The canonical NF-κB pathway differentially protects normal and human tumor cells from ROS-induced DNA damage

Cellular Signalling

Volumn 24, Issue 11, 2012, Pages 2007-2023

  Sfikas, Alexandros ^a,g   Batsi, Christina ^a   Tselikou, Evangelia ^a   Vartholomatos, George ^b   Monokrousos, Nikolaos ^c   Pappas, Periklis ^a   Christoforidis, Savvas ^a,c   Tzavaras, Theodoros ^a   Kanavaros, Panagiotis ^a   Gorgoulis, Vassilis G ^d   Marcu, Kenneth B ^c,e,f   Kolettas, Evangelos ^a  

^a UNIVERSITY OF IOANNINA   (Greece)

^b UNIVERSITY HOSPITAL OF IOANNINA   (Greece)

^c UNIVERSITY OF IOANNINA   (Greece)

^d UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^e STONY BROOK UNIVERSITY   (United States)

^f Laboratorio di Immunoreumatologia e Rigenerazione Tissutale   (Italy)

^g NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

DNA damage response; Human cells; Hydrogen peroxide; NF B signaling; Senescence

Indexed keywords

BETA GALACTOSIDASE; HISTONE H2AX; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P53; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR RELA;

APOPTOSIS; ARTICLE; CELL AGING; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROTECTION; CONTROLLED STUDY; DNA DAMAGE; EMBRYO; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; LUNG FIBROBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL;

APOPTOSIS; CELL AGING; CELL LINE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; DNA REPAIR; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; HYDROGEN PEROXIDE; I-KAPPA B KINASE; M PHASE CELL CYCLE CHECKPOINTS; NF-KAPPA B; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84865326113     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2012.06.010     Document Type: Article

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