Quercetin enhances 5-fluorouracil-induced apoptosis in MSI colorectal cancer cells through p53 modulation

Cancer Chemotherapy and Pharmacology

Volumn 68, Issue 6, 2011, Pages 1449-1457

  Xavier, Cristina P R ^a   Lima, Cristovao F ^a   Rohde, Mikkel ^b   Pereira Wilson, Cristina ^a  

^a UNIVERSITY OF MINHO   (Portugal)

^b DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

Author keywords

5 fluorouracil; Apoptosis; Colorectal carcinoma; p53; Quercetin

Indexed keywords

CASPASE 3; CASPASE 9; FLUOROURACIL; LUTEOLIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; QUERCETIN; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER COMBINATION CHEMOTHERAPY; CELL PROLIFERATION; COLORECTAL CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENTIATION; DRUG SENSITIVITY; GENE MUTATION; HUMAN; HUMAN CELL; IC 50; KNOCKOUT GENE; MICROSATELLITE INSTABILITY; MONOTHERAPY; NICK END LABELING; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; CASPASES; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; FLUOROURACIL; HUMANS; LUTEOLIN; QUERCETIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 82455175194     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-011-1641-9     Document Type: Article

References (38)

1. C Rupnarain Z Dlamini S Naicker K Bhoola 2004 Colon cancer: genomics and apoptotic events Biol Chem 385 449 464 15255176 10.1515/BC.2004.053 1:CAS:528:DC%2BD2cXlslaisb0%3D (Pubitemid 38967772)
2. CM Ribic DJ Sargent MJ Moore SN Thibodeau AJ French RM Goldberg SR Hamilton P Laurent-Puig R Gryfe LE Shepherd D Tu M Redston S Gallinger 2003 Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer N Engl J Med 349 247 257 12867608 10.1056/NEJMoa022289 1:CAS:528:DC%2BD3sXlsVGjsbY%3D (Pubitemid 36859476)
3. S Bhushan H McLeod CM Walko 2009 Role of pharmacogenetics as predictive biomarkers of response and/or toxicity in the treatment of colorectal cancer Clin Colorectal Cancer 8 15 21 19203892 10.3816/CCC.2009.n.003 1:CAS:528:DC%2BD1MXjtVylsr0%3D
4. RM Mader M Muller GG Steger 1998 Resistance to 5-fluorouracil Gen Pharmacol 31 661 666 9809460 10.1016/S0306-3623(98)00191-8 1:CAS:528: DyaK1cXntVCrsrk%3D (Pubitemid 28520040)
5. S Huerta EJ Goulet EH Livingston 2006 Colon cancer and apoptosis Am J Surg 191 517 526 16531147 10.1016/j.amjsurg.2005.11.009 1:CAS:528: DC%2BD28Xit1CktLY%3D (Pubitemid 43384150)
6. JM Davies RM Goldberg 2008 First-line therapeutic strategies in metastatic colorectal cancer Oncology (Williston Park) 22 1470 1479
7. R Jover P Zapater A Castells X Llor M Andreu J Cubiella V Pinol RM Xicola L Bujanda JM Rene J Clofent X Bessa JD Morillas D Nicolas-Perez A Paya C Alenda 2006 Mismatch repair status in the prediction of benefit from adjuvant fluorouracil chemotherapy in colorectal cancer Gut 55 848 855 16299036 10.1136/gut.2005.073015 1:CAS:528:DC%2BD28XlvVOht7c%3D (Pubitemid 43764557)
8. J Warusavitarne M Schnitzler 2007 The role of chemotherapy in microsatellite unstable (MSI-H) colorectal cancer Int J Colorectal Dis 22 739 748 17109103 10.1007/s00384-006-0228-0 (Pubitemid 46863751)
9. K Soreide EA Janssen H Soiland H Korner JP Baak 2006 Microsatellite instability in colorectal cancer Br J Surg 93 395 406 16555243 10.1002/bjs.5328 1:CAS:528:DC%2BD28XktFWnsL4%3D
10. FA Sinicrope DJ Sargent 2009 Clinical implications of microsatellite instability in sporadic colon cancers Curr Opin Oncol 21 369 373 19444104 10.1097/CCO.0b013e32832c94bd 1:CAS:528:DC%2BD1MXnsVehsrs%3D
11. R Seruca S Velho C Oliveira M Leite P Matos P Jordan 2009 Unmasking the role of KRAS and BRAF pathways in MSI colorectal tumors Expert Rev Gastroenterol Hepatol 3 5 9 19210107 10.1586/17474124.3.1.5
12. J Benhattar JP Cerottini E Saraga G Metthez JC Givel 1996 p53 mutations as a possible predictor of response to chemotherapy in metastatic colorectal carcinomas Int J Cancer 69 190 192 8682586 10.1002/(SICI)1097-0215(19960621)69: 3<190::AID-IJC7>3.0.CO;2-V 1:CAS:528:DyaK28XkvV2gsbs%3D (Pubitemid 26233297)
13. S Violette L Poulain E Dussaulx D Pepin AM Faussat J Chambaz JM Lacorte C Staedel T Lesuffleur 2002 Resistance of colon cancer cells to long-term 5-fluorouracil exposure is correlated to the relative level of Bcl-2 and Bcl-X(L) in addition to Bax and p53 status Int J Cancer 98 498 504 11920608 10.1002/ijc.10146 1:CAS:528:DC%2BD38XitlSrur4%3D (Pubitemid 34208549)
14. F Bunz PM Hwang C Torrance T Waldman Y Zhang L Dillehay J Williams C Lengauer KW Kinzler B Vogelstein 1999 Disruption of p53 in human cancer cells alters the responses to therapeutic agents J Clin Invest 104 263 269 10430607 10.1172/JCI6863 1:CAS:528:DyaK1MXkvFagsbc%3D
15. BL Adamsen KL Kravik OP Clausen PM De Angelis 2007 Apoptosis, cell cycle progression and gene expression in TP53-depleted HCT116 colon cancer cells in response to short-term 5-fluorouracil treatment Int J Oncol 31 1491 1500 17982676 1:CAS:528:DC%2BD2sXhsVKgur%2FO
16. S Mori Y Ogata K Shirouzu 2004 Biological features of sporadic colorectal carcinoma with high-frequency microsatellite instability: special reference to tumor proliferation and apoptosis Int J Clin Oncol 9 322 329 15375710 10.1007/s10147-004-0406-4 (Pubitemid 39277929)
17. S Hector JH Prehn 2009 Apoptosis signaling proteins as prognostic biomarkers in colorectal cancer: A review Biochim Biophys Acta 1795 117 129 19167459 1:CAS:528:DC%2BD1MXjvVWjsr4%3D
18. BB Aggarwal S Shishodia 2006 Molecular targets of dietary agents for prevention and therapy of cancer Biochem Pharmacol 71 1397 1421 16563357 10.1016/j.bcp.2006.02.009 1:CAS:528:DC%2BD28Xjs1Gls74%3D
19. S Ramos 2008 Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways Mol Nutr Food Res 52 507 526 18435439 10.1002/mnfr.200700326 1:CAS:528:DC%2BD1cXms1egt7k%3D
20. RA Subapriya Rajamanickam 2008 Natural products and colon cancer: current status and future prospects Drug Dev Res 69 460 471 19884979 10.1002/ddr.20276
21. EF Wagner AR Nebreda 2009 Signal integration by JNK and p38 MAPK pathways in cancer development Nat Rev Cancer 9 537 549 19629069 10.1038/nrc2694 1:CAS:528:DC%2BD1MXovFymu7w%3D
22. J Liu A Lin 2005 Role of JNK activation in apoptosis: a double-edged sword Cell Res 15 36 42 15686625 10.1038/sj.cr.7290262 (Pubitemid 41653963)
23. LR Coulthard DE White DL Jones MF McDermott SA Burchill 2009 p38(MAPK): stress responses from molecular mechanisms to therapeutics Trends Mol Med 15 369 379 19665431 10.1016/j.molmed.2009.06.005 1:CAS:528:DC%2BD1MXhtVehur%2FM
24. CP Xavier CF Lima A Preto R Seruca M Fernandes-Ferreira C Pereira-Wilson 2009 Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells Cancer Lett 281 162 170 19344998 10.1016/j.canlet.2009.02.041 1:CAS:528:DC%2BD1MXnsFajs7s%3D
25. J Gayet XP Zhou A Duval S Rolland JM Hoang P Cottu R Hamelin 2001 Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines Oncogene 20 5025 5032 11526487 10.1038/sj.onc. 1204611 1:CAS:528:DC%2BD3MXmtlCks70%3D (Pubitemid 32769792)
26. KW Barbour FG Berger 2008 Cell death in response to antimetabolites directed at thymidylate synthase Cancer Chemother Pharmacol 61 189 201 17396263 10.1007/s00280-007-0461-4 1:CAS:528:DC%2BD2sXhtlWrs7%2FM (Pubitemid 350160318)
27. F Bunz A Dutriaux C Lengauer T Waldman S Zhou JP Brown JM Sedivy KW Kinzler B Vogelstein 1998 Requirement for p53 and p21 to sustain G2 arrest after DNA damage Science 282 1497 1501 9822382 10.1126/science.282.5393.1497 1:CAS:528:DyaK1cXns1yqurc%3D (Pubitemid 28538613)
28. A Preto J Figueiredo S Velho A Ribeiro P Soares C Oliveira R Seruca 2008 BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations J Pathol 214 320 327 18098337 10.1002/path.2295 1:CAS:528:DC%2BD1cXivVSgt7s%3D (Pubitemid 351212387)
29. N Itoh S Semba M Ito H Takeda S Kawata M Yamakawa 2002 Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma Cancer 94 3127 3134 12115344 10.1002/cncr.10591 1:CAS:528:DC%2BD38XltlOqtbk%3D (Pubitemid 34670495)
30. M Osaki M Oshimura H Ito 2004 PI3K-Akt pathway: its functions and alterations in human cancer Apoptosis 9 667 676 15505410 10.1023/B:APPT. 0000045801.15585.dd 1:CAS:528:DC%2BD2cXovVKqu70%3D (Pubitemid 40941196)
31. PG Rychahou LN Jackson SR Silva S Rajaraman BM Evers 2006 Targeted molecular therapy of the PI3K pathway: therapeutic significance of PI3K subunit targeting in colorectal carcinoma Ann Surg 243 833 842 16772787 10.1097/01.sla.0000220040.66012.a9 discussion 843-844
32. N Thompson J Lyons 2005 Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery Curr Opin Pharmacol 5 350 356 15955734 10.1016/j.coph.2005.04.007 1:CAS:528:DC%2BD2MXlvFKlsL4%3D (Pubitemid 40932036)
33. JA McCubrey LS Steelman SL Abrams JT Lee F Chang FE Bertrand PM Navolanic DM Terrian RA Franklin AB D'Assoro JL Salisbury MC Mazzarino F Stivala M Libra 2006 Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance Adv Enzyme Regul 46 249 279 16854453 10.1016/j.advenzreg.2006.01.004 1:CAS:528:DC%2BD1cXhs12lurs%3D (Pubitemid 44301348)
34. XY Tang YQ Zhu WH Tao B Wei XL Lin 2007 Synergistic effect of triptolide combined with 5-fluorouracil on colon carcinoma Postgrad Med J 83 338 343 17488865 10.1136/pgmj.2006.055426 1:CAS:528:DC%2BD2sXmslKntL4%3D (Pubitemid 46797833)
35. YQ Zhang XQ Tang L Sun L Dong Y Qin HQ Liu H Xia JG Cao 2007 Rosiglitazone enhances fluorouracil-induced apoptosis of HT-29 cells by activating peroxisome proliferator-activated receptor gamma World J Gastroenterol 13 1534 1540 17461445 10.3748/wjg.13.6385 1:CAS:528: DC%2BD2sXlslKqt7g%3D (Pubitemid 46672661)
36. CZ Wang X Luo B Zhang WX Song M Ni S Mehendale JT Xie HH Aung TC He CS Yuan 2007 Notoginseng enhances anti-cancer effect of 5-fluorouracil on human colorectal cancer cells Cancer Chemother Pharmacol 60 69 79 17009031 10.1007/s00280-006-0350-2 (Pubitemid 46643720)
37. R Shi Q Huang X Zhu YB Ong B Zhao J Lu CN Ong HM Shen 2007 Luteolin sensitizes the anticancer effect of cisplatin via c-Jun NH2-terminal kinase-mediated p53 phosphorylation and stabilization Mol Cancer Ther 6 1338 1347 17431112 10.1158/1535-7163.MCT-06-0638 1:CAS:528:DC%2BD2sXktFams7w%3D (Pubitemid 46711997)
38. Q Hou 2008 Effect of staurosporine induced apoptosis of MCF7/GFP-Bax stable cell line on Bax translocation from cytosol into mitochondria Yao Xue Xue Bao 43 378 382 18664199 1:CAS:528:DC%2BD1cXnt12qs7c%3D