Cell senescence: Role in aging and age-related diseases

Aging: Facts and Theories

Volumn 39, Issue , 2014, Pages 45-61

  Campisi, Judith ^a   Robert, Ladislas ^b  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b HÔTEL DIEU   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84925848840     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1159/000358899     Document Type: Chapter

References (71)

1. Hayflick L: The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965;37: 614-636.
2. Hayflick L: Aging under glass. Exp Gerontol 1970;5: 291-303.
3. Hayflick L: The cellular basis for biological aging; in Finch CE, Hayflick L (eds): Handbook of the Biology of Aging. New York, VNR, 1977, pp 159-186.
4. Macieira-Coelho A: A Biology of Normal Proliferating Cells in vitro. Relevance for in vivo Aging. Basel, Karger, 1988.
5. Hayflick L: The role of telomeres and telomerase in aging and longevity determination; in Matson MP (ed): Telomerase, Aging and Disease. Adv Cell Aging Dis 2001;8: 185-198.
6. Campisi J: Cellular senescence as tumor-suppressor mechanism. Trends Cell Biol 2001;11: 27-31.
7. Campisi J: Review. Senescent cells, tumor suppression and organismal aging. Good citizens, bad neighbors. Cell 2005;120: 513-522.
8. Labat-Robert J, Robert L: The effect of cell-matrix interactions and aging on the malignant process. Adv Cancer Res 2007;98: 221-259.
9. Levine AJ, Oren M: The first 30 years of p53: growing ever more complex. Nat Rev Cancer 2009;9: 749-758.
10. Beausejour CM, Krtolica A, Galimi F, Narita M, Lowe SW, et al: Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J 2003;22: 4212-4222.
11. Campisi J: Aging, cellular senescence, and cancer. Ann Rev Physiol 2013;75: 685-705.
12. Dimri GP, Lee X, Basile G, Acosta M, Scott G, et al: A novel biomarker identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995;92: 9363-9367.
13. Ravelojaona V, Robert AM, Robert L: Expression of senescence-associated β-galactosidase (SA-β-Gal) by human skin fibroblasts, effect of advanced glycation end-products and fucoseor rhamnose-rich polysaccharides. Arch Gerontol Geriatr 2009;48: 151-154.
14. Robert L: Fritz Verzar was born 120 years ago: His contribution to experimental gerontology through collagen research as assessed after half a century. Arch Gerontol Geriatr 2006;43: 13-43.
15. Campisi J, d'Adda di Fagagna F: Cellular senescence:when bad things happen to good cells. Nat Rev Mol Cell Biol 2007;8: 729-740.
16. INK4a-RB pathway: molecular link between cellular senescence and tumor suppression. J Med Invest 2004;51: 146-153.
17. Collins CJ, Sedivy JM: Involvement of the INK4a/Arf gene locus in senescence. Aging Cell 2003;2: 145-150.
18. Krishnamurthy J, Torrice C, Ramsey MR, Kowalev GI, Al-Regaiey K, et al: Ink4a/Arf expression is a biomarker of aging. J Clin Invest 2004;114: 1299-1307.
19. INK4a positive cells in human skin reflects biological age. Aging Cell 2012;11: 722-725.
20. Herbig U, Fereira M, Condel I, Carey D, Sedivy JM: Cellular senescence in aging primates. Science 2006;311: 1257.
21. Rodier F, Munoz DP, Teachenor R, Chu V, Le O, et al: DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion J Cell Sci 2011;124: 68-81.
22. Rodier F, Coppé JP, Patil CK, Hoeijmakers WA, Munoz DP, et al: Persistent DNA damage signaling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol 2009;11: 973-979.
23. Sedelnikova OA, Horikawa I, Zimonjic DB, Popescu NC, Bonner WM, Barrett JC: Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat Cell Biol 2004;6: 168-170.
24. Wang C, Jurk D, Maddick M, Nelson G, Martin-Ruiz C, von Zglinicki T: DNA damage response and cellular senescence in tissues of aging mice. Aging Cell 2009;8: 311-323.
25. Narita M, Nunez S, Heard E, Narita M, Lin AW, et al: Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 2003;113: 703-716.
26. INK4a. Cell Cycle 2011;10: 457-468.
27. Collado M, Gil J, Efeyan A, Guerra C, Schumacher AJ, et al: Tumor biology: senescence in premalignant tumors. Nature 2005;436: 642.
28. Freund A, Laberge RM, Demaria M, Campisi J: Lamin B1 loss in a senescence-associated biomarker. Mol Biol Cell 2012;23: 2066-2075.
29. Shimi T, Butin-Israeli V, Adam SA, Hamanaka RB, Goldman AF, et al: The role of nuclear lamin B1 in cell proliferation and senescence. Genes Dev 2011;25: 2579-2593.
30. Campisi J, Andersen JK, Kapahi P, Melow S: Cellular senescence: a link between cancer and age-related degenerative disease? Semin Cancer Biol 2011;21: 354-359.
31. Coppé JP, Desprez PY, Krtolica A, Campisi J: The senescence-associated secretory phenotype: the dark side of tumor suppression. Ann Rev Pathol Med 2010;5: 99-118.
32. Freund A, Orjalo A, Desprez PY, Campisi J: Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med 2010;16: 238-248.
33. Coppé JP, Patil CK, Rodier F, Krtolica A, Beauséjour C, et al: A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen. PLoS One 2010; 5: e9188.
34. Yang G, Rosen DG, Zhang Z, Bast RC, Mills GB, et al: The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis. Proc Natl Acad Sci USA 2006;103: 16472-16477.
35. Bavik C, Coleman J, Dean JP, Knudsen B, Plymate S, Nelson PS: The gene expression program of prostate fibroblast senescence modulates neoplastic endothelial cell proliferation through paracrine mechanisms. Cancer Res 2006;66: 794-802.
36. Coppé JP, Kauser K, Campisi J, Beausejour CM: Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence. J Biol Chem 2006;281: 29568-29574.
37. Elzi DJ, Song M, Hakala K, Weintraub ST, Shiio Y: Wnt antagonist SFRP1 functions as secreted mediator of senescence. Mol Cell Biol 2012;21: 4388-4399.
38. Coppé JP, Patil CK, Rodier F, Sun Y, Munoz D, et al: Senescence-associated secretory phenotypes reveal cell non-autonomous functions of oncegenic RAS and the p53 tumor suppressor. PLoS Biol 2008;6: 2853-2868.
39. Acosta JC, O'Loghlen A, Banito A, Guijarro MV, Augert A, et al: Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 2008;133: 1006-1018.
40. Kuilman T, Michaloglu C, Vredeveld LCW, Douma S, van Doorn L, et al: Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 2008;133: 1019-1031.
41. Liu H, Fergusson MM, Castilho RM, Liu J, Cao L, et al: Augmented Wnt signaling in a mammalian model of accelerated aging. Science 2007;317: 803-806.
42. Laberge RM, Awad P, Campisi J, Desprez PY: Epithelial-mesenchymal transition induced by senescent fibroblasts. Cancer Microenviron 2012;5: 39-44.
43. Krtolica A, Larocque N, Genbacev O, Ilic D, Coppé JP, et al: GROα regulates human embryonic stem cell self-renewal or adoption of a neuronal fate. Differentiation 2011;81: 222-232.
44. Pricola KL, Kuhn NZ, Haleelm-Smith H, Song Y, Tuan RS: Interleukin-6 maintains bone marrow-derived mesenchymal stem cell stemness by an ERK1/2-dependent mechanism. J Cell Biochem 2009;108: 577-588.
45. Brack AS, Conboy MJ, Roy S, Lee M, Kuo CJ, et al: Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science 2007; 317:807-810.
46. Zhang D, Wang H, Tan Y: Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through the DNA-damage response and the p53/p21 pathway. PLoS One 2011;6: e21397.
47. INK4a induces cellular senescence without the associated inflammatory secretory phenotype. J Biol Chem 2011;286: 36396-36403.
48. Pazzoli E, Alspach E, Milczarek A, Prior J, Piwnica-Worms D, Stewart SA: Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression. Cancer Res 2012;72: 2251-2261.
49. Freund A, Patil PK, Campisi J: p38MAPK is a novel DNA-damage response-independent regulator of the senescence-associated secretory phenotype. EMBO J 2011;30: 1536-1548.
50. INK4a. Proc Natl Acad Sci USA 2006;103: 3645-3650.
51. Bhaumik D, Scott GK, Schokrpur S, Patil CK, Orjalo A, et al: MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging 2009;1: 402-411.
52. Orjalo A, Bhaumik D, Gengler B, Scott GK, Campisi J: Cell surface IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network. Proc Natl Acad Sci USA 2009;106: 17031-17036.
53. Parrinello S, Coppé JP, Krtolica A, Campisi J: Stromal-epithelial interactions in aging and cancer. Senescent fibroblasts alter epithelial cell differentiation. J Cell Sci 2005;118: 485-496.
54. Noureddine H, Gary-Bobo G, Alifano M, Marcos E, Saker M, et al: Pulmonary artery smooth muscle cell senescence is a pathogenic mechanism for pulmonary hypertension in chronic lung disease. Circ Res 2011;109: 543-553.
55. Ressler S, Bartkova J, Niederegger H, Bartek J, Scharffetter-Kochanek K, et al: p16 is a robust in vivo biomarker of cellular aging in human skin. Aging Cell 2006;5: 379-589.
56. Velarde MC, Flynn JM, Day NU, Melov S, Campisi J: Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging 2012;5: 3-12.
57. Bitto A, Sell C, Crowe E, Lorenzini A, Malaguti M, et al: Stress-induced senescence in human and rodent astrocytes. Exp Cell Res 2010;316: 2961-2968.
58. Salminen A, Olaja J, Kaarniranta K, Haappasalo A, Hiltunen M, Soininen H: Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype. Eur J Neurosci 2011;34: 3-11.
59. Roberts S, Evans EH, Kletsas D, Jaffray DC, Eisenstein SM: Senescence in human intervertebral discs. Eur Spine J 2006;15: 312-316.
60. Shane Anderson A, Loeser RF: Why is osteoarthritis an age-related disease? Best Pract Res Clin Rheumatol 2010;24: 15-26.
61. INK4a-positive senescent cells delays aging-associated disorders. Nature 2011;479: 232-236.
62. Binet R, Ythier D, Robles AI, Collado M, Larrieu D, et al: WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway. Cancer Res 2009;69: 9183-9191.
63. Krtolica A, Parrinello S, Lockett S, Desprez P, Campisi J: Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc Natl Acad Sci USA 2001;98: 12072-12077.
64. Liu D, Hornsby PJ: Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion. Cancer Res 2007;67: 3117-3126.
65. Sun Y, Campisi J, Higano C, Beer TM, Porter P, et al: Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B. Nat Med 2012;18: 1359-1368.
66. Gilbert LA, Hemann MT: DNA damage-mediated induction of a chemoresistant niche. Cell 2010;143: 355-366.
67. Chien Y, Scuoppo C, Wang X, Fang X, Balgley B, et al: Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity. Genes Dev 2011;25: 2125-2136.
68. Prieur A, Peeper DS: Cellular senescence in vivo: a barrier to tumorigenesis. Curr Opin Cell Biol 2008;20: 150-155.
69. Collado M, Serrano M: Senescence in tumors: evidence from mice and humans. Nat Rev Cancer 2010;10: 51-57.
70. Wajapeyee N, Serra RW, Zhu X, Mahalingam M, Green MR: Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 2008;132: 363-374.
71. Tsai KK, Chuang EY, Little JB, Yuan ZM: Cellular mechanisms for low-dose ionizing radiation-induced perturbation of the breast tissue microenvironment. Cancer Res 2005;65: 6734-6744.