E2F-1 overexpression correlates with decreased proliferation and better prognosis in adenocarcinomas of Barrett oesophagus

Journal of Clinical Pathology

Volumn 61, Issue 5, 2008, Pages 601-605

  Evangelou, K ^a   Kotsinas, A ^a   Mariolis Sapsakos, T ^a   Giannopoulos, A ^b   Tsantoulis, P K ^a   Constantinides, C ^c   Troupis, T G ^a   Salmas, M ^a   Kyroudis, A ^a   Kittas, C ^a   Gorgoulis, Vassilis G ^a,d  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

^c LAIKO GENERAL HOSPITAL   (Greece)

^d NONE   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; KI 67 ANTIGEN; PROTEIN P53; TRANSCRIPTION FACTOR E2F1;

ADULT; AGED; APOPTOSIS; ARTICLE; BARRETT ESOPHAGUS; CANCER SURVIVAL; CELL PROLIFERATION; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; ESOPHAGEAL ADENOCARCINOMA; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; BARRETT ESOPHAGUS; CELL PROLIFERATION; E2F1 TRANSCRIPTION FACTOR; ESOPHAGEAL NEOPLASMS; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; NEOPLASM STAGING; PRECANCEROUS CONDITIONS; PROGNOSIS; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 43549120978     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.2007.050963     Document Type: Article

References (28)

1. Siewert JR, Ott K. Are squamous and adenocarcinomas of the oesophagus the same disease? Semin Radiat Oncol 2007;17:38-44.
2. Kuwano H, Kato H, Miyazaki T, et al. Genetic alterations in esophageal cancer Surg Today 2005;35:7-18.
3. Kuo B, Urma D. Oesophagus - anatomy and development. In: Goyal R, Shaker R, eds. GI motility online. http://www.nature.com/gimo/contents/ reviews.html
4. Jenkins GJS, Doak SH, Parry JM, et al. Barrett's oesophagus: the genetic pathways involved in its progression to adenocarcinoma. Br J Surgery 2002;89:824-37.
5. Tsantoulis PK, Gorgoulis VG. Involvement of E2F transcription factor family in cancer. Eur J Cancer 2005;41:2403-14.
6. Bell LA, Ryan KM. Life and death decisions by E2F1. Cell Death Differ 2004;11:137-42.
7. Wyllie AH. E2F1 selects tumour cells for both life and death. J Pathol 2002;191:139-41.
8. Gorgoulis VG, Zacharatos P, Mariatos G, et al. Transcription factor E2F1 acts as a growth-promoting factor and is associated with adverse prognosis in non-small cell lung carcinomas. J Pathol 2002;198:142-56.
9. Zacharatos P, Kotsinas A, Evangelou K, et al. Distinct expression patterns of the transcription factor E2F1 in relation to tumour growth parameters in common human carcinomas. J Pathol 2004;203:744-53.
10. Eymin B, Gazzeri S, Brambilla C, et al. Distinct pattern of E2F1 expression in human lung tumours: E2F1 is upregulated in small cell lung carcinomas. Oncogene 2001;20:1678-87.
11. Saiz AD, Olvera M, Rezk S, et al. Immunohistochemical expression of cyclin D1, E2F1 and Ki-67 in benign and malignant thyroid lesions. J Pathol 2002;198:157-62.
12. Rabbani F, Richon VM, Orlow I, et al. Prognostic significance of transcription factor E2F1 in bladder cancer: genotypic and phenotypic characterization. J Natl Cancer Inst 1999;91:874-81.
13. Yamazaki K, Yajima T, Nagao T, et al: Expression of transcription factor E2F1 in pancreatic ductal carcinoma: an immunohistochemical study. Pathol Res Pract 2003;199:23-8.
14. Moller MB, Kania PW, Ino Y, et al. Frequent disruption of the RB1 pathway in diffuse large B cell lymphoma: prognostic significance of E2F1 and p16INK4A. Leukemia 2000;14:898-04.
15. Lai R, Medeiros LJ, Wilson CS, et al. Expression of the cell-cycle-related proteins E2F1, p53, mdm-2, p21waf-1, and Ki-67 in multiple myeloma: correlation with cyclin-D1 immunoreactivity. Mod Pathol 1998;11:642-7.
16. Wilson CS, Butch AW, Lai R, et al. Cyclin D1 and E2F1 immunoreactivity in bone marrow biopsy specimens of multiple myeloma: relationship to proliferative activity, cytogenetic abnormalities and DNA ploidy. Br J Haematol 2001;112:776-82.
17. Yamazaki K, Hasegawa M, Ohoka I, et al. Increased E2F1 expression via tumour cell proliferation and decreased apoptosis are correlated with adverse prognosis in patients with squamous cell carcinoma of the oesophagous. J Clin Pathol 2005;58:904-10.
18. Hadjiloucas I, Gilmore AP, Bundred NJ, et al. Assessment of apoptosis in human breast tissue using an antibody against the active form of caspase 3: relation to tumour histopathological characteristics. Br J Cancer 2001;85:1522-6.
19. Ebihara Y, Miyamoto M, Shichinohe T, et al. Over-expression of E2F1 in oesophageal squamous cell carcinoma correlates with tumor progression. Dis Oesophagus 2004;17:150-4.
20. Mega S, Miyamoto M, Ebihara Y, et al. Cyclin D1, E2F1 expression levels are associated with characteristics and prognosis of oesophageal squamous cell carcinoma. Dis Oesophagus 2005;18:109- 13.
21. Suzuki T, Yasui W, Yokozaki H, et al. Expression of the E2F family in human gastrointestinal carcinomas. Int J Cancer 1999;81:535-8.
22. Yasui W, Naka K, Suzuki T, et al. Expression of p27Kip1, cyclin E and E2F1 in primary and metastatic tumours of gastric carcinoma. Oncol Rep 1999;6:983-7.
23. Yasui W, Fujimoto J, Suzuki T, et al. Expression of cell-cycle-regulating transcription factor E2F1 in colorectal carcinomas. Pathobiology 1999;67:174-9.
24. Coggi G, Bosari S, Roncalli M, et al. p53 protein accumulation and p53 gene mutation in oesophageal carcinoma. A molecular and immunohistochemical study with clinicopathologic correlations. Cancer 1997;79:425-32.
25. Yang HL, Dong YB, Elliott MJ, et al. Caspase activation and changes in bcl-2 family member protein expression associated with E2F1-mediated apoptosis in human oesophageal cancer cells. Clin Cancer Res 2000;6:1579-89.
26. Itoshima T, Fujiwara T, Waku T, et al. Induction of apoptosis in human oesophageal cancer cells by sequential transfer of wild-type p53 and E2F1 genes: involvement of p53 accumulation via ARF-mediated MDM2 down-regulation. Clin Cancer Res 2000;6:2851-9.
27. Sbarbati A, Faccioli N, Ricci F, et al. Ultrastructural phenotype of "intestinal-type" cells in columnar-lined esophagus. Ultrastruct Pathol 2002;26:107-11.
28. Skandalakis JE, Ellis H. Embryologic and anatomic basis of oesophageal surgery. Surg Clin North Am 2000;80:85-155.