Inhibitory effect of luteolin on TNF-α-induced IL-8 production in human colon epithelial cells

International Immunopharmacology

Volumn 5, Issue 1, 2005, Pages 209-217

  Kim, Jin A ^a   Kim, Dae Ki ^b   Kang, Ok Hwa ^a   Choi, Yeon A ^a   Park, Hye Jung ^a   Choi, Suck Chei ^a   Kim, Tae Hyun ^a   Yun, Ki Jung ^a   Nah, Yong Ho ^a   Lee, Young Mi ^a  

^a Wonkwang University   (South Korea)

^b Chonbuk National University Medical School   (South Korea)

Author keywords

I B; Interleukin 8 (IL 8); Intestinal epithelial cells; Luteolin; MAPK; NF B

Indexed keywords

FLAVONOID; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; LUTEOLIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STIMULATION; COLON; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; LONICERA; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTI-INFLAMMATORY AGENTS; CELL SURVIVAL; DNA; HT29 CELLS; HUMANS; I-KAPPA B PROTEINS; INTERLEUKIN-8; LUTEOLIN; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN BINDING; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 10344222108     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2004.09.027     Document Type: Article

References (34)

1. S.K. Yang, L. Eckmann, A. Panja, and M.F. Kagnoff Differential and regulated expression of C-X-C, C-C, and C-chemokines by human colon epithelial cells Gastroenterology 113 1997 1214 1223
2. + exchanger blockade inhibits enterocyte inflammatory response and protects against colitis Am. J. Physiol.: Gasterointest. Liver Physiol. 283 2002 G122 G132
3. A.T. Gewirtz, P.O. Simon Jr., C.K. Schmitt, L.J. Taylor, C.H. Hagedorn, and A.D. O'Brien Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response J. Clin. Invest. 107 2001 99 109
4. L. Mazzucchelli, C. Hauser, K. Zgraggen, H. Wagner, M. Hess, and J.A. Laissue Expression of interleukin-8 gene in inflammatory bowel disease is related to the histologocal grade of active inflammation Am. J. Pathol. 144 1994 997 1007
5. Y.R. Mahida, M. Ceska, F. Effenberger, L. Kurlak, I. Lindley, and C.J. Hawkey Enhanced synthesis of neutrophil-activating peptide-1/interleukin-8 in active ulcerative colitis Clin. Sci. 82 1992 273 275
6. R.S. Izzo, K. Witkon, A.I. Chen, C. Hadjiyane, M.I. Weinstein, and C. Pellecchia Neutrophil activating peptide (interleukin-8) in colonic mucosa from patients with Crohn's disease Scand. J. Gastroenterol. 28 1993 296 300
7. K. Mitsuyama, A. Toyonaga, E. Sasaki, K. Watanabe, H. Tateishi, and T. Nishiyama IL-8 as an important chemoattractant for neutrophils in ulcerative colitis and Crohn's disease Clin. Exp. Immunol. 96 1994 432 436
8. P. Gibon, and O. Rosella Interleukin-8 secretion by colonic crypt cells in vitro: response to injury suppressed by butyrate and enhanced in inflammatory bowel disease Gut 37 1995 536 543
9. G.H. Waetzig, D. Seegert, P. Rosenstiel, S. Nikolaus, and S. Schreiber p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease J. Immunol. 168 2002 5342 5351
10. H.B. Jijon, W.J. Panenka, K.L. Madsen, and H.G. Parsons MAP kinases contribute to IL-8 secretion by intestinal epithelial cells via a posttranscriptional mechanism Am. J. Physiol., Cell Physiol. 283 2002 C31 C41
11. B. Van Den Blink, T. Ten Hove, G.R. Van Den Brink, M.P. Peppelenbosch, and S.J. Van Deventer From extracellular to intracellular targets, inhibiting MAP kinases in treatment of Crohn's disease Ann. N.Y. Acad. Sci. 973 2002 349 358
12. C. Jobin, C.A. Bradham, M.P. Russo, B. Juma, A.S. Narula, and D.A. Brenner Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor IκB kinase activity J. Immunol. 163 1999 3474 3483
13. A.E. Summers, C.J. Whelan, and M.E. Parsons Nicotinic acetylcholine receptor subunits and receptor activity in the epithelial cell line HT29. Life Sci. 72 2003 2091 2094
14. H. Zhou, and S. Mineshita The effect of berberine chloride on experimental colitis in rats in vivo and in vitro J. Pharmacol. Exp. Ther. 294 2000 822 829
15. A. Xagorari, A. Papapetropoulos, A. Mauromatis, M. Economou, T. Fotsis, and C. Roussos Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and pro-inflammatory cytokine production in macrophages J. Pharmacol. Exp. Ther. 296 2001 181 187
16. A. Xagorari, C. Roussos, and A. Papapetropoulos Inhibition of LPS-stimulated pathways in macrophages by the flavonoid luteolin Br. J. Pharmacol. 136 2002 1058 1064
17. A. Kotanidou, A. Xagorari, E. Bagli, P. Kitsanta, T. Fotsis, and A. Papapetropoulos Luteolin reduces lipopolysaccharide-induced lethal toxicity and expression of proinflammatory molecules in mice Am. J. Respir. Crit. Care Med. 165 2002 818 823
18. H. Ueda, C. Yamazaki, and M. Yamazaki Luteolin as an anti-inflammatory and anti-allergic constituent of Perilla frutescens Biol. Pharm. Bull. 25 2002 1197 1202
19. B.Y. Lee, J.W. Schrader, and S.U. Kim p38 MAP kinase regulates TNF-alpha production in human astrocytes and microglia by multiple mechanisms Cytokine 12 2000 874 880
20. B.L. Rodriguez, A. Rojas, J. Campos, T. Ledon, E. Valle, and W. Toledo Differential interleukin-8 response of intestinal epithelial cell line to reactogenic and nonreactogenic candidate vaccine strains of Vibrio cholerae Infect. Immun. 69 2001 613 616
21. S. Schoonbroodt, S. Legrand-Poels, M. Best-Belpomme, and J. Piette Activation of the NF-κB transcription factor in a T-lymphocytic cell line by hypochlorous acid Biochem. J. 321 1997 777 785
22. J.J. Hendriks, H.E. de Vries, S.M. van der Pol, T.K. van den Berg, E.A. van Tol, and C.D. Dijkstra Flavonoids inhibit myelin phagocytosis by macrophages; a structure-activity relationship study Biochem. Pharmacol. 65 2003 877 885
23. A.S. Baldwin Jr. The NF-kB and IκB proteins: new discoveries and insights Annu. Rev. Immunol. 14 1996 649 683
24. H. Gan, Q. Ouyang, D. Jia, and Q. Xia Activation of nuclear factor-κB and its relationship with cytokine gene expression in colonic mucosa of ulcerative colitis patients Zhonghua Neike Zazhi 41 2002 252 255
25. C. Jobin, O. Morteau, D.S. Han, and R. Balfour Sartor Specific NF-κB blockade selectively inhibits tumor necrosis factor-alpha-induced COX-2 but not constitutive COX-1 gene expression in HT-29 cells Immunology 95 1998 537 543
26. C. Jobin, L. Holt, C.A. Bradham, K. Streetz, D.A. Brenner, and R.B. Sartor TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells J. Immunol. 162 1999 4447 4454
27. B. Salh, K. Assi, V. Templeman, K. Parhar, D. Owen, and A. Gomez-Munoz Curcumin attenuates DNB-induced murine colitis Am. J. Physiol.: Gasterointest. Liver Physiol. 285 2003 G235 G243
28. A. Xagorari, A. Papapetropoulos, A. Mauromatis, M. Economou, T. Fotsis, and C. Roussos Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages J. Pharmacol. Exp. Ther. 296 2001 181 187
29. M. Kimata, M. Shichijo, T. Miura, I. Serizawa, N. Inagaki, and H. Nagai Effects of luteolin, quercetin and baicalein on immunoglobulin E-mediated mediator release from human cultured mast cells Clin. Exp. Allergy 30 2000 501 508
30. S.H. Kim, K.J. Shin, D. Kim, Y.H. Kim, M.S. Han, and T.G. Lee Luteolin inhibits the nuclear factor-κB transcriptional activity in Rat-1 fibroblasts Biochem. Pharmacol. 66 2003 955 963
31. J.S. Choi, Y.J. Choi, S.H. Park, J.S. Kang, and Y.H. Kang Flavones mitigate tumor necrosis factor-α-induced adhesion molecule upregulation in cultured human endothelial cells: role of nuclear factor-κB J. Nutr. 134 2004 1013 1019
32. M. Kimata, N. Inagaki, and H. Nagai Effects of luteolin and other flavonoids on IgE-mediated allergic reactions Plant. Med. 66 2000 25 29
33. E.J. Middleton, C. Kandaswami, and T.C. Theocharides The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease and cancer J. Pharmacol. Exp. Ther. 52 2000 673 751
34. E.H. Walker, M.E. Pacold, O. Perisic, L. Stephens, P.T. Hawkins, and M.P. Wymann Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine Mol. Cell 6 2000 909 919