharpe O., Erhart J.C., Chandra P.E., Lahey L.J., et al. Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4. Arthritis Res Ther 2012, 14:R7.
36. Wang M., Liu C., Zhang Y., Hao Y., Zhang X., Zhang Y.M. Protein interaction and microRNA network analysis in osteoarthritis meniscal cells. Genet Mol Res 2013, 12:738-746.
37. Clutterbuck A.L., Smith J.R., Allaway D., Harris P., Liddell S., Mobasheri A. High throughput proteomic analysis of the secretome in an explant model of articular cartilage inflammation. J Proteomics 2011, 74:704-715.
38. Baker N., Sharpe P., Culley K., Otero M., Bevan D., Newham P., et al. Dual regulation of metalloproteinase expression in chondrocytes by Wnt-1-inducible signaling pathway protein 3/CCN6. Arthritis Rheum 2012, 64:2289-2299.
39. Alaaeddine N., Olee T., Hashimoto S., Creighton-Achermann L., Lotz M. Production of the chemokine RANTES by articular chondrocytes and role in cartilage degradation. Arthritis Rheum 2001, 44:1633-1643.
40. Li W.Q., Dehnade F., Zafarullah M. Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway. J Immunol 2001, 166:3491-3498.
41. Loeser R.F., Goldring S.R., Scanzello C.R., Goldring M.B. Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum 2012, 64:1697-1707.
42. Peffers M.J., Beynon R.J., Clegg P.D. Absolute quantification of selected proteins in the human osteoarthritic secretome. Int J Mol Sci 2013, 14:20658-20681.
43. Stenberg J., Ruetschi U., Skioldebrand E., Karrholm J., Lindahl A. Quantitative proteomics reveals regulatory differences in the chondrocyte secretome from human medial and lateral femoral condyles in osteoarthritic patients. Proteome Sci 2013, 11:43.
44. Lourido L., Calamia V., Mateos J., Fernandez-Puente P., Fernandez-Tajes J., Blanco F.J., et al. Quantitative proteomic profiling of human articular cartilage degradation in osteoarthritis. J Proteome Res 2014, 13:6096-6106.
45. Swan A.L., Hillier K.L., Smith J.R., Allaway D., Liddell S., Bacardit J., et al. Analysis of mass spectrometry data from the secretome of an explant model of articular cartilage exposed to pro-inflammatory and anti-inflammatory stimuli using machine learning. BMC Musculoskelet Disord 2013, 14:349.
46. Williams A., Smith J.R., Allaway D., Harris P., Liddell S., Mobasheri A. Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1beta. Arthritis Res Ther 2013, 15:R223.
47. Freund A., Patil C.K., Campisi J. p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. EMBO J 2011, 30:1536-1548.
48. Baker D.J., Wijshake T., Tchkonia T., LeBrasseur N.K., Childs B.G., van de Sluis B., et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 2011, 479:232-236.
49. Sellam J., Berenbaum F. Is osteoarthritis a metabolic disease?. Joint Bone Spine 2013, 80:568-573.
50. Guilak F. Biomechanical factors in osteoarthritis. Best Pract Res Clin Rheumatol 2011, 25:815-823.
51. Delmonico M.J., Harris T.B., Visser M., Park S.W., Conroy M.B., Velasquez-Mieyer P., et al. Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr 2009, 90:1579-1585.
52. Tchkonia T., Morbeck D.E., Von Zglinicki T., Van Deursen J., Lustgarten J., Scrable H., et al. Fat tissue, aging, and cellular senescence. Aging Cell 2010, 9:667-684.
53. Messier S.P., Mihalko S.L., Legault C., Miller G.D., Nicklas B.J., DeVita P., et al. Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial. JAMA 2013, 310:1263-1273.
54. Beavers K.M., Ambrosius W.T., Nicklas B.J., Rejeski W.J. Independent and combined effects of physical activity and weight loss on inflammatory biomarkers in overweight and obese older adults. J Am Geriatr Soc 2013, 61:1089-1094.
55. Beavers K.M., Hsu F.C., Houston D.K., Beavers D.P., Harris T.B., Hue T.F., et al. The role of metabolic syndrome, adiposity, and inflammation in physical performance in the Health ABC Study. J Gerontol A Biol Sci Med Sci 2013, 68:617-623.
56. Distel E., Cadoudal T., Durant S., Poignard A., Chevalier X., Benelli C. The infrapatellar fat pad in knee osteoarthritis: an important source of interleukin-6 and its soluble receptor. Arthritis Rheum 2009, 60:3374-3377.
57. Chuckpaiwong B., Charles H.C., Kraus V.B., Guilak F., Nunley J.A. Age-associated increases in the size of the infrapatellar fat pad in knee osteoarthritis as measured by 3T MRI. J Orthop Res 2010, 28:1149-1154.
58. Hui W., Litherland G.J., Elias M.S., Kitson G.I., Cawston T.E., Rowan A.D., et al. Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases. Ann Rheum Dis 2012, 71:455-462.
59. Loeser R.F., Olex A.L., McNulty M.A., Carlson C.S., Callahan M.F., Ferguson C.M., et al. Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice. Arthritis Rheum 2012, 64:705-717.
60. Rubenhagen R., Schuttrumpf J.P., Sturmer K.M., Frosch K.H. Interleukin-7 levels in synovial fluid increase with age and MMP-1 levels decrease with progression of osteoarthritis. Acta Orthop 2012, 83:59-64.
61. Forsyth C.B., Cole A., Murphy G., Bienias J.L., Im H.J., Loeser R.F. Increased matrix metalloproteinase-13 production with aging by human articular chondrocytes in response to catabolic stimuli. J Gerontol A Biol Sci Med Sci 2005, 60:1118-1124.
62. Peffers M., Liu X., Clegg P. Transcriptomic signatures in cartilage ageing. Arthritis Res Ther 2013, 15:R98.
63. Brophy R.H., Rai M.F., Zhang Z., Torgomyan A., Sandell L.J. Molecular analysis of age and sex-related gene expression in meniscal tears with and without a concomitant anterior cruciate ligament tear. J Bone Joint Surg Am 2012, 94:385-393.