-
1
-
-
0030790548
-
Using structure to define the function of phosphoinositide 3-kinase family members
-
J. Domin, and M.D. Waterfield Using structure to define the function of phosphoinositide 3-kinase family members FEBS Lett 410 1997 91 95
-
(1997)
FEBS Lett
, vol.410
, pp. 91-95
-
-
Domin, J.1
Waterfield, M.D.2
-
2
-
-
0035190026
-
Cellular function of phosphoinositide 3-kinases: Implications for development, immunity, homeostasis, and cancer
-
R. Katso, K. Okkenhaug, and K. Ahmadi Cellular function of phosphoinositide 3-kinases: implications for development, immunity, homeostasis, and cancer Annu Rev Cell Dev Biol 17 2001 615 675
-
(2001)
Annu Rev Cell Dev Biol
, vol.17
, pp. 615-675
-
-
Katso, R.1
Okkenhaug, K.2
Ahmadi, K.3
-
3
-
-
0036632368
-
The phosphatidyllinositol 3-kinase-AKT pathway in human cancer
-
I. Vivanco, and C.L. Sawyers The phosphatidyllinositol 3-kinase-AKT pathway in human cancer Nat Rev Cancer 2 2002 489 501
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
4
-
-
0025201426
-
Purification and characterization of phosphoinositide 3-kinase from rat liver
-
C.L. Carpenter, B.C. Duckworth, and K.R. Auger Purification and characterization of phosphoinositide 3-kinase from rat liver J Biol Chem 265 1990 19704 19711
-
(1990)
J Biol Chem
, vol.265
, pp. 19704-19711
-
-
Carpenter, C.L.1
Duckworth, B.C.2
Auger, K.R.3
-
5
-
-
0026720350
-
Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit
-
I.D. Hiles, M. Otsu, and S. Volina Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit Cell 70 1992 419 429
-
(1992)
Cell
, vol.70
, pp. 419-429
-
-
Hiles, I.D.1
Otsu, M.2
Volina, S.3
-
6
-
-
0027309278
-
Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit
-
C.L. Carpenter, K.R. Auger, and M. Chanudhuri Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit J Biol Chem 268 1993 9478 9483
-
(1993)
J Biol Chem
, vol.268
, pp. 9478-9483
-
-
Carpenter, C.L.1
Auger, K.R.2
Chanudhuri, M.3
-
7
-
-
0032541677
-
Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis
-
A.C. Porter, and R.R. Vaillancourt Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis Oncogene 17 1998 1343 1352
-
(1998)
Oncogene
, vol.17
, pp. 1343-1352
-
-
Porter, A.C.1
Vaillancourt, R.R.2
-
8
-
-
0032497832
-
Structure and function of phosphoinositide 3-kinases
-
M.P. Wymann, and L. Pirola Structure and function of phosphoinositide 3-kinases Biochim Biophys Acta 1436 1998 127 150
-
(1998)
Biochim Biophys Acta
, vol.1436
, pp. 127-150
-
-
Wymann, M.P.1
Pirola, L.2
-
9
-
-
0033604577
-
Signaling by distinct classes of phosphoinositide 3-kinases
-
B. Vanhaesebroeck, and M.D. Waterfield Signaling by distinct classes of phosphoinositide 3-kinases Exp Cell Res 253 1999 239 254
-
(1999)
Exp Cell Res
, vol.253
, pp. 239-254
-
-
Vanhaesebroeck, B.1
Waterfield, M.D.2
-
10
-
-
0028500187
-
The activation of phosphoinositol 3-kinase by Ras
-
T. Kodaki, R. Woscholski, and B. Hallberg The activation of phosphoinositol 3-kinase by Ras Curr Biol 4 1994 798 806
-
(1994)
Curr Biol
, vol.4
, pp. 798-806
-
-
Kodaki, T.1
Woscholski, R.2
Hallberg, B.3
-
11
-
-
0028074316
-
Phosphatidylinositol-3-OH kinase as a direct target of Ras
-
P. Rodriguez-Viciana, P.H. Warne, and R. Dhand Phosphatidylinositol-3-OH kinase as a direct target of Ras Nature 370 1994 527 532
-
(1994)
Nature
, vol.370
, pp. 527-532
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Dhand, R.3
-
12
-
-
0029990003
-
Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutations
-
P. Rodriguez-Viciana, P.H. Warne, and B. Vanhaesebroeck Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutations EMBO J 15 1996 2442 2451
-
(1996)
EMBO J
, vol.15
, pp. 2442-2451
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Vanhaesebroeck, B.3
-
13
-
-
0023897684
-
Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate
-
M. Whitman, C.P. Downes, and M. Keeler Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate Nature 332 1988 644 646
-
(1988)
Nature
, vol.332
, pp. 644-646
-
-
Whitman, M.1
Downes, C.P.2
Keeler, M.3
-
14
-
-
0030913673
-
Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/AKT cellular survival pathway
-
A. Khwaja, P. Rodriguez-Viciana, and S. Wennstrom Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/AKT cellular survival pathway EMBO J 16 1997 2783 2793
-
(1997)
EMBO J
, vol.16
, pp. 2783-2793
-
-
Khwaja, A.1
Rodriguez-Viciana, P.2
Wennstrom, S.3
-
15
-
-
0034653608
-
The PI3K-PDK1 connection: More than just a road to PKB
-
B. Vanhaesebroeck, and D.R. Alessi The PI3K-PDK1 connection: more than just a road to PKB Biochem J 346 2000 561 576
-
(2000)
Biochem J
, vol.346
, pp. 561-576
-
-
Vanhaesebroeck, B.1
Alessi, D.R.2
-
16
-
-
0028601306
-
Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110 alpha (PIK3CA) gene
-
S. Volinia, I. Hiles, and E. Ormondroyd Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110 alpha (PIK3CA) gene Genomics 24 1994 472 477
-
(1994)
Genomics
, vol.24
, pp. 472-477
-
-
Volinia, S.1
Hiles, I.2
Ormondroyd, E.3
-
17
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Y. Samuels, Z. Wang, and A. Bardelli High frequency of mutations of the PIK3CA gene in human cancers Science 304 2004 554
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
-
18
-
-
7444250290
-
Mutation of the PIK3CA gene in ovarian and breast cancer
-
I.G. Campbell, S.E. Russel, and D.Y. Choong Mutation of the PIK3CA gene in ovarian and breast cancer Cancer Res 64 2004 7678 7681
-
(2004)
Cancer Res
, vol.64
, pp. 7678-7681
-
-
Campbell, I.G.1
Russel, S.E.2
Choong, D.Y.3
-
19
-
-
20044388328
-
PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas
-
J.W. Lee, Y.H. Soung, and S.Y. Kim PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas Oncogene 24 8 2005 1477 1480
-
(2005)
Oncogene
, vol.24
, Issue.8
, pp. 1477-1480
-
-
Lee, J.W.1
Soung, Y.H.2
Kim, S.Y.3
-
20
-
-
3442878125
-
Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas
-
D.K. Broderick, C. Di, and T.J. Parret Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas Cancer Res 64 2004 5048 5050
-
(2004)
Cancer Res
, vol.64
, pp. 5048-5050
-
-
Broderick, D.K.1
Di, C.2
Parret, T.J.3
-
21
-
-
16644393213
-
The PIK3CA gene is mutated with high frequency in human breast cancers
-
K.E. Bachman, P. Argani, and Y. Samuels The PIK3CA gene is mutated with high frequency in human breast cancers Cancer Biol Ther 3 2004 772 775
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 772-775
-
-
Bachman, K.E.1
Argani, P.2
Samuels, Y.3
-
22
-
-
22144491262
-
Mutations of PIK3CA in gastric adenocarcinoma
-
V.S. Li, C.W. Wong, and T.L. Chan Mutations of PIK3CA in gastric adenocarcinoma BMC Cancer 23,5 1 2005 29
-
(2005)
BMC Cancer
, vol.235
, Issue.1
, pp. 29
-
-
Li, V.S.1
Wong, C.W.2
Chan, T.L.3
-
23
-
-
0027285475
-
Ubiquitous somatic mutations in simple repeated sequences reveals a new mechanism for colonic carcinogenesis
-
Y. Ionov, M.A. Peinado, and S. Malkhosyan Ubiquitous somatic mutations in simple repeated sequences reveals a new mechanism for colonic carcinogenesis Nature 363 1993 558 561
-
(1993)
Nature
, vol.363
, pp. 558-561
-
-
Ionov, Y.1
Peinado, M.A.2
Malkhosyan, S.3
-
24
-
-
0038485895
-
Microsatellite instability in gastrointestinal tract tumors
-
A.J. Philp, W.A. Phillips, and S.P. Rockman Microsatellite instability in gastrointestinal tract tumors Int J Surg Investig 2 2000 267 274
-
(2000)
Int J Surg Investig
, vol.2
, pp. 267-274
-
-
Philp, A.J.1
Phillips, W.A.2
Rockman, S.P.3
-
25
-
-
0033762469
-
DNA methylation and gastrointestinal malignancies: Functional consequences and clinical implications
-
M. Toyota, F. Itoh, and K. Imai DNA methylation and gastrointestinal malignancies: functional consequences and clinical implications J Gastroenterol 35 2000 727 734
-
(2000)
J Gastroenterol
, vol.35
, pp. 727-734
-
-
Toyota, M.1
Itoh, F.2
Imai, K.3
-
26
-
-
0034465991
-
Microsatellite instability as a tool for the classification of gastric cancer
-
A.J. Simpson, O.L. Caballero, and S.D. Pena Microsatellite instability as a tool for the classification of gastric cancer Trends Mol Med 7 2001 76 80
-
(2001)
Trends Mol Med
, vol.7
, pp. 76-80
-
-
Simpson, A.J.1
Caballero, O.L.2
Pena, S.D.3
-
27
-
-
0037065954
-
Methylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancer
-
G. Deng, E. Peng, and J. Gum Methylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancer Br J Cancer 86 2002 574 579
-
(2002)
Br J Cancer
, vol.86
, pp. 574-579
-
-
Deng, G.1
Peng, E.2
Gum, J.3
-
28
-
-
0036569940
-
Mutations at coding repeat sequences in mismatch repair-deficient human cancers
-
A. Duval, and R. Hamelin Mutations at coding repeat sequences in mismatch repair-deficient human cancers Cancer Res 62 2002 2447 2454
-
(2002)
Cancer Res
, vol.62
, pp. 2447-2454
-
-
Duval, A.1
Hamelin, R.2
-
29
-
-
0035070638
-
Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancer
-
W.S. Samowitz, J.A. Holden, and K. Curtin Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancer Am J Pathol 158 2001 1517 1524
-
(2001)
Am J Pathol
, vol.158
, pp. 1517-1524
-
-
Samowitz, W.S.1
Holden, J.A.2
Curtin, K.3
-
30
-
-
0346057796
-
BRAF mutations characterize colon but not gastric with mismatch repair deficiency
-
C. Oliveira, M. Pinto, and A. Duval BRAF mutations characterize colon but not gastric with mismatch repair deficiency Oncogene 22 2003 9192 9196
-
(2003)
Oncogene
, vol.22
, pp. 9192-9196
-
-
Oliveira, C.1
Pinto, M.2
Duval, A.3
-
31
-
-
0842263902
-
Mutational analysis of BRAF and K-ras in gastric cancers: Absence of BRAF mutations in gastric cancers
-
I.J. Kim, J.H. Park, and H.C. Kang Mutational analysis of BRAF and K-ras in gastric cancers: absence of BRAF mutations in gastric cancers Hum Genet 114 2003 118 120
-
(2003)
Hum Genet
, vol.114
, pp. 118-120
-
-
Kim, I.J.1
Park, J.H.2
Kang, H.C.3
-
32
-
-
0141483004
-
Frequent Ki-ras mutations in gastric tumors of the MSI phenotype
-
C. Brennetot, A. Duval, and R. Hamelin Frequent Ki-ras mutations in gastric tumors of the MSI phenotype Gastroenterology 125 2003 1282 1290
-
(2003)
Gastroenterology
, vol.125
, pp. 1282-1290
-
-
Brennetot, C.1
Duval, A.2
Hamelin, R.3
-
33
-
-
9144271690
-
Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation
-
E. Domingo, E. Espin, and M. Armengol Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation Genes Chrom Cancer 39 2004 138 142
-
(2004)
Genes Chrom Cancer
, vol.39
, pp. 138-142
-
-
Domingo, E.1
Espin, E.2
Armengol, M.3
-
34
-
-
1642535480
-
BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer
-
G. Deng, I. Bell, and S. Crawley BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer Clin Cancer Res 10 2004 191 195
-
(2004)
Clin Cancer Res
, vol.10
, pp. 191-195
-
-
Deng, G.1
Bell, I.2
Crawley, S.3
-
35
-
-
0347382321
-
Mutations of BRAF are associated with extensive hMLH1 promoter methylation in sporadic colorectal carcinomas
-
K. Koinuma, K. Shitoh, and Y. Miyakura Mutations of BRAF are associated with extensive hMLH1 promoter methylation in sporadic colorectal carcinomas Int J Cancer 108 2004 237 242
-
(2004)
Int J Cancer
, vol.108
, pp. 237-242
-
-
Koinuma, K.1
Shitoh, K.2
Miyakura, Y.3
-
36
-
-
0345256381
-
Mutations of BRAF and KRAS in gastric cancer and their association with microsatellite instability
-
W. Zhao, T.L. Chan, and K. Chu Mutations of BRAF and KRAS in gastric cancer and their association with microsatellite instability Int J Cancer 108 2004 167 169
-
(2004)
Int J Cancer
, vol.108
, pp. 167-169
-
-
Zhao, W.1
Chan, T.L.2
Chu, K.3
-
37
-
-
3242655649
-
Alterations of the K-ras and p53 genes and microsatellite instability in sporadic colorectal carcinomas
-
A. Hasegawa, T. Fukushima, and M. Mashiko Alterations of the K-ras and p53 genes and microsatellite instability in sporadic colorectal carcinomas Anticancer Res 24 2004 2047 2052
-
(2004)
Anticancer Res
, vol.24
, pp. 2047-2052
-
-
Hasegawa, A.1
Fukushima, T.2
Mashiko, M.3
-
38
-
-
14144252004
-
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
-
S. Kang, A.G. Bader, and P.K. Vogt Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic Proc Natl Acad Sci USA 102 2005 802 807
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 802-807
-
-
Kang, S.1
Bader, A.G.2
Vogt, P.K.3
-
39
-
-
8744259822
-
Genetic alterations of phosphoinositide 3-kinase subunit genes in human glioblastomas
-
M. Mizoguchi, C.L. Nutt, and G. Mohapatra Genetic alterations of phosphoinositide 3-kinase subunit genes in human glioblastomas Brain Pathol 14 2004 372 377
-
(2004)
Brain Pathol
, vol.14
, pp. 372-377
-
-
Mizoguchi, M.1
Nutt, C.L.2
Mohapatra, G.3
-
40
-
-
5444224121
-
Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status
-
C. Oliveira, J.L. Westra, and D. Arango Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status Hum Mol Genet 13 2004 2303 2311
-
(2004)
Hum Mol Genet
, vol.13
, pp. 2303-2311
-
-
Oliveira, C.1
Westra, J.L.2
Arango, D.3
|