Impact of aging on the biology of breast cancer

Critical Reviews in Oncology/Hematology

Volumn 66, Issue 1, 2008, Pages 65-74

  Benz, Christopher C ^a  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

Author keywords

Age associated malignancies; Breast cancer; Cellular senescence; Estrogen receptor; Mammary gland involution; Prognostic and predictive biomarkers

Indexed keywords

ANDROSTENEDIONE; AROMATASE; ATM PROTEIN; BRCA1 PROTEIN; BRCA2 PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTRADIOL; ESTROGEN RECEPTOR; ESTRONE; HORMONE RECEPTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROGESTERONE RECEPTOR; PROTEIN P53; TESTOSTERONE;

AGING; ANGIOGENESIS; BREAST CANCER; BREAST CARCINOGENESIS; BREAST EPITHELIUM; CANCER INVASION; CANCER RISK; EPIGENETICS; GENE MUTATION; GENOMIC INSTABILITY; HUMAN; KAPLAN MEIER METHOD; MALIGNANT TRANSFORMATION; MAMMARY GLAND; MENOPAUSE; ONSET AGE; REVIEW;

AGE OF ONSET; AGING; BREAST; BREAST NEOPLASMS; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL CELLS; FEMALE; HUMANS; MENOPAUSE; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; RECEPTORS, ESTROGEN; STROMAL CELLS;

EID: 40049094626     PISSN: 10408428     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2007.09.001     Document Type: Review

References (40)

1. Thun M.J., and Jemal A. Cancer epidemiology. In: Kufe D.W., Bast R.C., Hait W.N., Hong W.K., Pollock R.E., Weichselbaum R.R., Holland J.F., and Frei III E. (Eds). Cancer 7 medicine (2006), BC Decker Inc., Hamilton 339-353
2. Jemal A., Siegel R., Ward E., Murray T., Xu J., and Thun M.J. Cancer statistics 2007. CA Cancer J Clin 57 (2007) 43-66
3. DevCan: Probability of developing or dying of cancer software. V6.1.0. 2006. Statistical Research and Applications Branch, National Cancer Institute (http://www.srab.cancer.gov/devcan).
4. Quong J., Eppenberger-Castori S., Moore III D., et al. Age-dependent changes in breast cancer hormone receptors and oxidant stress markers. Breast Cancer Res Treat 76 (2002) 221-236
5. Anderson W.F., Pfeiffer R.M., Dores G.M., and Sherman M.E. Comparison of age distribution patterns for different histopathologic types of breast cancer. Cancer Epidemiol Biomarkers Prev 15 (2006) 1899-1905
6. Well D., Yang H., Houseni M., et al. Age-related structural and metabolic changes in the pelvic reproductive end organs. Semin Nucl Med 37 (2007) 173-184
7. Milanese T.R., Hartmann L.C., Sellers T.A., et al. Age-related lobular involution and risk of breast cancer. J Natl Cancer Inst 98 (2006) 1600-1607
8. van Landeghem A.A., Poortman J., Nabuurs M., and Thijssen J.H. Endogenous concentration and subcellular distribution of estrogens in normal and malignant human breast tissue. Cancer Res 45 (1985) 2900-2906
9. Austad S.N. Why we age (1997), John Wiley & Sons Inc., New York
10. Cohen H.J. The cancer aging interface: a research agenda. J Clin Oncol 14 (2007) 1945-1948
11. DePinho R.A. The age of cancer. Nature 408 (2000) 248-254
12. Willett W.C., Rockhill B., Hankinson S.E., Hunter D.J., and Colditz G.A. Epidemiology and nongenetic causes of breast cancer. In: Harris J.R., Lippman M.E., Morrow M., and Osborne C.K. (Eds). Diseases of the breast. 2nd ed. (2000), Lippincott Williams & Wilkins, Philadelphia 175-220
13. Ralph D.A., Zhao L.P., Aston C.E., et al. Age-specific association of steroid hormone pathway gene polymorphisms with breast cancer risk. Cancer 109 (2007) 1940-1948
14. Russo J., Gusterson B.A., Rogers A.E., Russo I.H., Wellings S.R., and VanZwietein M.J. Comparative study of human and rat mammary tumorigenesis. Lab Invest 62 (1990) 244-278
15. Henson D.E., Tarone R.E., and Nsouli H. Lobular involution: the physiological prevention of breast cancer. J Natl Cancer Inst 98 (2006) 1589-1590
16. Campisi J. Aging, tumor suppression and cancer: high wire-act. Mech Ageing Dev 126 (2005) 51-58
17. Tyner S.D., Venkatachalam S., Choi J., et al. p53 mutant mice that display early aging-associated phenotypes. Nature 415 (2002) 45-53
18. Kim W.Y., and Sharpless N.E. The regulation of INK4/ARF in cancer and aging. Cell 127 (2006) 265-275
19. Serrano M., and Blasco M.A. Cancer and ageing: convergent and divergent mechanisms. Nat Rev Mol Cell Biol 8 (2007) 715-722
20. Puzianowska-Kuznicka M., and Kuznicki J. Genetic alterations in accelerated ageing syndromes: do they play a role in natural ageing. Int J Biochem Cell Biol 37 (2005) 947-960
21. Hoeijmakers J.H.J. Genome maintenance mechanisms are critical for preventing cancer as well as other aging-associated diseases. Mech Ageing Dev 128 (2007) 460-462
22. Zhang H. Molecular signaling and genetic pathways of senescence: its role in tumorigenesis and aging. J Cell Physiol 210 (2007) 567-574
23. Fridlyand J., Snijders A.M., Ylstra B., et al. Breast tumor copy number aberration phenotypes and genomic instability. BMC Cancer 6 (2006) 96
24. Jevapalan J.C., Ferreira M., Sedivy J.M., and Heerbig U. Accumulation of senescent cells in mitotic tissue of aging primates. Mech Ageing Dev 128 (2007) 36-44
25. Krtolica A., and Campisi J. Cancer and aging: a model for the cancer promoting effects of the aging stroma. Int J Biochem Cell Biol 34 (2002) 1401-1414
26. Liu D., and Hornsby P.J. Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion. Cancer Res 67 (2007) 3117-3126
27. Serrano M. Cancer regression by senescence. N Engl J Med 356 (2007) 1996-1997
28. Geigl J.B., Langer S., Barwisch S., Pfleghaar K., Lederer G., and Speicher M.R. Analysis of gene expression patterns and chromosomal changes associated with aging. Cancer Res 64 (2004) 8550-8557
29. Ly D.H., Lockhart D.J., Lerner R.A., and Schultz P.G. Mitotic misregulation and human aging. Science 287 (2000) 2486-2492
30. Issa J.P. Aging DNA methylation and cancer. Crit Rev Oncol/Hematol 32 (1999) 31-43
31. Richardson B. Impact of aging on DNA methylation. Ageing Res Rev 2 (2003) 245-261
32. Balducci L., and Beghe C. Cancer and age in the USA. Crit Rev Oncol Hematol 37 (2001) 137-145
33. Ershler W.B., and Longo D.L. Aging and cancer: issues of basic and clinical science. J Natl Cancer Inst 89 (1997) 1489-1497
34. Love R.R., Duc N.B., Dinh N.V., Quv T.T., Xin Y., and Havighurst T.C. Young age as an adverse prognostic factor in premenopausal women with operable breast cancer. Clin Breast Cancer 2 (2002) 294-298
35. Dubsky P.C., Gnant M.F., Taucher S., et al. Young age as an independent adverse prognostic factor in premenopausal patients with breast cancer. Clin Breast Cancer 3 (2002) 65-72
36. Eppenberger-Castori S., Moore D.H., Thor A.D., et al. Age-associated biomarker profiles of human breast cancer. Int J Biochem Cell Biol 34 (2002) 1318-1330
37. Zhou Y., Yau C., Gray J.W., et al. Enhanced NFκB and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer. BMC Cancer 7 (2007) 59
38. Chin K., DeVries S., Fridlyand J., et al. Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell 10 (2006) 529-541
39. Fedele V., Fridlyand J., Roydasgupta R., et al. Mutations in TP53 and associated genomic abnormalities are dependent on breast cancer estrogen receptor status and patient age. Proc Am Assoc Cancer Res 48 (2007) a2962
40. Yau C., Fedele V., Roydasgupta R., et al. Aging impacts transcriptome but not genome of hormone-dependent breast cancers. Breast Cancer Res 9 5 (2007) R59 [Epub ahead of print]