메뉴 건너뛰기




Volumn 103, Issue 2, 2016, Pages e29-e46

Molecular and biological hallmarks of ageing

Author keywords

[No Author keywords available]

Indexed keywords

ADULT STEM CELL; AGING; CELL AGING; CELL COMMUNICATION; GENETIC EPIGENESIS; GENETICS; GENOMIC INSTABILITY; HUMAN; LIFE EXPECTANCY; MITOCHONDRIAL DISEASES; NUTRITION; PHYSIOLOGY; PROTEOSTASIS DEFICIENCIES; TELOMERE;

EID: 84954508690     PISSN: 00071323     EISSN: 13652168     Source Type: Journal    
DOI: 10.1002/bjs.10053     Document Type: Review
Times cited : (207)

References (148)
  • 1
    • 84875294409 scopus 로고    scopus 로고
    • Longevity and aging
    • Kaeberlein M., Longevity and aging. F1000Prime Rep 2013; 5: 5.
    • (2013) F1000Prime Rep , vol.5 , Issue.5
    • Kaeberlein, M.1
  • 2
    • 0037218826 scopus 로고    scopus 로고
    • The biology of aging
    • Troen BR,. The biology of aging. Mt Sinai J Med 2003; 70: 3-22.
    • (2003) Mt Sinai J Med , vol.70 , pp. 3-22
    • Troen, B.R.1
  • 3
    • 84942425260 scopus 로고    scopus 로고
    • Enhanced eNOS activation as the fountain of youth for vascular disease: Is BPIFB4 what Ponce de Leõn was looking for?
    • Kraehling JR, Sessa WC,. Enhanced eNOS activation as the fountain of youth for vascular disease: is BPIFB4 what Ponce de Leõn was looking for? Circ Res 2015; 117: 309-310.
    • (2015) Circ Res , vol.117 , pp. 309-310
    • Kraehling, J.R.1    Sessa, W.C.2
  • 4
    • 84937518609 scopus 로고    scopus 로고
    • GDF11 and the mythical fountain of youth
    • Brun CE, Rudnicki MA,. GDF11 and the mythical fountain of youth. Cell Metab 2015; 22: 54-56.
    • (2015) Cell Metab , vol.22 , pp. 54-56
    • Brun, C.E.1    Rudnicki, M.A.2
  • 5
    • 84903158901 scopus 로고    scopus 로고
    • The search for antiaging interventions: From elixirs to fasting regimens
    • de Cabo R, Carmona-Gutierrez D, Bernier M, Hall MN, Madeo F,. The search for antiaging interventions: from elixirs to fasting regimens. Cell 2014; 157: 1515-1526.
    • (2014) Cell , vol.157 , pp. 1515-1526
    • De Cabo, R.1    Carmona-Gutierrez, D.2    Bernier, M.3    Hall, M.N.4    Madeo, F.5
  • 6
    • 84903995700 scopus 로고    scopus 로고
    • Aging: The blurry line between life and death
    • Liu J, Finkel T,. Aging: the blurry line between life and death. Curr Biol 2014; 24: R610-R613.
    • (2014) Curr Biol , vol.24 , pp. R610-R613
    • Liu, J.1    Finkel, T.2
  • 7
    • 84906807307 scopus 로고    scopus 로고
    • The truth about testosterone replacement therapy. Fountain of youth - or harbinger of health woes?
    • The truth about testosterone replacement therapy. Fountain of youth-or harbinger of health woes? Johns Hopkins Med Lett Health After 50 2014; 29: 1-2.
    • (2014) Johns Hopkins Med Lett Health after , vol.50 , Issue.29 , pp. 1-2
  • 9
    • 84885032859 scopus 로고    scopus 로고
    • Dopamine as the fountain of youth? Restoring decision making ability in older adults
    • Badugu S, Anderson W,. Dopamine as the fountain of youth? Restoring decision making ability in older adults. Neurosurgery 2013; 73: N19-N20.
    • (2013) Neurosurgery , vol.73 , pp. N19-N20
    • Badugu, S.1    Anderson, W.2
  • 10
    • 84949184110 scopus 로고    scopus 로고
    • The fountain of stem cell-based youth? Online portrayals of anti-aging stem cell technologies
    • Rachul CM, Percec I, Caulfield T,. The fountain of stem cell-based youth? Online portrayals of anti-aging stem cell technologies. Aesthetic Surg J 2015; 35: 730-736.
    • (2015) Aesthetic Surg J , vol.35 , pp. 730-736
    • Rachul, C.M.1    Percec, I.2    Caulfield, T.3
  • 12
    • 84922932233 scopus 로고    scopus 로고
    • The burden of disease in older people and implications for health policy and practice
    • Prince MJ, Wu F, Guo Y, Gutierrez Robledo LM, O'Donnell M, Sullivan R, et al., The burden of disease in older people and implications for health policy and practice. Lancet 2015; 385: 549-562.
    • (2015) Lancet , vol.385 , pp. 549-562
    • Prince, M.J.1    Wu, F.2    Guo, Y.3    Gutierrez Robledo, L.M.4    O'Donnell, M.5    Sullivan, R.6
  • 14
    • 84929493833 scopus 로고    scopus 로고
    • Why is aging conserved and what can we do about it?
    • e1002131
    • Pitt JN, Kaeberlein M,. Why is aging conserved and what can we do about it? PLoS Biol 2015; 13: e1002131.
    • (2015) PLoS Biol , vol.13
    • Pitt, J.N.1    Kaeberlein, M.2
  • 18
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA,. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 19
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA,. The hallmarks of cancer. Cell 2000; 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 20
    • 85015066476 scopus 로고    scopus 로고
    • DNA damage and repair
    • Friedberg EC,. DNA damage and repair. Nature 2003; 421: 436-440.
    • (2003) Nature , vol.421 , pp. 436-440
    • Friedberg, E.C.1
  • 21
    • 79956191022 scopus 로고    scopus 로고
    • Role of oxidative stress and DNA damage in human carcinogenesis
    • Kryston TB, Georgiev AB, Pissis P, Georgakilas AG,. Role of oxidative stress and DNA damage in human carcinogenesis. Mutat Res 2011; 711: 193-201.
    • (2011) Mutat Res , vol.711 , pp. 193-201
    • Kryston, T.B.1    Georgiev, A.B.2    Pissis, P.3    Georgakilas, A.G.4
  • 23
    • 79851511414 scopus 로고    scopus 로고
    • Molecular pathological epidemiology of colorectal neoplasia: An emerging transdisciplinary and interdisciplinary field
    • Ogino S, Chan AT, Fuchs CS, Giovannucci E,. Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field. Gut 2011; 60: 397-411.
    • (2011) Gut , vol.60 , pp. 397-411
    • Ogino, S.1    Chan, A.T.2    Fuchs, C.S.3    Giovannucci, E.4
  • 25
    • 35148879733 scopus 로고    scopus 로고
    • Ageing or cancer: A review on the role of caretakers and gatekeepers
    • van Heemst D, den Reijer PM, Westendorp RG,. Ageing or cancer: a review on the role of caretakers and gatekeepers. Eur J Cancer 2007; 43: 2144-2152.
    • (2007) Eur J Cancer , vol.43 , pp. 2144-2152
    • Van Heemst, D.1    Den Reijer, P.M.2    Westendorp, R.G.3
  • 26
    • 84904544470 scopus 로고    scopus 로고
    • +/sirtuin counteract the hallmarks of aging
    • +/sirtuin counteract the hallmarks of aging. Front Biosci (Landmark Ed) 2014; 19: 1300-1319.
    • (2014) Front Biosci (Landmark Ed) , vol.19 , pp. 1300-1319
    • Michan, S.1
  • 28
    • 84895756413 scopus 로고    scopus 로고
    • Both genetic and dietary factors underlie individual differences in DNA damage levels and DNA repair capacity
    • Slyskova J, Lorenzo Y, Karlsen A, Carlsen MH, Novosadova V, Blomhoff R, et al., Both genetic and dietary factors underlie individual differences in DNA damage levels and DNA repair capacity. DNA Repair (Amst) 2014; 16: 66-73.
    • (2014) DNA Repair (Amst) , vol.16 , pp. 66-73
    • Slyskova, J.1    Lorenzo, Y.2    Karlsen, A.3    Carlsen, M.H.4    Novosadova, V.5    Blomhoff, R.6
  • 29
    • 84923341901 scopus 로고    scopus 로고
    • Early telomerase inactivation accelerates aging independently of telomere length
    • Xie Z, Jay KA, Smith DL, Zhang Y, Liu Z, Zheng J, et al., Early telomerase inactivation accelerates aging independently of telomere length. Cell 2015; 160: 928-939.
    • (2015) Cell , vol.160 , pp. 928-939
    • Xie, Z.1    Jay, K.A.2    Smith, D.L.3    Zhang, Y.4    Liu, Z.5    Zheng, J.6
  • 31
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick L, Moorhead PS,. The serial cultivation of human diploid cell strains. Exp Cell Res 1961; 25: 585-621.
    • (1961) Exp Cell Res , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 32
    • 0030177489 scopus 로고    scopus 로고
    • Telomeres, telomerase, and aging: Origin of the theory
    • Olovnikov AM,. Telomeres, telomerase, and aging: origin of the theory. Exp Gerontol 1996; 31: 443-448.
    • (1996) Exp Gerontol , vol.31 , pp. 443-448
    • Olovnikov, A.M.1
  • 33
    • 0037308404 scopus 로고    scopus 로고
    • Association between telomere length in blood and mortality in people aged 60 years or older
    • Cawthon RM, Smith KR, O'Brien E, Sivatchenko A, Kerber RA,. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 2003; 361: 393-395.
    • (2003) Lancet , vol.361 , pp. 393-395
    • Cawthon, R.M.1    Smith, K.R.2    O'Brien, E.3    Sivatchenko, A.4    Kerber, R.A.5
  • 34
    • 34548667973 scopus 로고    scopus 로고
    • Telomere length, stem cells and aging
    • Blasco MA,. Telomere length, stem cells and aging. Nat Chem Biol 2007; 3: 640-649.
    • (2007) Nat Chem Biol , vol.3 , pp. 640-649
    • Blasco, M.A.1
  • 35
    • 84871969335 scopus 로고    scopus 로고
    • Sowing the seeds of cancer: Telomeres and age-associated tumorigenesis
    • Pereira B, Ferreira MG,. Sowing the seeds of cancer: telomeres and age-associated tumorigenesis. Curr Opin Oncol 2013; 25: 93-98.
    • (2013) Curr Opin Oncol , vol.25 , pp. 93-98
    • Pereira, B.1    Ferreira, M.G.2
  • 38
    • 84955508187 scopus 로고    scopus 로고
    • Shortened telomere length is associated with paroxysmal atrial fibrillation among cardiovascular patients enrolled in the Intermountain Heart Collaborative Study
    • Carlquist JF, Knight S, Cawthon RM, Le VT, Bunch TJ, Horne BD, et al., Shortened telomere length is associated with paroxysmal atrial fibrillation among cardiovascular patients enrolled in the Intermountain Heart Collaborative Study. Heart Rhythm 2015; doi: 10.1016/j.hrthm.2015.07.032/.
    • (2015) Heart Rhythm
    • Carlquist, J.F.1    Knight, S.2    Cawthon, R.M.3    Le, V.T.4    Bunch, T.J.5    Horne, B.D.6
  • 41
    • 80855144438 scopus 로고    scopus 로고
    • Epigenetic-aging-signature to determine age in different tissues
    • Koch CM, Wagner W,. Epigenetic-aging-signature to determine age in different tissues. Aging (Albany NY) 2011; 3: 1018-1027.
    • (2011) Aging (Albany NY) , vol.3 , pp. 1018-1027
    • Koch, C.M.1    Wagner, W.2
  • 42
    • 84872806231 scopus 로고    scopus 로고
    • Genome-wide methylation profiles reveal quantitative views of human aging rates
    • Hannum G, Guinney J, Zhao L, Zhang L, Hughes G, Sadda S, et al., Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell 2013; 49: 359-367.
    • (2013) Mol Cell , vol.49 , pp. 359-367
    • Hannum, G.1    Guinney, J.2    Zhao, L.3    Zhang, L.4    Hughes, G.5    Sadda, S.6
  • 45
    • 84857117928 scopus 로고
    • Histone exchange and histone modifications during transcription and aging
    • Das C, Tyler JK,. Histone exchange and histone modifications during transcription and aging. Biochim Biophys Acta 2013; 1819: 332-342.
    • (1819) Biochim Biophys Acta , vol.2013 , pp. 332-342
    • Das, C.1    Tyler, J.K.2
  • 46
    • 78651293534 scopus 로고    scopus 로고
    • MiRBase: Integrating microRNA annotation and deep-sequencing data
    • Kozomara A, Griffiths-Jones S,. miRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res 2011; 39: D152-D157.
    • (2011) Nucleic Acids Res , vol.39 , pp. D152-D157
    • Kozomara, A.1    Griffiths-Jones, S.2
  • 47
    • 84863555312 scopus 로고    scopus 로고
    • Impact of microRNA regulation on variation in human gene expression
    • Lu J, Clark AG,. Impact of microRNA regulation on variation in human gene expression. Genome Res 2012; 22: 1243-1254.
    • (2012) Genome Res , vol.22 , pp. 1243-1254
    • Lu, J.1    Clark, A.G.2
  • 48
    • 77958517467 scopus 로고    scopus 로고
    • MiRNA profile associated with replicative senescence, extended cell culture, and ectopic telomerase expression in human foreskin fibroblasts
    • e12519
    • Bonifacio LN, Jarstfer MB,. MiRNA profile associated with replicative senescence, extended cell culture, and ectopic telomerase expression in human foreskin fibroblasts. PLoS One 2010; 5: e12519.
    • (2010) PLoS One , vol.5
    • Bonifacio, L.N.1    Jarstfer, M.B.2
  • 50
    • 77950200010 scopus 로고    scopus 로고
    • The genetics of ageing
    • Kenyon CJ,. The genetics of ageing. Nature 2010; 464: 504-512.
    • (2010) Nature , vol.464 , pp. 504-512
    • Kenyon, C.J.1
  • 51
    • 84962213369 scopus 로고    scopus 로고
    • MicroRNAs (MiRs) precisely regulate immune system development and function in immunosenescence process
    • [Epub ahead of print]
    • Aalaei-Andabili SH, Rezaei N,. MicroRNAs (MiRs) precisely regulate immune system development and function in immunosenescence process. Int Rev Immunol 2015; [Epub ahead of print].
    • (2015) Int Rev Immunol
    • Aalaei-Andabili, S.H.1    Rezaei, N.2
  • 52
    • 84949086655 scopus 로고    scopus 로고
    • Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: Quantifying the epidemiological transition
    • GBD 2013 DALYs and HALE Collaborators
    • GBD 2013 DALYs and HALE Collaborators, Murray CJ, Barber RM, Foreman KJ, Abbasoglu Ozgoren A, Abd-Allah F, Abera SF, et al., Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition. Lancet 2015; 386: 2145-2191.
    • (2015) Lancet , vol.386 , pp. 2145-2191
    • Murray, C.J.1    Barber, R.M.2    Foreman, K.J.3    Abbasoglu Ozgoren, A.4    Abd-Allah, F.5    Abera, S.F.6
  • 53
    • 84927698872 scopus 로고    scopus 로고
    • Common features of chromatin in aging and cancer: Cause or coincidence?
    • Zane L, Sharma V, Misteli T,. Common features of chromatin in aging and cancer: cause or coincidence? Trends Cell Biol 2014; 24: 686-694.
    • (2014) Trends Cell Biol , vol.24 , pp. 686-694
    • Zane, L.1    Sharma, V.2    Misteli, T.3
  • 54
    • 84876075247 scopus 로고    scopus 로고
    • Molecular pathways and cellular metabolism in colorectal cancer
    • Hagland HR, Berg M, Jolma IW, Carlsen A, Søreide K,. Molecular pathways and cellular metabolism in colorectal cancer. Dig Surg 2013; 30: 12-25.
    • (2013) Dig Surg , vol.30 , pp. 12-25
    • Hagland, H.R.1    Berg, M.2    Jolma, I.W.3    Carlsen, A.4    Søreide, K.5
  • 55
    • 84892909863 scopus 로고    scopus 로고
    • Aging and epigenetic drift: A vicious cycle
    • Issa JP,. Aging and epigenetic drift: a vicious cycle. J Clin Invest 2014; 124: 24-29.
    • (2014) J Clin Invest , vol.124 , pp. 24-29
    • Issa, J.P.1
  • 56
    • 84928012878 scopus 로고    scopus 로고
    • Ageing-associated changes in the human DNA methylome: Genomic locations and effects on gene expression
    • Marttila S, Kananen L, Hayrynen S, Jylhava J, Nevalainen T, Hervonen A, et al., Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression. BMC Genomics 2015; 16: 179.
    • (2015) BMC Genomics , vol.16 , pp. 179
    • Marttila, S.1    Kananen, L.2    Hayrynen, S.3    Jylhava, J.4    Nevalainen, T.5    Hervonen, A.6
  • 57
    • 84908874237 scopus 로고    scopus 로고
    • Molecular biology: Remove, reuse, recycle
    • Eisenstein M., Molecular biology: remove, reuse, recycle. Nature 2014; 514: S2-S4.
    • (2014) Nature , vol.514 , pp. S2-S4
    • Eisenstein, M.1
  • 58
    • 84930746830 scopus 로고    scopus 로고
    • The biology of proteostasis in aging and disease
    • Labbadia J, Morimoto RI,. The biology of proteostasis in aging and disease. Annu Rev Biochem 2015; 84: 435-464.
    • (2015) Annu Rev Biochem , vol.84 , pp. 435-464
    • Labbadia, J.1    Morimoto, R.I.2
  • 59
    • 84864454491 scopus 로고    scopus 로고
    • SHSP in the eye lens: Crystallin mutations, cataract and proteostasis
    • Clark AR, Lubsen NH, Slingsby C,. sHSP in the eye lens: crystallin mutations, cataract and proteostasis. Int J Biochem Cell Biol 2012; 44: 1687-1697.
    • (2012) Int J Biochem Cell Biol , vol.44 , pp. 1687-1697
    • Clark, A.R.1    Lubsen, N.H.2    Slingsby, C.3
  • 60
    • 79251498807 scopus 로고    scopus 로고
    • Protein homeostasis and aging: The importance of exquisite quality control
    • Koga H, Kaushik S, Cuervo AM,. Protein homeostasis and aging: the importance of exquisite quality control. Ageing Res Rev 2011; 10: 205-215.
    • (2011) Ageing Res Rev , vol.10 , pp. 205-215
    • Koga, H.1    Kaushik, S.2    Cuervo, A.M.3
  • 62
    • 84943355219 scopus 로고    scopus 로고
    • The detection and role of heat shock protein 70 in various nondisease conditions and disease conditions: A literature review
    • Qu B, Jia Y, Liu Y, Wang H, Ren G, Wang H,. The detection and role of heat shock protein 70 in various nondisease conditions and disease conditions: a literature review. Cell Stress Chaperones 2015; 20: 885-892.
    • (2015) Cell Stress Chaperones , vol.20 , pp. 885-892
    • Qu, B.1    Jia, Y.2    Liu, Y.3    Wang, H.4    Ren, G.5    Wang, H.6
  • 67
    • 77950994646 scopus 로고    scopus 로고
    • Autophagy: Cellular and molecular mechanisms
    • Glick D, Barth S, Macleod KF,. Autophagy: cellular and molecular mechanisms. J Pathol 2010; 221: 3-12.
    • (2010) J Pathol , vol.221 , pp. 3-12
    • Glick, D.1    Barth, S.2    Macleod, K.F.3
  • 68
    • 79953043473 scopus 로고    scopus 로고
    • Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy
    • e10
    • Morselli E, Maiuri MC, Markaki M, Megalou E, Pasparaki A, Palikaras K, et al., Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis 2010; 1: e10.
    • (2010) Cell Death Dis , vol.1
    • Morselli, E.1    Maiuri, M.C.2    Markaki, M.3    Megalou, E.4    Pasparaki, A.5    Palikaras, K.6
  • 71
    • 84881545650 scopus 로고    scopus 로고
    • Potentially functional polymorphisms in ATG10 are associated with risk of breast cancer in a Chinese population
    • Qin Z, Xue J, He Y, Ma H, Jin G, Chen J, et al., Potentially functional polymorphisms in ATG10 are associated with risk of breast cancer in a Chinese population. Gene 2013; 527: 491-495.
    • (2013) Gene , vol.527 , pp. 491-495
    • Qin, Z.1    Xue, J.2    He, Y.3    Ma, H.4    Jin, G.5    Chen, J.6
  • 72
    • 84929857344 scopus 로고    scopus 로고
    • The relationship of autophagy defects to cartilage damage during joint aging in a mouse model
    • Carames B, Olmer M, Kiosses WB, Lotz MK,. The relationship of autophagy defects to cartilage damage during joint aging in a mouse model. Arthritis Rheumatol 2015; 67: 1568-1576.
    • (2015) Arthritis Rheumatol , vol.67 , pp. 1568-1576
    • Carames, B.1    Olmer, M.2    Kiosses, W.B.3    Lotz, M.K.4
  • 73
    • 84906259908 scopus 로고    scopus 로고
    • Decreased activity of osteocyte autophagy with aging may contribute to the bone loss in senile population
    • Chen K, Yang YH, Jiang SD, Jiang LS,. Decreased activity of osteocyte autophagy with aging may contribute to the bone loss in senile population. Histochem Cell Biol 2014; 142: 285-295.
    • (2014) Histochem Cell Biol , vol.142 , pp. 285-295
    • Chen, K.1    Yang, Y.H.2    Jiang, S.D.3    Jiang, L.S.4
  • 74
    • 84893714992 scopus 로고    scopus 로고
    • Autophagy in aging and neurodegenerative diseases: Implications for pathogenesis and therapy
    • Tan CC, Yu JT, Tan MS, Jiang T, Zhu XC, Tan L,. Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapy. Neurobiol Aging 2014; 35: 941-957.
    • (2014) Neurobiol Aging , vol.35 , pp. 941-957
    • Tan, C.C.1    Yu, J.T.2    Tan, M.S.3    Jiang, T.4    Zhu, X.C.5    Tan, L.6
  • 76
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, et al., Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009; 460: 392-395.
    • (2009) Nature , vol.460 , pp. 392-395
    • Harrison, D.E.1    Strong, R.2    Sharp, Z.D.3    Nelson, J.F.4    Astle, C.M.5    Flurkey, K.6
  • 80
    • 33751072349 scopus 로고    scopus 로고
    • Resveratrol improves health and survival of mice on a high-calorie diet
    • Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, et al., Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006; 444: 337-342.
    • (2006) Nature , vol.444 , pp. 337-342
    • Baur, J.A.1    Pearson, K.J.2    Price, N.L.3    Jamieson, H.A.4    Lerin, C.5    Kalra, A.6
  • 82
    • 84869444066 scopus 로고    scopus 로고
    • Insulin resistance and aging: A cause or a protective response?
    • Barzilai N, Ferrucci L,. Insulin resistance and aging: a cause or a protective response? J Gerontol A Biol Sci Med Sci 2012; 67: 1329-1331.
    • (2012) J Gerontol A Biol Sci Med Sci , vol.67 , pp. 1329-1331
    • Barzilai, N.1    Ferrucci, L.2
  • 84
    • 84923790921 scopus 로고    scopus 로고
    • Tipping the metabolic scales towards increased longevity in mammals
    • Riera CE, Dillin A,. Tipping the metabolic scales towards increased longevity in mammals. Nat Cell Biol 2015; 17: 196-203.
    • (2015) Nat Cell Biol , vol.17 , pp. 196-203
    • Riera, C.E.1    Dillin, A.2
  • 85
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy life span - From yeast to humans
    • Fontana L, Partridge L, Longo VD,. Extending healthy life span-from yeast to humans. Science 2010; 328: 321-326.
    • (2010) Science , vol.328 , pp. 321-326
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 86
    • 79952108510 scopus 로고    scopus 로고
    • Oncogenic mutations of PIK3CA in human cancers
    • Samuels Y, Waldman T,. Oncogenic mutations of PIK3CA in human cancers. Curr Top Microbiol Immunol 2010; 347: 21-41.
    • (2010) Curr Top Microbiol Immunol , vol.347 , pp. 21-41
    • Samuels, Y.1    Waldman, T.2
  • 87
    • 84883463134 scopus 로고    scopus 로고
    • Dietary restriction in C. Elegans: Recent advances
    • Cypser JR, Kitzenberg D, Park S-K,. Dietary restriction in C. elegans: recent advances. Exp Gerontol 2013; 48: 1014-1017.
    • (2013) Exp Gerontol , vol.48 , pp. 1014-1017
    • Cypser, J.R.1    Kitzenberg, D.2    Park, S.-K.3
  • 88
    • 84883464257 scopus 로고    scopus 로고
    • Resveratrol vs. Calorie restriction: Data from rodents to humans
    • Lam YY, Peterson CM, Ravussin E,. Resveratrol vs. Calorie restriction: data from rodents to humans. Exp Gerontol 2013; 48: 1018-1024.
    • (2013) Exp Gerontol , vol.48 , pp. 1018-1024
    • Lam, Y.Y.1    Peterson, C.M.2    Ravussin, E.3
  • 89
    • 84883462013 scopus 로고    scopus 로고
    • Fasting or caloric restriction for healthy aging
    • Anton S, Leeuwenburgh C,. Fasting or caloric restriction for healthy aging. Exp Gerontol 2013; 48: 1003-1005.
    • (2013) Exp Gerontol , vol.48 , pp. 1003-1005
    • Anton, S.1    Leeuwenburgh, C.2
  • 90
    • 40949165265 scopus 로고    scopus 로고
    • The future of obesity: New drugs versus lifestyle interventions
    • Scheen AJ,. The future of obesity: new drugs versus lifestyle interventions. Expert Opin Investig Drugs 2008; 17: 263-267.
    • (2008) Expert Opin Investig Drugs , vol.17 , pp. 263-267
    • Scheen, A.J.1
  • 91
    • 84923349090 scopus 로고    scopus 로고
    • Calorie restriction mimetics: Can you have your cake and eat it, too?
    • Ingram DK, Roth GS,. Calorie restriction mimetics: can you have your cake and eat it, too? Ageing Res Rev 2015; 20: 46-62.
    • (2015) Ageing Res Rev , vol.20 , pp. 46-62
    • Ingram, D.K.1    Roth, G.S.2
  • 92
    • 84912103909 scopus 로고    scopus 로고
    • Obesity and diabetes in an aging population: Time to rethink definitions and management?
    • vii
    • Rothberg AE, Halter JB,. Obesity and diabetes in an aging population: time to rethink definitions and management? Clin Geriatr Med 2015; 31: 1-15, vii.
    • (2015) Clin Geriatr Med , vol.31 , pp. 1-15
    • Rothberg, A.E.1    Halter, J.B.2
  • 93
    • 84901834147 scopus 로고    scopus 로고
    • Bariatric surgery and diet-induced long-term caloric restriction protect subcutaneous adipose-derived stromal/progenitor cells and prolong their life span in formerly obese humans
    • Mitterberger MC, Mattesich M, Zwerschke W,. Bariatric surgery and diet-induced long-term caloric restriction protect subcutaneous adipose-derived stromal/progenitor cells and prolong their life span in formerly obese humans. Exp Gerontol 2014; 56: 106-113.
    • (2014) Exp Gerontol , vol.56 , pp. 106-113
    • Mitterberger, M.C.1    Mattesich, M.2    Zwerschke, W.3
  • 95
    • 79960845908 scopus 로고    scopus 로고
    • Fasting vs dietary restriction in cellular protection and cancer treatment: From model organisms to patients
    • Lee C, Longo VD,. Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients. Oncogene 2011; 30: 3305-3316.
    • (2011) Oncogene , vol.30 , pp. 3305-3316
    • Lee, C.1    Longo, V.D.2
  • 96
    • 84940887447 scopus 로고    scopus 로고
    • The update on transcriptional regulation of autophagy in normal and pathologic cells: A novel therapeutic target
    • Zhang Z, Guo M, Zhao S, Xu W, Shao J, Zhang F, et al., The update on transcriptional regulation of autophagy in normal and pathologic cells: a novel therapeutic target. Biomed Pharmacother 2015; 74: 17-29.
    • (2015) Biomed Pharmacother , vol.74 , pp. 17-29
    • Zhang, Z.1    Guo, M.2    Zhao, S.3    Xu, W.4    Shao, J.5    Zhang, F.6
  • 97
    • 84879602902 scopus 로고    scopus 로고
    • Evaluating and responding to mitochondrial dysfunction: The mitochondrial unfolded-protein response and beyond
    • Haynes CM, Fiorese CJ, Lin YF,. Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond. Trends Cell Biol 2013; 23: 311-318.
    • (2013) Trends Cell Biol , vol.23 , pp. 311-318
    • Haynes, C.M.1    Fiorese, C.J.2    Lin, Y.F.3
  • 99
    • 84941739003 scopus 로고
    • The role of mitochondrial dysfunction in age-related diseases
    • Lane RK, Hilsabeck T, Rea SL,. The role of mitochondrial dysfunction in age-related diseases. Biochim Biophys Acta 2015; 1847: 1837-1400.
    • (1847) Biochim Biophys Acta , vol.2015 , pp. 1837-1400
    • Lane, R.K.1    Hilsabeck, T.2    Rea, S.L.3
  • 101
    • 65549096847 scopus 로고    scopus 로고
    • Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: Insulin resistance, friend or foe?
    • Nunn AVW, Bell JD, Guy GW,. Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe? Nutr Metab (Lond) 2009; 6: 16.
    • (2009) Nutr Metab (Lond) , vol.6 , pp. 16
    • Nunn, A.V.W.1    Bell, J.D.2    Guy, G.W.3
  • 102
    • 80055027842 scopus 로고    scopus 로고
    • Mammalian target of rapamycin: A central node of complex signaling cascades
    • Dobashi Y, Watanabe Y, Miwa C, Suzuki S, Koyama S,. Mammalian target of rapamycin: a central node of complex signaling cascades. Int J Clin Exp Pathol 2011; 4: 476-495.
    • (2011) Int J Clin Exp Pathol , vol.4 , pp. 476-495
    • Dobashi, Y.1    Watanabe, Y.2    Miwa, C.3    Suzuki, S.4    Koyama, S.5
  • 103
    • 63849149937 scopus 로고    scopus 로고
    • LKB1 and AMP-activated protein kinase control of mTOR signalling and growth
    • Shaw RJ,. LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. Acta Physiol (Oxf) 2009; 196: 65-80.
    • (2009) Acta Physiol (Oxf) , vol.196 , pp. 65-80
    • Shaw, R.J.1
  • 104
    • 84874594425 scopus 로고    scopus 로고
    • The sirtuin family's role in aging and age-associated pathologies
    • Hall JA, Dominy JE, Lee Y, Puigserver P,. The sirtuin family's role in aging and age-associated pathologies. J Clin Invest 2013; 123: 973-979.
    • (2013) J Clin Invest , vol.123 , pp. 973-979
    • Hall, J.A.1    Dominy, J.E.2    Lee, Y.3    Puigserver, P.4
  • 105
    • 12144290563 scopus 로고    scopus 로고
    • Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    • Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, et al., Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004; 303: 2011-2015.
    • (2004) Science , vol.303 , pp. 2011-2015
    • Brunet, A.1    Sweeney, L.B.2    Sturgill, J.F.3    Chua, K.F.4    Greer, P.L.5    Lin, Y.6
  • 106
    • 71349087186 scopus 로고    scopus 로고
    • Origin and evolution of the free radical theory of aging: A brief personal history, 1954-2009
    • Harman D., Origin and evolution of the free radical theory of aging: a brief personal history, 1954-2009. Biogerontology 2009; 10: 773-781.
    • (2009) Biogerontology , vol.10 , pp. 773-781
    • Harman, D.1
  • 107
    • 84901756876 scopus 로고    scopus 로고
    • The paradox of mitochondrial dysfunction and extended longevity
    • Munkacsy E, Rea SL,. The paradox of mitochondrial dysfunction and extended longevity. Exp Gerontol 2014; 56: 221-233.
    • (2014) Exp Gerontol , vol.56 , pp. 221-233
    • Munkacsy, E.1    Rea, S.L.2
  • 108
    • 35648947912 scopus 로고    scopus 로고
    • Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans
    • e259
    • Rea SL, Ventura N, Johnson TE,. Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. PLoS Biol 2007; 5: e259.
    • (2007) PLoS Biol , vol.5
    • Rea, S.L.1    Ventura, N.2    Johnson, T.E.3
  • 109
    • 68949150810 scopus 로고    scopus 로고
    • Mitochondrial functional complementation in mitochondrial DNA-based diseases
    • Nakada K, Sato A, Hayashi J,. Mitochondrial functional complementation in mitochondrial DNA-based diseases. Int J Biochem Cell Biol 2009; 41: 1907-1913.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 1907-1913
    • Nakada, K.1    Sato, A.2    Hayashi, J.3
  • 110
    • 84900295547 scopus 로고    scopus 로고
    • Mitohormesis
    • Yun J, Finkel T,. Mitohormesis. Cell Metab 2014; 19: 757-766.
    • (2014) Cell Metab , vol.19 , pp. 757-766
    • Yun, J.1    Finkel, T.2
  • 111
    • 78650455712 scopus 로고    scopus 로고
    • A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans
    • e1000556
    • Yang W, Hekimi S,. A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans. PLoS Biol 2010; 8: e1000556.
    • (2010) PLoS Biol , vol.8
    • Yang, W.1    Hekimi, S.2
  • 112
    • 84900299463 scopus 로고    scopus 로고
    • The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. Elegans
    • Yee C, Yang W, Hekimi S,. The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. Elegans. Cell 2014; 157: 897-909.
    • (2014) Cell , vol.157 , pp. 897-909
    • Yee, C.1    Yang, W.2    Hekimi, S.3
  • 113
    • 80053124673 scopus 로고    scopus 로고
    • Taking a 'good' look at free radicals in the aging process
    • Hekimi S, Lapointe J, Wen Y,. Taking a 'good' look at free radicals in the aging process. Trends Cell Biol 2011; 21: 569-576.
    • (2011) Trends Cell Biol , vol.21 , pp. 569-576
    • Hekimi, S.1    Lapointe, J.2    Wen, Y.3
  • 114
    • 78650944949 scopus 로고    scopus 로고
    • The cell-non-autonomous nature of electron transport chain-mediated longevity
    • Durieux J, Wolff S, Dillin A,. The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell 2011; 144: 79-91.
    • (2011) Cell , vol.144 , pp. 79-91
    • Durieux, J.1    Wolff, S.2    Dillin, A.3
  • 115
    • 77649311383 scopus 로고    scopus 로고
    • Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. Elegans healthspan via AMPK, LKB1, and SKN-1
    • e8758
    • Onken B, Driscoll M,. Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans healthspan via AMPK, LKB1, and SKN-1. PLoS One 2010; 5: e8758.
    • (2010) PLoS One , vol.5
    • Onken, B.1    Driscoll, M.2
  • 117
    • 84455161659 scopus 로고    scopus 로고
    • Further support to the uncoupling-to-survive theory: The genetic variation of human UCP genes is associated with longevity
    • e29650
    • Rose G, Crocco P, De Rango F, Montesanto A, Passarino G,. Further support to the uncoupling-to-survive theory: the genetic variation of human UCP genes is associated with longevity. PLoS One 2011; 6: e29650.
    • (2011) PLoS One , vol.6
    • Rose, G.1    Crocco, P.2    De Rango, F.3    Montesanto, A.4    Passarino, G.5
  • 118
    • 14544282413 scopus 로고    scopus 로고
    • Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
    • Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P,. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 2005; 434: 113-118.
    • (2005) Nature , vol.434 , pp. 113-118
    • Rodgers, J.T.1    Lerin, C.2    Haas, W.3    Gygi, S.P.4    Spiegelman, B.M.5    Puigserver, P.6
  • 120
    • 84930039315 scopus 로고    scopus 로고
    • How do changes in the mtDNA and mitochondrial dysfunction influence cancer and cancer therapy? Challenges, opportunities and models
    • van Gisbergen MW, Voets AM, Starmans MH, de Coo IF, Yadak R, Hoffmann RF, et al., How do changes in the mtDNA and mitochondrial dysfunction influence cancer and cancer therapy? Challenges, opportunities and models. Mutat Res 2015; 764: 16-30.
    • (2015) Mutat Res , vol.764 , pp. 16-30
    • Van Gisbergen, M.W.1    Voets, A.M.2    Starmans, M.H.3    De Coo, I.F.4    Yadak, R.5    Hoffmann, R.F.6
  • 121
    • 84901288438 scopus 로고    scopus 로고
    • The role of senescent cells in ageing
    • van Deursen JM,. The role of senescent cells in ageing. Nature 2014; 509: 439-446.
    • (2014) Nature , vol.509 , pp. 439-446
    • Van Deursen, J.M.1
  • 122
    • 84873638532 scopus 로고    scopus 로고
    • Aging, cellular senescence, and cancer
    • Campisi J., Aging, cellular senescence, and cancer. Annu Rev Physiol 2013; 75: 685-705.
    • (2013) Annu Rev Physiol , vol.75 , pp. 685-705
    • Campisi, J.1
  • 124
    • 84874599388 scopus 로고    scopus 로고
    • Coming of age: Molecular drivers of aging and therapeutic opportunities
    • Newgard CB, Sharpless NE,. Coming of age: molecular drivers of aging and therapeutic opportunities. J Clin Invest 2013; 123: 946-950.
    • (2013) J Clin Invest , vol.123 , pp. 946-950
    • Newgard, C.B.1    Sharpless, N.E.2
  • 125
    • 84874603171 scopus 로고    scopus 로고
    • Cellular senescence and the senescent secretory phenotype: Therapeutic opportunities
    • Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL,. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J Clin Invest 2013; 123: 966-972.
    • (2013) J Clin Invest , vol.123 , pp. 966-972
    • Tchkonia, T.1    Zhu, Y.2    Van Deursen, J.3    Campisi, J.4    Kirkland, J.L.5
  • 126
    • 20444370974 scopus 로고    scopus 로고
    • What has senescence got to do with cancer?
    • Dimri GP,. What has senescence got to do with cancer? Cancer Cell 2005; 7: 505-512.
    • (2005) Cancer Cell , vol.7 , pp. 505-512
    • Dimri, G.P.1
  • 127
    • 34447543913 scopus 로고    scopus 로고
    • Cellular senescence in cancer and aging
    • Collado M, Blasco MA, Serrano M,. Cellular senescence in cancer and aging. Cell 2007; 130: 223-233.
    • (2007) Cell , vol.130 , pp. 223-233
    • Collado, M.1    Blasco, M.A.2    Serrano, M.3
  • 128
    • 84908450979 scopus 로고    scopus 로고
    • Endothelial cell senescence and age-related vascular diseases
    • Tian XL, Li Y,. Endothelial cell senescence and age-related vascular diseases. J Genet Genomics 2014; 41: 485-495.
    • (2014) J Genet Genomics , vol.41 , pp. 485-495
    • Tian, X.L.1    Li, Y.2
  • 129
    • 84924140282 scopus 로고    scopus 로고
    • Cellular senescence in ageing, age-related disease and longevity
    • Sikora E, Bielak-Zmijewska A, Mosieniak G,. Cellular senescence in ageing, age-related disease and longevity. Curr Vasc Pharmacol 2014; 12: 698-706.
    • (2014) Curr Vasc Pharmacol , vol.12 , pp. 698-706
    • Sikora, E.1    Bielak-Zmijewska, A.2    Mosieniak, G.3
  • 130
    • 84981287114 scopus 로고    scopus 로고
    • P16INK4a positive cells in human skin are indicative of local elastic fiber morphology, facial wrinkling, and perceived age
    • [Epub ahead of print]
    • Waaijer ME, Gunn DA, Adams PD, Pawlikowski JS, Griffiths CE, van Heemst D, et al., P16INK4a positive cells in human skin are indicative of local elastic fiber morphology, facial wrinkling, and perceived age. J Gerontol A Biol Sci Med 2015; [Epub ahead of print].
    • (2015) J Gerontol A Biol Sci Med
    • Waaijer, M.E.1    Gunn, D.A.2    Adams, P.D.3    Pawlikowski, J.S.4    Griffiths, C.E.5    Van Heemst, D.6
  • 133
    • 84866442827 scopus 로고    scopus 로고
    • Review: A meta-analysis of GWAS and age-associated diseases
    • Jeck WR, Siebold AP, Sharpless NE,. Review: a meta-analysis of GWAS and age-associated diseases. Aging Cell 2012; 11: 727-731.
    • (2012) Aging Cell , vol.11 , pp. 727-731
    • Jeck, W.R.1    Siebold, A.P.2    Sharpless, N.E.3
  • 134
    • 84922624477 scopus 로고    scopus 로고
    • Reversible cell cycle inhibition and premature aging features imposed by conditional expression of p16Ink4a
    • Boquoi A, Arora S, Chen T, Litwin S, Koh J, Enders GH,. Reversible cell cycle inhibition and premature aging features imposed by conditional expression of p16Ink4a. Aging Cell 2015; 14: 139-147.
    • (2015) Aging Cell , vol.14 , pp. 139-147
    • Boquoi, A.1    Arora, S.2    Chen, T.3    Litwin, S.4    Koh, J.5    Enders, G.H.6
  • 136
    • 84864306922 scopus 로고    scopus 로고
    • Immune surveillance of senescent cells - Biological significance in cancer- and non-cancer pathologies
    • Hoenicke L, Zender L,. Immune surveillance of senescent cells-biological significance in cancer- and non-cancer pathologies. Carcinogenesis 2012; 33: 1123-1126.
    • (2012) Carcinogenesis , vol.33 , pp. 1123-1126
    • Hoenicke, L.1    Zender, L.2
  • 137
    • 81855169964 scopus 로고    scopus 로고
    • Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
    • Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, et al., Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature 2011; 479: 547-551.
    • (2011) Nature , vol.479 , pp. 547-551
    • Kang, T.W.1    Yevsa, T.2    Woller, N.3    Hoenicke, L.4    Wuestefeld, T.5    Dauch, D.6
  • 138
    • 84890458719 scopus 로고    scopus 로고
    • Immunosurveillance of senescent cells: The bright side of the senescence program
    • Sagiv A, Krizhanovsky V,. Immunosurveillance of senescent cells: the bright side of the senescence program. Biogerontology 2013; 14: 617-628.
    • (2013) Biogerontology , vol.14 , pp. 617-628
    • Sagiv, A.1    Krizhanovsky, V.2
  • 139
    • 84939566590 scopus 로고    scopus 로고
    • Immunosenescence: Implications for response to infection and vaccination in older people
    • Pera A, Campos C, Lõpez N, Hassouneh F, Alonso C, Tarazona R, et al., Immunosenescence: implications for response to infection and vaccination in older people. Maturitas 2015; 82: 50-55.
    • (2015) Maturitas , vol.82 , pp. 50-55
    • Pera, A.1    Campos, C.2    Lõpez, N.3    Hassouneh, F.4    Alonso, C.5    Tarazona, R.6
  • 140
    • 77949881221 scopus 로고    scopus 로고
    • The senescence-associated secretory phenotype: The dark side of tumor suppression
    • Coppé JP, Desprez PY, Krtolica A, Campisi J,. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol 2010; 5: 99-118.
    • (2010) Annu Rev Pathol , vol.5 , pp. 99-118
    • Coppé, J.P.1    Desprez, P.Y.2    Krtolica, A.3    Campisi, J.4
  • 141
    • 84925283137 scopus 로고    scopus 로고
    • Physiological and pathological consequences of cellular senescence
    • Burton DG, Krizhanovsky V,. Physiological and pathological consequences of cellular senescence. Cell Mol Life Sci 2014; 71: 4373-4386.
    • (2014) Cell Mol Life Sci , vol.71 , pp. 4373-4386
    • Burton, D.G.1    Krizhanovsky, V.2
  • 142
    • 84907598269 scopus 로고    scopus 로고
    • Acute Care and Emergency Surgery (ACES) Group. Sarcopenia is a predictor of outcomes in very elderly patients undergoing emergency surgery
    • Du Y, Karvellas CJ, Baracos V, Williams DC, Khadaroo RG,; Acute Care and Emergency Surgery (ACES) Group. Sarcopenia is a predictor of outcomes in very elderly patients undergoing emergency surgery. Surgery 2014; 156: 521-527.
    • (2014) Surgery , vol.156 , pp. 521-527
    • Du, Y.1    Karvellas, C.J.2    Baracos, V.3    Williams, D.C.4    Khadaroo, R.G.5
  • 143
    • 84983059084 scopus 로고    scopus 로고
    • From inflammaging to healthy aging by dietary lifestyle choices: Is epigenetics the key to personalized nutrition?
    • 33
    • Szarc vel Szic K, Declerck K, Vidakovic M, Vanden Berghe W,. From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition? Clin Epigenetics 2015; 7: 33.
    • (2015) Clin Epigenetics , vol.7
    • Szarc vel Szic, K.1    Declerck, K.2    Vidakovic, M.3    Vanden Berghe, W.4
  • 144
    • 58149119644 scopus 로고    scopus 로고
    • Exploring the complex relations between inflammation and aging (inflamm-aging): Anti-inflamm-aging remodelling of inflamm-aging, from robustness to frailty
    • Giunta S., Exploring the complex relations between inflammation and aging (inflamm-aging): anti-inflamm-aging remodelling of inflamm-aging, from robustness to frailty. Inflamm Res 2008; 57: 558-563.
    • (2008) Inflamm Res , vol.57 , pp. 558-563
    • Giunta, S.1
  • 145
    • 84930624664 scopus 로고    scopus 로고
    • Pre-operative, high-IL-6 blood level is a risk factor of post-operative delirium onset in old patients
    • Capri M, Yani SL, Chattat R, Fortuna D, Bucci L, Lanzarini C, et al., Pre-operative, high-IL-6 blood level is a risk factor of post-operative delirium onset in old patients. Front Endocrinol (Lausanne) 2014; 5: 173.
    • (2014) Front Endocrinol (Lausanne) , vol.5 , pp. 173
    • Capri, M.1    Yani, S.L.2    Chattat, R.3    Fortuna, D.4    Bucci, L.5    Lanzarini, C.6
  • 146
    • 84929452481 scopus 로고    scopus 로고
    • Sarcopenia - The search for emerging biomarkers
    • Kalinkovich A, Livshits G,. Sarcopenia-the search for emerging biomarkers. Ageing Res Rev 2015; 22: 58-71.
    • (2015) Ageing Res Rev , vol.22 , pp. 58-71
    • Kalinkovich, A.1    Livshits, G.2
  • 147
    • 84906556907 scopus 로고    scopus 로고
    • Ageing: Develop models of frailty
    • Howlett SE, Rockwood K,. Ageing: develop models of frailty. Nature 2014; 512: 253.
    • (2014) Nature , vol.512 , pp. 253
    • Howlett, S.E.1    Rockwood, K.2
  • 148
    • 77950199929 scopus 로고    scopus 로고
    • Age-related inflammation: The contribution of different organs, tissues and systems. How to face it for therapeutic approaches
    • Cevenini E, Caruso C, Candore G, Capri M, Nuzzo D, Duro G, et al., Age-related inflammation: the contribution of different organs, tissues and systems. How to face it for therapeutic approaches. Curr Pharm Des 2010; 16: 609-618.
    • (2010) Curr Pharm des , vol.16 , pp. 609-618
    • Cevenini, E.1    Caruso, C.2    Candore, G.3    Capri, M.4    Nuzzo, D.5    Duro, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.