Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies

Biochemical Pharmacology

Volumn 85, Issue 11, 2013, Pages 1579-1587

  Shanmugam, Muthu K ^a   Dai, Xiaoyun ^a   Kumar, Alan Prem ^a,b,c,d   Tan, Benny K H ^a   Sethi, Gautam ^a,b   Bishayee, Anupam ^e  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c CURTIN UNIVERSITY   (Australia)

^d UNIVERSITY OF NORTH TEXAS   (United States)

^e American University of Health Sciences   (United States)

Author keywords

Apoptosis; Cancer; Chemoprevention; NF B; STAT3; Ursolic acid

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; BECLIN 1; CASPASE 3; CASPASE 9; CHEMOKINE RECEPTOR CXCR4; CYCLIN D; CYCLOOXYGENASE 2; GELATINASE B; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 8; JANUS KINASE 1; JANUS KINASE 2; MAMMALIAN TARGET OF RAPAMYCIN; MYC PROTEIN; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN KINASE P60; REACTIVE OXYGEN METABOLITE; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SURVIVIN; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; URSOLIC ACID; VASCULOTROPIN;

ANTIANGIOGENIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ASTROCYTOMA; AUTOPHAGY; BLADDER CARCINOMA; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER INHIBITION; CANCER PREVENTION; CANCER THERAPY; CARCINOGENESIS; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL STRAIN HL 60; CHRONIC MYELOID LEUKEMIA; CLINICAL STUDY; COLORECTAL CARCINOMA; CYTOTOXICITY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG ISOLATION; ENZYME ACTIVATION; ENZYME INDUCTION; HUMAN; IN VITRO STUDY; LEUKEMIA; LEUKEMIA CELL; LIVER CELL CARCINOMA; LUNG CARCINOMA; METASTASIS; MOLECULARLY TARGETED THERAPY; MULTIPLE MYELOMA; NONHUMAN; OVARY CARCINOMA; PANCREAS CARCINOMA; PHASE 1 CLINICAL TRIAL (TOPIC); PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; PROSTATE CARCINOMA; REVIEW; SIGNAL TRANSDUCTION; SKIN CARCINOMA; STOMACH CANCER; TUMOR INVASION;

EID: 84877594282     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.03.006     Document Type: Note

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