Sowing the seeds of cancer: Telomeres and age-associated tumorigenesis

Current Opinion in Oncology

Volumn 25, Issue 1, 2013, Pages 93-98

  Pereira, Branca ^a   Ferreira, Miguel G ^a  

^a INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

Author keywords

Ageing; Cancer; Senescence; Telomerase; Telomeres

Indexed keywords

REACTIVE OXYGEN METABOLITE; TELOMERASE;

CARCINOGENESIS; CELL AGING; CELL DIVISION; CELL PROLIFERATION; CELL TRANSFORMATION; ENZYME ACTIVITY; EPITHELIAL MESENCHYMAL TRANSITION; GENE MUTATION; GENOMIC INSTABILITY; HUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SENESCENCE; TELOMERE; TUMOR MICROENVIRONMENT;

AGING; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; NEOPLASMS; TELOMERASE; TELOMERE;

EID: 84871969335     PISSN: 10408746     EISSN: 1531703X     Source Type: Journal    
DOI: 10.1097/CCO.0b013e32835b6358     Document Type: Review

References (47)

1. Bray F, Ren JS, Masuyer E, Ferlay J. Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer 2012
2. Medawar P. An unsolved problem in biology. London: H.K. Lewis & Co.; 1952
3. Peto R, Roe FJ, Lee PN, et al. Cancer and ageing in mice and men. Br J Cancer 1975; 32:411-426
4. Lynch M. Evolution of the mutation rate. Trends Genet 2010; 26:345- 352
5. DeGregori J. Evolved tumor suppression: Why are we so good at not getting cancer? Cancer Res 2011; 71:3739-3744
6. Caulin AF, Maley CC. Peto's Paradox: Evolution's prescription for cancer prevention. Trends Ecol Evol 2011; 26:175-182
7. Gomes NM, Ryder OA, Houck ML, et al. Comparative biology of mammalian telomeres: Hypotheses on ancestral states and the roles of telomeres in longevity determination. Aging Cell 2011; 10:761-768
8. De Lange T. How telomeres solve the end-protection problem? Science 2009; 326:948-952
9. Carneiro T, Khair L, Reis CC, et al. Telomeres avoid end detection by severing the checkpoint signal transduction pathway. Nature 2010; 467:228-232
10. Forsyth NR, Wright WE, Shay JW. Telomerase and differentiation in multicellular organisms: Turn it off, turn it on, and turn it off again. Differentiation 2002; 69:188-197
11. Suram A, Kaplunov J, Patel PL, et al. Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions. EMBO J 2012; 31:2839-2851
12. Fumagalli M, Rossiello F, Clerici M, et al. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat Cell Biol 2012; 14:355-365
13. Hewitt G, Jurk D, Marques FD, et al. Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence. Nat Commun 2012; 3:708. See Ref. [12
14. Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res 1961; 25:585-621
15. Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990; 345:458-460
16. Bodnar AG, Ouellette M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998; 279:349-352
17. Edwards PA. Fusion genes and chromosome translocations in the common epithelial cancers. J Pathol 2010; 220:244-254
18. Murnane JP. Telomere dysfunction and chromosome instability. Mutat Res 2012; 730:28-36
19. Artandi SE, Chang S, Lee SL, et al. Telomere dysfunction promotes nonreciprocal translocations and epithelial cancers in mice. Nature 2000; 406:641-645
20. Sahin E, Colla S, Liesa M, et al. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature 2011; 470:359-365
21. Lawless C, Jurk D, Gillespie CS, et al. A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations. PLoS One 2012; 7:e32117
22. Davoli T, Denchi EL, de Lange T. Persistent telomere damage induces bypass of mitosis and tetraploidy. Cell 2010; 141:81-93
23. Davoli T, de Lange T. Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells. Cancer Cell 2012; 21:765-776
24. Artandi SE, DePinho RA. Telomeres and telomerase in cancer. Carcinogenesis 2010; 31:9-18
25. Shay JW, Wright WE. Role of telomeres and telomerase in cancer. Semin Cancer Biol 2011; 21:349-353
26. Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer 1997; 33:787-791
27. Ding Z, Wu CJ, Jaskelioff M, et al. Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell 2012; 148:896-907
28. Buseman CM, Wright WE, Shay JW. Is telomerase a viable target in cancer?Mutat Res 2012; 730:90-97
29. Blagosklonny MV. Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: Terminology for TOR-driven aging. Aging (Albany NY) 2012; 4:159-165
30. Ogrunc M, d'Adda di Fagagna F. Never-ageing cellular senescence. Eur J Cancer 2011; 47:1616-1622
31. Jeyapalan JC, Ferreira M, Sedivy JM, Herbig U. Accumulation of senescent cells in mitotic tissue of aging primates. Mech Ageing Dev 2007; 128:36-44
32. Coppe JP, Patil CK, Rodier F, et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 2008; 6:2853-2868
33. Rodier F, Munoz DP, Teachenor R, et al. DNA-SCARS: Distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion. J Cell Sci 2011; 124:68-81
34. Jun JI, Lau LF. The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat Cell Biol 2010; 12:676-685
35. Acosta JC, O'Loghlen A, Banito A, et al. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 2008; 133:1006-1018
36. Rodier F, Campisi J. Four faces of cellular senescence. J Cell Biol 2011; 192:547-556
37. Baker DJ, Wijshake T, Tchkonia T, et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 2011; 479:232-236
38. Colotta F, Allavena P, Sica A, et al. Cancer-related inflammation, the seventh hallmark of cancer: Links to genetic instability. Carcinogenesis 2009; 30:1073-1081
39. Krtolica A, Parrinello S, Lockett S, et al. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging. Proc Natl Acad Sci USA 2001; 98:12072-12077
40. Parrinello S, Coppe JP, Krtolica A, Campisi J. Stromal-epithelial interactions in aging and cancer: Senescent fibroblasts alter epithelial cell differentiation. J Cell Sci 2005; 118:485-496
41. Coppe JP, Kauser K, Campisi J, Beausejour CM. Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence. J Biol Chem 2006; 281:29568-29574
42. Liu D, Hornsby PJ. Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion. Cancer Res 2007; 67:3117-3126
43. Risques RA, Lai LA, Himmetoglu C, et al. Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation. Cancer Res 2011; 71:1669-1679
44. Gonzalez-Suarez E, Samper E, Ramirez A, et al. Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J 2001; 20:2619-2630
45. Artandi SE, Alson S, Tietze MK, et al. Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proc Natl Acad Sci USA 2002; 99:8191-8196
46. De Jesus BB, Schneeberger K, Vera E, et al. The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence. Aging Cell 2011; 10:604-621
47. Bernardes de Jesus B, Vera E, Schneeberger K, et al. Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. EMBO Mol Med 2012; 4:691-704