Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

Aging Cell

Volumn 11, Issue 6, 2012, Pages 996-1004

  Jurk, Diana ^a   Wang, Chunfang ^b   Miwa, Satomi ^a   Maddick, Mandy ^a   Korolchuk, Viktor ^a   Tsolou, Avgi ^c   Gonos, Efstathios S ^c   Thrasivoulou, Christopher ^d   Jill Saffrey, M ^b   Cameron, Kerry ^a   von Zglinicki, Thomas ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b OPEN UNIVERSITY   (United Kingdom)

^c INSTITUTE OF BIOLOGY   (Greece)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Aging; Brain; Inflammation; Neurons; Oxidative stress; Senescence

Indexed keywords

BETA GALACTOSIDASE; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P21; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; IN VIVO STUDY; MALE; MOUSE; NERVE CELL; NONHUMAN; OXIDATIVE COUPLING; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PURKINJE CELL; SENESCENCE; SIGNAL TRANSDUCTION; TELOMERE;

AGING; ANIMALS; BETA-GALACTOSIDASE; CALORIC RESTRICTION; CELL AGING; CELL COUNT; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; MITOSIS; MYENTERIC PLEXUS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENOTYPE; PURKINJE CELLS; REACTIVE OXYGEN SPECIES; RNA; SIGNAL TRANSDUCTION; TELOMERASE; TELOMERE;

MUS;

EID: 84869186918     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2012.00870.x     Document Type: Article

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