Irinotecan induces senescence and apoptosis in colonic cells in vitro

Toxicology Letters

Volumn 214, Issue 1, 2012, Pages 1-8

  Rudolf, Emil ^a   John, Stanislav ^a   Cervinka, Miroslav ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Apoptosis; Colonic cells; DNA damage; Irinotecan; P53; Premature senescence

Indexed keywords

ACTIN; IRINOTECAN; MICRORNA 128A; MICRORNA 34A; MICRORNA 449A; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P16; PROTEIN P21; PROTEIN P53; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL FATE; CELL TYPE; CELLULAR STRESS RESPONSE; COLORECTAL CANCER; CONTROLLED STUDY; DNA DAMAGE; DRUG CYTOTOXICITY; FIBROBLAST; HUMAN; HUMAN CELL; INTESTINE CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CAMPTOTHECIN; CARCINOMA; CELL AGING; COLON; COLORECTAL NEOPLASMS; DNA DAMAGE; FIBROBLASTS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HCT116 CELLS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM PROTEINS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84865409542     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.08.004     Document Type: Article

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