-
1
-
-
3142757400
-
Raf promotes human herpesvirus-8 (HHV-8/KSHV) infection
-
Akula S.M., Ford P.W., Whitman A.G., Hamden K.H., Shelton J.G., and McCubrey J.A. Raf promotes human herpesvirus-8 (HHV-8/KSHV) infection. Oncogene 23 (2004) 5227-5241
-
(2004)
Oncogene
, vol.23
, pp. 5227-5241
-
-
Akula, S.M.1
Ford, P.W.2
Whitman, A.G.3
Hamden, K.H.4
Shelton, J.G.5
McCubrey, J.A.6
-
2
-
-
19344370532
-
B-Raf dependent expression of vascular endothelial growth factor-A in Kaposi's sarcoma-associated herpesvirus infected human B cells
-
Akula S.M., Ford P.W., Whitman A.G., Hamden K.E., Bryan B.A., Cook P.P., et al. B-Raf dependent expression of vascular endothelial growth factor-A in Kaposi's sarcoma-associated herpesvirus infected human B cells. Blood 105 (2005) 4516-4522
-
(2005)
Blood
, vol.105
, pp. 4516-4522
-
-
Akula, S.M.1
Ford, P.W.2
Whitman, A.G.3
Hamden, K.E.4
Bryan, B.A.5
Cook, P.P.6
-
3
-
-
0028293931
-
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1
-
Alessi D.R., Saito Y., Campbell D.G., Cohen P., Sithanandam G., Rapp U., et al. Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1. EMBO J 13 (1994) 1610-1619
-
(1994)
EMBO J
, vol.13
, pp. 1610-1619
-
-
Alessi, D.R.1
Saito, Y.2
Campbell, D.G.3
Cohen, P.4
Sithanandam, G.5
Rapp, U.6
-
4
-
-
4143074965
-
An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor in signaling in hepatocarcinogenesis and in the resistance of hepatocarcinoma cells against drug-induced apoptosis
-
Alexia C., Fallot G., Lasfer M., Schweizer-Groyer G., and Groyer A. An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor in signaling in hepatocarcinogenesis and in the resistance of hepatocarcinoma cells against drug-induced apoptosis. Biochem Pharmacol 68 (2004) 1003-1015
-
(2004)
Biochem Pharmacol
, vol.68
, pp. 1003-1015
-
-
Alexia, C.1
Fallot, G.2
Lasfer, M.3
Schweizer-Groyer, G.4
Groyer, A.5
-
5
-
-
0038726089
-
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK
-
Allan L.A., Morrice N., Brady S., Magee G., Pathak S., and Clarke P.R. Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK. Nat Cell Biol 7 (2003) 647-654
-
(2003)
Nat Cell Biol
, vol.7
, pp. 647-654
-
-
Allan, L.A.1
Morrice, N.2
Brady, S.3
Magee, G.4
Pathak, S.5
Clarke, P.R.6
-
6
-
-
0242468891
-
CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK)
-
Allen L.F., Sebolt-Leopold J., and Meyer M.B. CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK). Sem Oncol 30 (2003) 105-116
-
(2003)
Sem Oncol
, vol.30
, pp. 105-116
-
-
Allen, L.F.1
Sebolt-Leopold, J.2
Meyer, M.B.3
-
7
-
-
0032563961
-
Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms
-
Barnard D., Diaz B., Clawson D., and Marshall M. Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms. Oncogene 17 (1998) 1539-1547
-
(1998)
Oncogene
, vol.17
, pp. 1539-1547
-
-
Barnard, D.1
Diaz, B.2
Clawson, D.3
Marshall, M.4
-
8
-
-
0031671581
-
Microtubule-damaging drugs triggered bcl2 phosphorylation-requirement of phosphorylation on both serine-70 and serine-87 residues of bcl2 protein
-
Basu A., and Haldar S. Microtubule-damaging drugs triggered bcl2 phosphorylation-requirement of phosphorylation on both serine-70 and serine-87 residues of bcl2 protein. Int J Oncol 13 (1998) 659-664
-
(1998)
Int J Oncol
, vol.13
, pp. 659-664
-
-
Basu, A.1
Haldar, S.2
-
9
-
-
0031755805
-
The mitogen-activated protein kinase pathway mediates growth arrest or E1A-dependent apoptosis in SKBR3 human breast cancer cells
-
Blagosklonny M.V. The mitogen-activated protein kinase pathway mediates growth arrest or E1A-dependent apoptosis in SKBR3 human breast cancer cells. Int J Cancer 78 (1997) 511-517
-
(1997)
Int J Cancer
, vol.78
, pp. 511-517
-
-
Blagosklonny, M.V.1
-
10
-
-
0032715399
-
Drug-resistance enables selective killing of resistant leukemia cells: exploiting of drug resistance instead of reversal
-
Blagosklonny M.V. Drug-resistance enables selective killing of resistant leukemia cells: exploiting of drug resistance instead of reversal. Leukemia 13 (1999) 2031-2035
-
(1999)
Leukemia
, vol.13
, pp. 2031-2035
-
-
Blagosklonny, M.V.1
-
11
-
-
85047695528
-
Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs
-
Blagosklonny M.V. Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs. Leukemia 16 (2002) 455-462
-
(2002)
Leukemia
, vol.16
, pp. 455-462
-
-
Blagosklonny, M.V.1
-
12
-
-
0029913172
-
Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway
-
Blagosklonny M.V., Schulte T., Nguyen P., Trepel J., and Neckers L.M. Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway. Cancer Res 56 (1996) 1851-1854
-
(1996)
Cancer Res
, vol.56
, pp. 1851-1854
-
-
Blagosklonny, M.V.1
Schulte, T.2
Nguyen, P.3
Trepel, J.4
Neckers, L.M.5
-
13
-
-
0030614514
-
Defects in p21WAF1/CIP1, Rb and c-myc signaling in phorbol ester-resistant cancer cells
-
Blagosklonny M.V., Prabhu N.S., and El-Deiry W.S. Defects in p21WAF1/CIP1, Rb and c-myc signaling in phorbol ester-resistant cancer cells. Cancer Res 57 (1997) 320-325
-
(1997)
Cancer Res
, vol.57
, pp. 320-325
-
-
Blagosklonny, M.V.1
Prabhu, N.S.2
El-Deiry, W.S.3
-
14
-
-
0032874677
-
Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs
-
Blalock W.L., Weinstein-Oppenheimer C., Chang F., Hoyle P.E., Wang X.-Y., Algate P.A., et al. Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs. Leukemia 13 (1999) 1109-1166
-
(1999)
Leukemia
, vol.13
, pp. 1109-1166
-
-
Blalock, W.L.1
Weinstein-Oppenheimer, C.2
Chang, F.3
Hoyle, P.E.4
Wang, X.-Y.5
Algate, P.A.6
-
15
-
-
0034719381
-
A conditionally active form of MEK1 results in autocrine transformation of human and mouse hematopoietic cells
-
Blalock W.L., Pearce M., Steelman L.S., Franklin R.A., McCarthy S.A., Cherwinski H., et al. A conditionally active form of MEK1 results in autocrine transformation of human and mouse hematopoietic cells. Oncogene 19 (2000) 526-536
-
(2000)
Oncogene
, vol.19
, pp. 526-536
-
-
Blalock, W.L.1
Pearce, M.2
Steelman, L.S.3
Franklin, R.A.4
McCarthy, S.A.5
Cherwinski, H.6
-
16
-
-
0036847024
-
Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling
-
Brummer T., Shaw P.E., Reth M., and Misawa Y. Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling. EMBO J 21 (2002) 5611-5622
-
(2002)
EMBO J
, vol.21
, pp. 5611-5622
-
-
Brummer, T.1
Shaw, P.E.2
Reth, M.3
Misawa, Y.4
-
17
-
-
0034659736
-
Ras mediates the cAMP-dependent activation of extracellular signal-regulated in melanocytes
-
Busca R., Abbe P., Mantous F., Aberdam E., Peyssonnaux C., Eychene A., et al. Ras mediates the cAMP-dependent activation of extracellular signal-regulated in melanocytes. EMBO J 19 (2000) 2900-2910
-
(2000)
EMBO J
, vol.19
, pp. 2900-2910
-
-
Busca, R.1
Abbe, P.2
Mantous, F.3
Aberdam, E.4
Peyssonnaux, C.5
Eychene, A.6
-
18
-
-
0035913161
-
Cip1 induced by Raf is associated with increased Cdk4 activity in hematopoietic cells
-
Cip1 induced by Raf is associated with increased Cdk4 activity in hematopoietic cells. Oncogene 20 (2001) 4354-4364
-
(2001)
Oncogene
, vol.20
, pp. 4354-4364
-
-
Chang, F.1
McCubrey, J.A.2
-
19
-
-
0036581985
-
Raf-induced cell cycle progression in human TF-1 hematopoietic cells
-
Chang F., Steelman L.S., and McCubrey J.A. Raf-induced cell cycle progression in human TF-1 hematopoietic cells. Cell Cycle 1 (2002) 220-226
-
(2002)
Cell Cycle
, vol.1
, pp. 220-226
-
-
Chang, F.1
Steelman, L.S.2
McCubrey, J.A.3
-
20
-
-
0037810249
-
Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention
-
Chang F., Steelman L.S., Lee J.T., Shelton J.G., Navolanic P.M., Blalock W.L., et al. Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Leukemia 17 (2003) 1263-1293
-
(2003)
Leukemia
, vol.17
, pp. 1263-1293
-
-
Chang, F.1
Steelman, L.S.2
Lee, J.T.3
Shelton, J.G.4
Navolanic, P.M.5
Blalock, W.L.6
-
21
-
-
0037352170
-
Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy
-
Chang F., Lee J.T., Navolanic P.M., Steelman J.G., Blalock W.L., Franklin R.A., et al. Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia 17 (2003) 590-603
-
(2003)
Leukemia
, vol.17
, pp. 590-603
-
-
Chang, F.1
Lee, J.T.2
Navolanic, P.M.3
Steelman, J.G.4
Blalock, W.L.5
Franklin, R.A.6
-
22
-
-
0030889954
-
Selective inhibition of A-Raf and C-Raf mRNA expression by antisense oligodeoxynucleotides in Rat vascular smooth muscle cells: role of A-Raf and C-Raf in serum-induced proliferation
-
Cioffi C.L., Garay M., Johnston J.F., McGraw K., Boggs R.T., Hreniuk B.D., et al. Selective inhibition of A-Raf and C-Raf mRNA expression by antisense oligodeoxynucleotides in Rat vascular smooth muscle cells: role of A-Raf and C-Raf in serum-induced proliferation. Mol Pharmacol 51 (1997) 383-389
-
(1997)
Mol Pharmacol
, vol.51
, pp. 383-389
-
-
Cioffi, C.L.1
Garay, M.2
Johnston, J.F.3
McGraw, K.4
Boggs, R.T.5
Hreniuk, B.D.6
-
23
-
-
0037631323
-
Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein
-
Corbit K.C., Trakul N., Eves E.M., Diaz B., Marshall M., and Rosner M.R. Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein. J Biol Chem 278 (2003) 13061-13068
-
(2003)
J Biol Chem
, vol.278
, pp. 13061-13068
-
-
Corbit, K.C.1
Trakul, N.2
Eves, E.M.3
Diaz, B.4
Marshall, M.5
Rosner, M.R.6
-
24
-
-
0032515027
-
Regulation of cell death protease caspase 9 by phosphorylation
-
Crdone M.H., Roy N., Stennicke H.R., Salvesen G.S., Franke T.F., Stanbridge E., et al. Regulation of cell death protease caspase 9 by phosphorylation. Science 282 (1998) 1318-1321
-
(1998)
Science
, vol.282
, pp. 1318-1321
-
-
Crdone, M.H.1
Roy, N.2
Stennicke, H.R.3
Salvesen, G.S.4
Franke, T.F.5
Stanbridge, E.6
-
25
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davis H., Bignell G.R., Cox C., Stephens P., Edkins S., Clegg S., et al. Mutations of the BRAF gene in human cancer. Nature 417 (2002) 949-954
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davis, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
-
26
-
-
0037342272
-
Raf-1 and Bcl-2 induce distinct and common pathways which contribute to breast cancer drug resistance
-
Davis J.M., Weinstein-Oppenheimer C.R., Steelman L.S., Navolanic P.N., Hu W., Konopleva M., et al. Raf-1 and Bcl-2 induce distinct and common pathways which contribute to breast cancer drug resistance. Clin Cancer Res 9 (2003) 1161-1170
-
(2003)
Clin Cancer Res
, vol.9
, pp. 1161-1170
-
-
Davis, J.M.1
Weinstein-Oppenheimer, C.R.2
Steelman, L.S.3
Navolanic, P.N.4
Hu, W.5
Konopleva, M.6
-
27
-
-
0034652115
-
Survival function of ERK1/2 as an IL-3 activated, staurosporine-resistant Bcl2 kinases
-
Deng X., Ruvolo P., Carr B., and May Jr. W.S. Survival function of ERK1/2 as an IL-3 activated, staurosporine-resistant Bcl2 kinases. Proc Natl Acad Sci USA 97 (2000) 1578-1583
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 1578-1583
-
-
Deng, X.1
Ruvolo, P.2
Carr, B.3
May Jr., W.S.4
-
28
-
-
1842739136
-
Regulation of Bcl2 phosphorylation and potential significance for leukemic cell chemoresistance
-
Deng X., Kornblau S.M., Ruvulo P.P., and May Jr. W.S. Regulation of Bcl2 phosphorylation and potential significance for leukemic cell chemoresistance. JNCI Monogr 28 (2001) 30-37
-
(2001)
JNCI Monogr
, vol.28
, pp. 30-37
-
-
Deng, X.1
Kornblau, S.M.2
Ruvulo, P.P.3
May Jr., W.S.4
-
29
-
-
0037080956
-
Regulation of Raf-1 activation and signaling by dephosphosphorylation
-
Dhillon A.S., Meikle S., Yazici Z., Eulitz M., and Kolch W. Regulation of Raf-1 activation and signaling by dephosphosphorylation. EMBO J 21 (2002) 64-71
-
(2002)
EMBO J
, vol.21
, pp. 64-71
-
-
Dhillon, A.S.1
Meikle, S.2
Yazici, Z.3
Eulitz, M.4
Kolch, W.5
-
30
-
-
0030756069
-
Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling
-
Diaz B., Barnard D., Filson A., MacDonald S., King A., and Marshall M. Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling. Mol Cell Biol 17 (1997) 4509-4516
-
(1997)
Mol Cell Biol
, vol.17
, pp. 4509-4516
-
-
Diaz, B.1
Barnard, D.2
Filson, A.3
MacDonald, S.4
King, A.5
Marshall, M.6
-
31
-
-
9644283719
-
Binding activity of H-Ras is necessary for in vivo inhibition of ASK1 activity
-
Du J., Cai S.H., Shi Z., and Nagase F. Binding activity of H-Ras is necessary for in vivo inhibition of ASK1 activity. Cell Res 14 (2004) 148-154
-
(2004)
Cell Res
, vol.14
, pp. 148-154
-
-
Du, J.1
Cai, S.H.2
Shi, Z.3
Nagase, F.4
-
32
-
-
0027364980
-
Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase
-
Fabian J.R., Daar I.O., and Morrison D.K. Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase. Mol Cell Biol 13 (1993) 7170-7179
-
(1993)
Mol Cell Biol
, vol.13
, pp. 7170-7179
-
-
Fabian, J.R.1
Daar, I.O.2
Morrison, D.K.3
-
33
-
-
0027944852
-
Activation of Raf-1 by 14-3-3 proteins
-
Fantl W.J., Muslin A.J., Kikuchi A., Martin J.A., MacNicol A.M., Gross R.W., et al. Activation of Raf-1 by 14-3-3 proteins. Nature 371 (1994) 612-614
-
(1994)
Nature
, vol.371
, pp. 612-614
-
-
Fantl, W.J.1
Muslin, A.J.2
Kikuchi, A.3
Martin, J.A.4
MacNicol, A.M.5
Gross, R.W.6
-
34
-
-
0032896457
-
RAS mutations and clonality analysis in children with juvenile myelomonocytic leukemia (JMML)
-
Flotho C., Valcamonica S., Mach-Pascual S., Schmahl G., Corral L., Ritterbach J., et al. RAS mutations and clonality analysis in children with juvenile myelomonocytic leukemia (JMML). Leukemia 13 (1999) 32-37
-
(1999)
Leukemia
, vol.13
, pp. 32-37
-
-
Flotho, C.1
Valcamonica, S.2
Mach-Pascual, S.3
Schmahl, G.4
Corral, L.5
Ritterbach, J.6
-
35
-
-
11844253327
-
Vascular endothelial growth factor augments human Herpesvirus-8 (HHV-8/KSHV) infection
-
Ford P.W., Hamden K.E., Whitman A.G., McCubrey J.A., and Akula S.M. Vascular endothelial growth factor augments human Herpesvirus-8 (HHV-8/KSHV) infection. Cancer Biol Ther 3 (2004) 876-881
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 876-881
-
-
Ford, P.W.1
Hamden, K.E.2
Whitman, A.G.3
McCubrey, J.A.4
Akula, S.M.5
-
36
-
-
1342299898
-
Mutation analysis of the B-Raf, A-Raf and Raf-1 genes in human colorectal adenocarcinomas
-
Fransen K., Klinntenas M., Osterstrom A., Dimberg J., Monsteis H.J., and Soderkvist P. Mutation analysis of the B-Raf, A-Raf and Raf-1 genes in human colorectal adenocarcinomas. Carcinogensis 25 (2004) 527-533
-
(2004)
Carcinogensis
, vol.25
, pp. 527-533
-
-
Fransen, K.1
Klinntenas, M.2
Osterstrom, A.3
Dimberg, J.4
Monsteis, H.J.5
Soderkvist, P.6
-
37
-
-
0034841661
-
Phosphoinositide 3-kinase signalling in breast cancer: how big a role might it play?
-
Fry M.J. Phosphoinositide 3-kinase signalling in breast cancer: how big a role might it play?. Breast Cancer Res 3 (2001) 304-312
-
(2001)
Breast Cancer Res
, vol.3
, pp. 304-312
-
-
Fry, M.J.1
-
38
-
-
0038275924
-
Effects of raf kinase inhibitor protein on suppression of prostate cancer metastasis
-
Fu Z., Smith P.C., Zhang L., Rubin M.A., Dunn R.L., Yao Z., et al. Effects of raf kinase inhibitor protein on suppression of prostate cancer metastasis. JNCI 95 (2003) 878-889
-
(2003)
JNCI
, vol.95
, pp. 878-889
-
-
Fu, Z.1
Smith, P.C.2
Zhang, L.3
Rubin, M.A.4
Dunn, R.L.5
Yao, Z.6
-
39
-
-
5444227865
-
Guilty as charged: B-Raf is a human oncogene
-
Garnett M.J., and Marais R. Guilty as charged: B-Raf is a human oncogene. Cancer Cell 6 (2004) 313-319
-
(2004)
Cancer Cell
, vol.6
, pp. 313-319
-
-
Garnett, M.J.1
Marais, R.2
-
40
-
-
0034282892
-
Negative regulation of the serine/threonine kinase B-Raf by Akt
-
Guan K.L., Figueroa C., Brtva T.R., Zhu T., Taylor J., Barber T.D., et al. Negative regulation of the serine/threonine kinase B-Raf by Akt. J Biol Chem 275 (2000) 27354-27359
-
(2000)
J Biol Chem
, vol.275
, pp. 27354-27359
-
-
Guan, K.L.1
Figueroa, C.2
Brtva, T.R.3
Zhu, T.4
Taylor, J.5
Barber, T.D.6
-
41
-
-
0028540185
-
Antiapoptosis potential of bcl-2 oncogene by dephosphorylation
-
Haldar S., Jena N., and Croce C.M. Antiapoptosis potential of bcl-2 oncogene by dephosphorylation. Biochem Cell Biol 72 (1994) 455-462
-
(1994)
Biochem Cell Biol
, vol.72
, pp. 455-462
-
-
Haldar, S.1
Jena, N.2
Croce, C.M.3
-
42
-
-
0033179479
-
Paradoxical activation of Raf by a novel Raf inhibitor
-
Hall-Jackson C.A., Eyers P.A., Cohen P., Goedert M., Boyle F.T., Hewitt N., et al. Paradoxical activation of Raf by a novel Raf inhibitor. Chem Biol 6 (1999) 559-568
-
(1999)
Chem Biol
, vol.6
, pp. 559-568
-
-
Hall-Jackson, C.A.1
Eyers, P.A.2
Cohen, P.3
Goedert, M.4
Boyle, F.T.5
Hewitt, N.6
-
43
-
-
8644291553
-
Raf induced vascular endothelial growth factor augments Kaposi's Sarcoma-associated herpesvirus (KSHV/HHV-8) infection
-
Hamden K.E., Ford P.W., Whitman A.G., McCubrey J.A., and Akula S.M. Raf induced vascular endothelial growth factor augments Kaposi's Sarcoma-associated herpesvirus (KSHV/HHV-8) infection. J Virol 78 (2004) 13381-13390
-
(2004)
J Virol
, vol.78
, pp. 13381-13390
-
-
Hamden, K.E.1
Ford, P.W.2
Whitman, A.G.3
McCubrey, J.A.4
Akula, S.M.5
-
44
-
-
11844296672
-
Raf and VEGF: emerging therapeutic targets in Kaposi's Sarcoma-associated herpesviurs infection and angiogenesis in hematopoietic and non-hematopoietic tumors
-
Hamden K.E., Ford P.W., Whitman A.G., Shelton J.G., McCubrey J.A., and Akula S.M. Raf and VEGF: emerging therapeutic targets in Kaposi's Sarcoma-associated herpesviurs infection and angiogenesis in hematopoietic and non-hematopoietic tumors. Leukemia 19 (2005) 18-26
-
(2005)
Leukemia
, vol.19
, pp. 18-26
-
-
Hamden, K.E.1
Ford, P.W.2
Whitman, A.G.3
Shelton, J.G.4
McCubrey, J.A.5
Akula, S.M.6
-
45
-
-
0000784537
-
Identification of potent, selective kinase inhibitors of Raf
-
Heimbrook D.C., Huber H.E., Stirdivant S.M., Claremon D., Liverton N., Patrick D.R., et al. Identification of potent, selective kinase inhibitors of Raf. Proc Am Assoc Cancer Res 39 (1998) 558
-
(1998)
Proc Am Assoc Cancer Res
, vol.39
, pp. 558
-
-
Heimbrook, D.C.1
Huber, H.E.2
Stirdivant, S.M.3
Claremon, D.4
Liverton, N.5
Patrick, D.R.6
-
46
-
-
0037089089
-
Extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK)-independent functions of Raf kinases
-
Hindley A., and Kolch W. Extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK)-independent functions of Raf kinases. J Cell Sci 115 (2002) 1575-1581
-
(2002)
J Cell Sci
, vol.115
, pp. 1575-1581
-
-
Hindley, A.1
Kolch, W.2
-
47
-
-
0034076367
-
Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism
-
Hoyle P.E., Moye P.W., Steelman L.S., Blalock W.L., Franklin R.A., Pearce M., et al. Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism. Leukemia 14 (2000) 642-656
-
(2000)
Leukemia
, vol.14
, pp. 642-656
-
-
Hoyle, P.E.1
Moye, P.W.2
Steelman, L.S.3
Blalock, W.L.4
Franklin, R.A.5
Pearce, M.6
-
48
-
-
0036111802
-
Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO)
-
Jucker M., Sudel K., Horn S., Sickel M., Wegner W., Fiedler W., et al. Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO). Leukemia 16 (2002) 894-901
-
(2002)
Leukemia
, vol.16
, pp. 894-901
-
-
Jucker, M.1
Sudel, K.2
Horn, S.3
Sickel, M.4
Wegner, W.5
Fiedler, W.6
-
49
-
-
1842557438
-
Raf kinase inhibitor protein: a prostate cancer metastasis suppressor gene
-
Keller E.T., Fu Z., Yeung K., and Brennan M. Raf kinase inhibitor protein: a prostate cancer metastasis suppressor gene. Cancer Lett 207 (2004) 131-137
-
(2004)
Cancer Lett
, vol.207
, pp. 131-137
-
-
Keller, E.T.1
Fu, Z.2
Yeung, K.3
Brennan, M.4
-
50
-
-
0030048861
-
Effect of the activated Raf protein kinase on the human multidrug resistance 1 (MDR1) gene promoter
-
Kim S.H., Lee S.H., Kwak N.H., Kang C.D., and Chung B.S. Effect of the activated Raf protein kinase on the human multidrug resistance 1 (MDR1) gene promoter. Cancer Lett 98 (1996) 199-205
-
(1996)
Cancer Lett
, vol.98
, pp. 199-205
-
-
Kim, S.H.1
Lee, S.H.2
Kwak, N.H.3
Kang, C.D.4
Chung, B.S.5
-
51
-
-
13844317894
-
EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
-
Kobayashi S., Boggon T.J., Dayaram T., Janne P.A., Kocher O., Meyerson M., et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med 352 (2005) 830-832
-
(2005)
N Engl J Med
, vol.352
, pp. 830-832
-
-
Kobayashi, S.1
Boggon, T.J.2
Dayaram, T.3
Janne, P.A.4
Kocher, O.5
Meyerson, M.6
-
52
-
-
0035451062
-
To be or not to be: a question of B-Raf
-
Kolch W. To be or not to be: a question of B-Raf. Trends Neurosci 21 (2001) 498-500
-
(2001)
Trends Neurosci
, vol.21
, pp. 498-500
-
-
Kolch, W.1
-
53
-
-
0027326410
-
Protein kinase Cα activates RAF-1 by direct phosphorylation
-
Kolch W., Heidecker G., Kochs G., Hummel R., Vahidi H., Mischak H., et al. Protein kinase Cα activates RAF-1 by direct phosphorylation. Nature 364 (1993) 249-252
-
(1993)
Nature
, vol.364
, pp. 249-252
-
-
Kolch, W.1
Heidecker, G.2
Kochs, G.3
Hummel, R.4
Vahidi, H.5
Mischak, H.6
-
54
-
-
0032931508
-
Contribution of phosphatidylinositol 3-kinase to radiation resistance in human melanoma cells
-
Krasilnikov M., Adler V., Fuchs S.Y., Dong Z., Haimovitz-Friedman A., Herlyn M., et al. Contribution of phosphatidylinositol 3-kinase to radiation resistance in human melanoma cells. Mol Carcinog 24 (1999) 64-69
-
(1999)
Mol Carcinog
, vol.24
, pp. 64-69
-
-
Krasilnikov, M.1
Adler, V.2
Fuchs, S.Y.3
Dong, Z.4
Haimovitz-Friedman, A.5
Herlyn, M.6
-
55
-
-
0036238817
-
The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention
-
Lee Jr. J.T., and McCubrey J.A. The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention. Leukemia 16 (2002) 486-507
-
(2002)
Leukemia
, vol.16
, pp. 486-507
-
-
Lee Jr., J.T.1
McCubrey, J.A.2
-
56
-
-
0042666798
-
-
Lee Jr JT, McCubrey JA. BAY 43-9006 Bayer. Curr Opin Invest drugs 2003;4:757-63.
-
-
-
-
57
-
-
8544230666
-
PI3K activation leads to MRP1 expression and subsequent chemoresistance in advanced prostate cancer cells
-
Lee J.T., Steelman L.S., and McCubrey J.A. PI3K activation leads to MRP1 expression and subsequent chemoresistance in advanced prostate cancer cells. Cancer Res 64 (2004) 8397-8404
-
(2004)
Cancer Res
, vol.64
, pp. 8397-8404
-
-
Lee, J.T.1
Steelman, L.S.2
McCubrey, J.A.3
-
58
-
-
22344440866
-
Modulation of Raf/MEK/ERK pathway in prostate cancer drug resistance
-
Lee J.T., Steelman L.S., and McCubrey J.A. Modulation of Raf/MEK/ERK pathway in prostate cancer drug resistance. Int J Oncol (2005) 1637-1645
-
(2005)
Int J Oncol
, pp. 1637-1645
-
-
Lee, J.T.1
Steelman, L.S.2
McCubrey, J.A.3
-
59
-
-
0346752519
-
BRAF mutations in non-Hodgkin's lymphoma
-
Lee J.W., Yoo N.J., Soung Y.H., Kim H.S., Park W.S., Kim S.Y., et al. BRAF mutations in non-Hodgkin's lymphoma. Br J Cancer 89 (2003) 1958-1960
-
(2003)
Br J Cancer
, vol.89
, pp. 1958-1960
-
-
Lee, J.W.1
Yoo, N.J.2
Soung, Y.H.3
Kim, H.S.4
Park, W.S.5
Kim, S.Y.6
-
60
-
-
0742272051
-
BRaf mutations in acute leukemias
-
Lee J.W., Soung Y.H., Park W.S., Kim S.Y., Nam S.W., Min W.S., et al. BRaf mutations in acute leukemias. Leukemia 18 (2004) 170-172
-
(2004)
Leukemia
, vol.18
, pp. 170-172
-
-
Lee, J.W.1
Soung, Y.H.2
Park, W.S.3
Kim, S.Y.4
Nam, S.W.5
Min, W.S.6
-
61
-
-
26444468886
-
Analysis of BRAF mutation in primary and metastatic melanoma
-
Libra M., Malaponte G., Navolanic P.M., Gangemi P., Bevelacqua V., Proietti L., et al. Analysis of BRAF mutation in primary and metastatic melanoma. Cell Cycle 4 (2005) 1382-1384
-
(2005)
Cell Cycle
, vol.4
, pp. 1382-1384
-
-
Libra, M.1
Malaponte, G.2
Navolanic, P.M.3
Gangemi, P.4
Bevelacqua, V.5
Proietti, L.6
-
62
-
-
0033564514
-
The phosphatidylinositol 3′-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells
-
Lin J., Adam R.M., Santiestevan E., and Freeman M.R. The phosphatidylinositol 3′-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells. Cancer Res 59 (1999) 2891-2897
-
(1999)
Cancer Res
, vol.59
, pp. 2891-2897
-
-
Lin, J.1
Adam, R.M.2
Santiestevan, E.3
Freeman, M.R.4
-
63
-
-
0034939761
-
Overexpression of phosphatidylinositol 3-kinase in human lung cancer
-
Lin X., Bohle A.S., Dohrmann P., Leuschner I., Schulz A., Kremer B., et al. Overexpression of phosphatidylinositol 3-kinase in human lung cancer. Langenbecks Arch Surg 386 (2001) 293-301
-
(2001)
Langenbecks Arch Surg
, vol.386
, pp. 293-301
-
-
Lin, X.1
Bohle, A.S.2
Dohrmann, P.3
Leuschner, I.4
Schulz, A.5
Kremer, B.6
-
64
-
-
0030950537
-
Cooperating oncogenes converge to regulate cyclin/Cdk complexes
-
Lloyd A.C., Obermuller F., Staddon S., Barth C.F., McMahon M., and Land H. Cooperating oncogenes converge to regulate cyclin/Cdk complexes. Genes Dev 11 (1997) 663-677
-
(1997)
Genes Dev
, vol.11
, pp. 663-677
-
-
Lloyd, A.C.1
Obermuller, F.2
Staddon, S.3
Barth, C.F.4
McMahon, M.5
Land, H.6
-
65
-
-
0029811985
-
Oligomerization activates c-Raf-1 through a Ras-dependent mechanism
-
Luo Z., Tzivion G., Belshaw P.J., Vavvas D., Marshall M., and Avruch J. Oligomerization activates c-Raf-1 through a Ras-dependent mechanism. Nature 383 (1996) 181-185
-
(1996)
Nature
, vol.383
, pp. 181-185
-
-
Luo, Z.1
Tzivion, G.2
Belshaw, P.J.3
Vavvas, D.4
Marshall, M.5
Avruch, J.6
-
66
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch T.J., Bell D.W., Sordella R., Gurubhagavatula S., Okimoto R.A., Brannigan B.W., et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350 (2004) 2129-2139
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
-
69
-
-
0031041171
-
Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases
-
Marais R., Light Y., Paterson H.F., Mason C.S., and Marshall C.J. Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases. J Biol Chem 272 (1997) 4378-4383
-
(1997)
J Biol Chem
, vol.272
, pp. 4378-4383
-
-
Marais, R.1
Light, Y.2
Paterson, H.F.3
Mason, C.S.4
Marshall, C.J.5
-
70
-
-
0034174516
-
Tyrosine phosphorylation of the p85 subunit of phosphatidylinositol 3-kinase correlates with high proliferation rates in sublines derived from the Jurkat leukemia
-
Martinez-Lorenzo M.J., Anel A., Monleon I., Sierra J.J., Pineiro A., Naval J., et al. Tyrosine phosphorylation of the p85 subunit of phosphatidylinositol 3-kinase correlates with high proliferation rates in sublines derived from the Jurkat leukemia. Int J Biochem Cell Biol 32 (2000) 435-445
-
(2000)
Int J Biochem Cell Biol
, vol.32
, pp. 435-445
-
-
Martinez-Lorenzo, M.J.1
Anel, A.2
Monleon, I.3
Sierra, J.J.4
Pineiro, A.5
Naval, J.6
-
71
-
-
0033561041
-
Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation
-
Mason C.S., Springer C.J., Cooper R.G., Superti-Furga G., Marshall C.J., and Marais R. Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation. EMBO J 18 (1999) 2137-2148
-
(1999)
EMBO J
, vol.18
, pp. 2137-2148
-
-
Mason, C.S.1
Springer, C.J.2
Cooper, R.G.3
Superti-Furga, G.4
Marshall, C.J.5
Marais, R.6
-
72
-
-
18444381728
-
Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory
-
Mazzucchelli C., Vantaggiato C., Ciamei A., Fasano S., Pakhotin P., Krezel W., et al. Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory. Neuron 34 (2002) 807-820
-
(2002)
Neuron
, vol.34
, pp. 807-820
-
-
Mazzucchelli, C.1
Vantaggiato, C.2
Ciamei, A.3
Fasano, S.4
Pakhotin, P.5
Krezel, W.6
-
73
-
-
0029130410
-
Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes
-
McCarthy S.A., Samuels M.L., Pritchard C.A., Abraham J.A., and McMahon M. Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes. Genes Dev 9 (1995) 1953-1964
-
(1995)
Genes Dev
, vol.9
, pp. 1953-1964
-
-
McCarthy, S.A.1
Samuels, M.L.2
Pritchard, C.A.3
Abraham, J.A.4
McMahon, M.5
-
74
-
-
0030974039
-
Rapid phosphorylation of Ets-2 accompanies mitogen-activated protein kinase activation and the induction of heparin-binding epidermal growth factor gene expression by oncogenic Raf-1
-
McCarthy S.A., Chen D., Yang B.S., Garcia Ramirez J.J., Cherwinski H., Chen X.R., et al. Rapid phosphorylation of Ets-2 accompanies mitogen-activated protein kinase activation and the induction of heparin-binding epidermal growth factor gene expression by oncogenic Raf-1. Mol Cell Biol 17 (1997) 2401-2412
-
(1997)
Mol Cell Biol
, vol.17
, pp. 2401-2412
-
-
McCarthy, S.A.1
Chen, D.2
Yang, B.S.3
Garcia Ramirez, J.J.4
Cherwinski, H.5
Chen, X.R.6
-
75
-
-
0031761118
-
Differential abilities of activated Raf oncoproteins to abrogate cytokine-dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells
-
McCubrey J.A., Steelman L.S., Hoyle P.E., Blalock W.L., Weinstein-Oppenheimer C., Franklin R.A., et al. Differential abilities of activated Raf oncoproteins to abrogate cytokine-dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells. Leukemia 12 (1998) 1903-1929
-
(1998)
Leukemia
, vol.12
, pp. 1903-1929
-
-
McCubrey, J.A.1
Steelman, L.S.2
Hoyle, P.E.3
Blalock, W.L.4
Weinstein-Oppenheimer, C.5
Franklin, R.A.6
-
76
-
-
0035224494
-
Interactions between the PI3K and Raf signaling pathways can result in the transformation of hematopoietic cells
-
McCubrey J.A., Lee J.T., Steelman L.S., Blalock W.L., Moye P.W., Chang F., et al. Interactions between the PI3K and Raf signaling pathways can result in the transformation of hematopoietic cells. Cancer Det Prev 25 (2001) 375-393
-
(2001)
Cancer Det Prev
, vol.25
, pp. 375-393
-
-
McCubrey, J.A.1
Lee, J.T.2
Steelman, L.S.3
Blalock, W.L.4
Moye, P.W.5
Chang, F.6
-
77
-
-
0038697566
-
Raf proteins and cancer: B-Raf is identified as a mutational target
-
Mercer K.E., and Pritchard C.A. Raf proteins and cancer: B-Raf is identified as a mutational target. Biochim Biophys Acta 1653 (2003) 25-40
-
(2003)
Biochim Biophys Acta
, vol.1653
, pp. 25-40
-
-
Mercer, K.E.1
Pritchard, C.A.2
-
78
-
-
0034823632
-
Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia
-
Milella M., Kornblau S.M., Estrov Z., Carter B.Z., Lapillone H., Harris D., et al. Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia. J Clin Invest 108 (2001) 851-859
-
(2001)
J Clin Invest
, vol.108
, pp. 851-859
-
-
Milella, M.1
Kornblau, S.M.2
Estrov, Z.3
Carter, B.Z.4
Lapillone, H.5
Harris, D.6
-
79
-
-
0036566242
-
Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAP pathways in acute myelogenous leukemia
-
Milella M., Estrov Z., Kornblau S.M., Carter B.Z., Konopleva M., Tari A., et al. Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAP pathways in acute myelogenous leukemia. Blood 99 (2002) 3461-3464
-
(2002)
Blood
, vol.99
, pp. 3461-3464
-
-
Milella, M.1
Estrov, Z.2
Kornblau, S.M.3
Carter, B.Z.4
Konopleva, M.5
Tari, A.6
-
80
-
-
0029055029
-
v-Raf activates transcription of growth-responsive promoters via GC-rich sequences that bind the transcription factor Sp1
-
Mitenberger R.J., Farham P.J., Smith D.E., Stommell J.M., and Cornwell M.M. v-Raf activates transcription of growth-responsive promoters via GC-rich sequences that bind the transcription factor Sp1. Cell Growth Differ 6 (1995) 549-556
-
(1995)
Cell Growth Differ
, vol.6
, pp. 549-556
-
-
Mitenberger, R.J.1
Farham, P.J.2
Smith, D.E.3
Stommell, J.M.4
Cornwell, M.M.5
-
81
-
-
0036219609
-
Hsp90inhibitors as novel cancer chemotherapeutic agents
-
Neckers L. Hsp90inhibitors as novel cancer chemotherapeutic agents. Trends Mol Med 8 (2002) S55-S61
-
(2002)
Trends Mol Med
, vol.8
-
-
Neckers, L.1
-
82
-
-
0033959620
-
The survival function of the BCR-ABL oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf
-
Neshat M.S., Raitano A.B., Wang H.G., Reed J.C., and Sawyers C.L. The survival function of the BCR-ABL oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf. Mol Cell Biol 20 (2000) 1179-1186
-
(2000)
Mol Cell Biol
, vol.20
, pp. 1179-1186
-
-
Neshat, M.S.1
Raitano, A.B.2
Wang, H.G.3
Reed, J.C.4
Sawyers, C.L.5
-
83
-
-
0036185848
-
The protein kinase B/Akt signalling pathway in human malignancy
-
Nicholson K.M., and Anderson N.G. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal 14 (2002) 381-395
-
(2002)
Cell Signal
, vol.14
, pp. 381-395
-
-
Nicholson, K.M.1
Anderson, N.G.2
-
84
-
-
11144267126
-
Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1
-
O'Neill E., Rushworth L., Baccarini M., and Kolch W. Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1. Science 306 (2004) 2267-2270
-
(2004)
Science
, vol.306
, pp. 2267-2270
-
-
O'Neill, E.1
Rushworth, L.2
Baccarini, M.3
Kolch, W.4
-
86
-
-
0033835922
-
Induction of postmitotic neuroretina cell proliferation by distinct Ras downstream signaling pathways
-
Peyssonnaux C., Provot S., Felder-Schmittbuhl M.P., Calothy G., and Eychéne A. Induction of postmitotic neuroretina cell proliferation by distinct Ras downstream signaling pathways. Mol Cell Biol 20 (2000) 7068-7079
-
(2000)
Mol Cell Biol
, vol.20
, pp. 7068-7079
-
-
Peyssonnaux, C.1
Provot, S.2
Felder-Schmittbuhl, M.P.3
Calothy, G.4
Eychéne, A.5
-
87
-
-
0036709020
-
Fidelity and spatio-temporal control in MAP kinase (ERKs) signaling
-
Pouyssegur J., Volmat V., and Lenormand P. Fidelity and spatio-temporal control in MAP kinase (ERKs) signaling. Biochem Pharm 64 (2002) 755-763
-
(2002)
Biochem Pharm
, vol.64
, pp. 755-763
-
-
Pouyssegur, J.1
Volmat, V.2
Lenormand, P.3
-
88
-
-
0030133927
-
Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene
-
Pritchard C.A., Bolin L., Slattery R., Murray R., and McMahon M. Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene. Curr Biol 6 (1996) 614-617
-
(1996)
Curr Biol
, vol.6
, pp. 614-617
-
-
Pritchard, C.A.1
Bolin, L.2
Slattery, R.3
Murray, R.4
McMahon, M.5
-
89
-
-
0037194728
-
Tumorigenesis: Raf/Ras oncogenes and mismatch-repair status
-
Rajagopalan H., Bardelli A., Lengauer C., Kinzler K.N., Vogelstein B., and Velculesccu V.E. Tumorigenesis: Raf/Ras oncogenes and mismatch-repair status. Nature 418 (2002) 934
-
(2002)
Nature
, vol.418
, pp. 934
-
-
Rajagopalan, H.1
Bardelli, A.2
Lengauer, C.3
Kinzler, K.N.4
Vogelstein, B.5
Velculesccu, V.E.6
-
90
-
-
0031985094
-
Activated Raf-1 causes cell cycle arrest in small cell lung cancer cells
-
Ravi R.K., Weber E., McMahon M., Williams J.R., Baylin S., Mal A., et al. Activated Raf-1 causes cell cycle arrest in small cell lung cancer cells. J Clin Invest 101 (1998) 153-159
-
(1998)
J Clin Invest
, vol.101
, pp. 153-159
-
-
Ravi, R.K.1
Weber, E.2
McMahon, M.3
Williams, J.R.4
Baylin, S.5
Mal, A.6
-
91
-
-
0033559698
-
Raf-1-induced cell cycle arrest in LNCap human prostate cancer cells
-
Ravi R.K., McMahon M., Yangang Z., Williams J.R., Dillehay L.E., Nelkin B.C., et al. Raf-1-induced cell cycle arrest in LNCap human prostate cancer cells. J Cell Biochem 72 (1999) 458-469
-
(1999)
J Cell Biochem
, vol.72
, pp. 458-469
-
-
Ravi, R.K.1
McMahon, M.2
Yangang, Z.3
Williams, J.R.4
Dillehay, L.E.5
Nelkin, B.C.6
-
92
-
-
0033607784
-
Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt
-
Rommel C., Clarke B.A., Zimmermann S., Nuñez L., Rossman R., Reid K., et al. Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt. Science 286 (1999) 1738-1741
-
(1999)
Science
, vol.286
, pp. 1738-1741
-
-
Rommel, C.1
Clarke, B.A.2
Zimmermann, S.3
Nuñez, L.4
Rossman, R.5
Reid, K.6
-
93
-
-
0032526544
-
Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant
-
Salomoni P., Wasik M.A., Riedel R.F., Reiss K., Choi J.K., Skorski T., et al. Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant. J Exp Med 187 (1998) 1995-2007
-
(1998)
J Exp Med
, vol.187
, pp. 1995-2007
-
-
Salomoni, P.1
Wasik, M.A.2
Riedel, R.F.3
Reiss, K.4
Choi, J.K.5
Skorski, T.6
-
94
-
-
0031832770
-
The Raf-1 protein mediates insulin-like growth factor-induced proliferation of erythroid progenitor cells
-
Sanders M.R., Lu H., Walker F., Sorbad S., and Dainiak N. The Raf-1 protein mediates insulin-like growth factor-induced proliferation of erythroid progenitor cells. Stem Cells 16 (1998) 200-207
-
(1998)
Stem Cells
, vol.16
, pp. 200-207
-
-
Sanders, M.R.1
Lu, H.2
Walker, F.3
Sorbad, S.4
Dainiak, N.5
-
95
-
-
0038476605
-
Effects of the Raf/MEK/ERK and PI3K signal transduction pathways on the abrogation of cytokine dependence and prevention of apoptosis in hematopoietic cells
-
Shelton J.G., Steelman L.S., Lee J.T., Knapp S.L., Blalock W.L., Moye P.M., et al. Effects of the Raf/MEK/ERK and PI3K signal transduction pathways on the abrogation of cytokine dependence and prevention of apoptosis in hematopoietic cells. Oncogene 24 (2003) 2478-2492
-
(2003)
Oncogene
, vol.24
, pp. 2478-2492
-
-
Shelton, J.G.1
Steelman, L.S.2
Lee, J.T.3
Knapp, S.L.4
Blalock, W.L.5
Moye, P.M.6
-
96
-
-
0141502211
-
Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation
-
Shelton J.G., Moye P.W., Steelman L.S., Blalock W.L., Lee J.T., Franklin R.A., et al. Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation. Leukemia 17 (2003) 1765-1782
-
(2003)
Leukemia
, vol.17
, pp. 1765-1782
-
-
Shelton, J.G.1
Moye, P.W.2
Steelman, L.S.3
Blalock, W.L.4
Lee, J.T.5
Franklin, R.A.6
-
97
-
-
3843138659
-
B-Raf and insulin synergistically prevent apoptosis and induce cell cycle progression in hematopoietic cells
-
Shelton J.G., Chang F., Lee J.T., Franklin R.A., Steelman L.S., and McCubrey J.A. B-Raf and insulin synergistically prevent apoptosis and induce cell cycle progression in hematopoietic cells. Cell Cycle 3 (2004) 189-196
-
(2004)
Cell Cycle
, vol.3
, pp. 189-196
-
-
Shelton, J.G.1
Chang, F.2
Lee, J.T.3
Franklin, R.A.4
Steelman, L.S.5
McCubrey, J.A.6
-
98
-
-
27144441838
-
The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers-what's genetics got to do with it?
-
Shelton J.G., Steelman L.S., Abrams S.L., Bertrand F.E., Franklin R.A., McMahon M., et al. The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers-what's genetics got to do with it?. Exp Opin Ther Targets 9 (2005) 1009-1030
-
(2005)
Exp Opin Ther Targets
, vol.9
, pp. 1009-1030
-
-
Shelton, J.G.1
Steelman, L.S.2
Abrams, S.L.3
Bertrand, F.E.4
Franklin, R.A.5
McMahon, M.6
-
99
-
-
25144481913
-
Conditional EGFR promotes cell cycle progression and prevention of apoptosis in the absence of autocrine cytokines
-
Shelton J.G., Steelman L.S., Abrams S.L., White E.R., Akula S.M., Bertrand F.E., et al. Conditional EGFR promotes cell cycle progression and prevention of apoptosis in the absence of autocrine cytokines. Cell Cycle 4 (2005) 822-830
-
(2005)
Cell Cycle
, vol.4
, pp. 822-830
-
-
Shelton, J.G.1
Steelman, L.S.2
Abrams, S.L.3
White, E.R.4
Akula, S.M.5
Bertrand, F.E.6
-
100
-
-
4143066760
-
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
-
Sordella R., Bell D.W., Haber D.A., and Settleman J. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science 305 (2004) 1163-1167
-
(2004)
Science
, vol.305
, pp. 1163-1167
-
-
Sordella, R.1
Bell, D.W.2
Haber, D.A.3
Settleman, J.4
-
101
-
-
1242307380
-
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis
-
Steelman L.S., Pohnert S.C., Shelton J.G., Franklin R.A., Bertrand F.E., and McCubrey J.A. JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis. Leukemia 18 (2004) 189-218
-
(2004)
Leukemia
, vol.18
, pp. 189-218
-
-
Steelman, L.S.1
Pohnert, S.C.2
Shelton, J.G.3
Franklin, R.A.4
Bertrand, F.E.5
McCubrey, J.A.6
-
102
-
-
11144310076
-
The complexity of PTEN: mutation, marker and potential target for therapeutic intervention
-
Steelman L.S., Bertrand F.E., and McCubrey J.A. The complexity of PTEN: mutation, marker and potential target for therapeutic intervention. Exp Opin Ther Targets 8 (2004) 537-550
-
(2004)
Exp Opin Ther Targets
, vol.8
, pp. 537-550
-
-
Steelman, L.S.1
Bertrand, F.E.2
McCubrey, J.A.3
-
103
-
-
0035383768
-
FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia
-
Stirewalt D.L., Kopecky K.J., Meshinchi S., Appelbaum F.R., Slovak M.L., Willman C.L., et al. FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia. Blood 97 (2001) 3589-3595
-
(2001)
Blood
, vol.97
, pp. 3589-3595
-
-
Stirewalt, D.L.1
Kopecky, K.J.2
Meshinchi, S.3
Appelbaum, F.R.4
Slovak, M.L.5
Willman, C.L.6
-
104
-
-
0027411995
-
Developmental and cell lineage specificity of raf family gene expression in mouse
-
Wadewitz A.G., Winer M.A., and Wolgemuth D.J. Developmental and cell lineage specificity of raf family gene expression in mouse. Oncogene 8 (1993) 1055-1062
-
(1993)
Oncogene
, vol.8
, pp. 1055-1062
-
-
Wadewitz, A.G.1
Winer, M.A.2
Wolgemuth, D.J.3
-
105
-
-
12144289677
-
Mechanism of activation of the Raf-MEK signaling pathway by oncogenic mutations of B-Raf
-
Wan P.T., Garnett M.J., Ros S.M., Lee S., Niculescu-Duvaz D., Good V.M., et al. Mechanism of activation of the Raf-MEK signaling pathway by oncogenic mutations of B-Raf. Cell 116 (2004) 856-867
-
(2004)
Cell
, vol.116
, pp. 856-867
-
-
Wan, P.T.1
Garnett, M.J.2
Ros, S.M.3
Lee, S.4
Niculescu-Duvaz, D.5
Good, V.M.6
-
106
-
-
0034808394
-
Role of the Raf signal transduction cascade in the in vitro resistance to the anticancer drug doxorubicin
-
Weinstein-Oppenheimer C.R., Henríquez-Roldán C.F., Davis J., Navolanic P.M., Saleh O.A., Steelman L.S., et al. Role of the Raf signal transduction cascade in the in vitro resistance to the anticancer drug doxorubicin. Clin Cancer Res 7 (2001) 2892-2907
-
(2001)
Clin Cancer Res
, vol.7
, pp. 2892-2907
-
-
Weinstein-Oppenheimer, C.R.1
Henríquez-Roldán, C.F.2
Davis, J.3
Navolanic, P.M.4
Saleh, O.A.5
Steelman, L.S.6
-
107
-
-
0030977312
-
Endothelial apoptosis in Braf-deficient mice
-
Wojnowski L., Zimmer A.M., Bec T.W., Hahn H., Bernal R., Rapp U.R., et al. Endothelial apoptosis in Braf-deficient mice. Nat Genet 16 (1997) 293-297
-
(1997)
Nat Genet
, vol.16
, pp. 293-297
-
-
Wojnowski, L.1
Zimmer, A.M.2
Bec, T.W.3
Hahn, H.4
Bernal, R.5
Rapp, U.R.6
-
109
-
-
1142273472
-
Altered states: selectively drugging the Hsp90 cancer chaperone
-
Workman P. Altered states: selectively drugging the Hsp90 cancer chaperone. Trends Mol Med 10 (2004) 47-51
-
(2004)
Trends Mol Med
, vol.10
, pp. 47-51
-
-
Workman, P.1
-
110
-
-
0032508517
-
Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase
-
Yan J., Roy S., Apolloni A., Lane A., and Hancock J.F. Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase. J Biol Chem 273 (1998) 24052-24056
-
(1998)
J Biol Chem
, vol.273
, pp. 24052-24056
-
-
Yan, J.1
Roy, S.2
Apolloni, A.3
Lane, A.4
Hancock, J.F.5
-
111
-
-
0028037057
-
Expression of activated Raf accelerates cell differentiation and RB protein down-regulation but not hypophosphorylation
-
Yen A., Williams M., Platko J.D., Der C., and Hisaka M. Expression of activated Raf accelerates cell differentiation and RB protein down-regulation but not hypophosphorylation. Eur J Cell Biol 65 (1994) 103-113
-
(1994)
Eur J Cell Biol
, vol.65
, pp. 103-113
-
-
Yen, A.1
Williams, M.2
Platko, J.D.3
Der, C.4
Hisaka, M.5
-
112
-
-
0033539167
-
Suppression of Raf-1 kinase activity and MAP kinase signaling by RKIP
-
Yeung K., Seitz T., Li S., Janosch P., McFerran B., Kaiser C., et al. Suppression of Raf-1 kinase activity and MAP kinase signaling by RKIP. Nature 401 (1999) 173-177
-
(1999)
Nature
, vol.401
, pp. 173-177
-
-
Yeung, K.1
Seitz, T.2
Li, S.3
Janosch, P.4
McFerran, B.5
Kaiser, C.6
-
113
-
-
0038650902
-
Coadministration of UCN-01 with MEK1/2 inhibitors potently induces apoptosis in BCR/ABL+ leukemia cells sensitive and resistant to STI571
-
Yu C., Dai Y., Dent P., and Grant S. Coadministration of UCN-01 with MEK1/2 inhibitors potently induces apoptosis in BCR/ABL+ leukemia cells sensitive and resistant to STI571. Cancer Biol Ther 1 (2002) 674-682
-
(2002)
Cancer Biol Ther
, vol.1
, pp. 674-682
-
-
Yu, C.1
Dai, Y.2
Dent, P.3
Grant, S.4
-
114
-
-
0037112438
-
Similarity of the phenotypic patterns associated with B-Raf and KRAS mutations in colorectal neoplasia
-
Yuen S.T., Davies H., Chan T.L., Ho J.W., Bignell G.R., Cox C., et al. Similarity of the phenotypic patterns associated with B-Raf and KRAS mutations in colorectal neoplasia. Cancer Res 62 (2002) 6451-6455
-
(2002)
Cancer Res
, vol.62
, pp. 6451-6455
-
-
Yuen, S.T.1
Davies, H.2
Chan, T.L.3
Ho, J.W.4
Bignell, G.R.5
Cox, C.6
-
115
-
-
33748040128
-
Two novel activating germiline mutations of the c-Raf proto-oncogene predisposing to solid tumors and therapy related acute myeloid leukemia
-
Zebisch A., Staber P.B., Fischereder K., Bodner C., Hiden K., Linkesch W., et al. Two novel activating germiline mutations of the c-Raf proto-oncogene predisposing to solid tumors and therapy related acute myeloid leukemia. Blood Suppl 920 (2004)
-
(2004)
Blood Suppl
, vol.920
-
-
Zebisch, A.1
Staber, P.B.2
Fischereder, K.3
Bodner, C.4
Hiden, K.5
Linkesch, W.6
-
116
-
-
0006174941
-
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not Bcl-XL
-
Zha J., Harada H., Yang E., Jockel J., and Korsmeyer S.J. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not Bcl-XL. Cell 87 (1996) 589-592
-
(1996)
Cell
, vol.87
, pp. 589-592
-
-
Zha, J.1
Harada, H.2
Yang, E.3
Jockel, J.4
Korsmeyer, S.J.5
-
117
-
-
0035943615
-
Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf
-
Zhang B.H., Tang E.D., Zhu T., Greenberg M.E., Vojtek A.B., and Guan K.L. Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf. J Biol Chem 276 (2001) 31620-31626
-
(2001)
J Biol Chem
, vol.276
, pp. 31620-31626
-
-
Zhang, B.H.1
Tang, E.D.2
Zhu, T.3
Greenberg, M.E.4
Vojtek, A.B.5
Guan, K.L.6
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