Ursolic Acid Simultaneously Targets Multiple Signaling Pathways to Suppress Proliferation and Induce Apoptosis in Colon Cancer Cells

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Wang, Jingshu ^a   Liu, Liqun ^c   Qiu, Huijuan ^a   Zhang, Xiaohong ^b   Guo, Wei ^b   Chen, Wangbing ^a   Tian, Yun ^a   Fu, Lingyi ^a   Shi, Dingbo ^a   Cheng, Jianding ^d   Huang, Wenlin ^a,e   Deng, Wuguo ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b DALIAN MEDICAL UNIVERSITY   (China)

^c SUN YAT SEN UNIVERSITY   (China)

^d SUN YAT SEN UNIVERSITY   (China)

^e Guangzhou Double Bioproduct Inc   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; CASPASE; CYCLOOXYGENASE 2; CYTOCHROME C; E1A ASSOCIATED P300 PROTEIN; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROSTAGLANDIN E2; URSOLIC ACID; UVOMORULIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CARCINOGENESIS; CELL PROLIFERATION; CELL VIABILITY; CLONOGENESIS; COLON CANCER; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; NEUROMODULATION; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

ACETYLATION; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; COLONIC NEOPLASMS; CYCLOOXYGENASE 2; CYTOCHROMES C; DINOPROSTONE; E1A-ASSOCIATED P300 PROTEIN; HUMANS; NF-KAPPA B; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TIME FACTORS; TRITERPENES;

EID: 84878493132     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063872     Document Type: Article

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