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Volumn 4, Issue 2, 2015, Pages 112-122

Medicinal plants of the genuses Salvia and Hypericum are sources of anticolon cancer compounds: Effects on PI3K/Akt and MAP kinases pathways

Author keywords

Colorectal cancer; Hypericum; MAPK; Nutraceuticals; PI3K Akt; Salvia

Indexed keywords

ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLYCOGEN SYNTHASE KINASE 3; GUANINE NUCLEOTIDE BINDING PROTEIN; HYPERICUM ANDROSAEMUM EXTRACT; HYPERICUM PERFORATUM EXTRACT; LUTEOLIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PLANT EXTRACT; PROTEIN BAD; PROTEIN KINASE B; PROTEIN MDM2; PROTEIN P21; PROTEIN P27; QUERCETIN; RAS PROTEIN; ROSMARINIC ACID; SALVIA FRUTICOSA EXTRACT; SALVIA MENTHAEFOLIA EXTRACT; SALVIA MILTIORRHIZA EXTRACT; SALVIA OFFICINALIS EXTRACT; SOMATOMEDIN RECEPTOR; TRANSCRIPTION FACTOR FOXO; UNCLASSIFIED DRUG; UNINDEXED DRUG; URSOLIC ACID; WORTMANNIN;

EID: 84959297030     PISSN: None     EISSN: 22134344     Source Type: Journal    
DOI: 10.1016/j.phanu.2015.11.002     Document Type: Review
Times cited : (7)

References (170)
  • 1
    • 72449176846 scopus 로고    scopus 로고
    • Molecular origins of cancer: molecular basis of colorectal cancer
    • Markowitz S.D., Bertagnolli M.M. Molecular origins of cancer: molecular basis of colorectal cancer. N. Engl. J. Med. 2009, 361(25):2449-2460.
    • (2009) N. Engl. J. Med. , vol.361 , Issue.25 , pp. 2449-2460
    • Markowitz, S.D.1    Bertagnolli, M.M.2
  • 2
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon E.R., Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990, 61(5):759-767.
    • (1990) Cell , vol.61 , Issue.5 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 3
    • 79751489596 scopus 로고    scopus 로고
    • Molecular genetics of colorectal cancer
    • Fearon E.R. Molecular genetics of colorectal cancer. Annu. Rev. Pathol. 2011, 6:479-507.
    • (2011) Annu. Rev. Pathol. , vol.6 , pp. 479-507
    • Fearon, E.R.1
  • 4
    • 33947586770 scopus 로고    scopus 로고
    • Genetic alterations in sporadic and hereditary colorectal cancer: implementations for screening and follow-up
    • Souglakos J. Genetic alterations in sporadic and hereditary colorectal cancer: implementations for screening and follow-up. Dig Dis. 2007, 25(1):9-19.
    • (2007) Dig Dis. , vol.25 , Issue.1 , pp. 9-19
    • Souglakos, J.1
  • 5
    • 67650759744 scopus 로고    scopus 로고
    • Evolving treatment of advanced colon cancer
    • Segal N.H., Saltz L.B. Evolving treatment of advanced colon cancer. Annu. Rev. Med. 2009, 60:207-219.
    • (2009) Annu. Rev. Med. , vol.60 , pp. 207-219
    • Segal, N.H.1    Saltz, L.B.2
  • 7
    • 84903714221 scopus 로고    scopus 로고
    • Medicinal plants combating against cancer - a green anticancer approach
    • Sultana S., Asif H.M., Nazar H.M., et al. Medicinal plants combating against cancer - a green anticancer approach. Asian Pac. J. Cancer Prev. 2014, 15(11):4385-4394.
    • (2014) Asian Pac. J. Cancer Prev. , vol.15 , Issue.11 , pp. 4385-4394
    • Sultana, S.1    Asif, H.M.2    Nazar, H.M.3
  • 8
    • 84855281811 scopus 로고    scopus 로고
    • Natural products: promising resources for cancer drug discovery
    • Mondal S., Bandyopadhyay S., Ghosh M.K., et al. Natural products: promising resources for cancer drug discovery. Anticancer Agents Med. Chem. 2012, 12(1):49-75.
    • (2012) Anticancer Agents Med. Chem. , vol.12 , Issue.1 , pp. 49-75
    • Mondal, S.1    Bandyopadhyay, S.2    Ghosh, M.K.3
  • 9
    • 38449108705 scopus 로고    scopus 로고
    • Diet and colorectal cancer: review of the evidence
    • Ryan-Harshman M., Aldoori W. Diet and colorectal cancer: review of the evidence. Can. Fam. Phys. 2007, 53(11):1913-1920.
    • (2007) Can. Fam. Phys. , vol.53 , Issue.11 , pp. 1913-1920
    • Ryan-Harshman, M.1    Aldoori, W.2
  • 10
    • 84857598658 scopus 로고    scopus 로고
    • Nutraceuticals for protection and healing of gastrointestinal mucosa
    • Romano M., Vitaglione P., Sellitto S., D'Argenio G. Nutraceuticals for protection and healing of gastrointestinal mucosa. Curr. Med. Chem. 2012, 19(1):109-117.
    • (2012) Curr. Med. Chem. , vol.19 , Issue.1 , pp. 109-117
    • Romano, M.1    Vitaglione, P.2    Sellitto, S.3    D'Argenio, G.4
  • 11
    • 85006207581 scopus 로고    scopus 로고
    • Adherence to Mediterranean diet and risk of cancer: an updated systematic review and meta-analysis of observational studies
    • Schwingshackl L., Hoffmann G. Adherence to Mediterranean diet and risk of cancer: an updated systematic review and meta-analysis of observational studies. Cancer Med. 2015.
    • (2015) Cancer Med.
    • Schwingshackl, L.1    Hoffmann, G.2
  • 12
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Surh Y.J. Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer 2003, 3(10):768-780.
    • (2003) Nat. Rev. Cancer , vol.3 , Issue.10 , pp. 768-780
    • Surh, Y.J.1
  • 13
    • 0033807245 scopus 로고    scopus 로고
    • Effects of tea consumption on nutrition and health
    • Yang C.S., Landau J.M. Effects of tea consumption on nutrition and health. J. Nutr. 2000, 130(10):2409-2412.
    • (2000) J. Nutr. , vol.130 , Issue.10 , pp. 2409-2412
    • Yang, C.S.1    Landau, J.M.2
  • 14
    • 35348923465 scopus 로고    scopus 로고
    • Tea and cancer prevention: molecular mechanisms and human relevance
    • Yang C.S., Lambert J.D., Ju J., Lu G., Sang S. Tea and cancer prevention: molecular mechanisms and human relevance. Toxicol. Appl. Pharmacol. 2007, 224(3):265-273.
    • (2007) Toxicol. Appl. Pharmacol. , vol.224 , Issue.3 , pp. 265-273
    • Yang, C.S.1    Lambert, J.D.2    Ju, J.3    Lu, G.4    Sang, S.5
  • 15
    • 80555123045 scopus 로고    scopus 로고
    • Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications
    • Singh B.N., Shankar S., Srivastava R.K. Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications. Biochem. Pharmacol. 2011, 82(12):1807-1821.
    • (2011) Biochem. Pharmacol. , vol.82 , Issue.12 , pp. 1807-1821
    • Singh, B.N.1    Shankar, S.2    Srivastava, R.K.3
  • 16
    • 46049101668 scopus 로고    scopus 로고
    • Cancer prevention by tea and tea polyphenols
    • Yang C.S., Ju J., Lu G., et al. Cancer prevention by tea and tea polyphenols. Asia Pac. J. Clin. Nutr. 2008, 17(Suppl. 1):245-248.
    • (2008) Asia Pac. J. Clin. Nutr. , vol.17 , pp. 245-248
    • Yang, C.S.1    Ju, J.2    Lu, G.3
  • 17
    • 0034928799 scopus 로고    scopus 로고
    • Inhibition of carcinogenesis by dietary polyphenolic compounds
    • Yang C.S., Landau J.M., Huang M.T., Newmark H.L. Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu. Rev. Nutr. 2001, 21:381-406.
    • (2001) Annu. Rev. Nutr. , vol.21 , pp. 381-406
    • Yang, C.S.1    Landau, J.M.2    Huang, M.T.3    Newmark, H.L.4
  • 18
    • 78149497094 scopus 로고    scopus 로고
    • Targeting specific cell signaling transduction pathways by dietary and medicinal phytochemicals in cancer chemoprevention
    • Neergheen V.S., Bahorun T., Taylor E.W., Jen L.S., Aruoma O.I. Targeting specific cell signaling transduction pathways by dietary and medicinal phytochemicals in cancer chemoprevention. Toxicology 2010, 278(2):229-241.
    • (2010) Toxicology , vol.278 , Issue.2 , pp. 229-241
    • Neergheen, V.S.1    Bahorun, T.2    Taylor, E.W.3    Jen, L.S.4    Aruoma, O.I.5
  • 19
    • 0037298781 scopus 로고    scopus 로고
    • Redox-sensitive mechanisms of phytochemical-mediated inhibition of cancer cell proliferation (review)
    • Loo G. Redox-sensitive mechanisms of phytochemical-mediated inhibition of cancer cell proliferation (review). J. Nutr. Biochem. 2003, 14(2):64-73.
    • (2003) J. Nutr. Biochem. , vol.14 , Issue.2 , pp. 64-73
    • Loo, G.1
  • 20
    • 33847349283 scopus 로고    scopus 로고
    • Reactive oxygen species: a breath of life or death?
    • Fruehauf J.P., Meyskens F.L. Reactive oxygen species: a breath of life or death?. Clin. Cancer Res. 2007, 13(3):789-794.
    • (2007) Clin. Cancer Res. , vol.13 , Issue.3 , pp. 789-794
    • Fruehauf, J.P.1    Meyskens, F.L.2
  • 23
    • 48649095089 scopus 로고    scopus 로고
    • Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways
    • Ramos S. Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways. Mol. Nutr. Food Res. 2008, 52(5):507-526.
    • (2008) Mol. Nutr. Food Res. , vol.52 , Issue.5 , pp. 507-526
    • Ramos, S.1
  • 24
    • 84910134369 scopus 로고    scopus 로고
    • Targeting apoptosis pathways in cancer and perspectives with natural compounds from mother nature
    • Millimouno F.M., Dong J., Yang L., Li J., Li X. Targeting apoptosis pathways in cancer and perspectives with natural compounds from mother nature. Cancer Prev. Res. (Phila.) 2014, 7(11):1081-1107.
    • (2014) Cancer Prev. Res. (Phila.) , vol.7 , Issue.11 , pp. 1081-1107
    • Millimouno, F.M.1    Dong, J.2    Yang, L.3    Li, J.4    Li, X.5
  • 26
    • 79955655749 scopus 로고    scopus 로고
    • Chinese herbal medicines as adjuvant treatment during chemo- or radio-therapy for cancer
    • Qi F., Li A., Inagaki Y., et al. Chinese herbal medicines as adjuvant treatment during chemo- or radio-therapy for cancer. Biosci. Trends 2010, 4(6):297-307.
    • (2010) Biosci. Trends , vol.4 , Issue.6 , pp. 297-307
    • Qi, F.1    Li, A.2    Inagaki, Y.3
  • 27
    • 84949757774 scopus 로고    scopus 로고
    • Cancer therapy with phytochemicals: evidence from clinical studies
    • Hosseini A., Ghorbani A. Cancer therapy with phytochemicals: evidence from clinical studies. Avicenna J. Phytomed. 2015, 5(2):84-97.
    • (2015) Avicenna J. Phytomed. , vol.5 , Issue.2 , pp. 84-97
    • Hosseini, A.1    Ghorbani, A.2
  • 28
    • 84978458683 scopus 로고    scopus 로고
    • Evidence-based phytotherapy in Europe: Where do we stand?
    • Furst R., Zundorf I. Evidence-based phytotherapy in Europe: Where do we stand?. Plant. Med. 2016, 2015.
    • (2016) Plant. Med. , pp. 2015
    • Furst, R.1    Zundorf, I.2
  • 29
    • 74349116384 scopus 로고    scopus 로고
    • Phytotherapeutics: an evaluation of the potential of 1000 plants
    • Cravotto G., Boffa L., Genzini L., Garella D. Phytotherapeutics: an evaluation of the potential of 1000 plants. J. Clin. Pharm. Ther. 2010, 35(1):11-48.
    • (2010) J. Clin. Pharm. Ther. , vol.35 , Issue.1 , pp. 11-48
    • Cravotto, G.1    Boffa, L.2    Genzini, L.3    Garella, D.4
  • 30
    • 33748063941 scopus 로고    scopus 로고
    • Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance
    • McCubrey J.A., Steelman L.S., Abrams S.L., et al. Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance. Adv. Enzyme Regul. 2006, 46:249-279.
    • (2006) Adv. Enzyme Regul. , vol.46 , pp. 249-279
    • McCubrey, J.A.1    Steelman, L.S.2    Abrams, S.L.3
  • 31
    • 33947594129 scopus 로고    scopus 로고
    • Hyperactive Ras in developmental disorders and cancer
    • Schubbert S., Shannon K., Bollag G. Hyperactive Ras in developmental disorders and cancer. Nat. Rev. Cancer 2007, 7(4):295-308.
    • (2007) Nat. Rev. Cancer , vol.7 , Issue.4 , pp. 295-308
    • Schubbert, S.1    Shannon, K.2    Bollag, G.3
  • 32
    • 84861147473 scopus 로고    scopus 로고
    • A comprehensive survey of Ras mutations in cancer
    • Prior I.A., Lewis P.D., Mattos C. A comprehensive survey of Ras mutations in cancer. Cancer Res. 2012, 72(10):2457-2467.
    • (2012) Cancer Res. , vol.72 , Issue.10 , pp. 2457-2467
    • Prior, I.A.1    Lewis, P.D.2    Mattos, C.3
  • 33
    • 42149083899 scopus 로고    scopus 로고
    • Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers
    • Barault L., Veyries N., Jooste V., et al. Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers. Int. J. Cancer 2008, 122:2255-2259.
    • (2008) Int. J. Cancer , vol.122 , pp. 2255-2259
    • Barault, L.1    Veyries, N.2    Jooste, V.3
  • 34
    • 68549136810 scopus 로고    scopus 로고
    • Assessment of K-ras mutation: a step toward personalized medicine for patients with colorectal cancer
    • Jiang Y., Kimchi E.T., Staveley-O'Carroll K.F., Cheng H., Ajani J.A. Assessment of K-ras mutation: a step toward personalized medicine for patients with colorectal cancer. Cancer 2009, 115(16):3609-3617.
    • (2009) Cancer , vol.115 , Issue.16 , pp. 3609-3617
    • Jiang, Y.1    Kimchi, E.T.2    Staveley-O'Carroll, K.F.3    Cheng, H.4    Ajani, J.A.5
  • 35
    • 33846048042 scopus 로고    scopus 로고
    • KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression
    • Oliveira C., Velho S., Moutinho C., et al. KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression. Oncogene 2007, 26(1):158-163.
    • (2007) Oncogene , vol.26 , Issue.1 , pp. 158-163
    • Oliveira, C.1    Velho, S.2    Moutinho, C.3
  • 36
    • 51849128358 scopus 로고    scopus 로고
    • PI3K in oncogenic cellular transformation
    • Zhao L., Vogt P.K., Class I. PI3K in oncogenic cellular transformation. Oncogene 2008, 27(41):5486-5496.
    • (2008) Oncogene , vol.27 , Issue.41 , pp. 5486-5496
    • Zhao, L.1    Vogt, P.K.2    Class, I.3
  • 37
    • 1642617693 scopus 로고    scopus 로고
    • PI3K/Akt signalling pathway and cancer
    • Vara J.A.F., Casado E., de Castro J., et al. PI3K/Akt signalling pathway and cancer. Cancer Treat. Rev. 2004, 30(2):193-204.
    • (2004) Cancer Treat. Rev. , vol.30 , Issue.2 , pp. 193-204
    • Vara, J.A.F.1    Casado, E.2    de Castro, J.3
  • 38
    • 27744459507 scopus 로고    scopus 로고
    • Mechanisms of disease: PI3K/AKT signaling in gastrointestinal cancers
    • Michl P., Downward J. Mechanisms of disease: PI3K/AKT signaling in gastrointestinal cancers. Z. Gastroenterol. 2005, 43(10):1133-1139.
    • (2005) Z. Gastroenterol. , vol.43 , Issue.10 , pp. 1133-1139
    • Michl, P.1    Downward, J.2
  • 39
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: navigating downstream
    • Manning B.D., Cantley L.C. AKT/PKB signaling: navigating downstream. Cell 2007, 129(7):1261-1274.
    • (2007) Cell , vol.129 , Issue.7 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 40
    • 23844445836 scopus 로고    scopus 로고
    • Colorectal cancer: mutations in a signalling pathway
    • Parsons D.W., Wang T.L., Samuels Y., et al. Colorectal cancer: mutations in a signalling pathway. Nature 2005, 436(7052):792.
    • (2005) Nature , vol.436 , Issue.7052 , pp. 792
    • Parsons, D.W.1    Wang, T.L.2    Samuels, Y.3
  • 41
    • 53149097362 scopus 로고    scopus 로고
    • BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?
    • Velho S., Moutinho C., Cirnes L., et al. BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?. BMC Cancer 2008, 8:255.
    • (2008) BMC Cancer , vol.8 , pp. 255
    • Velho, S.1    Moutinho, C.2    Cirnes, L.3
  • 42
    • 34147172885 scopus 로고    scopus 로고
    • Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis
    • Wang J., Kuropatwinski K., Hauser J., et al. Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis. Mol. Cancer Ther. 2007, 6(3):1143-1150.
    • (2007) Mol. Cancer Ther. , vol.6 , Issue.3 , pp. 1143-1150
    • Wang, J.1    Kuropatwinski, K.2    Hauser, J.3
  • 43
    • 34250835879 scopus 로고    scopus 로고
    • Mutant PIK3CA-bearing colon cancer cells display increased metastasis in an orthotopic model
    • Guo X.N., Rajput A., Rose R., et al. Mutant PIK3CA-bearing colon cancer cells display increased metastasis in an orthotopic model. Cancer Res. 2007, 67(12):5851-5858.
    • (2007) Cancer Res. , vol.67 , Issue.12 , pp. 5851-5858
    • Guo, X.N.1    Rajput, A.2    Rose, R.3
  • 44
    • 22144452507 scopus 로고    scopus 로고
    • The prevalence of PIK3CA mutations in gastric and colon cancer
    • Velho S., Oliveira C., Ferreira A., et al. The prevalence of PIK3CA mutations in gastric and colon cancer. Eur. J. Cancer 2005, 41(11):1649-1654.
    • (2005) Eur. J. Cancer , vol.41 , Issue.11 , pp. 1649-1654
    • Velho, S.1    Oliveira, C.2    Ferreira, A.3
  • 45
    • 54249159640 scopus 로고    scopus 로고
    • PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation
    • Oda K., Okada J., Timmerman L., et al. PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation. Cancer Res. 2008, 68(19):8127-8136.
    • (2008) Cancer Res. , vol.68 , Issue.19 , pp. 8127-8136
    • Oda, K.1    Okada, J.2    Timmerman, L.3
  • 46
    • 0036195196 scopus 로고    scopus 로고
    • AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis
    • Roy H.K., Olusola B.F., Clemens D.L., et al. AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis. Carcinogenesis 2002, 23(1):201-205.
    • (2002) Carcinogenesis , vol.23 , Issue.1 , pp. 201-205
    • Roy, H.K.1    Olusola, B.F.2    Clemens, D.L.3
  • 47
    • 1242307944 scopus 로고    scopus 로고
    • Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma
    • Khaleghpour K., Li Y., Banville D., Yu Z., Shen S.H. Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma. Carcinogenesis 2004, 25(2):241-248.
    • (2004) Carcinogenesis , vol.25 , Issue.2 , pp. 241-248
    • Khaleghpour, K.1    Li, Y.2    Banville, D.3    Yu, Z.4    Shen, S.H.5
  • 48
    • 0037096804 scopus 로고    scopus 로고
    • Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma
    • Itoh N., Semba S., Ito M., et al. Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma. Cancer 2002, 94(12):3127-3134.
    • (2002) Cancer , vol.94 , Issue.12 , pp. 3127-3134
    • Itoh, N.1    Semba, S.2    Ito, M.3
  • 50
    • 43049131769 scopus 로고    scopus 로고
    • Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations
    • LoPiccolo J., Blumenthal G.M., Bernstein W.B., Dennis P.A. Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations. Drug Resist. Updat. 2008, 11(1-2):32-50.
    • (2008) Drug Resist. Updat. , vol.11 , Issue.1-2 , pp. 32-50
    • LoPiccolo, J.1    Blumenthal, G.M.2    Bernstein, W.B.3    Dennis, P.A.4
  • 51
    • 27844598284 scopus 로고    scopus 로고
    • The Akt/PKB pathway: molecular target for cancer drug discovery
    • Cheng J.Q., Lindsley C.W., Cheng G.Z., Yang H., Nicosia S.V. The Akt/PKB pathway: molecular target for cancer drug discovery. Oncogene 2005, 24(50):7482-7492.
    • (2005) Oncogene , vol.24 , Issue.50 , pp. 7482-7492
    • Cheng, J.Q.1    Lindsley, C.W.2    Cheng, G.Z.3    Yang, H.4    Nicosia, S.V.5
  • 52
    • 32944465388 scopus 로고    scopus 로고
    • Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway
    • Granville C.A., Memmott R.M., Gills J.J., Dennis P.A. Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway. Clin. Cancer Res. 2006, 12(3 Pt 1):679-689.
    • (2006) Clin. Cancer Res. , vol.12 , Issue.3 , pp. 679-689
    • Granville, C.A.1    Memmott, R.M.2    Gills, J.J.3    Dennis, P.A.4
  • 53
    • 34248563299 scopus 로고    scopus 로고
    • Role of mitogen-activated protein kinase kinase kinases in signal integration
    • Cuevas B.D., Abell A.N., Johnson G.L. Role of mitogen-activated protein kinase kinase kinases in signal integration. Oncogene 2007, 26(22):3159-3171.
    • (2007) Oncogene , vol.26 , Issue.22 , pp. 3159-3171
    • Cuevas, B.D.1    Abell, A.N.2    Johnson, G.L.3
  • 54
    • 17844368327 scopus 로고    scopus 로고
    • The MAPK signalling pathways and colorectal cancer
    • Fang J.Y., Richardson B.C. The MAPK signalling pathways and colorectal cancer. Lancet Oncol. 2005, 6(5):322-327.
    • (2005) Lancet Oncol. , vol.6 , Issue.5 , pp. 322-327
    • Fang, J.Y.1    Richardson, B.C.2
  • 55
    • 20344365798 scopus 로고    scopus 로고
    • BRAF mutation associated with dysregulation of apoptosis in human colorectal neoplasms
    • Ikehara N., Semba S., Sakashita M., et al. BRAF mutation associated with dysregulation of apoptosis in human colorectal neoplasms. Int. J. Cancer 2005, 115(6):943-950.
    • (2005) Int. J. Cancer , vol.115 , Issue.6 , pp. 943-950
    • Ikehara, N.1    Semba, S.2    Sakashita, M.3
  • 56
    • 3442879332 scopus 로고    scopus 로고
    • Colorectal tumors frequently express phosphorylated mitogen-activated protein kinase
    • Lee S.H., Lee J.W., Soung Y.H., et al. Colorectal tumors frequently express phosphorylated mitogen-activated protein kinase. APMIS 2004, 112(4-5):233-238.
    • (2004) APMIS , vol.112 , Issue.4-5 , pp. 233-238
    • Lee, S.H.1    Lee, J.W.2    Soung, Y.H.3
  • 57
    • 66249116702 scopus 로고    scopus 로고
    • PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers
    • Wee S., Jagani Z., Xiang K.X., et al. PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers. Cancer Res. 2009, 69(10):4286-4293.
    • (2009) Cancer Res. , vol.69 , Issue.10 , pp. 4286-4293
    • Wee, S.1    Jagani, Z.2    Xiang, K.X.3
  • 58
    • 69049087664 scopus 로고    scopus 로고
    • Cellular signaling perturbation by natural products
    • Sarkar F.H., Li Y., Wang Z., Kong D. Cellular signaling perturbation by natural products. Cell Signal. 2009, 21(11):1541-1547.
    • (2009) Cell Signal. , vol.21 , Issue.11 , pp. 1541-1547
    • Sarkar, F.H.1    Li, Y.2    Wang, Z.3    Kong, D.4
  • 59
    • 33646028804 scopus 로고    scopus 로고
    • Molecular targets of dietary agents for prevention and therapy of cancer
    • Aggarwal B.B., Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem. Pharmacol. 2006, 71(10):1397-1421.
    • (2006) Biochem. Pharmacol. , vol.71 , Issue.10 , pp. 1397-1421
    • Aggarwal, B.B.1    Shishodia, S.2
  • 60
    • 84889063414 scopus 로고    scopus 로고
    • Synergy effects of herb extracts: pharmacokinetics and pharmacodynamic basis
    • Yang Y., Zhang Z., Li S., et al. Synergy effects of herb extracts: pharmacokinetics and pharmacodynamic basis. Fitoterapia 2014, 92:133-147.
    • (2014) Fitoterapia , vol.92 , pp. 133-147
    • Yang, Y.1    Zhang, Z.2    Li, S.3
  • 61
    • 58149240953 scopus 로고    scopus 로고
    • Natural products and colon cancer: current status and future prospects
    • Rajamanickam S., Agarwal R. Natural products and colon cancer: current status and future prospects. Drug Dev. Res. 2008, 69(7):460-471.
    • (2008) Drug Dev. Res. , vol.69 , Issue.7 , pp. 460-471
    • Rajamanickam, S.1    Agarwal, R.2
  • 62
    • 84880418538 scopus 로고    scopus 로고
    • Dietary influence on MAPK-signaling pathways and risk of colon and rectal cancer
    • Slattery M.L., Lundgreen A., Wolff R.K. Dietary influence on MAPK-signaling pathways and risk of colon and rectal cancer. Nutr. Cancer 2013, 65(5):729-738.
    • (2013) Nutr. Cancer , vol.65 , Issue.5 , pp. 729-738
    • Slattery, M.L.1    Lundgreen, A.2    Wolff, R.K.3
  • 63
    • 0038731072 scopus 로고    scopus 로고
    • Variability in phenolic composition of Hypericum androsaemum
    • Valentao P., Dias A., Ferreira M., et al. Variability in phenolic composition of Hypericum androsaemum. Nat. Prod. Res. 2003, 17(2):135-140.
    • (2003) Nat. Prod. Res. , vol.17 , Issue.2 , pp. 135-140
    • Valentao, P.1    Dias, A.2    Ferreira, M.3
  • 64
    • 2642548960 scopus 로고    scopus 로고
    • Variation of the essential oil content and composition in leaves from cultivated plants of Hypericum androsaemum L
    • Guedes A.P., Amorim L.R., Vicente A., Fernandes-Ferreira M. Variation of the essential oil content and composition in leaves from cultivated plants of Hypericum androsaemum L. Phytochem. Anal. 2004, 15(3):146-151.
    • (2004) Phytochem. Anal. , vol.15 , Issue.3 , pp. 146-151
    • Guedes, A.P.1    Amorim, L.R.2    Vicente, A.3    Fernandes-Ferreira, M.4
  • 65
    • 1942424059 scopus 로고    scopus 로고
    • Protective activity of Hypericum androsaemum infusion against tert-butyl hydroperoxide-induced oxidative damage in isolated rat hepatocytes
    • Valentao P., Carvalho M., Fernandes E., et al. Protective activity of Hypericum androsaemum infusion against tert-butyl hydroperoxide-induced oxidative damage in isolated rat hepatocytes. J. Ethnopharmacol. 2004, 92(1):79-84.
    • (2004) J. Ethnopharmacol. , vol.92 , Issue.1 , pp. 79-84
    • Valentao, P.1    Carvalho, M.2    Fernandes, E.3
  • 66
    • 0036780372 scopus 로고    scopus 로고
    • Antioxidant activity of Hypericum androsaemum infusion: scavenging activity against superoxide radical, hydroxyl radical and hypochlorous acid
    • Valentao P., Fernandes E., Carvalho F., et al. Antioxidant activity of Hypericum androsaemum infusion: scavenging activity against superoxide radical, hydroxyl radical and hypochlorous acid. Biol. Pharm. Bull. 2002, 25(10):1320-1323.
    • (2002) Biol. Pharm. Bull. , vol.25 , Issue.10 , pp. 1320-1323
    • Valentao, P.1    Fernandes, E.2    Carvalho, F.3
  • 67
    • 4344716319 scopus 로고    scopus 로고
    • Hypericum androsaemum infusion increases tert-butyl hydroperoxide-induced mice hepatotoxicity in vivo
    • Valentao P., Carvalho M., Carvalho F., et al. Hypericum androsaemum infusion increases tert-butyl hydroperoxide-induced mice hepatotoxicity in vivo. J. Ethnopharmacol. 2004, 94(2-3):345-351.
    • (2004) J. Ethnopharmacol. , vol.94 , Issue.2-3 , pp. 345-351
    • Valentao, P.1    Carvalho, M.2    Carvalho, F.3
  • 68
    • 84864753595 scopus 로고    scopus 로고
    • Hypericum androsaemum water extract inhibits proliferation in human colorectal cancer cells through effects on MAP kinases and PI3K/Akt pathway
    • Xavier C.P., Lima C.F., Fernandes-Ferreira M., Pereira-Wilson C. Hypericum androsaemum water extract inhibits proliferation in human colorectal cancer cells through effects on MAP kinases and PI3K/Akt pathway. Food Funct. 2012, 3(8):844-852.
    • (2012) Food Funct. , vol.3 , Issue.8 , pp. 844-852
    • Xavier, C.P.1    Lima, C.F.2    Fernandes-Ferreira, M.3    Pereira-Wilson, C.4
  • 69
    • 77951103850 scopus 로고    scopus 로고
    • Chlorogenic acid differentially alters hepatic and small intestinal thiol redox status without protecting against azoxymethane-induced colon carcinogenesis in mice
    • Park H.J., Davis S.R., Liang H.Y., Rosenberg D.W., Bruno R.S. Chlorogenic acid differentially alters hepatic and small intestinal thiol redox status without protecting against azoxymethane-induced colon carcinogenesis in mice. Nutr. Cancer 2010, 62(3):362-370.
    • (2010) Nutr. Cancer , vol.62 , Issue.3 , pp. 362-370
    • Park, H.J.1    Davis, S.R.2    Liang, H.Y.3    Rosenberg, D.W.4    Bruno, R.S.5
  • 70
    • 70449624957 scopus 로고    scopus 로고
    • Cytotoxic activity of flavonoids from the flowers of Chrysanthemum morifolium on human colon cancer Colon205 cells
    • Xie Y.Y., Yuan D., Yang J.Y., Wang L.H., Wu C.F. Cytotoxic activity of flavonoids from the flowers of Chrysanthemum morifolium on human colon cancer Colon205 cells. J. Asian Nat. Prod. Res. 2009, 11(9):771-778.
    • (2009) J. Asian Nat. Prod. Res. , vol.11 , Issue.9 , pp. 771-778
    • Xie, Y.Y.1    Yuan, D.2    Yang, J.Y.3    Wang, L.H.4    Wu, C.F.5
  • 71
    • 33645872700 scopus 로고    scopus 로고
    • The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression
    • Belkaid A., Currie J.C., Desgagnes J., Annabi B. The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression. Cancer Cell Int. 2006, 6:7.
    • (2006) Cancer Cell Int. , vol.6 , pp. 7
    • Belkaid, A.1    Currie, J.C.2    Desgagnes, J.3    Annabi, B.4
  • 72
    • 24744434694 scopus 로고    scopus 로고
    • A phenolic compound, 5-caffeoylquinic acid (chlorogenic acid), is a new type and strong matrix metalloproteinase-9 inhibitor: isolation and identification from methanol extract of Euonymus alatus
    • Jin U.H., Lee J.Y., Kang S.K., et al. A phenolic compound, 5-caffeoylquinic acid (chlorogenic acid), is a new type and strong matrix metalloproteinase-9 inhibitor: isolation and identification from methanol extract of Euonymus alatus. Life Sci. 2005, 77(22):2760-2769.
    • (2005) Life Sci. , vol.77 , Issue.22 , pp. 2760-2769
    • Jin, U.H.1    Lee, J.Y.2    Kang, S.K.3
  • 73
    • 23044442718 scopus 로고    scopus 로고
    • Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid
    • Feng R., Lu Y., Bowman L.L., et al. Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid. J. Biol. Chem. 2005, 280(30):27888-27895.
    • (2005) J. Biol. Chem. , vol.280 , Issue.30 , pp. 27888-27895
    • Feng, R.1    Lu, Y.2    Bowman, L.L.3
  • 74
    • 0034998557 scopus 로고    scopus 로고
    • St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties
    • Barnes J., Anderson L.A., Phillipson J.D. St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties. J. Pharm. Pharmacol. 2001, 53(5):583-600.
    • (2001) J. Pharm. Pharmacol. , vol.53 , Issue.5 , pp. 583-600
    • Barnes, J.1    Anderson, L.A.2    Phillipson, J.D.3
  • 75
    • 84899494066 scopus 로고    scopus 로고
    • Hypericum perforatum: pharmacokinetic, mechanism of action, tolerability, and clinical drug-drug interactions
    • Russo E., Scicchitano F., Whalley B.J., et al. Hypericum perforatum: pharmacokinetic, mechanism of action, tolerability, and clinical drug-drug interactions. Phytother. Res. 2014, 28(5):643-655.
    • (2014) Phytother. Res. , vol.28 , Issue.5 , pp. 643-655
    • Russo, E.1    Scicchitano, F.2    Whalley, B.J.3
  • 76
    • 0842269732 scopus 로고    scopus 로고
    • Cytotoxic activity of Hypericum perforatum L. on K562 erythroleukemic cells: differential effects between methanolic extract and hypericin
    • Roscetti G., Franzese O., Comandini A., Bonmassar E. Cytotoxic activity of Hypericum perforatum L. on K562 erythroleukemic cells: differential effects between methanolic extract and hypericin. Phytother. Res. 2004, 18(1):66-72.
    • (2004) Phytother. Res. , vol.18 , Issue.1 , pp. 66-72
    • Roscetti, G.1    Franzese, O.2    Comandini, A.3    Bonmassar, E.4
  • 77
    • 29144435235 scopus 로고    scopus 로고
    • The lipophilic extract of Hypericum perforatum exerts significant cytotoxic activity against T24 and NBT-II urinary bladder tumor cells
    • Skalkos D., Stavropoulos N.E., Tsimaris I., et al. The lipophilic extract of Hypericum perforatum exerts significant cytotoxic activity against T24 and NBT-II urinary bladder tumor cells. Plant. Med. 2005, 71(11):1030-1035.
    • (2005) Plant. Med. , vol.71 , Issue.11 , pp. 1030-1035
    • Skalkos, D.1    Stavropoulos, N.E.2    Tsimaris, I.3
  • 78
    • 2542465858 scopus 로고    scopus 로고
    • Hypericum perforatum methanolic extract inhibits growth of human prostatic carcinoma cell line orthotopically implanted in nude mice
    • Martarelli D., Martarelli B., Pediconi D., et al. Hypericum perforatum methanolic extract inhibits growth of human prostatic carcinoma cell line orthotopically implanted in nude mice. Cancer Lett. 2004, 210(1):27-33.
    • (2004) Cancer Lett. , vol.210 , Issue.1 , pp. 27-33
    • Martarelli, D.1    Martarelli, B.2    Pediconi, D.3
  • 79
    • 33744908069 scopus 로고    scopus 로고
    • Hypericum perforatum L. extract - novel photosensitizer against human bladder cancer cells
    • Stavropoulos N.E., Kim A., Nseyo U.U., et al. Hypericum perforatum L. extract - novel photosensitizer against human bladder cancer cells. J. Photochem. Photobiol. B 2006, 84(1):64-69.
    • (2006) J. Photochem. Photobiol. B , vol.84 , Issue.1 , pp. 64-69
    • Stavropoulos, N.E.1    Kim, A.2    Nseyo, U.U.3
  • 80
    • 77649229910 scopus 로고    scopus 로고
    • Hypericins as potential leads for new therapeutics
    • Karioti A., Bilia A.R. Hypericins as potential leads for new therapeutics. Int. J. Mol. Sci. 2010, 11(2):562-594.
    • (2010) Int. J. Mol. Sci. , vol.11 , Issue.2 , pp. 562-594
    • Karioti, A.1    Bilia, A.R.2
  • 81
    • 0035187530 scopus 로고    scopus 로고
    • Hypericin and pseudohypericin in some Hypericum species
    • Kitanov G.M. Hypericin and pseudohypericin in some Hypericum species. Biochem. Syst. Ecol. 2001, 29(2):171-178.
    • (2001) Biochem. Syst. Ecol. , vol.29 , Issue.2 , pp. 171-178
    • Kitanov, G.M.1
  • 82
    • 0037151372 scopus 로고    scopus 로고
    • St. John's Wort: more implications for cancer patients
    • Mansky P.J., Straus S.E. St. John's Wort: more implications for cancer patients. J. Natl. Cancer Inst. 2002, 94(16):1187-1188.
    • (2002) J. Natl. Cancer Inst. , vol.94 , Issue.16 , pp. 1187-1188
    • Mansky, P.J.1    Straus, S.E.2
  • 83
    • 84881556028 scopus 로고    scopus 로고
    • Relevance of in vitro and clinical data for predicting CYP3A4-mediated herb-drug interactions in cancer patients
    • Goey A.K., Mooiman K.D., Beijnen J.H., Schellens J.H., Meijerman I. Relevance of in vitro and clinical data for predicting CYP3A4-mediated herb-drug interactions in cancer patients. Cancer Treat. Rev. 2013, 39(7):773-783.
    • (2013) Cancer Treat. Rev. , vol.39 , Issue.7 , pp. 773-783
    • Goey, A.K.1    Mooiman, K.D.2    Beijnen, J.H.3    Schellens, J.H.4    Meijerman, I.5
  • 84
    • 84894114674 scopus 로고    scopus 로고
    • Drug interactions with phytotherapeutics in oncology
    • Haefeli W.E., Carls A. Drug interactions with phytotherapeutics in oncology. Expert Opin. Drug Metab. Toxicol. 2014, 10(3):359-377.
    • (2014) Expert Opin. Drug Metab. Toxicol. , vol.10 , Issue.3 , pp. 359-377
    • Haefeli, W.E.1    Carls, A.2
  • 85
    • 3242709450 scopus 로고    scopus 로고
    • Pharmacokinetic interactions of drugs with St John's wort
    • Zhou S., Chan E., Pan S.Q., Huang M., Lee E.J. Pharmacokinetic interactions of drugs with St John's wort. J. Psychopharmacol. 2004, 18(2):262-276.
    • (2004) J. Psychopharmacol. , vol.18 , Issue.2 , pp. 262-276
    • Zhou, S.1    Chan, E.2    Pan, S.Q.3    Huang, M.4    Lee, E.J.5
  • 86
    • 33645960092 scopus 로고    scopus 로고
    • Bioactive triterpenoids from Salvia species
    • Topcu G. Bioactive triterpenoids from Salvia species. J. Nat. Prod. 2006, 69(3):482-487.
    • (2006) J. Nat. Prod. , vol.69 , Issue.3 , pp. 482-487
    • Topcu, G.1
  • 87
    • 84917727174 scopus 로고    scopus 로고
    • Multiple pro-apoptotic targets of abietane diterpenoids from Salvia species
    • Akaberi M., Mehri S., Iranshahi M. Multiple pro-apoptotic targets of abietane diterpenoids from Salvia species. Fitoterapia 2015, 100:118-132.
    • (2015) Fitoterapia , vol.100 , pp. 118-132
    • Akaberi, M.1    Mehri, S.2    Iranshahi, M.3
  • 88
    • 33747264571 scopus 로고    scopus 로고
    • In vitro antiproliferative effect of six Salvia species on human tumor cell lines
    • Fiore G., Nencini C., Cavallo F., et al. In vitro antiproliferative effect of six Salvia species on human tumor cell lines. Phytother. Res. 2006, 20(8):701-703.
    • (2006) Phytother. Res. , vol.20 , Issue.8 , pp. 701-703
    • Fiore, G.1    Nencini, C.2    Cavallo, F.3
  • 89
    • 0034729274 scopus 로고    scopus 로고
    • Salvia miltiorrhiza inhibits cell growth and induces apoptosis in human hepatoma HepG(2) cells
    • Liu J., Shen H.M., Ong C.N. Salvia miltiorrhiza inhibits cell growth and induces apoptosis in human hepatoma HepG(2) cells. Cancer Lett. 2000, 153(1-2):85-93.
    • (2000) Cancer Lett. , vol.153 , Issue.1-2 , pp. 85-93
    • Liu, J.1    Shen, H.M.2    Ong, C.N.3
  • 90
    • 84933526245 scopus 로고    scopus 로고
    • Salvia miltiorrhiza: traditional medicinal uses, chemistry, and pharmacology
    • Su C.Y., Ming Q.L., Rahman K., Han T., Qin L.P. Salvia miltiorrhiza: traditional medicinal uses, chemistry, and pharmacology. Chin. J. Nat. Med. 2015, 13(3):163-182.
    • (2015) Chin. J. Nat. Med. , vol.13 , Issue.3 , pp. 163-182
    • Su, C.Y.1    Ming, Q.L.2    Rahman, K.3    Han, T.4    Qin, L.P.5
  • 91
    • 84923037985 scopus 로고    scopus 로고
    • Cytotoxic effects of solvent-extracted active components of Bunge on human cancer cell lines
    • Sung B., Chung H.S., Kim M., et al. Cytotoxic effects of solvent-extracted active components of Bunge on human cancer cell lines. Exp. Ther. Med. 2015, 9(4):1421-1428.
    • (2015) Exp. Ther. Med. , vol.9 , Issue.4 , pp. 1421-1428
    • Sung, B.1    Chung, H.S.2    Kim, M.3
  • 92
    • 84901824508 scopus 로고    scopus 로고
    • The anticancer properties of Salvia miltiorrhiza Bunge (Danshen): a systematic review
    • Chen X., Guo J., Bao J., Lu J., Wang Y. The anticancer properties of Salvia miltiorrhiza Bunge (Danshen): a systematic review. Med. Res. Rev. 2014, 34(4):768-794.
    • (2014) Med. Res. Rev. , vol.34 , Issue.4 , pp. 768-794
    • Chen, X.1    Guo, J.2    Bao, J.3    Lu, J.4    Wang, Y.5
  • 93
    • 84978459798 scopus 로고    scopus 로고
    • Neuroprotective, antimicrobial, antioxidant, chemotherapeutic, and antidiabetic properties of Salvia reuterana: a mini review
    • Jafari E., Andalib S., Abed A., Rafieian-Kopaei M., Vaseghi G. Neuroprotective, antimicrobial, antioxidant, chemotherapeutic, and antidiabetic properties of Salvia reuterana: a mini review. Avicenna J. Phytomed. 2015, 5(1):10-16.
    • (2015) Avicenna J. Phytomed. , vol.5 , Issue.1 , pp. 10-16
    • Jafari, E.1    Andalib, S.2    Abed, A.3    Rafieian-Kopaei, M.4    Vaseghi, G.5
  • 94
    • 53449100849 scopus 로고    scopus 로고
    • South African Salvia species: a review of biological activities and phytochemistry
    • Kamatou G.P., Makunga N.P., Ramogola W.P., Viljoen A.M. South African Salvia species: a review of biological activities and phytochemistry. J. Ethnopharmacol. 2008, 119(3):664-672.
    • (2008) J. Ethnopharmacol. , vol.119 , Issue.3 , pp. 664-672
    • Kamatou, G.P.1    Makunga, N.P.2    Ramogola, W.P.3    Viljoen, A.M.4
  • 95
    • 84874967969 scopus 로고    scopus 로고
    • Inhibitory and cytotoxic activities of Salvia officinalis L. Extract on human lymphoma and leukemia cells by induction of apoptosis
    • Zare Shahneh F., Valiyari S., Baradaran B., et al. Inhibitory and cytotoxic activities of Salvia officinalis L. Extract on human lymphoma and leukemia cells by induction of apoptosis. Adv. Pharm. Bull. 2013, 3(1):51-55.
    • (2013) Adv. Pharm. Bull. , vol.3 , Issue.1 , pp. 51-55
    • Zare Shahneh, F.1    Valiyari, S.2    Baradaran, B.3
  • 96
    • 84885715219 scopus 로고    scopus 로고
    • In vitro cytotoxic activity of four plants used in Persian traditional medicine
    • Zare Shahneh F., Baradaran B., Orangi M., Zamani F. In vitro cytotoxic activity of four plants used in Persian traditional medicine. Adv. Pharm. Bull. 2013, 3(2):453-455.
    • (2013) Adv. Pharm. Bull. , vol.3 , Issue.2 , pp. 453-455
    • Zare Shahneh, F.1    Baradaran, B.2    Orangi, M.3    Zamani, F.4
  • 97
    • 84865339937 scopus 로고    scopus 로고
    • Phytochemical profile of Rosmarinus officinalis and Salvia officinalis extracts and correlation to their antioxidant and anti-proliferative activity
    • Kontogianni V.G., Tomic G., Nikolic I., et al. Phytochemical profile of Rosmarinus officinalis and Salvia officinalis extracts and correlation to their antioxidant and anti-proliferative activity. Food Chem. 2013, 136(1):120-129.
    • (2013) Food Chem. , vol.136 , Issue.1 , pp. 120-129
    • Kontogianni, V.G.1    Tomic, G.2    Nikolic, I.3
  • 98
    • 78649398038 scopus 로고    scopus 로고
    • In vitro and ex vivo antiangiogenic activity of Salvia officinalis
    • Keshavarz M., Mostafaie A., Mansouri K., et al. In vitro and ex vivo antiangiogenic activity of Salvia officinalis. Phytother. Res. 2010, 24(10):1526-1531.
    • (2010) Phytother. Res. , vol.24 , Issue.10 , pp. 1526-1531
    • Keshavarz, M.1    Mostafaie, A.2    Mansouri, K.3
  • 99
    • 84928788443 scopus 로고    scopus 로고
    • Pharmacogenomic characterization of cytotoxic compounds from Salvia officinalis in cancer cells
    • Kadioglu O., Efferth T. Pharmacogenomic characterization of cytotoxic compounds from Salvia officinalis in cancer cells. J. Nat. Prod. 2015, 78(4):762-775.
    • (2015) J. Nat. Prod. , vol.78 , Issue.4 , pp. 762-775
    • Kadioglu, O.1    Efferth, T.2
  • 100
    • 84878703883 scopus 로고    scopus 로고
    • Comparison of the antiproliferative activity of crude ethanol extracts of nine Salvia species grown in Jordan against breast cancer cell line models
    • Abu-Dahab R., Afifi F., Kasabri V., Majdalawi L., Naffa R. Comparison of the antiproliferative activity of crude ethanol extracts of nine Salvia species grown in Jordan against breast cancer cell line models. Pharmacogn. Mag. 2012, 8(32):319-324.
    • (2012) Pharmacogn. Mag. , vol.8 , Issue.32 , pp. 319-324
    • Abu-Dahab, R.1    Afifi, F.2    Kasabri, V.3    Majdalawi, L.4    Naffa, R.5
  • 101
    • 33947672305 scopus 로고    scopus 로고
    • Water and methanolic extracts of Salvia officinalis protect HepG2 cells from t-BHP induced oxidative damage
    • Lima C.F., Valentao P.C., Andrade P.B., et al. Water and methanolic extracts of Salvia officinalis protect HepG2 cells from t-BHP induced oxidative damage. Chem. Biol. Interact. 2007, 167(2):107-115.
    • (2007) Chem. Biol. Interact. , vol.167 , Issue.2 , pp. 107-115
    • Lima, C.F.1    Valentao, P.C.2    Andrade, P.B.3
  • 102
    • 70449627783 scopus 로고    scopus 로고
    • Salvia fruticosa, Salvia officinalis, and rosmarinic acid induce apoptosis and inhibit proliferation of human colorectal cell lines: the role in MAPK/ERK pathway
    • Xavier C.P., Lima C.F., Fernandes-Ferreira M., Pereira-Wilson C. Salvia fruticosa, Salvia officinalis, and rosmarinic acid induce apoptosis and inhibit proliferation of human colorectal cell lines: the role in MAPK/ERK pathway. Nutr. Cancer 2009, 61(4):564-571.
    • (2009) Nutr. Cancer , vol.61 , Issue.4 , pp. 564-571
    • Xavier, C.P.1    Lima, C.F.2    Fernandes-Ferreira, M.3    Pereira-Wilson, C.4
  • 103
    • 84864063441 scopus 로고    scopus 로고
    • Protection by Salvia extracts against oxidative and alkylation damage to DNA in human HCT15 and CO115 cells
    • Ramos A.A., Pedro D., Collins A.R., Pereira-Wilson C. Protection by Salvia extracts against oxidative and alkylation damage to DNA in human HCT15 and CO115 cells. J. Toxicol. Environ. Health A 2012, 75(13-15):765-775.
    • (2012) J. Toxicol. Environ. Health A , vol.75 , Issue.13-15 , pp. 765-775
    • Ramos, A.A.1    Pedro, D.2    Collins, A.R.3    Pereira-Wilson, C.4
  • 105
    • 84943616281 scopus 로고    scopus 로고
    • The effect of Greek herbal tea consumption on thyroid cancer: a case-control study
    • Riza E., Linos A., Petralias A., et al. The effect of Greek herbal tea consumption on thyroid cancer: a case-control study. Eur. J. Public Health 2015, 25(6):1001-1005.
    • (2015) Eur. J. Public Health , vol.25 , Issue.6 , pp. 1001-1005
    • Riza, E.1    Linos, A.2    Petralias, A.3
  • 108
    • 84875897578 scopus 로고    scopus 로고
    • The effect of rosmarinic acid on 1,2-dimethylhydrazine induced colon carcinogenesis
    • Venkatachalam K., Gunasekaran S., Jesudoss V.A., Namasivayam N. The effect of rosmarinic acid on 1,2-dimethylhydrazine induced colon carcinogenesis. Exp. Toxicol. Pathol. 2013, 65(4):409-418.
    • (2013) Exp. Toxicol. Pathol. , vol.65 , Issue.4 , pp. 409-418
    • Venkatachalam, K.1    Gunasekaran, S.2    Jesudoss, V.A.3    Namasivayam, N.4
  • 109
    • 77954870609 scopus 로고    scopus 로고
    • Inhibition of bone metastasis from breast carcinoma by rosmarinic acid
    • Xu Y., Jiang Z., Ji G., Liu J. Inhibition of bone metastasis from breast carcinoma by rosmarinic acid. Plant. Med. 2010, 76(10):956-962.
    • (2010) Plant. Med. , vol.76 , Issue.10 , pp. 956-962
    • Xu, Y.1    Jiang, Z.2    Ji, G.3    Liu, J.4
  • 110
    • 77951568810 scopus 로고    scopus 로고
    • Protective effect of rosmarinic acid on V79 cells evaluated by the micronucleus and comet assays
    • Furtado R.A., de Araujo F.R., Resende F.A., Cunha W.R., Tavares D.C. Protective effect of rosmarinic acid on V79 cells evaluated by the micronucleus and comet assays. J. Appl. Toxicol. 2010, 30(3):254-259.
    • (2010) J. Appl. Toxicol. , vol.30 , Issue.3 , pp. 254-259
    • Furtado, R.A.1    de Araujo, F.R.2    Resende, F.A.3    Cunha, W.R.4    Tavares, D.C.5
  • 111
    • 84927692649 scopus 로고    scopus 로고
    • Chemopreventive effects of rosmarinic acid on rat colon carcinogenesis
    • Furtado R.A., Oliveira B.R., Silva L.R., et al. Chemopreventive effects of rosmarinic acid on rat colon carcinogenesis. Eur. J. Cancer Prev. 2015, 24(2):106-112.
    • (2015) Eur. J. Cancer Prev. , vol.24 , Issue.2 , pp. 106-112
    • Furtado, R.A.1    Oliveira, B.R.2    Silva, L.R.3
  • 112
    • 84877975964 scopus 로고    scopus 로고
    • Reversal effect of rosmarinic acid on multidrug resistance in SGC7901/Adr cell
    • Li F.R., Fu Y.Y., Jiang D.H., et al. Reversal effect of rosmarinic acid on multidrug resistance in SGC7901/Adr cell. J. Asian Nat. Prod. Res. 2013, 15(3):276-285.
    • (2013) J. Asian Nat. Prod. Res. , vol.15 , Issue.3 , pp. 276-285
    • Li, F.R.1    Fu, Y.Y.2    Jiang, D.H.3
  • 113
    • 55949110359 scopus 로고    scopus 로고
    • Rosmarinic acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines
    • Scheckel K.A., Degner S.C., Romagnolo D.F. Rosmarinic acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines. J. Nutr. 2008, 138(11):2098-2105.
    • (2008) J. Nutr. , vol.138 , Issue.11 , pp. 2098-2105
    • Scheckel, K.A.1    Degner, S.C.2    Romagnolo, D.F.3
  • 114
    • 34548129609 scopus 로고    scopus 로고
    • Rosmarinic acid induces melanogenesis through protein kinase A activation signaling
    • Lee J., Kim Y.S., Park D. Rosmarinic acid induces melanogenesis through protein kinase A activation signaling. Biochem. Pharmacol. 2007, 74(7):960-968.
    • (2007) Biochem. Pharmacol. , vol.74 , Issue.7 , pp. 960-968
    • Lee, J.1    Kim, Y.S.2    Park, D.3
  • 115
    • 33749519154 scopus 로고    scopus 로고
    • Phenolic compounds protect HepG2 cells from oxidative damage: relevance of glutathione levels
    • Lima C.F., Fernandes-Ferreira M., Pereira-Wilson C. Phenolic compounds protect HepG2 cells from oxidative damage: relevance of glutathione levels. Life Sci. 2006, 79(21):2056-2068.
    • (2006) Life Sci. , vol.79 , Issue.21 , pp. 2056-2068
    • Lima, C.F.1    Fernandes-Ferreira, M.2    Pereira-Wilson, C.3
  • 116
    • 84927609979 scopus 로고    scopus 로고
    • Antioxidant activity and sensory evaluation of a rosmarinic acid-enriched extract of Salvia officinalis
    • Bakota E.L., Winkler-Moser J.K., Berhow M.A., Eller F.J., Vaughn S.F. Antioxidant activity and sensory evaluation of a rosmarinic acid-enriched extract of Salvia officinalis. J. Food Sci. 2015, 80(4):C711-7.
    • (2015) J. Food Sci. , vol.80 , Issue.4 , pp. C711-C717
    • Bakota, E.L.1    Winkler-Moser, J.K.2    Berhow, M.A.3    Eller, F.J.4    Vaughn, S.F.5
  • 117
    • 77949791181 scopus 로고    scopus 로고
    • Investigation of antioxidant and rosmarinic acid variation in the sage collection of the genebank in Gatersleben
    • Lamien-Meda A., Nell M., Lohwasser U., et al. Investigation of antioxidant and rosmarinic acid variation in the sage collection of the genebank in Gatersleben. J. Agric. Food Chem. 2010, 58(6):3813-3819.
    • (2010) J. Agric. Food Chem. , vol.58 , Issue.6 , pp. 3813-3819
    • Lamien-Meda, A.1    Nell, M.2    Lohwasser, U.3
  • 118
    • 51349127271 scopus 로고    scopus 로고
    • Multitargeted cancer prevention by quercetin
    • Murakami A., Ashida H., Terao J. Multitargeted cancer prevention by quercetin. Cancer Lett. 2008, 269(2):315-325.
    • (2008) Cancer Lett. , vol.269 , Issue.2 , pp. 315-325
    • Murakami, A.1    Ashida, H.2    Terao, J.3
  • 119
    • 43049176634 scopus 로고    scopus 로고
    • Health effects of quercetin: from antioxidant to nutraceutical
    • Boots A.W., Haenen G.R., Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur. J. Pharmacol. 2008, 585(2-3):325-337.
    • (2008) Eur. J. Pharmacol. , vol.585 , Issue.2-3 , pp. 325-337
    • Boots, A.W.1    Haenen, G.R.2    Bast, A.3
  • 120
    • 84862777378 scopus 로고    scopus 로고
    • Antitumor activities of quercetin and quercetin-5',8-disulfonate in human colon and breast cancer cell lines
    • Zhang H., Zhang M., Yu L., et al. Antitumor activities of quercetin and quercetin-5',8-disulfonate in human colon and breast cancer cell lines. Food Chem. Toxicol. 2012, 50(5):1589-1599.
    • (2012) Food Chem. Toxicol. , vol.50 , Issue.5 , pp. 1589-1599
    • Zhang, H.1    Zhang, M.2    Yu, L.3
  • 121
    • 0033634827 scopus 로고    scopus 로고
    • Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine
    • Walker E.H., Pacold M.E., Perisic O., et al. Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol. Cell 2000, 6(4):909-919.
    • (2000) Mol. Cell , vol.6 , Issue.4 , pp. 909-919
    • Walker, E.H.1    Pacold, M.E.2    Perisic, O.3
  • 122
    • 48649099511 scopus 로고    scopus 로고
    • Time-course regulation of quercetin on cell survival/proliferation pathways in human hepatoma cells
    • Granado-Serrano A.B., Angeles Martin M., Bravo L., Goya L., Ramos S. Time-course regulation of quercetin on cell survival/proliferation pathways in human hepatoma cells. Mol. Nutr. Food Res. 2008, 52(4):457-464.
    • (2008) Mol. Nutr. Food Res. , vol.52 , Issue.4 , pp. 457-464
    • Granado-Serrano, A.B.1    Angeles Martin, M.2    Bravo, L.3    Goya, L.4    Ramos, S.5
  • 123
    • 0041816456 scopus 로고    scopus 로고
    • Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability
    • Spencer J.P., Rice-Evans C., Williams R.J. Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability. J. Biol. Chem. 2003, 278(37):34783-34793.
    • (2003) J. Biol. Chem. , vol.278 , Issue.37 , pp. 34783-34793
    • Spencer, J.P.1    Rice-Evans, C.2    Williams, R.J.3
  • 124
    • 38849134933 scopus 로고    scopus 로고
    • Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine
    • Lee K.W., Kang N.J., Heo Y.S., et al. Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine. Cancer Res. 2008, 68(3):946-955.
    • (2008) Cancer Res. , vol.68 , Issue.3 , pp. 946-955
    • Lee, K.W.1    Kang, N.J.2    Heo, Y.S.3
  • 125
    • 33645836334 scopus 로고    scopus 로고
    • The antiproliferative effect of Quercetin in cancer cells is mediated via inhibition of the PI3K-Akt/PKB pathway
    • Gulati N., Laudet B., Zohrabian V.M., Murali R., Jhanwar-Uniyal M. The antiproliferative effect of Quercetin in cancer cells is mediated via inhibition of the PI3K-Akt/PKB pathway. Anticancer Res. 2006, 26(2A):1177-1181.
    • (2006) Anticancer Res. , vol.26 , Issue.2 A , pp. 1177-1181
    • Gulati, N.1    Laudet, B.2    Zohrabian, V.M.3    Murali, R.4    Jhanwar-Uniyal, M.5
  • 126
    • 2442623486 scopus 로고    scopus 로고
    • The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells
    • Nguyen T.T., Tran E., Nguyen T.H., et al. The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells. Carcinogenesis 2004, 25(5):647-659.
    • (2004) Carcinogenesis , vol.25 , Issue.5 , pp. 647-659
    • Nguyen, T.T.1    Tran, E.2    Nguyen, T.H.3
  • 127
    • 17844361910 scopus 로고    scopus 로고
    • Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro
    • van Erk M.J., Roepman P., van der Lende T.R., et al. Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur. J. Nutr. 2005, 44(3):143-156.
    • (2005) Eur. J. Nutr. , vol.44 , Issue.3 , pp. 143-156
    • van Erk, M.J.1    Roepman, P.2    van der Lende, T.R.3
  • 128
    • 33745806913 scopus 로고    scopus 로고
    • A preliminary investigation demonstrating the effect of quercetin on the expression of genes related to cell-cycle arrest, apoptosis and xenobiotic metabolism in human CO115 colon-adenocarcinoma cells using DNA microarray
    • Murtaza I., Marra G., Schlapbach R., et al. A preliminary investigation demonstrating the effect of quercetin on the expression of genes related to cell-cycle arrest, apoptosis and xenobiotic metabolism in human CO115 colon-adenocarcinoma cells using DNA microarray. Biotechnol. Appl. Biochem. 2006, 45(Pt 1):29-36.
    • (2006) Biotechnol. Appl. Biochem. , vol.45 , pp. 29-36
    • Murtaza, I.1    Marra, G.2    Schlapbach, R.3
  • 129
    • 14644404912 scopus 로고    scopus 로고
    • Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells
    • Kim W.K., Bang M.H., Kim E.S., et al. Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells. J. Nutr. Biochem. 2005, 16(3):155-162.
    • (2005) J. Nutr. Biochem. , vol.16 , Issue.3 , pp. 155-162
    • Kim, W.K.1    Bang, M.H.2    Kim, E.S.3
  • 130
    • 3042816689 scopus 로고    scopus 로고
    • Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells
    • Wenzel U., Herzog A., Kuntz S., Daniel H. Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells. Proteomics 2004, 4(7):2160-2174.
    • (2004) Proteomics , vol.4 , Issue.7 , pp. 2160-2174
    • Wenzel, U.1    Herzog, A.2    Kuntz, S.3    Daniel, H.4
  • 131
    • 84899499849 scopus 로고    scopus 로고
    • Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner
    • Kim G.T., Lee S.H., Kim J.I., Kim Y.M. Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner. Int. J. Mol. Med. 2014, 33(4):863-869.
    • (2014) Int. J. Mol. Med. , vol.33 , Issue.4 , pp. 863-869
    • Kim, G.T.1    Lee, S.H.2    Kim, J.I.3    Kim, Y.M.4
  • 132
    • 67349181288 scopus 로고    scopus 로고
    • Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells
    • Xavier C.P., Lima C.F., Preto A., et al. Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells. Cancer Lett. 2009, 281(2):162-170.
    • (2009) Cancer Lett. , vol.281 , Issue.2 , pp. 162-170
    • Xavier, C.P.1    Lima, C.F.2    Preto, A.3
  • 133
    • 0033988079 scopus 로고    scopus 로고
    • Quercetin inhibits p21-RAS expression in human colon cancer cell lines and in primary colorectal tumors
    • Ranelletti F.O., Maggiano N., Serra F.G., et al. Quercetin inhibits p21-RAS expression in human colon cancer cell lines and in primary colorectal tumors. Int. J. Cancer 2000, 85(3):438-445.
    • (2000) Int. J. Cancer , vol.85 , Issue.3 , pp. 438-445
    • Ranelletti, F.O.1    Maggiano, N.2    Serra, F.G.3
  • 134
    • 34447092454 scopus 로고    scopus 로고
    • Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells
    • Psahoulia F.H., Moumtzi S., Roberts M.L., et al. Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells. Carcinogenesis 2007, 28(5):1021-1031.
    • (2007) Carcinogenesis , vol.28 , Issue.5 , pp. 1021-1031
    • Psahoulia, F.H.1    Moumtzi, S.2    Roberts, M.L.3
  • 135
    • 82455175194 scopus 로고    scopus 로고
    • Quercetin enhances 5-fluorouracil-induced apoptosis in MSI colorectal cancer cells through p53 modulation
    • Xavier C.P., Lima C.F., Rohde M., Pereira-Wilson C. Quercetin enhances 5-fluorouracil-induced apoptosis in MSI colorectal cancer cells through p53 modulation. Cancer Chemother. Pharmacol. 2011, 68(6):1449-1457.
    • (2011) Cancer Chemother. Pharmacol. , vol.68 , Issue.6 , pp. 1449-1457
    • Xavier, C.P.1    Lima, C.F.2    Rohde, M.3    Pereira-Wilson, C.4
  • 136
    • 24944522546 scopus 로고    scopus 로고
    • Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin)
    • Volate S.R., Davenport D.M., Muga S.J., Wargovich M.J. Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin). Carcinogenesis 2005, 26(8):1450-1456.
    • (2005) Carcinogenesis , vol.26 , Issue.8 , pp. 1450-1456
    • Volate, S.R.1    Davenport, D.M.2    Muga, S.J.3    Wargovich, M.J.4
  • 137
    • 58649101636 scopus 로고    scopus 로고
    • Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis
    • Warren C.A., Paulhill K.J., Davidson L.A., et al. Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis. J. Nutr. 2009, 139(1):101-105.
    • (2009) J. Nutr. , vol.139 , Issue.1 , pp. 101-105
    • Warren, C.A.1    Paulhill, K.J.2    Davidson, L.A.3
  • 138
    • 0029999052 scopus 로고    scopus 로고
    • Phase I: clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition
    • Ferry D.R., Smith A., Malkhandi J., et al. Phase I: clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition. Clin. Cancer Res. 1996, 2(4):659-668.
    • (1996) Clin. Cancer Res. , vol.2 , Issue.4 , pp. 659-668
    • Ferry, D.R.1    Smith, A.2    Malkhandi, J.3
  • 139
    • 0035100834 scopus 로고    scopus 로고
    • Pre-clinical and clinical study of QC12, a water-soluble, pro-drug of quercetin
    • Mulholland P.J., Ferry D.R., Anderson D., et al. Pre-clinical and clinical study of QC12, a water-soluble, pro-drug of quercetin. Ann. Oncol. 2001, 12(2):245-248.
    • (2001) Ann. Oncol. , vol.12 , Issue.2 , pp. 245-248
    • Mulholland, P.J.1    Ferry, D.R.2    Anderson, D.3
  • 140
    • 0035990644 scopus 로고    scopus 로고
    • Effects of luteolin on the inhibition of proliferation and induction of apoptosis in human myeloid leukaemia cells
    • Ko W.G., Kang T.H., Lee S.J., Kim Y.C., Lee B.H. Effects of luteolin on the inhibition of proliferation and induction of apoptosis in human myeloid leukaemia cells. Phytother. Res. 2002, 16(3):295-298.
    • (2002) Phytother. Res. , vol.16 , Issue.3 , pp. 295-298
    • Ko, W.G.1    Kang, T.H.2    Lee, S.J.3    Kim, Y.C.4    Lee, B.H.5
  • 141
    • 0036327836 scopus 로고    scopus 로고
    • Blockade of the epidermal growth factor receptor tyrosine kinase activity by quercetin and luteolin leads to growth inhibition and apoptosis of pancreatic tumor cells
    • Lee L.T., Huang Y.T., Hwang J.J., et al. Blockade of the epidermal growth factor receptor tyrosine kinase activity by quercetin and luteolin leads to growth inhibition and apoptosis of pancreatic tumor cells. Anticancer Res. 2002, 22(3):1615-1627.
    • (2002) Anticancer Res. , vol.22 , Issue.3 , pp. 1615-1627
    • Lee, L.T.1    Huang, Y.T.2    Hwang, J.J.3
  • 142
    • 13444282282 scopus 로고    scopus 로고
    • Increase of Bax/Bcl-XL ratio and arrest of cell cycle by luteolin in immortalized human hepatoma cell line
    • Chang J., Hsu Y., Kuo P., et al. Increase of Bax/Bcl-XL ratio and arrest of cell cycle by luteolin in immortalized human hepatoma cell line. Life Sci. 2005, 76(16):1883-1893.
    • (2005) Life Sci. , vol.76 , Issue.16 , pp. 1883-1893
    • Chang, J.1    Hsu, Y.2    Kuo, P.3
  • 143
    • 33644764655 scopus 로고    scopus 로고
    • Inhibitory effect of luteolin on hepatocyte growth factor/scatter factor-induced HepG2 cell invasion involving both MAPK/ERKs and PI3K-Akt pathways
    • Lee W.J., Wu L.F., Chen W.K., Wang C.J., Tseng T.H. Inhibitory effect of luteolin on hepatocyte growth factor/scatter factor-induced HepG2 cell invasion involving both MAPK/ERKs and PI3K-Akt pathways. Chem. Biol. Interact. 2006, 160(2):123-133.
    • (2006) Chem. Biol. Interact. , vol.160 , Issue.2 , pp. 123-133
    • Lee, W.J.1    Wu, L.F.2    Chen, W.K.3    Wang, C.J.4    Tseng, T.H.5
  • 144
    • 13844275033 scopus 로고    scopus 로고
    • Induction apoptosis of luteolin in human hepatoma HepG2 cells involving mitochondria translocation of Bax/Bak and activation of JNK
    • Lee H.J., Wang C.J., Kuo H.C., et al. Induction apoptosis of luteolin in human hepatoma HepG2 cells involving mitochondria translocation of Bax/Bak and activation of JNK. Toxicol. Appl. Pharmacol. 2005, 203(2):124-131.
    • (2005) Toxicol. Appl. Pharmacol. , vol.203 , Issue.2 , pp. 124-131
    • Lee, H.J.1    Wang, C.J.2    Kuo, H.C.3
  • 145
    • 84905976525 scopus 로고    scopus 로고
    • Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review
    • Pandurangan A.K., Esa N.M. Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review. Asia. Pac. J. Cancer Prev. 2014, 15(14):5501-5508.
    • (2014) Asia. Pac. J. Cancer Prev. , vol.15 , Issue.14 , pp. 5501-5508
    • Pandurangan, A.K.1    Esa, N.M.2
  • 146
    • 10344222108 scopus 로고    scopus 로고
    • Inhibitory effect of luteolin on TNF-alpha-induced IL-8 production in human colon epithelial cells
    • Kim J.A., Kim D.K., Kang O.H., et al. Inhibitory effect of luteolin on TNF-alpha-induced IL-8 production in human colon epithelial cells. Int. Immunopharmacol. 2005, 5(1):209-217.
    • (2005) Int. Immunopharmacol. , vol.5 , Issue.1 , pp. 209-217
    • Kim, J.A.1    Kim, D.K.2    Kang, O.H.3
  • 147
    • 7044236785 scopus 로고    scopus 로고
    • Luteolin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells
    • Shi R.X., Ong C.N., Shen H.M. Luteolin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells. Oncogene 2004, 23(46):7712-7721.
    • (2004) Oncogene , vol.23 , Issue.46 , pp. 7712-7721
    • Shi, R.X.1    Ong, C.N.2    Shen, H.M.3
  • 148
    • 84862826072 scopus 로고    scopus 로고
    • Luteolin decreases IGF-II production and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells
    • Lim do Y., Cho H.J., Kim J., et al. Luteolin decreases IGF-II production and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells. BMC Gastroenterol. 2012, 12:9.
    • (2012) BMC Gastroenterol. , vol.12 , pp. 9
    • Lim do, Y.1    Cho, H.J.2    Kim, J.3
  • 149
    • 34248174931 scopus 로고    scopus 로고
    • Luteolin sensitizes the anticancer effect of cisplatin via c-Jun NH2-terminal kinase-mediated p53 phosphorylation and stabilization
    • Shi R., Huang Q., Zhu X., et al. Luteolin sensitizes the anticancer effect of cisplatin via c-Jun NH2-terminal kinase-mediated p53 phosphorylation and stabilization. Mol. Cancer Ther. 2007, 6(4):1338-1347.
    • (2007) Mol. Cancer Ther. , vol.6 , Issue.4 , pp. 1338-1347
    • Shi, R.1    Huang, Q.2    Zhu, X.3
  • 150
    • 54149090600 scopus 로고    scopus 로고
    • Protective role of luteolin on the status of lipid peroxidation and antioxidant defense against azoxymethane-induced experimental colon carcinogenesis
    • Ashokkumar P., Sudhandiran G. Protective role of luteolin on the status of lipid peroxidation and antioxidant defense against azoxymethane-induced experimental colon carcinogenesis. Biomed. Pharmacother. 2008, 62(9):590-597.
    • (2008) Biomed. Pharmacother. , vol.62 , Issue.9 , pp. 590-597
    • Ashokkumar, P.1    Sudhandiran, G.2
  • 151
    • 33947113796 scopus 로고    scopus 로고
    • Protective role of luteolin in 1,2-dimethylhydrazine induced experimental colon carcinogenesis
    • Manju V., Nalini N. Protective role of luteolin in 1,2-dimethylhydrazine induced experimental colon carcinogenesis. Cell Biochem. Funct. 2007, 25(2):189-194.
    • (2007) Cell Biochem. Funct. , vol.25 , Issue.2 , pp. 189-194
    • Manju, V.1    Nalini, N.2
  • 152
    • 84906823753 scopus 로고    scopus 로고
    • Pomegranate and its components as alternative treatment for prostate cancer
    • Wang L., Martins-Green M. Pomegranate and its components as alternative treatment for prostate cancer. Int. J. Mol. Sci. 2014, 15(9):14949-14966.
    • (2014) Int. J. Mol. Sci. , vol.15 , Issue.9 , pp. 14949-14966
    • Wang, L.1    Martins-Green, M.2
  • 153
    • 38949149637 scopus 로고    scopus 로고
    • Ursolic acid: an anti- and pro-inflammatory triterpenoid
    • Ikeda Y., Murakami A., Ohigashi H. Ursolic acid: an anti- and pro-inflammatory triterpenoid. Mol. Nutr. Food Res. 2008, 52(1):26-42.
    • (2008) Mol. Nutr. Food Res. , vol.52 , Issue.1 , pp. 26-42
    • Ikeda, Y.1    Murakami, A.2    Ohigashi, H.3
  • 154
    • 84921672973 scopus 로고    scopus 로고
    • Triterpenes as potentially cytotoxic compounds
    • Chudzik M., Korzonek-Szlacheta I., Krol W. Triterpenes as potentially cytotoxic compounds. Molecules 2015, 20(1):1610-1625.
    • (2015) Molecules , vol.20 , Issue.1 , pp. 1610-1625
    • Chudzik, M.1    Korzonek-Szlacheta, I.2    Krol, W.3
  • 155
    • 84877594282 scopus 로고    scopus 로고
    • Ursolic acid in cancer prevention and treatment: molecular targets, pharmacokinetics and clinical studies
    • Shanmugam M.K., Dai X., Kumar A.P., et al. Ursolic acid in cancer prevention and treatment: molecular targets, pharmacokinetics and clinical studies. Biochem. Pharmacol. 2013, 85(11):1579-1587.
    • (2013) Biochem. Pharmacol. , vol.85 , Issue.11 , pp. 1579-1587
    • Shanmugam, M.K.1    Dai, X.2    Kumar, A.P.3
  • 156
    • 77749311412 scopus 로고    scopus 로고
    • Ursolic acid overcomes Bcl-2-mediated resistance to apoptosis in prostate cancer cells involving activation of JNK-induced Bcl-2 phosphorylation and degradation
    • Zhang Y.X., Kong C.Z., Wang L.H., et al. Ursolic acid overcomes Bcl-2-mediated resistance to apoptosis in prostate cancer cells involving activation of JNK-induced Bcl-2 phosphorylation and degradation. J. Cell. Biochem. 2010, 109(4):764-773.
    • (2010) J. Cell. Biochem. , vol.109 , Issue.4 , pp. 764-773
    • Zhang, Y.X.1    Kong, C.Z.2    Wang, L.H.3
  • 157
    • 77951660302 scopus 로고    scopus 로고
    • Ursolic acid induces PC-3 cell apoptosis via activation of JNK and inhibition of Akt pathways in vitro
    • Zhang Y., Kong C., Zeng Y., et al. Ursolic acid induces PC-3 cell apoptosis via activation of JNK and inhibition of Akt pathways in vitro. Mol. Carcinog. 2010, 49(4):374-385.
    • (2010) Mol. Carcinog. , vol.49 , Issue.4 , pp. 374-385
    • Zhang, Y.1    Kong, C.2    Zeng, Y.3
  • 158
    • 67651233503 scopus 로고    scopus 로고
    • Phosphorylation of Bcl-2 and activation of caspase-3 via the c-Jun N-terminal kinase pathway in ursolic acid-induced DU145 cells apoptosis
    • Zhang Y.X., Kong C.Z., Wang H.Q., et al. Phosphorylation of Bcl-2 and activation of caspase-3 via the c-Jun N-terminal kinase pathway in ursolic acid-induced DU145 cells apoptosis. Biochimie 2009, 91(9):1173-1179.
    • (2009) Biochimie , vol.91 , Issue.9 , pp. 1173-1179
    • Zhang, Y.X.1    Kong, C.Z.2    Wang, H.Q.3
  • 159
    • 35348861389 scopus 로고    scopus 로고
    • Induction of apoptosis and regulation of the MAPK pathway by ursolic acid in human leukemia K562 cells
    • Liu X.S., Jiang J. Induction of apoptosis and regulation of the MAPK pathway by ursolic acid in human leukemia K562 cells. Plant. Med. 2007, 73(11):1192-1194.
    • (2007) Plant. Med. , vol.73 , Issue.11 , pp. 1192-1194
    • Liu, X.S.1    Jiang, J.2
  • 160
    • 77952625527 scopus 로고    scopus 로고
    • Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling
    • Yeh C.T., Wu C.H., Yen G.C. Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling. Mol. Nutr. Food Res. 2010, 54(9):1285-1295.
    • (2010) Mol. Nutr. Food Res. , vol.54 , Issue.9 , pp. 1285-1295
    • Yeh, C.T.1    Wu, C.H.2    Yen, G.C.3
  • 161
    • 33846509838 scopus 로고    scopus 로고
    • Regulation of the phosphatidylinositol 3-kinase-Akt and the mitogen-activated protein kinase pathways by ursolic acid in human endometrial cancer cells
    • Achiwa Y., Hasegawa K., Udagawa Y. Regulation of the phosphatidylinositol 3-kinase-Akt and the mitogen-activated protein kinase pathways by ursolic acid in human endometrial cancer cells. Biosci. Biotechnol. Biochem. 2007, 71(1):31-37.
    • (2007) Biosci. Biotechnol. Biochem. , vol.71 , Issue.1 , pp. 31-37
    • Achiwa, Y.1    Hasegawa, K.2    Udagawa, Y.3
  • 162
    • 77149131832 scopus 로고    scopus 로고
    • Effects of ursolic acid on the proliferation and apoptosis of human ovarian cancer cells
    • Wang X., Li L., Wang B., Xiang J. Effects of ursolic acid on the proliferation and apoptosis of human ovarian cancer cells. J. Huazhong Univ. Sci. Technol. Med. Sci. 2009, 29(6):761-764.
    • (2009) J. Huazhong Univ. Sci. Technol. Med. Sci. , vol.29 , Issue.6 , pp. 761-764
    • Wang, X.1    Li, L.2    Wang, B.3    Xiang, J.4
  • 163
    • 69949122837 scopus 로고    scopus 로고
    • Ursolic acid inhibits proliferation and induces apoptosis of HT-29 colon cancer cells by inhibiting the EGFR/MAPK pathway
    • Shan J.Z., Xuan Y.Y., Zheng S., Dong Q., Zhang S.Z. Ursolic acid inhibits proliferation and induces apoptosis of HT-29 colon cancer cells by inhibiting the EGFR/MAPK pathway. J. Zhejiang Univ. Sci. B 2009, 10(9):668-674.
    • (2009) J. Zhejiang Univ. Sci. B , vol.10 , Issue.9 , pp. 668-674
    • Shan, J.Z.1    Xuan, Y.Y.2    Zheng, S.3    Dong, Q.4    Zhang, S.Z.5
  • 164
    • 84878493132 scopus 로고    scopus 로고
    • Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cells
    • Wang J., Liu L., Qiu H., et al. Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cells. PLoS One 2013, 8(5):e3872.
    • (2013) PLoS One , vol.8 , Issue.5
    • Wang, J.1    Liu, L.2    Qiu, H.3
  • 165
    • 84885067636 scopus 로고    scopus 로고
    • Ursolic acid inhibits colorectal cancer angiogenesis through suppression of multiple signaling pathways
    • Lin J., Chen Y., Wei L., et al. Ursolic acid inhibits colorectal cancer angiogenesis through suppression of multiple signaling pathways. Int. J. Oncol. 2013, 43(5):1666-1674.
    • (2013) Int. J. Oncol. , vol.43 , Issue.5 , pp. 1666-1674
    • Lin, J.1    Chen, Y.2    Wei, L.3
  • 166
    • 84882373206 scopus 로고    scopus 로고
    • Ursolic acid promotes colorectal cancer cell apoptosis and inhibits cell proliferation via modulation of multiple signaling pathways
    • Lin J., Chen Y., Wei L., et al. Ursolic acid promotes colorectal cancer cell apoptosis and inhibits cell proliferation via modulation of multiple signaling pathways. Int. J. Oncol. 2013, 43(4):1235-1243.
    • (2013) Int. J. Oncol. , vol.43 , Issue.4 , pp. 1235-1243
    • Lin, J.1    Chen, Y.2    Wei, L.3
  • 167
    • 84875066821 scopus 로고    scopus 로고
    • Ursolic acid induces cell death and modulates autophagy through JNK pathway in apoptosis-resistant colorectal cancer cells
    • Xavier C.P., Lima C.F., Pedro D.F., et al. Ursolic acid induces cell death and modulates autophagy through JNK pathway in apoptosis-resistant colorectal cancer cells. J. Nutr. Biochem. 2013, 24(4):706-712.
    • (2013) J. Nutr. Biochem. , vol.24 , Issue.4 , pp. 706-712
    • Xavier, C.P.1    Lima, C.F.2    Pedro, D.F.3
  • 168
    • 84866392802 scopus 로고    scopus 로고
    • Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine
    • Prasad S., Yadav V.R., Sung B., et al. Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine. Clin. Cancer Res. 2012, 18(18):4942-4953.
    • (2012) Clin. Cancer Res. , vol.18 , Issue.18 , pp. 4942-4953
    • Prasad, S.1    Yadav, V.R.2    Sung, B.3
  • 169
    • 77953696173 scopus 로고    scopus 로고
    • Enhancement of chemotherapeutic agent-induced apoptosis by inhibition of NF-kappaB using ursolic acid
    • Li Y., Xing D., Chen Q., Chen W.R. Enhancement of chemotherapeutic agent-induced apoptosis by inhibition of NF-kappaB using ursolic acid. Int. J. Cancer 2010, 127(2):462-473.
    • (2010) Int. J. Cancer , vol.127 , Issue.2 , pp. 462-473
    • Li, Y.1    Xing, D.2    Chen, Q.3    Chen, W.R.4
  • 170
    • 84872337991 scopus 로고    scopus 로고
    • A phase I pharmacokinetic study of ursolic acid nanoliposomes in healthy volunteers and patients with advanced solid tumors
    • Zhu Z., Qian Z., Yan Z., et al. A phase I pharmacokinetic study of ursolic acid nanoliposomes in healthy volunteers and patients with advanced solid tumors. Int. J. Nanomed. 2013, 8:129-136.
    • (2013) Int. J. Nanomed. , vol.8 , pp. 129-136
    • Zhu, Z.1    Qian, Z.2    Yan, Z.3


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