Age-related inflammation: The contribution of different organs, tissues and systems. How to face it for therapeutic approaches

Current Pharmaceutical Design

Volumn 16, Issue 6, 2010, Pages 609-618

  Cevenini, E ^a   Caruso, C ^b   Candore, G ^b   Capri, M ^a   Nuzzo, D ^c   Duro, G ^c   Rizzo, C ^b   Colonna Romano, G ^b   Lio, D ^b   Di Carlo, D ^b   Palmas, M G ^a   Scurti, M ^a   Pini, E ^a   Franceschi, C ^a   Vasto, S ^b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

^c CNR Consiglio Nazionale delle Ricerche   (Italy)

Author keywords

Age related diseases; Ageing; Immunosenescence; Inflammation

Indexed keywords

CELECOXIB; INFLUENZA VACCINE; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PROBIOTIC AGENT;

ADIPOSE TISSUE; AGED; AGING; BRAIN TISSUE; CHRONIC INFLAMMATION; CLINICAL TRIAL; DIETARY INTAKE; DISEASE COURSE; DISEASE PREDISPOSITION; DRUG EFFICACY; DRUG SAFETY; ENTERITIS; EPIGENETICS; EXERCISE; GENETIC POLYMORPHISM; HUMAN; IMMUNE SYSTEM; INFLUENZA; INTESTINE FLORA; LIVER; LONGEVITY; META ANALYSIS; MUSCLE TISSUE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SYSTEMATIC REVIEW; UNSPECIFIED SIDE EFFECT; VACCINATION; ANIMAL; ANTIBODY SPECIFICITY; GENETICS; IMMUNOLOGY; INFLAMMATION; PATHOLOGY; TISSUE DISTRIBUTION;

AGING; ANIMALS; HUMANS; INFLAMMATION; LONGEVITY; ORGAN SPECIFICITY; TISSUE DISTRIBUTION;

EID: 77950199929     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161210790883840     Document Type: Review

References (143)

1. Vasto S, Scapagnini G, Bulati M, Candore G, Castiglia L, Colonna-Romano CR, et al. Biomarkers of Ageing. Front Biosci 2010; S2: 392-402.
2. Franceschi C, Bonafe M, Valensin S, Olivieri F, De Luca M, Ottaviani E, et al. Inflamm-ageing. An evolutionary perspective on immunosenescence. Ann NY Acad Sci 2000; 908: 244-254
3. Franceschi C, Capri M, Monti DI, Giunta S Olivieri F, Sevini F, et al. Inflamm-ageing and anti-inflammageing: a systemic perspective on ageing and longevity emerged from studies in humans. MAD 2007; 128: 92-105.
4. Franceschi C. Inflammageing as a major characteristic of old people: can it be prevented or cured? Nutr Rev 2007; 65: S173-6.
5. Vasto S, Candore G, Balistreri CR, Caruso M, Colonna-Romano G, Grimaldi MP, et al. Inflammatory networks in ageing, age-related diseases and longevity. Mech Ageing Dev 2007; 128: 83-91.
6. De Martinis M, Franceschi C, Monti D, Ginaldi L. Inflammation markers predicting frailty and mortality in the elderly. Exp Mol Pathol 2006; 80: 219-227
7. De Martinis, Franceschi C, Monti D, Ginaldi L. Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity. FEBS Lett 2005; 579: 2035-2039
8. Ginaldi L, D Martinis M, Monti D, Franceschi C. Chronic antigenic load and apoptosis in immunosenescence. Trends Immunol 2005; 26: 79-84.
9. Vasto S, Carruba G, Lio D, Colonna-Romano G, Di Bona D, Candore G, et al. Inflammation, ageing and cancer. Mech Ageing Dev 2009; 130: 40-45
10. Sander M, Avlund K, Lauritzen M, Gottlieb T, Halliwell B, Stevnsner T, et al. Ageing-from molecules to populations. Mech Ageing Dev 2008; 129: 614-623
11. Capri M, Salvioli S, Sevini F, Valensin S, Celani L, Monti D, et al. The genetics of human longevity. Ann NY Acad Sci 2006; 1067: 252-263
12. Candore G, Colonna-Romano G, Balistreri CR, Di Carlo D, Grimaldi MP, Listì F, et al. Biology of longevity: role of the innate immune system. Rejuvenation Res 2006; 9: 143-148
13. Bonafè M, Barbieri M, Marchegiani F, Olivieri F, Ragno E, Giampieri C, et al. Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. J Clin Endocrinol Metab 2003; 88: 3299-3304
14. Franceschi C, Valensin S, Fagnoni F, Barbi C, Bonafè M. Biomarkers of immunosenescence within an evolutionary perspective: the challenge of heterogeneity and the role of antigenic load. Exp Gerontol 1999; 34: 911-921
15. Finch CE, Crimmins EM. Inflammatory exposure and historical changes in human life-spans. Science 2004; 305: 1736-1739
16. Candore G, Balistreri CR, Bulati M, Colonna-Romano G, Di Bona D, Forte GI, et al. Immune-inflammatory responses in successful and unsuccessful ageing. G Gerontol 2009; 57: 145-152
17. Larbi A, Franceschi C, Mazzetti D, Solana R, Wiky A, Pawelec G. Ageing of the immune system as a prognostic factor for human longevity. Physiology 2008; 23: 64-74.
18. + T cells. Exp Gerontol 2004; 39: 1233-1243
19. + T cells dominate the memory compartments of exposed subjects. J Exp Med 2005; 202: 673-685
20. + T cells against cytomegalovirus in very old subjects. J Immunol 2007; 179: 4283-4291
21. Schmaltz HN, Fried LP, Xue QL, Walston J, Leng SX, Semba RD. Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women. J Am Geriatr Soc 2005; 53: 747-754
22. Koch S, Larbi A, Ozcelik D, Solana R, Gouttefangeas C, Attig S, et al. Cytomegalovirus infection: a driving force in human T cell immunosenescence. Ann NY Acad Sci 2007; 1114: 23-35.
23. Pawelec G, Akbar A, Caruso C, Solana R, Grubeck-Loebenstein B, Wikby A. Human immunosenescence: is it infectious? Immunol Rev 2005; 205: 257-268
24. Derhovanessian E, Larbi A, Pawelec G. Biomarkers of human immunosenescence: impact of Cytomegalovirus infection. Curr Opin Immunol 2009; 21: 440-445
25. Cipriano C, Caruso C, Lio D, Giacconi R, Malavolta M, Muti E, et al. The -308G/A polymorphism of TNF-alpha influences immunological parameters in old subjects affected by infectious diseases. Int J Immunogenet 2005; 32: 13-18
26. Bäckhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon JI. Host-bacterial mutualism in the human intestine. Science 2005; 307: 1915-1920
27. Gill SR, Pop M, Deboy RT, Eckburg PB, Turnbaugh PJ, Samuel BS, et al. Metagenomic analysis of the human distal gut microbiome. Science 2006; 312: 1355-1359
28. Ley RE, Peterson DA, Gordon JI. Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell 2006; 124: 837-848
29. Guarner F, Malagelada JR. Gut flora in health and disease. Lancet 2003; 361: 512-519
30. Hooper LV, Gordon JI. Commensal host-bacterial relationships in the gut. Science 2001; 292: 1115-1118
31. Nicholson JK, Holmes E, Wilson ID. Gut microorganisms, mammalian metabolism and personalized health care. Nat Rev Microbiol 2005; 3: 431-438
32. Ley RE, Bäckhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI. Obesity alters gut microbial ecology. Proc Natl Acad Sci USA 2005; 102: 11070-11075
33. Gore C, Munro K, Lay C, Bibiloni R, Morris J, Woodcock A, et al. Bifidobacterium pseudocatenulatum is associated with atopic eczema: a nested case-control study investigating the fecal microbiota of infants. J Allergy Clin Immunol 2008; 12: 135-140
34. Sokol H, Lepage P, Seksik P, Doré J, Marteau P. Molecular comparison of dominant microbiota associated with injured versus healthy mucosa in ulcerative colitis. Gut 2007; 56: 152-154
35. Kinross JM, von Roon AC, Holmes E, Darzi A, Nicholson JK. The human gut microbiome: implications for future health care. Curr Gastroenterol Rep 2008; 10: 396-403.
36. Othman M, Agüero R, Lin HC. Alterations in intestinal microbial flora and human disease. Curr Opin Gastroenterol 2008; 24: 11-16
37. van Tongeren SP, Slaets JP, Harmsen HJ, Welling GW. Fecal microbiota composition and frailty. Appl Environ Microbiol 2005; 71: 6438-6442
38. Mueller S, Saunier K, Hanisch C, Norin E, Alm L, Midtvedt T, et al. Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study. Appl Environ Microbiol 2006; 72: 1027-1033
39. Capri M, Monti D, Salvioli S, Lescai F, Pierini M, Altilia S, et al. Complexity of anti-immunosenescence strategies in humans. Artif Organs 2006; 30: 730-742
40. Candore G, Balistreri CR, Colonna-Romano G, Grimaldi MP, Lio D, Listi' F, et al. Immunosenescence and anti-immunosenescence therapies: the case of probiotics. Rejuvenation Res 2008; 11: 425-432
41. Sera Y, LaRue AC, Moussa O, Mehrotra M, Duncan JD, Williams CR, et al. Hematopoietic stem cell origin of adipocytes. Exp Hematol 2009; 37: 1108-1120
42. Rudin E, Barzilai N. Inflammatory peptides derived from adipose tissue. Immun Ageing 2005; 2: 1.
43. Semenkovich CF. Insulin resistance and atherosclerosis. J Clin Invest 2006; 116: 1813-1822
44. Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 2003; 112: 1785-1788
45. Hansson GK. Inflammatory mechanisms in atherosclerosis. J Thromb Haemost 2009; 7 (Suppl 1): 328-331
46. Surmi BK, Hasty AH. Macrophage infiltration into adipose tissue: initiation, propagation and remodelling. Future Lipidol 2008; 3: 545-556
47. Lorenzo M, Fernández-Veledo S, Vila-Bedmar R, Garcia-Guerra L, De Alvaro C, Nieto-Vazquez I. Insulin resistance induced by tumor necrosis factor-alpha in myocytes and brown adipocytes. J Anim Sci 2008; 86: E94-104.
48. Nieto-Vazquez I, Fernández-Veledo S, Krämer DK, Vila-Bedmar R, Garcia-Guerra L, Lorenzo M. Insulin resistance associated to obesity: the link TNF-alpha. Arch Physiol Biochem 2008; 114: 183-194
49. Fernández-Veledo S, Nieto-Vazquez I, Vila-Bedmar R, Garcia-Guerra L, Alonso-Chamorro M, Lorenzo M. Molecular mechanisms involved in obesity-associated insulin resistance: therapeutical approach. Arch Physiol Biochem 2009; 115: 227-239
50. Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997; 389: 610-614
51. rd LJ, Khosla S, Crowson CS, O'Connor MK, O'Fallon WM, Riggs BL. Epidemiology of sarcopenia. J Am Geriatr Soc 2000; 48: 625-630
52. Licastro F, Candore G, Lio D, Porcellini E, Colonna-Romano G, Franceschi C, et al. Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immun Ageing 2005; 2: 8.
53. Griffiths RD. Muscle mass, survival, and the elderly ICU patient. Nutrition 1996; 12: 456-458
54. Poehlman ET, Toth MJ, Fonong T. Exercise, substrate utilization and energy requirements in the elderly. Int J Obesity Relat Metab Disord 1995; 19: S93-6.
55. Cesari M, Penninx BW, Pahor M, Lauretani F, Corsi AM, Williams RG, et al. Inflammatory markers and physical performance in older persons: the InCHIANTI study. J Gerontol A Biol Sci Med Sci 2004; 59: 242-248
56. Cappola AR, Xue QL, Ferrucci L, Guralnik JM, Volpato S, Fried LP. Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women. J Clin Endocrinol Metab 2003; 88: 2019-2025
57. Schaap LA, Pluijm SM, Deeg DJ, Visser M. Inflammatory markers and loss of muscle mass (sarcopenia) and strength. Am J Med 2006; 119: 526. e9-17.
58. Roubenoff R. Catabolism of aging: is it an inflammatory process? Curr Opin Clin Nutr Metab Care 2003; 6: 295-299
59. Visser M, Pahor M, Taaffe DR, Goodpaster BH, Simonsick EM, Newman AB, et al. Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the health ABC study. J Gerontol A Biol Sci Med Sci 2002; 57: M326-32.
60. Ferrucci L, Penninx BW, Volpato S, Harris TB, Bandeen-Roche K, Balfour J, et al. Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels. J Am Geriatr Soc 2002; 50: 1947-1954
61. Baumgartner RN, Waters DL, Gallagher D, Morley JE, Garry PJ. Predictors of skeletal muscle mass in elderly men and women. Mech Ageing Dev 1999; 107:123-136
62. Krabbe KS, Pedersen M, Bruunsgaard H. Inflammatory mediators in the elderly. Exp Gerontol 2004; 39: 687-699
63. Lelbach A, Scharf JG, Ramadori G. Regulation of insulin-like growth factor-I and of insulin-like growth factor binding protein-1, -3 and -4 in cocultures of rat hepatocytes and Kupffer cells by interleukin-6. J Hepatol 2001; 35: 558-567
64. Barbieri M, Ferrucci L, Ragno E, Corsi A, Bandinelli S, Bonafe M, et al. Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons. Am J Physiol Endocrinol Metab 2003; 284: E481-7.
65. Pelosi L, Giacinti C, Nardis C, Borsellino G, Rizzuto E, Nicoletti C, et al. Local expression of IGF-1 accelerates muscle regeneration by rapidly modulating inflammatory cytokines and chemokines. FASEB J 2007; 21: 1393-1402
66. Petersen AM, Pedersen BK. The role of IL-6 in mediating the anti-inflammatory effects of exercise. Physiol Pharmacol 2006; 57: 43-51.
67. Pedersen BK. The anti-inflammatory effect of exercise: its role in diabetes and cardiovascular disease control. Essays Biochem 2006; 42: 105-117
68. Pedersen BK, Fischer CP. Physiological roles of muscle-derived interleukin-6 in response to exercise. Curr Opin Clin Nutr Metab Care 2007; 10: 265-271
69. Pedersen BK. IL-6 signalling in exercise and disease. Biochem Soc Trans 2007; 35: 1295-1297
70. Eikelenboom P, Veerhuis R, Scheper W, Rozemuller AJ, van Gool WA, Hoozemans JJ. The significance of neuroinflammation in understanding Alzheimer's disease. J Neural Transm 2006; 113: 1685-1695
71. Vasto S, Candore G, Listì F, Balistreri CR, Colonna-Romano G, Malavolta M, et al. Inflammation, genes and zinc in Alzheimer's disease. Brain Res Rev 2008; 58: 96-105.
72. Balistreri CR, Grimaldi MP, Chiappelli M, Licastro F, Castiglia L, Listì F, et al. Association between the polymorphisms of TLR4 and CD14 genes and Alzheimer's disease. Curr Pharm Des 2008; 14: 2672-2677
73. Di Bona D, Plaia A, Vasto S, Cavallone L, Lescai F, Franceschi C, et al. Association between the interleukin-1beta polymorphisms and Alzheimer's disease: a systematic review and meta-analysis. Brain Res Rev 2008; 59: 155-163
74. Vasto S, Candore G, Duro G, Lio D, Grimaldi MP, Caruso C. Alzheimer's disease and genetics of inflammation: a pharmacogenomic vision. Pharmacogenomics 2007; 8: 1735-1745
75. Listì F, Candore G, Balistreri CR, Grimaldi MP, Orlando V, Vasto S, et al. Association between the HLA-A2 allele and Alzheimer disease. Rejuvenation Res 2006; 9: 99-101.
76. Ruan L, Kang Z, Pei G, Le Y. Amyloid deposition and inflammation in Appswe/Ps1de9 mouse model of Alzheimer's disease. Curr Alzheimer Res 2009; 6: 531-540
77. Sersté T, Bourgeois N. Ageing and the liver. Acta Gastroenterol Belg 2006; 69: 296-298
78. Anantharaju A, Feller A, Chedid A. Aging Liver. Gerontology 2002; 48: 343-353
79. Schmucker DL. Liver function and phase I drug metabolism in the elderly: a paradox. Drugs Ageing 2001; 18: 837-851
80. Cescon M, Grazi GL, Ercolani G. Long-term survival of recipients of liver grafts from donors older than 80 years: is it achievable? Liver Transp 2003; 9: 1174-1180
81. Arii S, Imamura M. Physiological role of sinusoidal endothelial cells and Kupffer cells and their implication in the pathogenesis of liver injury. J Hepatobiliary Pancreatic Surg 2000; 7: 40-48
82. Hilmer SN, Cogger VC, Le Couteur DG. Basal activity of Kupffer cells increases with old age. J Gerontol A Biol Sci Med Sci 2007; 62: 973-978
83. Norman K, Pirlich M. Gastrointestinal tract in liver disease: which organ is sick? Curr Opin Clin Nutr Metab Care 2008; 11: 613-619
84. Greter M, Hofmann J, Becher B. Neo-lymphoid aggregates in the adult liver can initiate potent cell-mediated immunity. PLoS Biol 2009; 7: e1000109.
85. Armstrong BG, Mangtani P, Fletcher A, Kovats S, McMichael A, Pattenden S, et al. Effect of influenza vaccination on excess deaths occurring during periods of high circulation of influenza: cohort study in elderly people. BMJ 2004; 329: 660-664
86. Hedlund J, Christenson B, Lundbergh P, Ortqvist A. Effects of a large-scale intervention with influenza and 23-valent pneumococcal vaccines in elderly people: a 1-year follow-up. Vaccine 2003; 21: 3906-3911
87. Goodwin K, Viboud C, Simonsen L. Antibody response to influenza vaccination in the elderly: a quantitative review. Vaccine 2006; 24: 1159-1169
88. Jefferson T, Rivetti D, Rivetti A, Rudin M, Di Pietrantoni C, Demicheli V. Efficacy and effectiveness of influenza vaccines in elderly people: a systematic review. Lancet 2005; 366: 1165-1174
89. Trzonkowski P, Mysliwska J, Szmit E, Wieckiewicz J, Lukaszuk K, Brydak LB, et al. Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination an impact of immunosenescence. Vaccine 2003; 21: 3826-3836
90. Riddell SR, Watanabe KS, Goodrich JM, Li CR, Agha ME, Greenberg PD. Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones. Science 1992; 257: 238-241
91. Walter EA, Greenberg PD, Gilbert MJ, Finch RJ, Watanabe KS, Thomas ED, et al. Reconstitution of cellular immunity against Cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N Engl J Med 1995; 333: 1038-1044
92. Andre-Schmutz I, Dal Cortivo L, Hamel Y, Cavazzana-Calvo M. Gene transfer for activation of CMV specific T cells. Hum Immunol 2004; 65: 565-570
93. Pawelec G, Akbar A, Caruso C, Solana R, Grubeck-Loebenstein B, Wikby A. Human immunosenescence: Is it infectious? Immunol Rev 2005; 205: 257-268
94. Giorno L, Drioli E. Biocatalytic membrane reactors: applications and perspectives. Trends Biotechnol 2000; 18: 339-349
95. Yonekawa M, Kawamura A, Komai T, Agishi T, Adachi M. Extracorporeal granulocytapheresis for cancer and rheumatoid arthritis. Transfus Sci 1996; 17: 463-472
96. Ishizuka T, Kawata T, Shimizu Y, Utsugi M, Endou K, Hisada T, et al. Safety and efficacy of extracorporeal granulocyte and monocyte adsorption apheresis in patients with severe persistent bronchial asthma. Inflammation 2005; 29: 9-16.
97. Silverstein AM. Labeled antigens and antibodies: the evolution of magic markers and magic bullets. Nat Immunol 2004; 5: 1211-1217
98. Berzins SP, Uldrich AP, Sutherland JS, Gill J, Miller JF, Godfrey DI, et al. Thymic regeneration: teaching an old immune system new tricks. Trends Mol Med 2002; 8: 469-476
99. Muraro PA, Douek DC. Renewing the T cell repertoire to arrest autoimmune aggression. Trends Immunol 2006; 27: 61-67
100. Voehringer D, Liang HE, Locksley RM. Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice. J Immunol 2008; 180: 4742-4753
101. Watson J, McKay DM. The immunophysiological impact of bacterial CpG DNA on the gut. Clin Chim Acta 2006; 364: 1-11.
102. Sartor RB. Probiotic therapy of intestinal inflammation and infections. Curr Opin Gastroenterol 2005; 21:44-50.
103. Lammers KM, Brigidi P, Vitali B, Gionchetti P, Rizzello F, Caramelli E, et al. Immunomodulatory effects of probiotic bacteria DNA: IL-1 and IL-10 response in human peripheral blood mononuclear cells. FEMS Immunol Med Microbiol 2003; 38: 165-172
104. Shanahan F. Physiological basis for novel drug therapies used to treat the inflammatory bowel diseases I. Pathophysiological basis and prospects for probiotic therapy in inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol 2005; 288: G417-21.
105. Martin BK, Szekely C, Brandt J, Piantadosi S, Breitner JC, Craft S, et al. Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a and celecoxib. Arch Neurol 2008; 65: 896-905.
106. Bregman N, Karni A, Korczyn AD. Can treatment with nonsteroidal anti-inflammatory drugs protect from dementia? Arch Neurol 2009; 66: 539-540.
107. Caruso C, Balistreri CR, Candore G, Carruba G, Colonna-Romano G, Di Bona D, et al. Polymorphisms of pro-inflammatory genes and prostate cancer risk: a pharmacogenomic approach. Cancer Immunol Immunother 2009; 58: 1919-1933
108. Choi HK. Diet, alcohol, and gout: how do we advise patients given recent developments? Curr Rheumatol Rep 2005; 7: 220-226
109. Danese S, Sans M, Fiocchi C. Inflammatory bowel disease: the role of environmental factors. Autoimmun Rev 2004; 3: 394-400.
110. Chrysohoou C, Panagiotakos DB, Pitsavos C, Das UN, Stefanadis C. Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: The ATTICA Study. J Am Coll Cardiol 2004; 44: 152-158
111. Lopez-Garcia E, Schulze MB, Fung TT, Meigs JB, Rifai N, Manson JE, et al. Major dietary patterns are related to plasma concentrations of markers of inflammation and endothelial dysfunction. Am J Clin Nutr 2004; 80: 1029-1035
112. Trichopoulou A, Orfanos P, Norat T, Bueno-de-Mesquita B, Ocké MC, Peeters PH, et al. Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study. BMJ 2005; 330: 991.
113. Siddiqui RA, Shaikh SR, Sech LA, Yount HR, Stillwell W, Zaloga GP. Omega 3-fatty acids: health benefits and cellular mechanisms of action. Mini Rev Med Chem 2004; 4: 859-871
114. Bourre JM. Where to find omega-3 fatty acids and how feeding animals with diet enriched in omega-3 fatty acids to increase nutritional value of derived products for human: what is actually useful ? J Nutr Health Aging 2009; 9: 232-242
115. Margioris AN. Fatty acids and postprandial inflammation. Curr Opin Clin Nutr Metab Care 2009; 12: 129-137
116. Mocchegiani E, Muzzioli M, Giacconi R. Zinc and immunoresistance to infection in ageing: new biological tools. Trends Pharmacol Sci 2000; 21: 205-208
117. Fontana L, Klein S. Aging, adiposity, and calorie restriction. JAMA 2007; 297: 986-994
118. Rössner S. Obesity in the elderly - a future matter of concern? Obes Rev 2001; 2: 183-188
119. Franceschi C, Motta L, Motta M, Malaguarnera M, Capri M, Vasto S, et al. The extreme longevity: the state of the art in Italy. Exp Gerontol 2008; 43: 45-52.
120. Caruso C, Jirillo E. Drug targets in ageing and age-associated diseases. Curr Pharm Des 2008; 14: 2635-2636
121. Clowes JA, Riggs BL, Khosla S. The role of the immune system in the pathophysiology of osteoporosis. Immunol Rev 2005; 208:207-227
122. Moore ME, Piazza A, McCartney Y, Lynch MA. Evidence that vitamin D3 reverses age-related inflammatory changes in the rat hippocampus. Biochem Soc Trans 2005; 33: 573-577
123. Thomas DR. Vitamins in ageing, health, and longevity. Clin Interv Ageing 2006; 1: 81-91.
124. Barbosa KB, Bressan J, Zulet MA, Martínez Hernández JA. Influence of dietary intake on plasma biomarkers of oxidative stress in humans. An Sist Sanit Navar 2008; 31: 259-280
125. Salvioli S, Sikora E, Cooper EL, Franceschi C. Curcumin in cell death processes: a challenge for CAM of age-related pathologies. Evid Based Complement Alternat Med 2007; 4: 181-190
126. Sikora E, Bielak-Żmijewska A, Mosieniak G, Piwocka K. The promise of slow down ageing may come from curcumin. Curr Pharm Des 2010; 16: 884-892.
127. Knutson MD, Leeuwenburgh C. Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases. Nutr Rev 2008; 66: 591-596
128. Paffenbarger RS Jr, Kampert JB, Lee IM, Hyde RT, Leung RW, Wing AL. Changes in physical activity and other lifeway patterns influences longevity. Med Sci Sports Exerc 1994; 26: 857-865
129. Pedersen BK. The diseasome of physical inactivity- and the role of myokines in muscle-fat cross talk. J Physiol 2009; doi:10.1113/jphysiol.2009. 179515.
130. Buford TW, Cooke MB, Shelmadine BD, Hudson GM, Redd L, Willoughby DS. Effects of eccentric treadmill exercise on inflammatory gene expression in human skeletal muscle. Appl Physiol Nutr Metab 2009; 34: 745-753
131. Steensberg A, Fischer CP, Keller C, Moller K, Pedersen BK. IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. Am J Physiol Endocrinol Metab 2003; 285: E433-E437.
132. Mathur N, Pedersen BK. Exercise as a mean to control low-grade systemic inflammation. Mediators Inflamm 2008; 2008: 109502.
133. Nieman DC. Exercise, infection, and immunity. Int J Sports Med 1994; 15: S131-S41.
134. Wang Y, Simar D, Fiatarone SMA. Adaptations to exercise training within skeletal muscle in adults with type 2 diabetes or impaired glucose tolerance: a systematic review. Diabetes Metab Res Rev 2009; 25: 13-40.
135. Colbert LH, Visser M, Simonsick EM, Tracy RP, Newman AB, Kritchevsky SB, et al. Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study. J Am Geriatr Soc 2004; 52: 1098-1104
136. Krishan K, Dhoot GK. Changes in some troponin and insulin-like growth factor messenger ribonucleic acids in regenerating and denervated skeletal muscles. J Muscle Res Cell Motil 1996; 17: 513-521
137. Musarò A, McCullagh K, Paul A, Houghton L, Dobrowolny G, Molinaro M, et al. Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle. Nat Genet 2001; 27: 195-200.
138. Chung HY, Cesari M, Anton S, Marzetti E, Giovannini S, Seo AY, et al. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev 2009; 8: 18-30.
139. Giunta S. Exploring the complex relations between inflammation and aging (inflamm-aging): anti-inflamm-aging remodelling of inflamm- aging, from robustness to frailty. Inflamm Res 2008; 57: 558-563
140. Cevenini E, Invidia L, Lescai F, Salvioli S, Tieri P, Castellani G, et al. Human models of aging and longevity. Expert Opin Biol Ther. 2008; 8: 1393-1405
141. Evan GI, d'Adda di Fagagna F. Cellular senescence: hot or what? Curr Opin Genet Dev 2009; 19: 25-33
142. Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 2005; 120: 513-522
143. Cevenini E, Bellavista E, Tieri P, Castellani G, Lescai F, Francesconi M, et al. Systems Biology and Longevity: an emerging approach to identify innovative anti-aging targets and strategies. Curr Pharm Des 2010; 16: 802-813.