메뉴 건너뛰기




Volumn 67, Issue 6, 2015, Pages 1568-1576

The relationship of autophagy defects to cartilage damage during joint aging in a mouse model

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY PROTEIN 5; GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN LIGHT CHAIN 3; MICROTUBULE ASSOCIATED PROTEIN 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE P85; UNCLASSIFIED DRUG; ATG5 PROTEIN, MOUSE; MAP1LC3 PROTEIN, MOUSE; MICROTUBULE ASSOCIATED PROTEIN;

EID: 84929857344     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.39073     Document Type: Article
Times cited : (172)

References (42)
  • 2
    • 77955482258 scopus 로고    scopus 로고
    • Epidemiology of osteoarthritis
    • Zhang Y, Jordan JM., Epidemiology of osteoarthritis. Clin Geriatr Med 2010; 26: 355-69.
    • (2010) Clin Geriatr Med , vol.26 , pp. 355-369
    • Zhang, Y.1    Jordan, J.M.2
  • 3
    • 84861994775 scopus 로고    scopus 로고
    • Effects of aging on articular cartilage homeostasis
    • Lotz M, Loeser RF., Effects of aging on articular cartilage homeostasis. Bone 2012; 51: 241-8.
    • (2012) Bone , vol.51 , pp. 241-248
    • Lotz, M.1    Loeser, R.F.2
  • 4
    • 70450274965 scopus 로고    scopus 로고
    • Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways
    • Yin W, Park JI, Loeser RF., Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways. J Biol Chem 2009; 284: 31972-81.
    • (2009) J Biol Chem , vol.284 , pp. 31972-31981
    • Yin, W.1    Park, J.I.2    Loeser, R.F.3
  • 6
    • 80053900670 scopus 로고    scopus 로고
    • Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA
    • Lotz MK, Carames B., Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA. Nat Rev Rheumatol 2011; 7: 579-87.
    • (2011) Nat Rev Rheumatol , vol.7 , pp. 579-587
    • Lotz, M.K.1    Carames, B.2
  • 7
    • 84901047429 scopus 로고    scopus 로고
    • Proteostasis and the aging proteome in health and disease
    • Morimoto RI, Cuervo AM., Proteostasis and the aging proteome in health and disease. J Gerontol A Biol Sci Med Sci 2014; 69 Suppl 1: S33-8.
    • (2014) J Gerontol A Biol Sci Med Sci , vol.69 , pp. S33-S38
    • Morimoto, R.I.1    Cuervo, A.M.2
  • 8
    • 72949111893 scopus 로고    scopus 로고
    • Physiological functions of autophagy
    • Mizushima N., Physiological functions of autophagy. Curr Top Microbiol Immunol 2009; 335: 71-84.
    • (2009) Curr Top Microbiol Immunol , vol.335 , pp. 71-84
    • Mizushima, N.1
  • 10
    • 78651284554 scopus 로고    scopus 로고
    • The complexes of mammalian target of rapamycin
    • Zhou H, Huang S., The complexes of mammalian target of rapamycin. Curr Protein Pept Sci 2010; 11: 409-24.
    • (2010) Curr Protein Pept Sci , vol.11 , pp. 409-424
    • Zhou, H.1    Huang, S.2
  • 11
    • 77649128750 scopus 로고    scopus 로고
    • Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis
    • Carames B, Taniguchi N, Otsuki S, Blanco FJ, Lotz M., Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis. Arthritis Rheum 2010; 62: 791-801.
    • (2010) Arthritis Rheum , vol.62 , pp. 791-801
    • Carames, B.1    Taniguchi, N.2    Otsuki, S.3    Blanco, F.J.4    Lotz, M.5
  • 12
    • 84861981732 scopus 로고    scopus 로고
    • Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection
    • Carames B, Taniguchi N, Seino D, Blanco FJ, D'Lima D, Lotz M., Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection. Arthritis Rheum 2012; 64: 1182-92.
    • (2012) Arthritis Rheum , vol.64 , pp. 1182-1192
    • Carames, B.1    Taniguchi, N.2    Seino, D.3    Blanco, F.J.4    D'Lima, D.5    Lotz, M.6
  • 14
    • 1542283812 scopus 로고    scopus 로고
    • In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker
    • Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y., In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 2004; 15: 1101-11.
    • (2004) Mol Biol Cell , vol.15 , pp. 1101-1111
    • Mizushima, N.1    Yamamoto, A.2    Matsui, M.3    Yoshimori, T.4    Ohsumi, Y.5
  • 16
    • 59049100910 scopus 로고    scopus 로고
    • Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis
    • Taniguchi N, Carames B, Ronfani L, Ulmer U, Komiya S, Bianchi ME, et al., Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis. Proc Natl Acad Sci U S A 2009; 106: 1181-6.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 1181-1186
    • Taniguchi, N.1    Carames, B.2    Ronfani, L.3    Ulmer, U.4    Komiya, S.5    Bianchi, M.E.6
  • 17
    • 77956924858 scopus 로고    scopus 로고
    • The OARSI histopathology initiative: Recommendations for histological assessments of osteoarthritis in the mouse
    • Glasson SS, Chambers MG, Van Den Berg WB, Little CB., The OARSI histopathology initiative: recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis Cartilage 2010; 18 Suppl 3: S17-23.
    • (2010) Osteoarthritis Cartilage , vol.18 , pp. S17-S23
    • Glasson, S.S.1    Chambers, M.G.2    Van Den Berg, W.B.3    Little, C.B.4
  • 18
    • 0035985676 scopus 로고    scopus 로고
    • Grading of chronic synovitis: A histopathological grading system for molecular and diagnostic pathology
    • Krenn V, Morawietz L, Haupl T, Neidel J, Petersen I, Konig A., Grading of chronic synovitis: a histopathological grading system for molecular and diagnostic pathology. Pathol Res Pract 2002; 198: 317-25.
    • (2002) Pathol Res Pract , vol.198 , pp. 317-325
    • Krenn, V.1    Morawietz, L.2    Haupl, T.3    Neidel, J.4    Petersen, I.5    Konig, A.6
  • 19
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • Mizushima N, Yoshimori T, Levine B., Methods in mammalian autophagy research. Cell 2010; 140: 313-26.
    • (2010) Cell , vol.140 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 21
    • 56749170677 scopus 로고    scopus 로고
    • Autophagic cell death: The story of a misnomer
    • Kroemer G, Levine B., Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol 2008; 9: 1004-10.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 1004-1010
    • Kroemer, G.1    Levine, B.2
  • 22
    • 51349095898 scopus 로고    scopus 로고
    • Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function
    • Zhang C, Cuervo AM., Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. Nat Med 2008; 14: 959-65.
    • (2008) Nat Med , vol.14 , pp. 959-965
    • Zhang, C.1    Cuervo, A.M.2
  • 23
    • 77951915586 scopus 로고    scopus 로고
    • Autophagy during cardiac stress: Joys and frustrations of autophagy
    • Gottlieb RA, Mentzer RM., Autophagy during cardiac stress: joys and frustrations of autophagy. Annu Rev Physiol 2010; 72: 45-59.
    • (2010) Annu Rev Physiol , vol.72 , pp. 45-59
    • Gottlieb, R.A.1    Mentzer, R.M.2
  • 26
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, et al., Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009; 460: 392-5.
    • (2009) Nature , vol.460 , pp. 392-395
    • Harrison, D.E.1    Strong, R.2    Sharp, Z.D.3    Nelson, J.F.4    Astle, C.M.5    Flurkey, K.6
  • 27
    • 70349750492 scopus 로고    scopus 로고
    • Rapamycin protects against rotenone-induced apoptosis through autophagy induction
    • Pan T, Rawal P, Wu Y, Xie W, Jankovic J, Le W., Rapamycin protects against rotenone-induced apoptosis through autophagy induction. Neuroscience 2009; 164: 541-51.
    • (2009) Neuroscience , vol.164 , pp. 541-551
    • Pan, T.1    Rawal, P.2    Wu, Y.3    Xie, W.4    Jankovic, J.5    Le, W.6
  • 28
    • 77956305343 scopus 로고    scopus 로고
    • Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-β levels in a mouse model of Alzheimer's disease
    • Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, et al., Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-β levels in a mouse model of Alzheimer's disease. PLoS One 2010; 5: e9979.
    • (2010) PLoS One , vol.5 , pp. e9979
    • Spilman, P.1    Podlutskaya, N.2    Hart, M.J.3    Debnath, J.4    Gorostiza, O.5    Bredesen, D.6
  • 29
    • 0028839263 scopus 로고
    • Damage to type II collagen in aging and osteo arthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration
    • Hollander AP, Pidoux I, Reiner A, Rorabeck C, Bourne R, Poole AR., Damage to type II collagen in aging and osteo arthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration. J Clin Invest 1995; 96: 2859-69.
    • (1995) J Clin Invest , vol.96 , pp. 2859-2869
    • Hollander, A.P.1    Pidoux, I.2    Reiner, A.3    Rorabeck, C.4    Bourne, R.5    Poole, A.R.6
  • 30
    • 77953536591 scopus 로고    scopus 로고
    • Macroscopic assessment of cartilage shear: Effects of counter-surface roughness, synovial fluid lubricant, and compression offset
    • Nguyen QT, Wong BL, Chun J, Yoon YC, Talke FE, Sah RL., Macroscopic assessment of cartilage shear: effects of counter-surface roughness, synovial fluid lubricant, and compression offset. J Biomech 2010; 43: 1787-93.
    • (2010) J Biomech , vol.43 , pp. 1787-1793
    • Nguyen, Q.T.1    Wong, B.L.2    Chun, J.3    Yoon, Y.C.4    Talke, F.E.5    Sah, R.L.6
  • 31
    • 85007567623 scopus 로고    scopus 로고
    • Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis
    • E-pub ahead of print
    • Zhang Y, Vasheghani F, Li YH, Blati M, Simeone K, Fahmi H, et al., Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis. Ann Rheum Dis 2014. E-pub ahead of print.
    • (2014) Ann Rheum Dis
    • Zhang, Y.1    Vasheghani, F.2    Li, Y.H.3    Blati, M.4    Simeone, K.5    Fahmi, H.6
  • 33
    • 84907266449 scopus 로고    scopus 로고
    • Intra-articular administration of gelatin hydrogels incorporating rapamycin-micelles reduces the development of experimental osteoarthritis in a murine model
    • Matsuzaki T, Matsushita T, Tabata Y, Saito T, Matsumoto T, Nagai K, et al., Intra-articular administration of gelatin hydrogels incorporating rapamycin-micelles reduces the development of experimental osteoarthritis in a murine model. Biomaterials 2014; 35: 9904-11.
    • (2014) Biomaterials , vol.35 , pp. 9904-9911
    • Matsuzaki, T.1    Matsushita, T.2    Tabata, Y.3    Saito, T.4    Matsumoto, T.5    Nagai, K.6
  • 34
    • 79959831457 scopus 로고    scopus 로고
    • Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α
    • Terkeltaub R, Yang B, Lotz M, Liu-Bryan R., Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α. Arthritis Rheum 2011; 63: 1928-37.
    • (2011) Arthritis Rheum , vol.63 , pp. 1928-1937
    • Terkeltaub, R.1    Yang, B.2    Lotz, M.3    Liu-Bryan, R.4
  • 36
    • 77951259001 scopus 로고    scopus 로고
    • Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression
    • Bohensky J, Leshinsky S, Srinivas V, Shapiro IM., Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression. Pediatr Nephrol 2010; 25: 633-42.
    • (2010) Pediatr Nephrol , vol.25 , pp. 633-642
    • Bohensky, J.1    Leshinsky, S.2    Srinivas, V.3    Shapiro, I.M.4
  • 38
    • 66049155861 scopus 로고    scopus 로고
    • Regulation of autophagy in human and murine cartilage: Hypoxia-inducible factor 2 suppresses chondrocyte autophagy
    • Bohensky J, Terkhorn SP, Freeman TA, Adams CS, Garcia JA, Shapiro IM, et al., Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy. Arthritis Rheum 2009; 60: 1406-15.
    • (2009) Arthritis Rheum , vol.60 , pp. 1406-1415
    • Bohensky, J.1    Terkhorn, S.P.2    Freeman, T.A.3    Adams, C.S.4    Garcia, J.A.5    Shapiro, I.M.6
  • 39
    • 77953208836 scopus 로고    scopus 로고
    • Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development
    • Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, et al., Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development. Nat Med 2010; 16: 678-86.
    • (2010) Nat Med , vol.16 , pp. 678-686
    • Saito, T.1    Fukai, A.2    Mabuchi, A.3    Ikeda, T.4    Yano, F.5    Ohba, S.6
  • 40
    • 77953183739 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction
    • Yang S, Kim J, Ryu JH, Oh H, Chun CH, Kim BJ, et al., Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction. Nat Med 2010; 16: 687-93.
    • (2010) Nat Med , vol.16 , pp. 687-693
    • Yang, S.1    Kim, J.2    Ryu, J.H.3    Oh, H.4    Chun, C.H.5    Kim, B.J.6
  • 41
    • 0344197013 scopus 로고    scopus 로고
    • Sexual dimorphism in the osteoarthritis of STR/ort mice may be linked to articular cytokines
    • Mahr S, Menard J, Krenn V, Muller B., Sexual dimorphism in the osteoarthritis of STR/ort mice may be linked to articular cytokines. Ann Rheum Dis 2003; 62: 1234-7.
    • (2003) Ann Rheum Dis , vol.62 , pp. 1234-1237
    • Mahr, S.1    Menard, J.2    Krenn, V.3    Muller, B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.