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Volumn 68, Issue 19, 2008, Pages 8127-8136

PIK3CA cooperates with other phosphatidylinositol 3′-kinase pathway mutations to effect oncogenic transformation

Author keywords

[No Author keywords available]

Indexed keywords

AGAR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; K RAS PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE CA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P110; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 54249159640     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-0755     Document Type: Article
Times cited : (157)

References (49)
  • 1
    • 0030799706 scopus 로고    scopus 로고
    • Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
    • Stokoe D, Stephens LR, Copeland T, et al. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science 1997;277:567-70.
    • (1997) Science , vol.277 , pp. 567-570
    • Stokoe, D.1    Stephens, L.R.2    Copeland, T.3
  • 2
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004;350:2129-39.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 3
    • 0024337144 scopus 로고
    • Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
    • Slamon DJ, Godolphin W, Jones LA, et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 1989;244:707-12.
    • (1989) Science , vol.244 , pp. 707-712
    • Slamon, D.J.1    Godolphin, W.2    Jones, L.A.3
  • 4
    • 0023748414 scopus 로고
    • Genetic alterations during colorectal-tumor development
    • Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988;319:525-32.
    • (1988) N Engl J Med , vol.319 , pp. 525-532
    • Vogelstein, B.1    Fearon, E.R.2    Hamilton, S.R.3
  • 5
    • 0024376173 scopus 로고    scopus 로고
    • Bos JL. ras oncogenes in human cancer: a review. Cancer Res 1989;49:4682-9.
    • Bos JL. ras oncogenes in human cancer: a review. Cancer Res 1989;49:4682-9.
  • 6
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997;275:1943-7.
    • (1997) Science , vol.275 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3
  • 7
    • 84984777123 scopus 로고    scopus 로고
    • PTEN1 is frequently mutated in primary endometrial carcinomas
    • Kong D, Suzuki A, Zou TT, et al. PTEN1 is frequently mutated in primary endometrial carcinomas. Nat Genet 1997;17:143-4.
    • (1997) Nat Genet , vol.17 , pp. 143-144
    • Kong, D.1    Suzuki, A.2    Zou, T.T.3
  • 8
    • 11144358645 scopus 로고    scopus 로고
    • High frequency of mutations of the PIK3CA gene in human cancers
    • Samuels Y, Wang Z, Bardelli A, et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004;304:554.
    • (2004) Science , vol.304 , pp. 554
    • Samuels, Y.1    Wang, Z.2    Bardelli, A.3
  • 9
    • 1442274619 scopus 로고    scopus 로고
    • Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma
    • Tsao H, Goel V, Wu H, et al. Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma. J Invest Dermatol 2004;122:337-41.
    • (2004) J Invest Dermatol , vol.122 , pp. 337-341
    • Tsao, H.1    Goel, V.2    Wu, H.3
  • 10
    • 20144387695 scopus 로고    scopus 로고
    • PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma
    • Saal LH, Holm K, Maurer M, et al. PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res 2005;65:2554-9.
    • (2005) Cancer Res , vol.65 , pp. 2554-2559
    • Saal, L.H.1    Holm, K.2    Maurer, M.3
  • 11
    • 28244490997 scopus 로고    scopus 로고
    • High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma
    • Oda K, Stokoe D, Taketani Y, et al. High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma. Cancer Res 2005;65:10669-73.
    • (2005) Cancer Res , vol.65 , pp. 10669-10673
    • Oda, K.1    Stokoe, D.2    Taketani, Y.3
  • 12
    • 23844445836 scopus 로고    scopus 로고
    • Colorectal cancer: Mutations in a signalling pathway
    • Parsons DW, Wang TL, Samuels Y, et al. Colorectal cancer: mutations in a signalling pathway. Nature 2005;436:792.
    • (2005) Nature , vol.436 , pp. 792
    • Parsons, D.W.1    Wang, T.L.2    Samuels, Y.3
  • 13
    • 0342819718 scopus 로고
    • Mutations in the KRAS2 oncogene during progressive stages of human colon carcinoma
    • Burmer GC, Loeb LA. Mutations in the KRAS2 oncogene during progressive stages of human colon carcinoma. Proc Natl Acad Sci U S A 1989;86:2403-7.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 2403-2407
    • Burmer, G.C.1    Loeb, L.A.2
  • 14
    • 33845530231 scopus 로고    scopus 로고
    • Improved marker combination for detection of de novo genetic variation and aberrant DNA in colorectal neoplasia
    • Kann L, Han J, Ahlquist D, et al. Improved marker combination for detection of de novo genetic variation and aberrant DNA in colorectal neoplasia. Clin Chem 2006;52:2299-302.
    • (2006) Clin Chem , vol.52 , pp. 2299-2302
    • Kann, L.1    Han, J.2    Ahlquist, D.3
  • 15
    • 0026500084 scopus 로고
    • c-erbB-2 overexpression and histological type of in situ and invasive breast carcinoma
    • Somerville JE, Clarke LA, Biggart JD. c-erbB-2 overexpression and histological type of in situ and invasive breast carcinoma. J Clin Pathol 1992;45:16-20.
    • (1992) J Clin Pathol , vol.45 , pp. 16-20
    • Somerville, J.E.1    Clarke, L.A.2    Biggart, J.D.3
  • 16
    • 0036901502 scopus 로고    scopus 로고
    • The role of HER2/ neu overexpression/amplification in the progression of ductal carcinoma in situ to invasive carcinoma of the breast
    • Latta EK, Tjan S, Parkes RK, et al. The role of HER2/ neu overexpression/amplification in the progression of ductal carcinoma in situ to invasive carcinoma of the breast. Mod Pathol 2002;15:1318-25.
    • (2002) Mod Pathol , vol.15 , pp. 1318-1325
    • Latta, E.K.1    Tjan, S.2    Parkes, R.K.3
  • 17
    • 33646007353 scopus 로고    scopus 로고
    • HER2 status in pure ductal carcinoma in situ and in the intraductal and invasive components of invasive ductal carcinoma determined by fluorescence in situ hybridization and immunohistochemistry
    • Park K, Han S, Kim HJ, et al. HER2 status in pure ductal carcinoma in situ and in the intraductal and invasive components of invasive ductal carcinoma determined by fluorescence in situ hybridization and immunohistochemistry. Histopathology 2006;48:702-7.
    • (2006) Histopathology , vol.48 , pp. 702-707
    • Park, K.1    Han, S.2    Kim, H.J.3
  • 18
    • 0035220843 scopus 로고    scopus 로고
    • Mutational analysis of the PTEN gene in endometrial carcinoma and hyperplasia
    • Sun H, Enomoto T, Fujita M, et al. Mutational analysis of the PTEN gene in endometrial carcinoma and hyperplasia. Am J Clin Pathol 2001;115:32-8.
    • (2001) Am J Clin Pathol , vol.115 , pp. 32-38
    • Sun, H.1    Enomoto, T.2    Fujita, M.3
  • 19
    • 33750698981 scopus 로고    scopus 로고
    • PIK3CA and PTEN mutations in uterine endometrioid carcinoma and complex atypical hyperplasia
    • Hayes MP, Wang H, Espinal Witter R, et al. PIK3CA and PTEN mutations in uterine endometrioid carcinoma and complex atypical hyperplasia. Clin Cancer Res 2006;12:5932-5.
    • (2006) Clin Cancer Res , vol.12 , pp. 5932-5935
    • Hayes, M.P.1    Wang, H.2    Espinal Witter, R.3
  • 20
    • 33846854921 scopus 로고    scopus 로고
    • Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women
    • Maruyama N, Miyoshi Y, Taguchi T, et al. Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women. Clin Cancer Res 2007;13:408-14.
    • (2007) Clin Cancer Res , vol.13 , pp. 408-414
    • Maruyama, N.1    Miyoshi, Y.2    Taguchi, T.3
  • 21
    • 27644556527 scopus 로고    scopus 로고
    • Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance
    • Lim KH, Counter CM. Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance. Cancer Cell 2005;8:381-92.
    • (2005) Cancer Cell , vol.8 , pp. 381-392
    • Lim, K.H.1    Counter, C.M.2
  • 22
    • 28844448182 scopus 로고    scopus 로고
    • Oncogenic PI3K deregulates transcription and translation
    • Bader AG, Kang S, Zhao L, et al. Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer 2005;5:921-9.
    • (2005) Nat Rev Cancer , vol.5 , pp. 921-929
    • Bader, A.G.1    Kang, S.2    Zhao, L.3
  • 23
    • 31944448780 scopus 로고    scopus 로고
    • Oncogenic transformation induced by the p110β, -γ, and -δ isoforms of class I phosphoinositide 3-kinase
    • Kang S, Denley A, Vanhaesebroeck B, et al. Oncogenic transformation induced by the p110β, -γ, and -δ isoforms of class I phosphoinositide 3-kinase. Proc Natl Acad Sci U S A 2006;103:1289-94.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 1289-1294
    • Kang, S.1    Denley, A.2    Vanhaesebroeck, B.3
  • 24
    • 14644395545 scopus 로고    scopus 로고
    • REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase
    • Schwarzer R, Tondera D, Arnold W, et al. REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase. Oncogene 2005;24:1138-49.
    • (2005) Oncogene , vol.24 , pp. 1138-1149
    • Schwarzer, R.1    Tondera, D.2    Arnold, W.3
  • 25
    • 0035177216 scopus 로고    scopus 로고
    • Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
    • Elenbaas B, Spirio L, Koerner F, et al. Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev 2001;15:50-65.
    • (2001) Genes Dev , vol.15 , pp. 50-65
    • Elenbaas, B.1    Spirio, L.2    Koerner, F.3
  • 26
    • 0034802755 scopus 로고    scopus 로고
    • PTEN mutation located only outside exons 5, 6, and 7 is an independent predictor of favorable survival in endometrial carcinomas
    • Minaguchi T, Yoshikawa H, Oda K, et al. PTEN mutation located only outside exons 5, 6, and 7 is an independent predictor of favorable survival in endometrial carcinomas. Clin Cancer Res 2001;7:2636-42.
    • (2001) Clin Cancer Res , vol.7 , pp. 2636-2642
    • Minaguchi, T.1    Yoshikawa, H.2    Oda, K.3
  • 27
    • 33845209913 scopus 로고    scopus 로고
    • A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
    • Neve RM, Chin K, Fridlyand J, et al. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 2006;10:515-27.
    • (2006) Cancer Cell , vol.10 , pp. 515-527
    • Neve, R.M.1    Chin, K.2    Fridlyand, J.3
  • 28
    • 32244445352 scopus 로고    scopus 로고
    • PIK3CA mutation and histological type in breast carcinoma: High frequency of mutations in lobular carcinoma
    • Buttitta F, Felicioni L, Barassi F, et al. PIK3CA mutation and histological type in breast carcinoma: high frequency of mutations in lobular carcinoma. J Pathol 2006;208:350-5.
    • (2006) J Pathol , vol.208 , pp. 350-355
    • Buttitta, F.1    Felicioni, L.2    Barassi, F.3
  • 29
    • 0042307325 scopus 로고    scopus 로고
    • The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation
    • Holbro T, Beerli RR, Maurer F, et al. The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation. Proc Natl Acad Sci U S A 2003;100:8933-8.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8933-8938
    • Holbro, T.1    Beerli, R.R.2    Maurer, F.3
  • 30
    • 0031730476 scopus 로고    scopus 로고
    • Expression of c-erbB3 protein in primary breast carcinomas
    • Naidu R, Yadav M, Nair S, et al. Expression of c-erbB3 protein in primary breast carcinomas. Br J Cancer 1998;78:1385-90.
    • (1998) Br J Cancer , vol.78 , pp. 1385-1390
    • Naidu, R.1    Yadav, M.2    Nair, S.3
  • 31
    • 0037422206 scopus 로고    scopus 로고
    • Activation of ErbB3-3-kinase pathway is correlated with malignant phenotypes of adenocarcinomas
    • Kobayashi M, Iwamatsu A, Shinohara Kanda A, et al. Activation of ErbB3-3-kinase pathway is correlated with malignant phenotypes of adenocarcinomas. Oncogene 2003;22:1294-301.
    • (2003) Oncogene , vol.22 , pp. 1294-1301
    • Kobayashi, M.1    Iwamatsu, A.2    Shinohara Kanda, A.3
  • 32
    • 33847738628 scopus 로고    scopus 로고
    • Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b
    • Scott GK, Goga A, Bhaumik D, et al. Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b. J Biol Chem 2007;282:1479-86.
    • (2007) J Biol Chem , vol.282 , pp. 1479-1486
    • Scott, G.K.1    Goga, A.2    Bhaumik, D.3
  • 33
    • 0036279974 scopus 로고    scopus 로고
    • Reduced expression of PTEN correlates with breast cancer progression
    • Bose S, Crane A, Hibshoosh H, et al. Reduced expression of PTEN correlates with breast cancer progression. Hum Pathol 2002;33:405-9.
    • (2002) Hum Pathol , vol.33 , pp. 405-409
    • Bose, S.1    Crane, A.2    Hibshoosh, H.3
  • 34
    • 11144353897 scopus 로고    scopus 로고
    • Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor
    • Kalinichenko VV, Major ML, Wang X, et al. Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor. Genes Dev 2004;18:830-50.
    • (2004) Genes Dev , vol.18 , pp. 830-850
    • Kalinichenko, V.V.1    Major, M.L.2    Wang, X.3
  • 35
    • 33646383684 scopus 로고    scopus 로고
    • A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling
    • Knight ZA, Gonzalez B, Feldman ME, et al. A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling. Cell 2006;125:733-47.
    • (2006) Cell , vol.125 , pp. 733-747
    • Knight, Z.A.1    Gonzalez, B.2    Feldman, M.E.3
  • 36
    • 7444250290 scopus 로고    scopus 로고
    • Mutation of the PIK3CA gene in ovarian and breast cancer
    • Campbell IG, Russell SE, Choong DY, et al. Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res 2004;64:7678-81.
    • (2004) Cancer Res , vol.64 , pp. 7678-7681
    • Campbell, I.G.1    Russell, S.E.2    Choong, D.Y.3
  • 37
    • 14144252004 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
    • Kang S, Bader AG, Vogt PK. Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. Proc Natl Acad Sci U S A 2005;102:802-7.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 802-807
    • Kang, S.1    Bader, A.G.2    Vogt, P.K.3
  • 38
    • 20444374445 scopus 로고    scopus 로고
    • Mutant PIK3CA promotes cell growth and invasion of human cancer cells
    • Samuels Y, Diaz LA, Jr., Schmidt-Kittler O, et al. Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell 2005;7:561-73.
    • (2005) Cancer Cell , vol.7 , pp. 561-573
    • Samuels, Y.1    Diaz Jr., L.A.2    Schmidt-Kittler, O.3
  • 39
    • 31944444234 scopus 로고    scopus 로고
    • Cancer-specific mutations in PIK3CA are oncogenic in vivo
    • Bader AG, Kang S, Vogt PK. Cancer-specific mutations in PIK3CA are oncogenic in vivo. Proc Natl Acad Sci U S A 2006;103:1475-9.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 1475-1479
    • Bader, A.G.1    Kang, S.2    Vogt, P.K.3
  • 40
    • 33644507072 scopus 로고    scopus 로고
    • Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells
    • Sato M, Vaughan MB, Girard L, et al. Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells. Cancer Res 2006;66:2116-28.
    • (2006) Cancer Res , vol.66 , pp. 2116-2128
    • Sato, M.1    Vaughan, M.B.2    Girard, L.3
  • 41
    • 0344784889 scopus 로고    scopus 로고
    • Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase
    • Zhao JJ, Gjoerup OV, Subramanian RR, et al. Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase. Cancer Cell 2003;3:483-95.
    • (2003) Cancer Cell , vol.3 , pp. 483-495
    • Zhao, J.J.1    Gjoerup, O.V.2    Subramanian, R.R.3
  • 42
    • 33947199328 scopus 로고    scopus 로고
    • K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling
    • Campbell PM, Groehler AL, Lee KM, et al. K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling. Cancer Res 2007;67:2098-106.
    • (2007) Cancer Res , vol.67 , pp. 2098-2106
    • Campbell, P.M.1    Groehler, A.L.2    Lee, K.M.3
  • 43
    • 0032146038 scopus 로고    scopus 로고
    • PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma
    • Levine RL, Cargile CB, Blazes MS, et al. PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma. Cancer Res 1998;58:3254-8.
    • (1998) Cancer Res , vol.58 , pp. 3254-3258
    • Levine, R.L.1    Cargile, C.B.2    Blazes, M.S.3
  • 44
    • 0034671218 scopus 로고    scopus 로고
    • Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: Possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary
    • Sato N, Tsunoda H, Nishida M, et al. Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary. Cancer Res 2000;60:7052-6.
    • (2000) Cancer Res , vol.60 , pp. 7052-7056
    • Sato, N.1    Tsunoda, H.2    Nishida, M.3
  • 45
    • 13444269246 scopus 로고    scopus 로고
    • Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer
    • Dinulescu DM, Ince TA, Quade BJ, et al. Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer. Nat Med 2005;11:63-70.
    • (2005) Nat Med , vol.11 , pp. 63-70
    • Dinulescu, D.M.1    Ince, T.A.2    Quade, B.J.3
  • 46
    • 0034175984 scopus 로고    scopus 로고
    • Understanding Ras: It ain't over 'til it's over
    • Shields JM, Pruitt K, McFall A, et al. Understanding Ras: "it ain't over 'til it's over." Trends Cell Biol 2000;10:147-54.
    • (2000) Trends Cell Biol , vol.10 , pp. 147-154
    • Shields, J.M.1    Pruitt, K.2    McFall, A.3
  • 48
    • 0034635221 scopus 로고    scopus 로고
    • Roles of PLC-β2 and -β3 and PI3Kγ in chemoattractant-mediated signal transduction
    • Li Z, Jiang H, Xie W, et al. Roles of PLC-β2 and -β3 and PI3Kγ in chemoattractant-mediated signal transduction. Science 2000;287:1046-9.
    • (2000) Science , vol.287 , pp. 1046-1049
    • Li, Z.1    Jiang, H.2    Xie, W.3
  • 49
    • 34347395733 scopus 로고    scopus 로고
    • Trastuzumab-mechanism of action and use in clinical practice
    • Hudis CA. Trastuzumab-mechanism of action and use in clinical practice. N Engl J Med 2007;357:39-51.
    • (2007) N Engl J Med , vol.357 , pp. 39-51
    • Hudis, C.A.1


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