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Volumn 18, Issue 18, 2012, Pages 4942-4953

Ursolic acid inhibits growth and metastasis of human, colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: Chemosensitization with capecitabine

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CAPECITABINE; CD31 ANTIGEN; CYCLIN D1; EPIDERMAL GROWTH FACTOR RECEPTOR; FLICE INHIBITORY PROTEIN; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; KI 67 ANTIGEN; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P21; PROTEIN P53; STAT3 PROTEIN; SURVIVIN; URSOLIC ACID; VASCULOTROPIN;

EID: 84866392802     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-11-2805     Document Type: Article
Times cited : (161)

References (45)
  • 2
    • 80052410901 scopus 로고    scopus 로고
    • Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways
    • Prakobwong S, Gupta SC, Kim JH, Sung B, Pinlaor P, Hiraku Y, et al. Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways. Carcinogenesis 2011;32:1372-80.
    • (2011) Carcinogenesis , vol.32 , pp. 1372-1380
    • Prakobwong, S.1    Gupta, S.C.2    Kim, J.H.3    Sung, B.4    Pinlaor, P.5    Hiraku, Y.6
  • 3
    • 59449085264 scopus 로고    scopus 로고
    • Targeting inflammatory pathways for prevention and therapy of cancer: Short-term friend, long-term foe
    • Aggarwal BB, Vijayalekshmi RV, Sung B. Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe. Clin Cancer Res 2009;15:425-30.
    • (2009) Clin Cancer Res , vol.15 , pp. 425-430
    • Aggarwal, B.B.1    Vijayalekshmi, R.V.2    Sung, B.3
  • 4
    • 0028955388 scopus 로고
    • Epidermal growth factor-related peptides and their receptors in human malignancies
    • Salomon DS, Brandt R, Ciardiello F, Normanno N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 1995;19:183-232.
    • (1995) Crit Rev Oncol Hematol , vol.19 , pp. 183-232
    • Salomon, D.S.1    Brandt, R.2    Ciardiello, F.3    Normanno, N.4
  • 5
    • 0038501053 scopus 로고    scopus 로고
    • Targeting epidermal growth factor receptor-are we missing the mark?
    • Dancey JE, Freidlin B. Targeting epidermal growth factor receptor-are we missing the mark? Lancet 2003;362:62-4.
    • (2003) Lancet , vol.362 , pp. 62-64
    • Dancey, J.E.1    Freidlin, B.2
  • 6
    • 0029567968 scopus 로고
    • Pharmacology of oleanolic acid and ursolic acid
    • Liu J. Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol 1995;49:57 -68.
    • (1995) J Ethnopharmacol , vol.49 , pp. 57-68
    • Liu, J.1
  • 7
    • 84863463970 scopus 로고    scopus 로고
    • Ursolic acid induces apoptosis by suppressing the expression of FoxM1 in MCF-7 human breast cancer cells
    • Wang JS, Ren TN, Xi T. Ursolic acid induces apoptosis by suppressing the expression of FoxM1 in MCF-7 human breast cancer cells. Med Oncol 2012;29:10-5.
    • (2012) Med Oncol , vol.29 , pp. 10-15
    • Wang, J.S.1    Ren, T.N.2    Xi, T.3
  • 8
    • 0042530176 scopus 로고    scopus 로고
    • Ursolic acid inhibits proliferation and stimulates apoptosis in HT29 cells following activation of alkaline sphingomyelinase
    • Andersson D, Liu JJ, Nilsson A, Duan RD. Ursolic acid inhibits proliferation and stimulates apoptosis in HT29 cells following activation of alkaline sphingomyelinase. Anticancer Res 2003;23: 3317 - 22.
    • (2003) Anticancer Res , vol.23 , pp. 3317-3322
    • Andersson, D.1    Liu, J.J.2    Nilsson, A.3    Duan, R.D.4
  • 9
    • 4444356923 scopus 로고    scopus 로고
    • Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cells
    • Hsu YL, Kuo PL, Lin CC. Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cells. Life Sci 2004;75:2303-16.
    • (2004) Life Sci , vol.75 , pp. 2303-2316
    • Hsu, Y.L.1    Kuo, P.L.2    Lin, C.C.3
  • 10
    • 33845528108 scopus 로고    scopus 로고
    • Antiproliferative and antiviral mechanisms of ursolic acid and dexamethasone in cervical carcinoma cell lines
    • Yim EK, Lee MJ, Lee KH,UmSJ, Park JS. Antiproliferative and antiviral mechanisms of ursolic acid and dexamethasone in cervical carcinoma cell lines. Int J Gynecol Cancer 2006;16:2023-31.
    • (2006) Int J Gynecol Cancer , vol.16 , pp. 2023-2031
    • Yim, E.K.1    Lee, M.J.2    Lee, K.H.3    Um, S.J.4    Park, J.S.5
  • 11
    • 34548693457 scopus 로고    scopus 로고
    • Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells
    • Pathak AK, Bhutani M, Nair AS, Ahn KS, Chakraborty A, Kadara H, et al. Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. Mol Cancer Res 2007;5:943-55.
    • (2007) Mol Cancer Res , vol.5 , pp. 943-955
    • Pathak, A.K.1    Bhutani, M.2    Nair, A.S.3    Ahn, K.S.4    Chakraborty, A.5    Kadara, H.6
  • 12
    • 41849130295 scopus 로고    scopus 로고
    • Structuredependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives
    • Chadalapaka G, Jutooru I, McAlees A, Stefanac T, Safe S. Structuredependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives. Bioorg Med Chem Lett 2008;18:2633-9.
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 2633-2639
    • Chadalapaka, G.1    Jutooru, I.2    McAlees, A.3    Stefanac, T.4    Safe, S.5
  • 13
    • 13244255330 scopus 로고    scopus 로고
    • Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and caspase-3 activation in M4Beu melanoma cells
    • Harmand PO, Duval R, Delage C, Simon A. Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and caspase-3 activation in M4Beu melanoma cells. Int J Cancer 2005;114:1-11.
    • (2005) Int J Cancer , vol.114 , pp. 1-11
    • Harmand, P.O.1    Duval, R.2    Delage, C.3    Simon, A.4
  • 14
    • 77951660302 scopus 로고    scopus 로고
    • Ursolic acid induces PC-3 cell apoptosis via activation of JNK and inhibition of Akt pathways in vitro
    • Zhang Y, Kong C, Zeng Y, Wang L, Li Z, Wang H, et al. Ursolic acid induces PC-3 cell apoptosis via activation of JNK and inhibition of Akt pathways in vitro. Mol Carcinog 2010;49:374-85.
    • (2010) Mol Carcinog , vol.49 , pp. 374-385
    • Zhang, Y.1    Kong, C.2    Zeng, Y.3    Wang, L.4    Li, Z.5    Wang, H.6
  • 15
    • 0029885105 scopus 로고    scopus 로고
    • Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation
    • Singletary K, MacDonald C, Wallig M. Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. Cancer Lett 1996;104:43-8.
    • (1996) Cancer Lett , vol.104 , pp. 43-48
    • Singletary, K.1    MacDonald, C.2    Wallig, M.3
  • 16
    • 77952300961 scopus 로고    scopus 로고
    • Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in maleWistar rats
    • Gayathri R, Priya DK, Gunassekaran GR, Sakthisekaran D. Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in maleWistar rats. Asian Pac J Cancer Prev 2009;10:933- 8.
    • (2009) Asian Pac J Cancer Prev , vol.10 , pp. 933-938
    • Gayathri, R.1    Priya, D.K.2    Gunassekaran, G.R.3    Sakthisekaran, D.4
  • 17
    • 0027982986 scopus 로고
    • Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid
    • Huang MT, Ho CT, Wang ZY, Ferraro T, Lou YR, Stauber K, et al. Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. Cancer Res 1994;54:701-8.
    • (1994) Cancer Res , vol.54 , pp. 701-708
    • Huang, M.T.1    Ho, C.T.2    Wang, Z.Y.3    Ferraro, T.4    Lou, Y.R.5    Stauber, K.6
  • 18
    • 0032510164 scopus 로고    scopus 로고
    • Ursolic acid-induced down-regulation ofMMP-9gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells
    • Cha HJ, Park MT, Chung HY, Kim ND, Sato H, Seiki M, et al. Ursolic acid-induced down-regulation ofMMP-9gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells. Oncogene 1998;16:771-8.
    • (1998) Oncogene , vol.16 , pp. 771-778
    • Cha, H.J.1    Park, M.T.2    Chung, H.Y.3    Kim, N.D.4    Sato, H.5    Seiki, M.6
  • 19
    • 67650097012 scopus 로고    scopus 로고
    • Triterpenes augment the inhibitory effects of anticancer drugs on growth of human esophageal carcinoma cells in vitro and suppress experimental metastasis in vivo
    • Yamai H, Sawada N, Yoshida T, Seike J, Takizawa H, Kenzaki K, et al. Triterpenes augment the inhibitory effects of anticancer drugs on growth of human esophageal carcinoma cells in vitro and suppress experimental metastasis in vivo . Int J Cancer 2009;125: 952-60.
    • (2009) Int J Cancer , vol.125 , pp. 952-960
    • Yamai, H.1    Sawada, N.2    Yoshida, T.3    Seike, J.4    Takizawa, H.5    Kenzaki, K.6
  • 20
    • 0033860074 scopus 로고    scopus 로고
    • Apoptotic activity of ursolic acid may correlate with the inhibition of initiation of DNA replication
    • Kim DK, Baek JH, Kang CM, Yoo MA, Sung JW, Chung HY, et al. Apoptotic activity of ursolic acid may correlate with the inhibition of initiation of DNA replication. Int J Cancer 2000;87: 629- 36.
    • (2000) Int J Cancer , vol.87 , pp. 629-636
    • Kim, D.K.1    Baek, J.H.2    Kang, C.M.3    Yoo, M.A.4    Sung, J.W.5    Chung, H.Y.6
  • 21
    • 0031588350 scopus 로고    scopus 로고
    • Intracellular Ca2+ release mediates ursolic acid-induced apoptosis in human leukemic HL-60 cells
    • Baek JH, Lee YS, Kang CM, Kim JA, Kwon KS, Son HC, et al. Intracellular Ca2+ release mediates ursolic acid-induced apoptosis in human leukemic HL-60 cells. Int J Cancer 1997;73:725 -8.
    • (1997) Int J Cancer , vol.73 , pp. 725-728
    • Baek, J.H.1    Lee, Y.S.2    Kang, C.M.3    Kim, J.A.4    Kwon, K.S.5    Son, H.C.6
  • 22
    • 0034266625 scopus 로고    scopus 로고
    • Induction of apoptosis by ursolic acid through activation of caspases and downregulation of c-IAPs in human prostate epithelial cells
    • Choi YH, Baek JH, Yoo MA, Chung HY, Kim ND, KimKW. Induction of apoptosis by ursolic acid through activation of caspases and downregulation of c-IAPs in human prostate epithelial cells. Int J Oncol 2000;17:565-71.
    • (2000) Int J Oncol , vol.17 , pp. 565-571
    • Choi, Y.H.1    Baek, J.H.2    Yoo, M.A.3    Chung, H.Y.4    Kim, N.D.5    Kim, K.W.6
  • 24
    • 0042090509 scopus 로고    scopus 로고
    • Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: Correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1
    • Shishodia S, Majumdar S, Banerjee S, Aggarwal BB. Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. Cancer Res 2003;63: 4375- 83.
    • (2003) Cancer Res , vol.63 , pp. 4375-4383
    • Shishodia, S.1    Majumdar, S.2    Banerjee, S.3    Aggarwal, B.B.4
  • 25
    • 0034193436 scopus 로고    scopus 로고
    • Ursolic acid inhibits cyclooxygenase-2 transcription in human mammary epithelial cells
    • Subbaramaiah K, Michaluart P, Sporn MB, Dannenberg AJ. Ursolic acid inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. Cancer Res 2000;60:2399-404.
    • (2000) Cancer Res , vol.60 , pp. 2399-2404
    • Subbaramaiah, K.1    Michaluart, P.2    Sporn, M.B.3    Dannenberg, A.J.4
  • 26
    • 17144439794 scopus 로고    scopus 로고
    • Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages
    • Suh N, Honda T, Finlay HJ, Barchowsky A, Williams C, Benoit NE, et al. Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages. Cancer Res 1998;58:717-23.
    • (1998) Cancer Res , vol.58 , pp. 717-723
    • Suh, N.1    Honda, T.2    Finlay, H.J.3    Barchowsky, A.4    Williams, C.5    Benoit, N.E.6
  • 27
    • 0034477152 scopus 로고    scopus 로고
    • Cytostatic, cytotoxic and protein tyrosine kinase inhibitory activity of ursolic acid in A431 human tumor cells
    • Hollosy F, Meszaros G, Bokonyi G, Idei M, Seprödi A, Szende B, et al. Cytostatic, cytotoxic and protein tyrosine kinase inhibitory activity of ursolic acid in A431 human tumor cells. Anticancer Res 2000;20: 4563- 70.
    • (2000) Anticancer Res , vol.20 , pp. 4563-4570
    • Hollosy, F.1    Meszaros, G.2    Bokonyi, G.3    Idei, M.4    Seprödi, A.5    Szende, B.6
  • 28
    • 70249136561 scopus 로고    scopus 로고
    • Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model
    • Kunnumakkara AB, Diagaradjane P, Anand P, Harikumar KB, Deorukhkar A, Gelovani J, et al. Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model. Int J Cancer 2009;125:2187-97.
    • (2009) Int J Cancer , vol.125 , pp. 2187-2197
    • Kunnumakkara, A.B.1    Diagaradjane, P.2    Anand, P.3    Harikumar, K.B.4    Deorukhkar, A.5    Gelovani, J.6
  • 29
    • 0028275931 scopus 로고
    • Tumor necrosis factor and lymphotoxin. Qualitative and quantitative differences in the mediation of early and late cellular response
    • Chaturvedi MM, LaPushin R, Aggarwal BB. Tumor necrosis factor and lymphotoxin. Qualitative and quantitative differences in the mediation of early and late cellular response. J Biol Chem 1994; 269:14575- 83.
    • (1994) J Biol Chem , vol.269 , pp. 14575-14583
    • Chaturvedi, M.M.1    LaPushin, R.2    Aggarwal, B.B.3
  • 30
    • 79954422847 scopus 로고    scopus 로고
    • Development of a liquid chro-matography- Mass spectrometry method for the determination of ursolic acid in rat plasma and tissue: Application to the pharmacokinetic and tissue distribution study
    • Chen Q, Luo S, Zhang Y, Chen Z. Development of a liquid chro-matography- mass spectrometry method for the determination of ursolic acid in rat plasma and tissue: application to the pharmacokinetic and tissue distribution study. Anal Bioanal Chem 2011; 399:2877-84.
    • (2011) Anal Bioanal Chem , vol.399 , pp. 2877-2884
    • Chen, Q.1    Luo, S.2    Zhang, Y.3    Chen, Z.4
  • 31
    • 34247897031 scopus 로고    scopus 로고
    • Interaction index and different methods for determining drug interaction in combination therapy
    • Lee JJ, Kong M, Ayers GD, Lotan R. Interaction index and different methods for determining drug interaction in combination therapy. J Biopharm Stat 2007;17:461-80.
    • (2007) J Biopharm Stat , vol.17 , pp. 461-480
    • Lee, J.J.1    Kong, M.2    Ayers, G.D.3    Lotan, R.4
  • 32
    • 84952496879 scopus 로고
    • A note on the delta method
    • Oehlert GW. A note on the delta method. Am Stat 1992;46:27-9.
    • (1992) Am Stat , vol.46 , pp. 27-29
    • Oehlert, G.W.1
  • 35
    • 79956189197 scopus 로고    scopus 로고
    • Prognostic value of nuclear beta-catenin overexpression at invasive front in colorectal cancer for synchronous liver metastasis
    • Wang L, Cheng H, Liu Y, Wang L, Yu W, Zhang G, et al. Prognostic value of nuclear beta-catenin overexpression at invasive front in colorectal cancer for synchronous liver metastasis. Ann Surg Oncol 2011;18:1553-9.
    • (2011) Ann Surg Oncol , vol.18 , pp. 1553-1559
    • Wang, L.1    Cheng, H.2    Liu, Y.3    Wang, L.4    Yu, W.5    Zhang, G.6
  • 36
    • 2942741268 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma
    • Ma XT, Wang S, Ye YJ, Du RY, Cui ZR, Somsouk M. Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma. World J Gastroenterol 2004;10:1569-73.
    • (2004) World J Gastroenterol , vol.10 , pp. 1569-1573
    • Ma, X.T.1    Wang, S.2    Ye, Y.J.3    Du, R.Y.4    Cui, Z.R.5    Somsouk, M.6
  • 37
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irino-tecan- Refractory metastatic colorectal cancer
    • Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, Santoro A, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irino-tecan- refractory metastatic colorectal cancer. N Engl J Med 2004; 351:337-45.
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3    Khayat, D.4    Bleiberg, H.5    Santoro, A.6
  • 39
    • 1642314458 scopus 로고    scopus 로고
    • Inhibition of cytochrome P450 activities by oleanolic acid and ursolic acid in human liver microsomes
    • Kim KA, Lee JS, Park HJ, Kim JW, Kim CJ, Shim IS, et al. Inhibition of cytochrome P450 activities by oleanolic acid and ursolic acid in human liver microsomes. Life Sci 2004;74:2769-79.
    • (2004) Life Sci , vol.74 , pp. 2769-2779
    • Kim, K.A.1    Lee, J.S.2    Park, H.J.3    Kim, J.W.4    Kim, C.J.5    Shim, I.S.6
  • 40
    • 84655170171 scopus 로고    scopus 로고
    • Overexpression of SGLT1 and EGFR in colorectal cancer showing a correlation with the prognosis
    • Guo GF, Cai YC, Zhang B, Xu RH, Qiu HJ, Xia LP, et al. Overexpression of SGLT1 and EGFR in colorectal cancer showing a correlation with the prognosis. Med Oncol 2011;28 Suppl 1:S197 -203.
    • (2011) Med Oncol , vol.28 , Issue.SUPPL. 1
    • Guo, G.F.1    Cai, Y.C.2    Zhang, B.3    Xu, R.H.4    Qiu, H.J.5    Xia, L.P.6
  • 41
    • 69949122837 scopus 로고    scopus 로고
    • Ursolic acid inhibits proliferation and induces apoptosis of HT-29 colon cancer cells by inhibiting the EGFR/MAPK pathway
    • Shan JZ, Xuan YY, Zheng S, Dong Q, Zhang SZ. Ursolic acid inhibits proliferation and induces apoptosis of HT-29 colon cancer cells by inhibiting the EGFR/MAPK pathway. J Zhejiang Univ Sci B 2009; 10:668-74.
    • (2009) J Zhejiang Univ Sci B , vol.10 , pp. 668-674
    • Shan, J.Z.1    Xuan, Y.Y.2    Zheng, S.3    Dong, Q.4    Zhang, S.Z.5
  • 42
    • 77954203666 scopus 로고    scopus 로고
    • Antiangiogenic activity of ursolic acid
    • Kanjoormana M, Kuttan G. Antiangiogenic activity of ursolic acid. Integr Cancer Ther 2010;9:224-35.
    • (2010) Integr Cancer Ther , vol.9 , pp. 224-235
    • Kanjoormana, M.1    Kuttan, G.2
  • 43
    • 79960897861 scopus 로고    scopus 로고
    • Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model
    • Shanmugam MK, Manu KA, Ong TH, Ramachandran L, Surana R, Bist P, et al. Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model. Int J Cancer 2011;129:1552-63.
    • (2011) Int J Cancer , vol.129 , pp. 1552-1563
    • Shanmugam, M.K.1    Manu, K.A.2    Ong, T.H.3    Ramachandran, L.4    Surana, R.5    Bist, P.6
  • 44
    • 72449139066 scopus 로고    scopus 로고
    • MMP-9 (gelatinase B) expression is associated with disease-free survival and disease-specific survival in colorectal cancer patients
    • Bendardaf R, Buhmeida A, Hilska M, Laato M, Syrjänen S, Syrjänen K, et al. MMP-9 (gelatinase B) expression is associated with disease-free survival and disease-specific survival in colorectal cancer patients. Cancer Invest 2010;28:38-43.
    • (2010) Cancer Invest , vol.28 , pp. 38-43
    • Bendardaf, R.1    Buhmeida, A.2    Hilska, M.3    Laato, M.4    Syrjänen, S.5    Syrjänen, K.6
  • 45
    • 0032548870 scopus 로고    scopus 로고
    • Over-expression of ICAM-1, VCAM-1 and ELAM-1 might influence tumor progression in colorectal cancer
    • Maurer CA, Friess H, Kretschmann B, Wildi S,Müller C, Graber H, et al. Over-expression of ICAM-1, VCAM-1 and ELAM-1 might influence tumor progression in colorectal cancer. Int J Cancer 1998;79:76-81.
    • (1998) Int J Cancer , vol.79 , pp. 76-81
    • Maurer, C.A.1    Friess, H.2    Kretschmann, B.3    Wildi, S.4    Müller, C.5    Graber, H.6


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