Salvia fruticosa, salvia officinalis, and rosmarinic acid induce apoptosis and inhibit proliferation of human colorectal cell lines: The role in MAPK/ERK pathway

Nutrition and Cancer

Volumn 61, Issue 4, 2009, Pages 564-571

  Xavier, Cristina P R ^a   Lima, Cristovao F ^a   Fernandes Ferreira, Manuel ^a   Pereira Wilson, Cristina ^a  

^a UNIVERSITY OF MINHO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; ROSMARINIC ACID; SALVIA FRUTICOSA EXTRACT; SALVIA OFFICINALIS EXTRACT; UNCLASSIFIED DRUG; WATER;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL PROLIFERATION; COLON CARCINOMA; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENE MUTATION; HUMAN; HUMAN CELL; SALVIA; SALVIA FRUTICOSA; SIGNAL TRANSDUCTION;

ANALYSIS OF VARIANCE; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL PROLIFERATION; CINNAMATES; COLORECTAL NEOPLASMS; DEPSIDES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; IN SITU NICK-END LABELING; MAP KINASE SIGNALING SYSTEM; PHOSPHATIDYLINOSITOL 3-KINASES; PHYTOTHERAPY; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS C-AKT; RAS PROTEINS; SALVIA;

SALVIA; SALVIA FRUTICOSA; SALVIA OFFICINALIS;

EID: 70449627783     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1080/01635580802710733     Document Type: Article

References (39)

1. Cheng JQ, Lindsley CW, Cheng GZ,Yang H, andNicosia SV: TheAkt/PKB pathway: Molecular target for cancer drug discovery. Oncogene 24, 7482-7492, 2005.
2. Thompson N and Lyons J: Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery. Curr Opin Pharmacol 5, 350-356, 2005.
3. Barault L, Veyries N, Jooste V, Lecorre D, Chapusot C, et al.: Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers. Int J Cancer 122, 2255-2259, 2008.
4. McCubrey JA, Steelman LS, Abrams SL, Lee JT, Chang F, et al.: Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance. Adv Enzyme Regul 46, 249-279, 2006.
5. Karoui M, Tresallet C, Brouquet A, Radvanyi H, and Penna C: Colorectal carcinogenesis: 1. Hereditary predisposition and colorectal cancer. J Chir (Paris) 144, 13-18, 2007.
6. Preto A, Figueiredo J, Velho S, Ribeiro A, Soares P, et al.: BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations. J Pathol 214, 320-327, 2008.
7. Oliveira C, Velho S, Moutinho C, Ferreira A, Preto A, et al.: KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression. Oncogene 26, 158-163, 2007.
8. Oikonomou E and Pintzas A: Cancer genetics of sporadic colorectal cancer: BRAF and PI3KCA mutations, their impact on signaling and novel targeted therapies. Anticancer Res 26, 1077-1084, 2006.
9. Schubbert S, Shannon K, and Bollag G: Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer 7, 295-308, 2007.
10. Itoh N, Semba S, Ito M, Takeda H, Kawata S, et al.: Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma. Cancer 94, 3127-3134, 2002.
11. Roy HK, Olusola BF, Clemens DL, Karolski WJ, Ratashak A, et al.: AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis. Carcinogenesis 23, 201-205, 2002.
12. Velho S, Oliveira C, Ferreira A, Ferreira AC, Suriano G, et al.: The prevalence of PIK3CA mutations in gastric and colon cancer. Eur J Cancer 41, 1649-1654, 2005.
13. Khaleghpour K, Li Y, Banville D, Yu Z, and Shen SH: Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma. Carcinogenesis 25, 241-248, 2004.
14. Manson MM: Cancer prevention-the potential for diet to modulate molecular signalling. Trends Mol Med 9, 11-18, 2003.
15. Sarkar FH and Li YW: Targeting multiple signal pathways by chemopreventive agents for cancer prevention and therapy. Acta Pharmacol Sin 28, 1305-1315, 2007.
16. HemaIswarya S and Doble M: Potential synergism of natural products in the treatment of cancer. Phytother Res 20, 239-249, 2006.
17. Aggarwal BB and Shishodia S: Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71, 1397-1421, 2006.
18. Davis CD and Hord NG: Nutritional "omics" technologies for elucidating the role(s) of bioactive food components in colon cancer prevention. J Nutr 135, 2694-2697, 2005.
19. Davis CD and Milner JA: Biomarkers for diet and cancer prevention research: Potentials and challenges. Acta Pharmacol Sin 28, 1262-1273, 2007.
20. Yang CS and Landau JM: Effects of tea consumption on nutrition and health. J Nutr 130, 2409-2412, 2000.
21. Fiore G, Nencini C, Cavallo F, Capasso A, Bader A, et al.: In vitro antiproliferative effect of six Salvia species on human tumor cell lines. Phytother Res 20, 701-703, 2006.
22. Liu J, Shen HM, and Ong CN: Salvia miltiorrhiza inhibits cell growth and induces apoptosis in human hepatoma HepG(2) cells. Cancer Lett 153, 85-93, 2000.
23. Loo G: Redox-sensitive mechanisms of phytochemical-mediated inhibition of cancer cell proliferation (review). J Nutr Biochem 14, 64-73, 2003.
24. Fruehauf JP and Meyskens FL Jr: Reactive oxygen species: A breath of life or death? Clin Cancer Res 13, 789-794, 2007.
25. Lima CF, Valentao PC, Andrade PB, Seabra RM, Fernandes-Ferreira M, et al.:Water and methanolic extracts of Salvia officinalis protect HepG2 cells from t-BHP induced oxidative damage. Chem Biol Interact 167, 107-115, 2007.
26. Lima CF: Effects of Salvia officinalis in the liver: Relevance of glutathione levels. Unpublished Doctoral thesis. Braga, Portugal: University of Minho, 2006.
27. Lima CF, Fernandes-Ferreira M, and Pereira-Wilson C: Phenolic compounds protect HepG2 cells from oxidative damage: Relevance of glutathione levels. Life Sci 79, 2056-2068, 2006.
28. Gayet J, Zhou XP, Duval A, Rolland S, Hoang JM, et al.: Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines. Oncogene 20, 5025-5032, 2001.
29. Oliveira C, Pinto M, Duval A, Brennetot C, Domingo E, et al.: BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency. Oncogene 22, 9192-9196, 2003.
30. Lima CF, Andrade PB, Seabra RM, Fernandes-Ferreira M, and Pereira- Wilson C: The drinking of a Salvia officinalis infusion improves liver antioxidant status in mice and rats. J Ethnopharmacol 97, 383-389, 2005.
31. Solit DB, Garraway LA, Pratilas CA, Sawai A, Getz G, et al.: BRAF mutation predicts sensitivity to MEK inhibition. Nature 439, 358-362, 2006.
32. Psahoulia FH, Moumtzi S, Roberts ML, Sasazuki T, Shirasawa S, et al.: Quercetin mediates preferential degradation of oncogenic Ras and causesautophagy in Ha-RAS-transformed human colon cells. Carcinogenesis 28, 1021-1031, 2007.
33. Ranelletti FO, Maggiano N, Serra FG, Ricci R, Larocca LM, et al.: Quercetin inhibits p21-RAS expression in human colon cancer cell lines and in primary colorectal tumors. Int J Cancer 85, 438-445, 2000.
34. Kim DS, Kim HR, Woo ER, Hong ST, Chae HJ, et al.: Inhibitory effects of rosmarinic acid on adriamycin-induced apoptosis in H9c2 cardiac muscle cells by inhibiting reactive oxygen species and the activations of c-Jun N-terminal kinase and extracellular signal-regulated kinase. Biochem Pharmacol 70, 1066-1078, 2005.
35. Lee J,Kim YS, and Park D:Rosmarinic acid induces melanogenesis through protein kinase A activation signaling. Biochem Pharmacol 74, 960-968, 2007.
36. Kolettas E, Thomas C, Leneti E, Skoufos I, Mbatsi C, et al.: Rosmarinic acid failed to suppress hydrogen peroxide-mediated apoptosis but induced apoptosis of Jurkat cells which was suppressed by Bcl-2. Mol Cell Biochem 285, 111-120, 2006.
37. Hur YG, Yun Y, and Won J: Rosmarinic acid induces p56lck-dependent apoptosis in Jurkat and peripheral T cells via mitochondrial pathway independent from Fas/Fas ligand interaction. J Immunol 172, 79-87, 2004.
38. Lin CS, Kuo CL, Wang JP, Cheng JS, Huang ZW, et al.: Growth inhibitory and apoptosis inducing effect of Perilla frutescens extract on human hepatoma HepG2 cells. J Ethnopharmacol 112, 557-567, 2007.
39. Hur YG, Suh CH, Kim S, and Won J: Rosmarinic acid induces apoptosis of activated T cells from rheumatoid arthritis patients via mitochondrial pathway. J Clin Immunol 27, 36-45, 2007.