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Volumn 20, Issue 1, 2015, Pages 1610-1625

Triterpenes as potentially cytotoxic compounds

Author keywords

Cytotoxicity; Triterpenes

Indexed keywords

TRITERPENE;

EID: 84921672973     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules20011610     Document Type: Review
Times cited : (158)

References (98)
  • 1
    • 84921697863 scopus 로고    scopus 로고
    • accessed on 26 October 2014
    • World Health Organization. Available online: http://www.who.int/mediacentre/factsheets/fs297/en/ (accessed on 26 October 2014).
  • 3
    • 84878936959 scopus 로고    scopus 로고
    • Pentacyclic triterpenes from Manilkara bidentata resin. Isolation, identification and biological properties
    • Rhourri-Frih, B.; Renimel, I.; Chaimbault, P.; André, P.; Herbette, G.; Lafosse, M. Pentacyclic triterpenes from Manilkara bidentata resin. Isolation, identification and biological properties. Fitoterapia 2013, 88, 101-108.
    • (2013) Fitoterapia , vol.88 , pp. 101-108
    • Rhourri-Frih, B.1    Renimel, I.2    Chaimbault, P.3    André, P.4    Herbette, G.5    Lafosse, M.6
  • 4
    • 84865158204 scopus 로고    scopus 로고
    • Bioguided isolation of pentacyclic triterpenes from the leaves of Alstonia scholaris (Linn.) R. Br. Growing in Egypt
    • El-Askary, H.I.; El-Olemy, M.M.; Salama, M.M.; Sleem, A.A.; Amer, M.H. Bioguided isolation of pentacyclic triterpenes from the leaves of Alstonia scholaris (Linn.) R. Br. growing in Egypt. Nat. Prod. Res. 2012, 26, 1755-1758.
    • (2012) Nat. Prod. Res. , vol.26 , pp. 1755-1758
    • El-Askary, H.I.1    El-Olemy, M.M.2    Salama, M.M.3    Sleem, A.A.4    Amer, M.H.5
  • 5
    • 84883246221 scopus 로고    scopus 로고
    • Triterpene glycosides from the sea cucumber Eupentacta fraudatrix. Structure and biological action of cucumariosides I1, I3, I4, three new minor disulfated pentaosides
    • Silchenko, A.S.; Kalinovsky, A.I.; Avilov, S.A.; Andryjaschenko, P.V.; Dmitrenok, P.S.; Martyyas, E.A.; Kalinin, V.I. Triterpene glycosides from the sea cucumber Eupentacta fraudatrix. Structure and biological action of cucumariosides I1, I3, I4, three new minor disulfated pentaosides. Nat. Prod. Commun. 2013, 8, 1053-1058.
    • (2013) Nat. Prod. Commun. , vol.8 , pp. 1053-1058
    • Silchenko, A.S.1    Kalinovsky, A.I.2    Avilov, S.A.3    Andryjaschenko, P.V.4    Dmitrenok, P.S.5    Martyyas, E.A.6    Kalinin, V.I.7
  • 7
    • 84878263659 scopus 로고    scopus 로고
    • Lanostane triterpenoids from the mushroom Naematoloma fasciculare
    • Kim, K.H.; Moon, E.; Choi, S.U.; Kim, S.Y.; Lee, K.R. Lanostane triterpenoids from the mushroom Naematoloma fasciculare. J. Nat. Prod. 2013, 76, 845-851.
    • (2013) J. Nat. Prod. , vol.76 , pp. 845-851
    • Kim, K.H.1    Moon, E.2    Choi, S.U.3    Kim, S.Y.4    Lee, K.R.5
  • 8
    • 84890846334 scopus 로고    scopus 로고
    • Triterpenes from Euphorbia hirta and their cytotoxicity
    • Ragasa, C.Y.; Cornelio, K.B. Triterpenes from Euphorbia hirta and their cytotoxicity. Chin. J. Nat. Med. 2013, 11, 528-533.
    • (2013) Chin. J. Nat. Med. , vol.11 , pp. 528-533
    • Ragasa, C.Y.1    Cornelio, K.B.2
  • 9
    • 41149161673 scopus 로고    scopus 로고
    • 3rd ed.; Wydawnictwo Naukowe PWN: Warszawa, Poland
    • rd ed.; Wydawnictwo Naukowe PWN: Warszawa, Poland, 2005; pp. 1035-1045.
    • (2005) Chemia Organiczna , pp. 1035-1045
    • McMurry, J.1
  • 11
    • 58149357667 scopus 로고    scopus 로고
    • Betulinic acid: A natural product with anticancer activity
    • Fulda, S. Betulinic acid: A natural product with anticancer activity. Mol. Nutr. Food Res. 2009, 53, 140-146.
    • (2009) Mol. Nutr. Food Res. , vol.53 , pp. 140-146
    • Fulda, S.1
  • 12
    • 79955034094 scopus 로고    scopus 로고
    • Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer
    • Bishayee, A.; Ahmed, S.; Brankov, N.; Perloff, M. Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer. Front. Biosci. (Landmark Ed.) 2011, 16, 980-996.
    • (2011) Front. Biosci. (Landmark Ed.) , pp. 980-996
    • Bishayee, A.1    Ahmed, S.2    Brankov, N.3    Perloff, M.4
  • 18
    • 84877856260 scopus 로고    scopus 로고
    • Antimicrobial activity and cytotoxicity of triterpenes isolated from leaves of Maytenus undata (Celastraceae)
    • Mokoka, T.A.; McGaw, L.J.; Mdee, L.K.; Bagla, V.P.; Iwalewa, E.O.; Eloff, J.N. Antimicrobial activity and cytotoxicity of triterpenes isolated from leaves of Maytenus undata (Celastraceae). BMC Complement. Altern. Med. 2013, 13, doi:10.1186/1472-6882-13-111.
    • (2013) BMC Complement. Altern. Med. , vol.13
    • Mokoka, T.A.1    McGaw, L.J.2    Mdee, L.K.3    Bagla, V.P.4    Iwalewa, E.O.5    Eloff, J.N.6
  • 19
    • 84892553678 scopus 로고    scopus 로고
    • Design, synthesis, and anti-tumor activity of novel betulinic acid derivatives
    • Liu, J.H.; Tang, J.; Zhu, Z.F.; Chen, L. Design, synthesis, and anti-tumor activity of novel betulinic acid derivatives. J. Asian Nat. Prod. Res . 2014, 16, 34-42.
    • (2014) J. Asian Nat. Prod. Res , vol.16 , pp. 34-42
    • Liu, J.H.1    Tang, J.2    Zhu, Z.F.3    Chen, L.4
  • 22
    • 0035342477 scopus 로고    scopus 로고
    • An evaluation of the colorimetric assays based on enzymatic reactions used in the measurement of human natural cytotoxicity
    • Niu, Q.; Zhao, C.; Jing, Z. An evaluation of the colorimetric assays based on enzymatic reactions used in the measurement of human natural cytotoxicity. J. Immunol. Methods 2001, 251, 11-19.
    • (2001) J. Immunol. Methods , vol.251 , pp. 11-19
    • Niu, Q.1    Zhao, C.2    Jing, Z.3
  • 23
    • 46349084467 scopus 로고    scopus 로고
    • Comparison of four different colorimetric and fluorometric cytotoxicity assays in a zebrafish liver cell line
    • Bopp, S.K.; Lettieri, T. Comparison of four different colorimetric and fluorometric cytotoxicity assays in a zebrafish liver cell line. BMC Pharmacol. 2008, 8, doi:10.1186/1471-2210-8-8.
    • (2008) BMC Pharmacol. , vol.8
    • Bopp, S.K.1    Lettieri, T.2
  • 24
    • 0030514288 scopus 로고    scopus 로고
    • Comparison of two colorimetric assays as cytotoxicity endpoints for an in vitro screen for antitumour agents
    • Fricker, S.P.; Buckley, R.G. Comparison of two colorimetric assays as cytotoxicity endpoints for an in vitro screen for antitumour agents. Anticancer Res. 1996, 16, 3755-3760.
    • (1996) Anticancer Res. , vol.16 , pp. 3755-3760
    • Fricker, S.P.1    Buckley, R.G.2
  • 25
    • 84861196055 scopus 로고    scopus 로고
    • Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid
    • Urban, M.; VLK, M.; Dzubak, P.; Hajduch, M.; Sarek, J. Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid. Bioorg. Med. Chem. 2012, 20, 3666-3674.
    • (2012) Bioorg. Med. Chem. , vol.20 , pp. 3666-3674
    • Urban, M.1    Vlk, M.2    Dzubak, P.3    Hajduch, M.4    Sarek, J.5
  • 26
    • 84882292882 scopus 로고    scopus 로고
    • Preparation of betulinic acid derivatives by chemical and biotransformation methods and detrmination of cytotoxicity against selected cancer cell lines
    • Baratto, L.C.; Porsani, M.V.; Pimentel, I.C.; Pereira Netto, A.B.; Paschke, R.; Oliveira, B.H. Preparation of betulinic acid derivatives by chemical and biotransformation methods and detrmination of cytotoxicity against selected cancer cell lines. Eur. J. Med. Chem. 2013, 68, 121-131.
    • (2013) Eur. J. Med. Chem. , vol.68 , pp. 121-131
    • Baratto, L.C.1    Porsani, M.V.2    Pimentel, I.C.3    Pereira Netto, A.B.4    Paschke, R.5    Oliveira, B.H.6
  • 27
    • 84862796321 scopus 로고    scopus 로고
    • New ionic derivatives of betulinic acid as highly potent anti-cancer agents
    • Challa, S.; Zhao, H.; Gumbs, A.; Chetty, C.S.; Bose, H.S. New ionic derivatives of betulinic acid as highly potent anti-cancer agents. Bioorg. Med. Chem. Lett. 2012, 22, 1734-1738.
    • (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 1734-1738
    • Challa, S.1    Zhao, H.2    Gumbs, A.3    Chetty, C.S.4    Bose, H.S.5
  • 28
    • 79955855304 scopus 로고    scopus 로고
    • Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells
    • Chen, G.; Zhang, X.; Zhao, M.; Wang, Y.; Cheng, X.; Wang, D.; Xu, Y.; Du, Z.; Yu, X. Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells. BMC Cancer 2011, 11, doi:10.1186/1471-2407-11-170.
    • (2011) BMC Cancer , vol.11
    • Chen, G.1    Zhang, X.2    Zhao, M.3    Wang, Y.4    Cheng, X.5    Wang, D.6    Xu, Y.7    Du, Z.8    Yu, X.9
  • 30
    • 84862798176 scopus 로고    scopus 로고
    • Two new cytotoxic triterpenoid saponins from the roots of Clematis argentilucida
    • Hai, W.; Cheng, H.; Zhao, M.; Wang, Y.; Hong, L.; Tang, H.; Tian, X. Two new cytotoxic triterpenoid saponins from the roots of Clematis argentilucida. Fitoterapia 2012, 83, 759-764.
    • (2012) Fitoterapia , vol.83 , pp. 759-764
    • Hai, W.1    Cheng, H.2    Zhao, M.3    Wang, Y.4    Hong, L.5    Tang, H.6    Tian, X.7
  • 32
    • 80053623753 scopus 로고    scopus 로고
    • Triterpenes and a triterpene glucoside from Dysoxylum cumingianum
    • Kurimoto, S.; Kashiwada, Y.; Lee, K.H.; Takaishi, Y. Triterpenes and a triterpene glucoside from Dysoxylum cumingianum. Phytochemistry 2011, 72, 2205-2211.
    • (2011) Phytochemistry , vol.72 , pp. 2205-2211
    • Kurimoto, S.1    Kashiwada, Y.2    Lee, K.H.3    Takaishi, Y.4
  • 33
    • 84903644720 scopus 로고    scopus 로고
    • Cycloartane Triterpenoids from Euphorbia Macrostegia with their Cytotoxicity against MDA-MB48 and MCF-7 Cancer Cell Lines
    • Baniadam, S.; Rahiminejad, M.R.; Ghannadian, M.; Saeidi, H.; Ayatollahi, A.M.; Aghaei, M. Cycloartane Triterpenoids from Euphorbia Macrostegia with their Cytotoxicity against MDA-MB48 and MCF-7 Cancer Cell Lines. Iran J. Pharm. Res. 2014, 13, 135-141.
    • (2014) Iran J. Pharm. Res. , vol.13 , pp. 135-141
    • Baniadam, S.1    Rahiminejad, M.R.2    Ghannadian, M.3    Saeidi, H.4    Ayatollahi, A.M.5    Aghaei, M.6
  • 35
    • 84899089450 scopus 로고    scopus 로고
    • Three new cucurbitane triterpenoids from Hemsleya penxianensis and their cytotoxic activities
    • Xu, X.; Bai, H.; Zhou, L.; Deng, Z.; Zhong, H.; Wu, Z.; Yao, Q. Three new cucurbitane triterpenoids from Hemsleya penxianensis and their cytotoxic activities. Bioorg. Med. Chem. Lett. 2014, 24, 2159-2162.
    • (2014) Bioorg. Med. Chem. Lett. , vol.24 , pp. 2159-2162
    • Xu, X.1    Bai, H.2    Zhou, L.3    Deng, Z.4    Zhong, H.5    Wu, Z.6    Yao, Q.7
  • 36
    • 84864769489 scopus 로고    scopus 로고
    • Triterpene saponins from Pleurospermum kamtschaticum and their biological activity
    • Lee, I.K.; Choi, S.U.; Lee, K.R. Triterpene saponins from Pleurospermum kamtschaticum and their biological activity. Chem. Pharm. Bull. 2012, 60, 1011-1018.
    • (2012) Chem. Pharm. Bull. , vol.60 , pp. 1011-1018
    • Lee, I.K.1    Choi, S.U.2    Lee, K.R.3
  • 37
  • 39
    • 84860783215 scopus 로고    scopus 로고
    • Studies on the constituents of Cimicifuga foetida collected in Guizhou Province and their cytotoxic activities
    • Lu, L.; Chen, J.C.; Li, Y.; Qing, C.; Wang, Y.Y.; Nian, Y.; Qiu, M.H. Studies on the constituents of Cimicifuga foetida collected in Guizhou Province and their cytotoxic activities. Chem. Pharm. Bull. 2012, 60, 571-577.
    • (2012) Chem. Pharm. Bull. , vol.60 , pp. 571-577
    • Lu, L.1    Chen, J.C.2    Li, Y.3    Qing, C.4    Wang, Y.Y.5    Nian, Y.6    Qiu, M.H.7
  • 40
    • 84904792755 scopus 로고    scopus 로고
    • Comparison of the apoptotic effects of supercritical fluid extracts of Antrodia cinnamomea mycelia on hepatocellular carcinoma cells
    • Lien, H.M.; Chiu, C.H.; Chen, C.C.; Chang, W.L.; Chyau, C.C.; Peng, R.Y. Comparison of the apoptotic effects of supercritical fluid extracts of Antrodia cinnamomea mycelia on hepatocellular carcinoma cells. Molecules 2014, 19, 9033-9050.
    • (2014) Molecules , vol.19 , pp. 9033-9050
    • Lien, H.M.1    Chiu, C.H.2    Chen, C.C.3    Chang, W.L.4    Chyau, C.C.5    Peng, R.Y.6
  • 41
    • 84903828087 scopus 로고    scopus 로고
    • Cytotoxic effect of triterpenoids from the root bark of Hibiscus syriacus
    • Shi, L.S.; Wu, C.H.; Yang, T.C.; Yao, C.W.; Lin, H.C.; Chang, W.L. Cytotoxic effect of triterpenoids from the root bark of Hibiscus syriacus . Fitoterapia 2014, 97, 184-191.
    • (2014) Fitoterapia , vol.97 , pp. 184-191
    • Shi, L.S.1    Wu, C.H.2    Yang, T.C.3    Yao, C.W.4    Lin, H.C.5    Chang, W.L.6
  • 45
    • 84916597314 scopus 로고    scopus 로고
    • Separation of triterpenoid saponins from the root of Bupleurum falcatum by counter current chromatography: The relationship between the partition coefficients and solvent system composition
    • Lee, K.J.; Xu, M.Y.; Shehzad, O.; Seo, E.K.; Kim, Y.S. Separation of triterpenoid saponins from the root of Bupleurum falcatum by counter current chromatography: The relationship between the partition coefficients and solvent system composition. J. Sep. Sci. 2014, 37, 3587-3594.
    • (2014) J. Sep. Sci. , vol.37 , pp. 3587-3594
    • Lee, K.J.1    Xu, M.Y.2    Shehzad, O.3    Seo, E.K.4    Kim, Y.S.5
  • 46
    • 84897611761 scopus 로고    scopus 로고
    • Caspicaosides E-K, triterpenoid saponins and cytotoxic acylated saponins from fruits of Gleditsia caspica Desf
    • Melek, F.R.; Kassem, I.A.; Miyase, T.; Fayad, W. Caspicaosides E-K, triterpenoid saponins and cytotoxic acylated saponins from fruits of Gleditsia caspica Desf. Phytochemistry 2014, 100, 110-119.
    • (2014) Phytochemistry , vol.100 , pp. 110-119
    • Melek, F.R.1    Kassem, I.A.2    Miyase, T.3    Fayad, W.4
  • 48
    • 84918787825 scopus 로고    scopus 로고
    • Triterpenoid saponin augmention of saporin-based immunotoxin cytotoxicity for human leukaemia and lymphoma cells is partially immunospecific and target molecule dependent
    • Holmes, S.E.; Bachran, C.; Fuchs, H.; Weng, A.; Melzig, M.F.; Flavell, S.U.; Flavell, D.J. Triterpenoid saponin augmention of saporin-based immunotoxin cytotoxicity for human leukaemia and lymphoma cells is partially immunospecific and target molecule dependent. Immunopharmacol. Immunotoxicol. 2015, 37, 42-55.
    • (2015) Immunopharmacol. Immunotoxicol. , vol.37 , pp. 42-55
    • Holmes, S.E.1    Bachran, C.2    Fuchs, H.3    Weng, A.4    Melzig, M.F.5    Flavell, S.U.6    Flavell, D.J.7
  • 49
    • 84903934720 scopus 로고    scopus 로고
    • Triterpenoid saponins from the roots of Clematis argentilucida
    • Zhao, M.; Ma, N.; Qiu, F.; Tian, X.; Zhang, Y.; Tang, H.; Liu, X. Triterpenoid saponins from the roots of Clematis argentilucida. Fitoterapia 2014, 97, 234-240.
    • (2014) Fitoterapia , vol.97 , pp. 234-240
    • Zhao, M.1    Ma, N.2    Qiu, F.3    Tian, X.4    Zhang, Y.5    Tang, H.6    Liu, X.7
  • 51
    • 32044438924 scopus 로고    scopus 로고
    • Limonoids: Overview of significant bioactive triterpenes distributed in plants kingdom
    • Roy, A.; Saraf, S. Limonoids: Overview of significant bioactive triterpenes distributed in plants kingdom. Biol. Pharm. Bull. 2006, 29, 191-201.
    • (2006) Biol. Pharm. Bull. , vol.29 , pp. 191-201
    • Roy, A.1    Saraf, S.2
  • 52
    • 84906691749 scopus 로고    scopus 로고
    • Limonoids from the Leaves and Twigs of Walsura yunnanensis
    • Ji, K.L.; Zhang, P.; Hu, H.B.; Hua, S.; Liao, S.G.; Xu, Y.K. Limonoids from the Leaves and Twigs of Walsura yunnanensis. J. Nat. Prod. 2014, 77, 1764-1769.
    • (2014) J. Nat. Prod. , vol.77 , pp. 1764-1769
    • Ji, K.L.1    Zhang, P.2    Hu, H.B.3    Hua, S.4    Liao, S.G.5    Xu, Y.K.6
  • 54
    • 84875124615 scopus 로고    scopus 로고
    • Cytotoxic constituents from the fungus Daldinia colconcentrica (Xylariaceae)
    • Quang, D.N.; Lam, D.M.; Hanh, N.T.; Que, D.D. Cytotoxic constituents from the fungus Daldinia colconcentrica (Xylariaceae). Nat. Prod. Res. 2013, 27, 486-490.
    • (2013) Nat. Prod. Res. , vol.27 , pp. 486-490
    • Quang, D.N.1    Lam, D.M.2    Hanh, N.T.3    Que, D.D.4
  • 58
    • 77955379648 scopus 로고    scopus 로고
    • Anticancer activity of 3-O-acylated betulinic acid derivatives obtained by enzymatic synthesis
    • Ahmad, F.B.; Ghaffari Moghaddam, M.; Basri, M.; Abdul Rahman, M.B. Anticancer activity of 3-O-acylated betulinic acid derivatives obtained by enzymatic synthesis. Biosci. Biotechnol. Biochem. 2010, 74, 1025-1029.
    • (2010) Biosci. Biotechnol. Biochem. , vol.74 , pp. 1025-1029
    • Ahmad, F.B.1    Ghaffari Moghaddam, M.2    Basri, M.3    Abdul Rahman, M.B.4
  • 59
    • 68649104244 scopus 로고    scopus 로고
    • Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity
    • Santos, R.C.; Salvador, J.A.; Marín, S.; Cascante, M. Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity. Bioorg. Med. Chem. 2009, 17, 6241-6250.
    • (2009) Bioorg. Med. Chem. , vol.17 , pp. 6241-6250
    • Santos, R.C.1    Salvador, J.A.2    Marín, S.3    Cascante, M.4
  • 61
    • 63549116461 scopus 로고    scopus 로고
    • Synthesis, cytotoxicity, and haemolytic activity of chacotrioside lupane-type neosaponins and their germanicane-type rearrangement products
    • Gauthier, C.; Legault, J.; Piochon, M.; Lavoie, S.; Tremblay, S.; Pichette, A. Synthesis, cytotoxicity, and haemolytic activity of chacotrioside lupane-type neosaponins and their germanicane-type rearrangement products. Bioorg. Med. Chem. Lett. 2009, 19, 2310-2314.
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 2310-2314
    • Gauthier, C.1    Legault, J.2    Piochon, M.3    Lavoie, S.4    Tremblay, S.5    Pichette, A.6
  • 62
    • 84886735294 scopus 로고    scopus 로고
    • PI3-kinase inhibition synergistically promoted the anti-tumor effect of lupeol in hepatocellular carcinoma
    • Liu, F.; He, Y.; Liang, Y.; Wen, L.; Zhu, Y.; Wu, Y.; Zhao, L.; Li, Y.; Mao, X.; Liu, H. PI3-kinase inhibition synergistically promoted the anti-tumor effect of lupeol in hepatocellular carcinoma. Cancer Cell Int. 2013, 13, doi:10.1186/1475-2867-13-108.
    • (2013) Cancer Cell Int. , vol.13
    • Liu, F.1    He, Y.2    Liang, Y.3    Wen, L.4    Zhu, Y.5    Wu, Y.6    Zhao, L.7    Li, Y.8    Mao, X.9    Liu, H.10
  • 63
    • 79953768579 scopus 로고    scopus 로고
    • Growth inhibition and apoptosis induced by lupeol, a dietary triterpene, in human hepatocellular carcinoma cells
    • He, Y.; Liu, F.; Zhang, L.; Wu, Y.; Hu, B.; Zhang, Y.; Li, Y.; Liu, H. Growth inhibition and apoptosis induced by lupeol, a dietary triterpene, in human hepatocellular carcinoma cells. Biol. Pharm. Bull. 2011, 34, 517-522.
    • (2011) Biol. Pharm. Bull. , vol.34 , pp. 517-522
    • He, Y.1    Liu, F.2    Zhang, L.3    Wu, Y.4    Hu, B.5    Zhang, Y.6    Li, Y.7    Liu, H.8
  • 64
    • 84886769058 scopus 로고    scopus 로고
    • The dietary terpene lupeol targets colorectal cancer cells with constitutively active Wnt/β-catenin signaling
    • Tarapore, R.S.; Siddiqui, I.A.; Adhami, V.M.; Spiegelman, V.S.; Mukhtar, H. The dietary terpene lupeol targets colorectal cancer cells with constitutively active Wnt/β-catenin signaling. Mol. Nutr. Food Res. 2013, 57, 1950-1958.
    • (2013) Mol. Nutr. Food Res. , vol.57 , pp. 1950-1958
    • Tarapore, R.S.1    Siddiqui, I.A.2    Adhami, V.M.3    Spiegelman, V.S.4    Mukhtar, H.5
  • 66
    • 84863552204 scopus 로고    scopus 로고
    • Ursolic acid from Oldenlandia diffusa induces apoptosis via activation of caspases and phosphorylation of glycogen synthase kinase 3 beta in SK-OV-3 ovarian cancer cells
    • Song, Y.H.; Jeong, S.J.; Kwon, H.Y.; Kim, B.; Kim, S.H.; Yoo, D.Y. Ursolic acid from Oldenlandia diffusa induces apoptosis via activation of caspases and phosphorylation of glycogen synthase kinase 3 beta in SK-OV-3 ovarian cancer cells. Biol. Pharm. Bull. 2012, 35, 1022-1028.
    • (2012) Biol. Pharm. Bull. , vol.35 , pp. 1022-1028
    • Song, Y.H.1    Jeong, S.J.2    Kwon, H.Y.3    Kim, B.4    Kim, S.H.5    Yoo, D.Y.6
  • 67
    • 84863432050 scopus 로고    scopus 로고
    • Ursolic acid inhibits growth and induces apoptosis in gemcitabine-resistant human pancreatic cancer via the JNK and PI3K/Akt/NF-κB pathways
    • Li, J.; Liang, X.; Yang, X. Ursolic acid inhibits growth and induces apoptosis in gemcitabine-resistant human pancreatic cancer via the JNK and PI3K/Akt/NF-κB pathways. Oncol. Rep. 2012, 28, 501-510.
    • (2012) Oncol. Rep. , vol.28 , pp. 501-510
    • Li, J.1    Liang, X.2    Yang, X.3
  • 68
    • 84894118193 scopus 로고    scopus 로고
    • Inhibition of Wnt/β-catenin signaling mediates ursolic acid-induced apoptosis in PC-3 prostate cancer cells
    • Park, J.H.; Kwon, H.Y.; Sohn, E.J.; Kim, K.A.; Kim, B.; Jeong, S.J.; Song, J.H.; Koo, J.S.; Kim, S.H. Inhibition of Wnt/β-catenin signaling mediates ursolic acid-induced apoptosis in PC-3 prostate cancer cells. Pharmacol. Rep. 2013, 65, 1366-1374.
    • (2013) Pharmacol. Rep. , vol.65 , pp. 1366-1374
    • Park, J.H.1    Kwon, H.Y.2    Sohn, E.J.3    Kim, K.A.4    Kim, B.5    Jeong, S.J.6    Song, J.H.7    Koo, J.S.8    Kim, S.H.9
  • 69
    • 84883157800 scopus 로고    scopus 로고
    • Cytotoxic activity of ursolic acid derivatives obtained by isolation and oxidative derivatization
    • Mazumder, K.; Tanaka, K.; Fukase, K. Cytotoxic activity of ursolic acid derivatives obtained by isolation and oxidative derivatization. Molecules 2013, 18, 8929-8944.
    • (2013) Molecules , vol.18 , pp. 8929-8944
    • Mazumder, K.1    Tanaka, K.2    Fukase, K.3
  • 70
    • 79957503743 scopus 로고    scopus 로고
    • In vitro and in vivo anticancer activity evaluation of ursolic acid derivatives
    • Shao, J.W.; Dai, Y.C.; Xue, J.P.; Wang, J.C.; Lin, F.P.; Guo, Y.H. In vitro and in vivo anticancer activity evaluation of ursolic acid derivatives. Eur. J. Med. Chem. 2011, 46, 2652-2661.
    • (2011) Eur. J. Med. Chem. , vol.46 , pp. 2652-2661
    • Shao, J.W.1    Dai, Y.C.2    Xue, J.P.3    Wang, J.C.4    Lin, F.P.5    Guo, Y.H.6
  • 71
    • 84868242594 scopus 로고    scopus 로고
    • Synthesis and cytotoxicity of novel ursolic acid derivatives containing an acyl piperazine moiety
    • Liu, M.C.; Yang, S.J.; Jin, L.H.; Hu, D.Y.; Xue, W.; Song, B.A.; Yang, S. Synthesis and cytotoxicity of novel ursolic acid derivatives containing an acyl piperazine moiety. Eur. J. Med. Chem. 2012, 58, 128-135.
    • (2012) Eur. J. Med. Chem. , vol.58 , pp. 128-135
    • Liu, M.C.1    Yang, S.J.2    Jin, L.H.3    Hu, D.Y.4    Xue, W.5    Song, B.A.6    Yang, S.7
  • 72
    • 84862808482 scopus 로고    scopus 로고
    • Synthesis and evaluation of ursolic acid derivatives as potent cytotoxic agents
    • Bai, K.K.; Yu, Z.; Chen, F.L.; Li, F.; Li, W.Y.; Guo, Y.H. Synthesis and evaluation of ursolic acid derivatives as potent cytotoxic agents. Bioorg. Med. Chem. Lett. 2012, 22, 2488-2493.
    • (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 2488-2493
    • Bai, K.K.1    Yu, Z.2    Chen, F.L.3    Li, F.4    Li, W.Y.5    Guo, Y.H.6
  • 73
    • 71749115319 scopus 로고    scopus 로고
    • Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species
    • Tu, H.Y.; Huang, A.M.; Wei, B.L.; Gan, K.H.; Hour, T.C.; Yang, S.C.; Pu, Y.S.; Lin, C.N. Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species. Bioorg. Med. Chem. 2009, 17, 7265-7274.
    • (2009) Bioorg. Med. Chem. , vol.17 , pp. 7265-7274
    • Tu, H.Y.1    Huang, A.M.2    Wei, B.L.3    Gan, K.H.4    Hour, T.C.5    Yang, S.C.6    Pu, Y.S.7    Lin, C.N.8
  • 74
    • 84919399202 scopus 로고    scopus 로고
    • Anti-cancer effects of ursane triterpenoid as a single agent and in combination with cisplatin in bladder cancer
    • Lin, K.W.; Huang, A.M.; Lin, C.C.; Chang, C.C.; Hsu, W.C.; Hour, T.C.; Pu, Y.S.; Lin, C.N. Anti-cancer effects of ursane triterpenoid as a single agent and in combination with cisplatin in bladder cancer. Eur. J. Pharmacol . 2014, 740, 742-751.
    • (2014) Eur. J. Pharmacol , vol.740 , pp. 742-751
    • Lin, K.W.1    Huang, A.M.2    Lin, C.C.3    Chang, C.C.4    Hsu, W.C.5    Hour, T.C.6    Pu, Y.S.7    Lin, C.N.8
  • 75
    • 84890816801 scopus 로고    scopus 로고
    • The chemical and biological potential of C ring modified triterpenoids
    • Siewert, B.; Wiemann, J.; Köwitsch, A.; Csuk, R. The chemical and biological potential of C ring modified triterpenoids. Eur. J. Med. Chem. 2013, 72, 84-101.
    • (2013) Eur. J. Med. Chem. , vol.72 , pp. 84-101
    • Siewert, B.1    Wiemann, J.2    Köwitsch, A.3    Csuk, R.4
  • 76
    • 84872675334 scopus 로고    scopus 로고
    • Apoptosis-induced cell death due to oleanolic acid in HaCaT keratinocyte cells-A proof-of-principle approach for chemopreventive drug development
    • George, V.C.; Kumar, D.R.; Suresh, P.K.; Kumar, R.A. Apoptosis-induced cell death due to oleanolic acid in HaCaT keratinocyte cells-A proof-of-principle approach for chemopreventive drug development. Asian Pac. J. Cancer Prev. 2012, 13, 2015-2020.
    • (2012) Asian Pac. J. Cancer Prev. , vol.13 , pp. 2015-2020
    • George, V.C.1    Kumar, D.R.2    Suresh, P.K.3    Kumar, R.A.4
  • 77
    • 84875225510 scopus 로고    scopus 로고
    • Synthesis and cytotoxicity evaluation of oleanolic acid derivatives
    • Hao, J.; Liu, J.; Wen, X.; Sun, H. Synthesis and cytotoxicity evaluation of oleanolic acid derivatives. Bioorg. Med. Chem. Lett. 2013, 23, 2074-2077.
    • (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 2074-2077
    • Hao, J.1    Liu, J.2    Wen, X.3    Sun, H.4
  • 78
    • 84877079384 scopus 로고    scopus 로고
    • Synthesis and antitumor activities of naturally occurring oleanolic acid triterpenoid saponins and their derivatives
    • Liu, Q.; Liu, H.; Zhang, L.; Guo, T.; Wang, P.; Geng, M.; Li, Y. Synthesis and antitumor activities of naturally occurring oleanolic acid triterpenoid saponins and their derivatives. Eur. J. Med. Chem. 2013, 64, 1-15.
    • (2013) Eur. J. Med. Chem. , vol.64 , pp. 1-15
    • Liu, Q.1    Liu, H.2    Zhang, L.3    Guo, T.4    Wang, P.5    Geng, M.6    Li, Y.7
  • 79
    • 77950354775 scopus 로고    scopus 로고
    • HCV protease inhibitory, cytotoxic and apoptosis-inducing effects of oleanolic acid derivatives
    • Ma, C.M.; Wu, X.H.; Masao, H.; Wang, X.J.; Kano, Y. HCV protease inhibitory, cytotoxic and apoptosis-inducing effects of oleanolic acid derivatives. J. Pharm. Pharm. Sci. 2009, 12, 243-248.
    • (2009) J. Pharm. Pharm. Sci. , vol.12 , pp. 243-248
    • Ma, C.M.1    Wu, X.H.2    Masao, H.3    Wang, X.J.4    Kano, Y.5
  • 82
    • 84894621225 scopus 로고    scopus 로고
    • Cytotoxic oleanane-type triterpenoid saponins from the Rhizomes of Anemone rivularis var. Flore-minore
    • Wang, X.; Wang, M.; Xu, M.; Wang, Y.; Tang, H.; Sun, X. Cytotoxic oleanane-type triterpenoid saponins from the Rhizomes of Anemone rivularis var. flore-minore. Molecules 2014, 19, 2121-2134.
    • (2014) Molecules , vol.19 , pp. 2121-2134
    • Wang, X.1    Wang, M.2    Xu, M.3    Wang, Y.4    Tang, H.5    Sun, X.6
  • 83
    • 84872046234 scopus 로고    scopus 로고
    • Tetracyclic triterpenoids and terpenylated coumarins from the bark of Ailanthus altissima ("Tree of Heaven")
    • Hong, Z.L.; Xiong, J.; Wu, S.B.; Zhu, J.J.; Hong, J.L.; Zhao, Y.; Xia, G.; Hu, J.F. Tetracyclic triterpenoids and terpenylated coumarins from the bark of Ailanthus altissima ("Tree of Heaven"). Phytochemistry 2013, 86, 159-167.
    • (2013) Phytochemistry , vol.86 , pp. 159-167
    • Hong, Z.L.1    Xiong, J.2    Wu, S.B.3    Zhu, J.J.4    Hong, J.L.5    Zhao, Y.6    Xia, G.7    Hu, J.F.8
  • 84
    • 84890445132 scopus 로고    scopus 로고
    • Anti-tumor activity of three novel derivatives of ginsenoside on colorectal cancer cells
    • Xia, X.; Jiang, B.; Liu, W.; Wang, P.; Mou, Y.; Liu, Y.; Zhao, Y.; Bi, X. Anti-tumor activity of three novel derivatives of ginsenoside on colorectal cancer cells. Steroids 2014, 80, 24-29.
    • (2014) Steroids , vol.80 , pp. 24-29
    • Xia, X.1    Jiang, B.2    Liu, W.3    Wang, P.4    Mou, Y.5    Liu, Y.6    Zhao, Y.7    Bi, X.8
  • 85
    • 80055002174 scopus 로고    scopus 로고
    • Fasciculols H and I, two lanostane derivatives from Chinese mushroom Naematoloma fasciculare
    • Shi, X.W.; Li, X.J.; Gao, J.M.; Zhang, X.C. Fasciculols H and I, two lanostane derivatives from Chinese mushroom Naematoloma fasciculare. Chem. Biodivers. 2011, 8, 1864-1870.
    • (2011) Chem. Biodivers. , vol.8 , pp. 1864-1870
    • Shi, X.W.1    Li, X.J.2    Gao, J.M.3    Zhang, X.C.4
  • 87
    • 54349114907 scopus 로고    scopus 로고
    • Cytotoxic and anti-oxidant activities of lanostane-type triterpenes isolated from Poria cocos
    • Zhou, L.; Zhang, Y.; Gapter, L.A.; Ling, H.; Agarwal, R.; Ng, K.Y. Cytotoxic and anti-oxidant activities of lanostane-type triterpenes isolated from Poria cocos. Chem. Pharm. Bull (Tokyo) 2008, 56, 1459-1462.
    • (2008) Chem. Pharm. Bull (Tokyo) , vol.56 , pp. 1459-1462
    • Zhou, L.1    Zhang, Y.2    Gapter, L.A.3    Ling, H.4    Agarwal, R.5    Ng, K.Y.6
  • 90
    • 70349269114 scopus 로고    scopus 로고
    • Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells
    • Yeh, C.T.; Rao, Y.K.; Yao, C.J.; Yeh, C.F.; Li, C.H.; Chuang, S.E.; Luong, J.H.; Lai, G.M.; Tzeng, Y.M. Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells. Cancer Lett. 2009, 285, 73-79.
    • (2009) Cancer Lett. , vol.285 , pp. 73-79
    • Yeh, C.T.1    Rao, Y.K.2    Yao, C.J.3    Yeh, C.F.4    Li, C.H.5    Chuang, S.E.6    Luong, J.H.7    Lai, G.M.8    Tzeng, Y.M.9
  • 91
    • 77953269709 scopus 로고    scopus 로고
    • Antitumor activities of dammarane triterpene saponins from Bacopa monniera
    • Peng, L.; Zhou, Y.; Kong de, Y.; Zhang, W.D. Antitumor activities of dammarane triterpene saponins from Bacopa monniera . Phytother. Res. 2010, 24, 864-868.
    • (2010) Phytother. Res. , vol.24 , pp. 864-868
    • Peng, L.1    Zhou, Y.2    Kong De, Y.3    Zhang, W.D.4
  • 92
    • 78751646573 scopus 로고    scopus 로고
    • Novel dammarane-type sapogenins from Panax ginseng berry and their biological activities
    • Zhao, J.M.; Li, N.; Zhang, H.; Wu, C.F.; Piao, H.R.; Zhao, Y.Q. Novel dammarane-type sapogenins from Panax ginseng berry and their biological activities. Bioorg. Med. Chem. Lett . 2011, 21, 1027-1031.
    • (2011) Bioorg. Med. Chem. Lett , vol.21 , pp. 1027-1031
    • Zhao, J.M.1    Li, N.2    Zhang, H.3    Wu, C.F.4    Piao, H.R.5    Zhao, Y.Q.6
  • 93
    • 84880045842 scopus 로고    scopus 로고
    • Dammarane-type saponins from heat-processed Gynostemma pentaphyllum show fortified activity against A549 cells
    • Piao, X.L.; Wu, Q.; Yang, J.; Park, S.Y.; Chen, D.J.; Liu, H.M. Dammarane-type saponins from heat-processed Gynostemma pentaphyllum show fortified activity against A549 cells. Arch. Pharm. Res. 2013, 36, 874-879.
    • (2013) Arch. Pharm. Res. , vol.36 , pp. 874-879
    • Piao, X.L.1    Wu, Q.2    Yang, J.3    Park, S.Y.4    Chen, D.J.5    Liu, H.M.6
  • 94
    • 72049084474 scopus 로고    scopus 로고
    • Dammarane-type saponins from the flower buds of Panax ginseng and their effects on human leukemia cells
    • Nguyen, H.T.; Song, G.Y.; Kim, J.A.; Hyun, J.H.; Kang, H.K.; Kim, Y.H. Dammarane-type saponins from the flower buds of Panax ginseng and their effects on human leukemia cells. Bioorg. Med. Chem. Lett. 2010, 20, 309-314.
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 309-314
    • Nguyen, H.T.1    Song, G.Y.2    Kim, J.A.3    Hyun, J.H.4    Kang, H.K.5    Kim, Y.H.6
  • 96
    • 67349150128 scopus 로고    scopus 로고
    • Dammarane-type saponins from Panax quinquefolium and their inhibition activity on human breast cancer MCF-7 cells
    • Qiu, Y.K.; Dou, D.Q.; Cai, L.P.; Jiang, H.P.; Kang, T.G.; Yang, B.Y.; Kuang, H.X.; Li, M.Z. Dammarane-type saponins from Panax quinquefolium and their inhibition activity on human breast cancer MCF-7 cells. Fitoterapia 2009, 80, 219-222.
    • (2009) Fitoterapia , vol.80 , pp. 219-222
    • Qiu, Y.K.1    Dou, D.Q.2    Cai, L.P.3    Jiang, H.P.4    Kang, T.G.5    Yang, B.Y.6    Kuang, H.X.7    Li, M.Z.8
  • 98
    • 70350057600 scopus 로고    scopus 로고
    • Anticancer efficacy of squalenoyl gemcitabine nanomedicine on 60 human tumor cell panel and on experimental tumor
    • Reddy, L.H.; Renoir, J.M.; Marsaud, V.; Lepetre-Mouelhi, S.; Desmaële, D.; Couvreur, P. Anticancer efficacy of squalenoyl gemcitabine nanomedicine on 60 human tumor cell panel and on experimental tumor. Mol. Pharm. 2009, 6, 1526-1535.
    • (2009) Mol. Pharm. , vol.6 , pp. 1526-1535
    • Reddy, L.H.1    Renoir, J.M.2    Marsaud, V.3    Lepetre-Mouelhi, S.4    Desmaële, D.5    Couvreur, P.6


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