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Volumn 24, Issue 11, 2014, Pages 686-694

Common features of chromatin in aging and cancer: Cause or coincidence?

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HISTONE; LONG UNTRANSLATED RNA; CHROMATIN;

EID: 84927698872     PISSN: 09628924     EISSN: 18793088     Source Type: Journal    
DOI: 10.1016/j.tcb.2014.07.001     Document Type: Review
Times cited : (55)

References (141)
  • 2
    • 84875186053 scopus 로고    scopus 로고
    • The cell biology of genomes: bringing the double helix to life
    • Misteli T. The cell biology of genomes: bringing the double helix to life. Cell 2013, 152:1209-1212.
    • (2013) Cell , vol.152 , pp. 1209-1212
    • Misteli, T.1
  • 3
    • 84897268444 scopus 로고    scopus 로고
    • Dietary epigenetics in cancer and aging
    • Tollefsbol T.O. Dietary epigenetics in cancer and aging. Cancer Treat. Res. 2014, 159:257-267.
    • (2014) Cancer Treat. Res. , vol.159 , pp. 257-267
    • Tollefsbol, T.O.1
  • 4
    • 84877930649 scopus 로고    scopus 로고
    • Targeting histone modifications - epigenetics in cancer
    • Waldmann T., Schneider R. Targeting histone modifications - epigenetics in cancer. Curr. Opin. Cell Biol. 2013, 25:184-189.
    • (2013) Curr. Opin. Cell Biol. , vol.25 , pp. 184-189
    • Waldmann, T.1    Schneider, R.2
  • 5
    • 80053144962 scopus 로고    scopus 로고
    • A decade of exploring the cancer epigenome - biological and translational implications
    • Baylin S.B., Jones P.A. A decade of exploring the cancer epigenome - biological and translational implications. Nat. Rev. Cancer 2011, 11:726-734.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 726-734
    • Baylin, S.B.1    Jones, P.A.2
  • 6
    • 84863621527 scopus 로고    scopus 로고
    • Cancer epigenetics: from mechanism to therapy
    • Dawson M.A., Kouzarides T. Cancer epigenetics: from mechanism to therapy. Cell 2012, 150:12-27.
    • (2012) Cell , vol.150 , pp. 12-27
    • Dawson, M.A.1    Kouzarides, T.2
  • 7
    • 79551615733 scopus 로고    scopus 로고
    • Chromatin: a molecular interface between cancer and aging
    • Cruickshanks H.A., Adams P.D. Chromatin: a molecular interface between cancer and aging. Curr. Opin. Genet. Dev. 2011, 21:100-106.
    • (2011) Curr. Opin. Genet. Dev. , vol.21 , pp. 100-106
    • Cruickshanks, H.A.1    Adams, P.D.2
  • 8
    • 84878864199 scopus 로고    scopus 로고
    • The hallmarks of aging
    • Lopez-Otin C., et al. The hallmarks of aging. Cell 2013, 153:1194-1217.
    • (2013) Cell , vol.153 , pp. 1194-1217
    • Lopez-Otin, C.1
  • 9
    • 84878115461 scopus 로고    scopus 로고
    • Aging epigenetics: causes and consequences
    • Huidobro C., et al. Aging epigenetics: causes and consequences. Mol. Aspects Med. 2013, 34:765-781.
    • (2013) Mol. Aspects Med. , vol.34 , pp. 765-781
    • Huidobro, C.1
  • 10
    • 84856253068 scopus 로고    scopus 로고
    • Epigenetic mechanisms and genome stability
    • Putiri E.L., Robertson K.D. Epigenetic mechanisms and genome stability. Clin. Epigenetics 2011, 2:299-314.
    • (2011) Clin. Epigenetics , vol.2 , pp. 299-314
    • Putiri, E.L.1    Robertson, K.D.2
  • 11
    • 34249683635 scopus 로고    scopus 로고
    • Cross-talk between aging and cancer: the epigenetic language
    • Fraga M.F., et al. Cross-talk between aging and cancer: the epigenetic language. Ann. N. Y. Acad. Sci. 2007, 1100:60-74.
    • (2007) Ann. N. Y. Acad. Sci. , vol.1100 , pp. 60-74
    • Fraga, M.F.1
  • 12
    • 79956330964 scopus 로고    scopus 로고
    • CpG islands and the regulation of transcription
    • Deaton A.M., Bird A. CpG islands and the regulation of transcription. Genes Dev. 2011, 25:1010-1022.
    • (2011) Genes Dev. , vol.25 , pp. 1010-1022
    • Deaton, A.M.1    Bird, A.2
  • 13
    • 77954661906 scopus 로고    scopus 로고
    • DNA hypomethylation in cancer cells
    • Ehrlich M. DNA hypomethylation in cancer cells. Epigenomics 2009, 1:239-259.
    • (2009) Epigenomics , vol.1 , pp. 239-259
    • Ehrlich, M.1
  • 14
    • 33644846509 scopus 로고    scopus 로고
    • Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction?
    • Baylin S.B., Ohm J.E. Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction?. Nat. Rev. Cancer 2006, 6:107-116.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 107-116
    • Baylin, S.B.1    Ohm, J.E.2
  • 15
    • 84893397675 scopus 로고    scopus 로고
    • Senescent cells harbour features of the cancer epigenome
    • Cruickshanks H.A., et al. Senescent cells harbour features of the cancer epigenome. Nat. Cell Biol. 2013, 15:1495-1506.
    • (2013) Nat. Cell Biol. , vol.15 , pp. 1495-1506
    • Cruickshanks, H.A.1
  • 16
    • 23044514669 scopus 로고    scopus 로고
    • Epigenetic differences arise during the lifetime of monozygotic twins
    • Fraga M.F., et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl. Acad. Sci U.S.A. 2005, 102:10604-10609.
    • (2005) Proc. Natl. Acad. Sci U.S.A. , vol.102 , pp. 10604-10609
    • Fraga, M.F.1
  • 17
    • 77951169806 scopus 로고    scopus 로고
    • Distinctive patterns of age-dependent hypomethylation in interspersed repetitive sequences
    • Jintaridth P., Mutirangura A. Distinctive patterns of age-dependent hypomethylation in interspersed repetitive sequences. Physiol. Genomics 2010, 41:194-200.
    • (2010) Physiol. Genomics , vol.41 , pp. 194-200
    • Jintaridth, P.1    Mutirangura, A.2
  • 18
    • 84869841618 scopus 로고    scopus 로고
    • Alu and LINE-1 methylation and lung function in the Normative Aging Study
    • Lange N.E., et al. Alu and LINE-1 methylation and lung function in the Normative Aging Study. BMJ Open 2012, 2:e001231.
    • (2012) BMJ Open , vol.2
    • Lange, N.E.1
  • 19
    • 39449103319 scopus 로고    scopus 로고
    • Genome-wide tracking of unmethylated DNA Alu repeats in normal and cancer cells
    • Rodriguez J., et al. Genome-wide tracking of unmethylated DNA Alu repeats in normal and cancer cells. Nucleic Acids Res. 2008, 36:770-784.
    • (2008) Nucleic Acids Res. , vol.36 , pp. 770-784
    • Rodriguez, J.1
  • 20
    • 70149099610 scopus 로고    scopus 로고
    • Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context
    • Christensen B.C., et al. Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet. 2009, 5:e1000602.
    • (2009) PLoS Genet. , vol.5
    • Christensen, B.C.1
  • 21
    • 84862979818 scopus 로고    scopus 로고
    • Distinct DNA methylomes of newborns and centenarians
    • Heyn H., et al. Distinct DNA methylomes of newborns and centenarians. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:10522-10527.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 10522-10527
    • Heyn, H.1
  • 22
    • 79955779160 scopus 로고    scopus 로고
    • Repetitive element hypomethylation in blood leukocyte DNA and cancer incidence, prevalence, and mortality in elderly individuals: the Normative Aging Study
    • Zhu Z.Z., et al. Repetitive element hypomethylation in blood leukocyte DNA and cancer incidence, prevalence, and mortality in elderly individuals: the Normative Aging Study. Cancer Causes Control 2011, 22:437-447.
    • (2011) Cancer Causes Control , vol.22 , pp. 437-447
    • Zhu, Z.Z.1
  • 23
    • 42149122648 scopus 로고    scopus 로고
    • Line region hypomethylation is associated with lifestyle and differs by human papillomavirus status in head and neck squamous cell carcinomas
    • Furniss C.S., et al. Line region hypomethylation is associated with lifestyle and differs by human papillomavirus status in head and neck squamous cell carcinomas. Cancer Epidemiol. Biomarkers Prev. 2008, 17:966-971.
    • (2008) Cancer Epidemiol. Biomarkers Prev. , vol.17 , pp. 966-971
    • Furniss, C.S.1
  • 24
    • 84895793450 scopus 로고    scopus 로고
    • LINE-1 hypomethylation, DNA copy number alterations, and CDK6 amplification in esophageal squamous cell carcinoma
    • Baba Y., et al. LINE-1 hypomethylation, DNA copy number alterations, and CDK6 amplification in esophageal squamous cell carcinoma. Clin. Cancer Res. 2014, 20:1114-1124.
    • (2014) Clin. Cancer Res. , vol.20 , pp. 1114-1124
    • Baba, Y.1
  • 25
    • 84885752915 scopus 로고    scopus 로고
    • Correction: genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myeloma
    • Aoki Y., et al. Correction: genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myeloma. Genome Med. 2013, 5:88.
    • (2013) Genome Med. , vol.5 , pp. 88
    • Aoki, Y.1
  • 26
    • 77649083131 scopus 로고    scopus 로고
    • Implications of LINE1 methylation for bladder cancer risk in women
    • Wilhelm C.S., et al. Implications of LINE1 methylation for bladder cancer risk in women. Clin. Cancer Res. 2010, 16:1682-1689.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 1682-1689
    • Wilhelm, C.S.1
  • 27
    • 58149399844 scopus 로고    scopus 로고
    • Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer
    • Daskalos A., et al. Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer. Int. J. Cancer 2009, 124:81-87.
    • (2009) Int. J. Cancer , vol.124 , pp. 81-87
    • Daskalos, A.1
  • 28
    • 0032480226 scopus 로고    scopus 로고
    • DNA hypomethylation leads to elevated mutation rates
    • Chen R.Z., et al. DNA hypomethylation leads to elevated mutation rates. Nature 1998, 395:89-93.
    • (1998) Nature , vol.395 , pp. 89-93
    • Chen, R.Z.1
  • 29
    • 0242584449 scopus 로고    scopus 로고
    • Induction of tumors in mice by genomic hypomethylation
    • Gaudet F., et al. Induction of tumors in mice by genomic hypomethylation. Science 2003, 300:489-492.
    • (2003) Science , vol.300 , pp. 489-492
    • Gaudet, F.1
  • 30
    • 20144374299 scopus 로고    scopus 로고
    • Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice
    • Sakatani T., et al. Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science 2005, 307:1976-1978.
    • (2005) Science , vol.307 , pp. 1976-1978
    • Sakatani, T.1
  • 31
    • 84874771985 scopus 로고    scopus 로고
    • Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives
    • Spruijt C.G., et al. Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives. Cell 2013, 152:1146-1159.
    • (2013) Cell , vol.152 , pp. 1146-1159
    • Spruijt, C.G.1
  • 32
    • 77951116072 scopus 로고    scopus 로고
    • CpG islands influence chromatin structure via the CpG-binding protein Cfp1
    • Thomson J.P., et al. CpG islands influence chromatin structure via the CpG-binding protein Cfp1. Nature 2010, 464:1082-1086.
    • (2010) Nature , vol.464 , pp. 1082-1086
    • Thomson, J.P.1
  • 33
    • 84886111619 scopus 로고    scopus 로고
    • DNA methylation age of human tissues and cell types
    • Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013, 14:R115.
    • (2013) Genome Biol. , vol.14
    • Horvath, S.1
  • 34
    • 78649881517 scopus 로고    scopus 로고
    • CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer
    • Lujambio A., et al. CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer. Oncogene 2010, 29:6390-6401.
    • (2010) Oncogene , vol.29 , pp. 6390-6401
    • Lujambio, A.1
  • 35
    • 0028001087 scopus 로고
    • Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon
    • Issa J.P., et al. Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat. Genet. 1994, 7:536-540.
    • (1994) Nat. Genet. , vol.7 , pp. 536-540
    • Issa, J.P.1
  • 36
    • 77950650405 scopus 로고    scopus 로고
    • Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer
    • Teschendorff A.E., et al. Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res. 2010, 20:440-446.
    • (2010) Genome Res. , vol.20 , pp. 440-446
    • Teschendorff, A.E.1
  • 37
    • 48649100069 scopus 로고    scopus 로고
    • Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells
    • McGarvey K.M., et al. Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells. Cancer Res. 2008, 68:5753-5759.
    • (2008) Cancer Res. , vol.68 , pp. 5753-5759
    • McGarvey, K.M.1
  • 38
    • 84860577189 scopus 로고    scopus 로고
    • A DNA hypermethylation module for the stem/progenitor cell signature of cancer
    • Easwaran H., et al. A DNA hypermethylation module for the stem/progenitor cell signature of cancer. Genome Res. 2012, 22:837-849.
    • (2012) Genome Res. , vol.22 , pp. 837-849
    • Easwaran, H.1
  • 39
    • 33745056414 scopus 로고    scopus 로고
    • Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer
    • Agrelo R., et al. Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:8822-8827.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 8822-8827
    • Agrelo, R.1
  • 40
    • 21244491570 scopus 로고    scopus 로고
    • Inactivation of the lamin A/C gene by CpG island promoter hypermethylation in hematologic malignancies, and its association with poor survival in nodal diffuse large B-cell lymphoma
    • Agrelo R., et al. Inactivation of the lamin A/C gene by CpG island promoter hypermethylation in hematologic malignancies, and its association with poor survival in nodal diffuse large B-cell lymphoma. J. Clin. Oncol. 2005, 23:3940-3947.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 3940-3947
    • Agrelo, R.1
  • 41
    • 70349859881 scopus 로고    scopus 로고
    • DNA damage, aging, and cancer
    • Hoeijmakers J.H. DNA damage, aging, and cancer. N. Engl. J. Med. 2009, 361:1475-1485.
    • (2009) N. Engl. J. Med. , vol.361 , pp. 1475-1485
    • Hoeijmakers, J.H.1
  • 42
    • 0141839825 scopus 로고    scopus 로고
    • Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts
    • Casillas M.A., et al. Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts. Mol. Cell. Biochem. 2003, 252:33-43.
    • (2003) Mol. Cell. Biochem. , vol.252 , pp. 33-43
    • Casillas, M.A.1
  • 43
    • 0035679346 scopus 로고    scopus 로고
    • Differential maintenance and de novo methylating activity by three DNA methyltransferases in aging and immortalized fibroblasts
    • Lopatina N., et al. Differential maintenance and de novo methylating activity by three DNA methyltransferases in aging and immortalized fibroblasts. J. Cell. Biochem. 2002, 84:324-334.
    • (2002) J. Cell. Biochem. , vol.84 , pp. 324-334
    • Lopatina, N.1
  • 44
    • 9744251005 scopus 로고    scopus 로고
    • Biochemistry and biology of mammalian DNA methyltransferases
    • Hermann A., et al. Biochemistry and biology of mammalian DNA methyltransferases. Cell. Mol. Life Sci. 2004, 61:2571-2587.
    • (2004) Cell. Mol. Life Sci. , vol.61 , pp. 2571-2587
    • Hermann, A.1
  • 45
    • 0033563083 scopus 로고    scopus 로고
    • CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression
    • Eads C.A., et al. CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression. Cancer Res. 1999, 59:2302-2306.
    • (1999) Cancer Res. , vol.59 , pp. 2302-2306
    • Eads, C.A.1
  • 46
    • 0033153303 scopus 로고    scopus 로고
    • The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors
    • Robertson K.D., et al. The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res. 1999, 27:2291-2298.
    • (1999) Nucleic Acids Res. , vol.27 , pp. 2291-2298
    • Robertson, K.D.1
  • 47
    • 84904541089 scopus 로고    scopus 로고
    • Interpreting the language of histone and DNA modifications
    • Rothbart S.B., Strahl B.D. Interpreting the language of histone and DNA modifications. Biochim. Biophys. Acta 2014, 10.1016/j.bbagrm.2014.03.001.
    • (2014) Biochim. Biophys. Acta
    • Rothbart, S.B.1    Strahl, B.D.2
  • 48
    • 80052942443 scopus 로고    scopus 로고
    • Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification
    • Tan M., et al. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell 2011, 146:1016-1028.
    • (2011) Cell , vol.146 , pp. 1016-1028
    • Tan, M.1
  • 50
    • 67149099680 scopus 로고    scopus 로고
    • Histone H4 lysine 16 acetylation regulates cellular lifespan
    • Dang W., et al. Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature 2009, 459:802-807.
    • (2009) Nature , vol.459 , pp. 802-807
    • Dang, W.1
  • 51
    • 77956520661 scopus 로고    scopus 로고
    • Elevated histone expression promotes life span extension
    • Feser J., et al. Elevated histone expression promotes life span extension. Mol. Cell 2010, 39:724-735.
    • (2010) Mol. Cell , vol.39 , pp. 724-735
    • Feser, J.1
  • 52
    • 77957814604 scopus 로고    scopus 로고
    • Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres
    • O'Sullivan R.J., et al. Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres. Nat. Struct. Mol. Biol. 2010, 17:1218-1225.
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 1218-1225
    • O'Sullivan, R.J.1
  • 53
    • 84880585547 scopus 로고    scopus 로고
    • Lysosome-mediated processing of chromatin in senescence
    • Ivanov A., et al. Lysosome-mediated processing of chromatin in senescence. J. Cell Biol. 2013, 202:129-143.
    • (2013) J. Cell Biol. , vol.202 , pp. 129-143
    • Ivanov, A.1
  • 54
    • 84893931097 scopus 로고    scopus 로고
    • Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging
    • Hu Z., et al. Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging. Genes Dev. 2014, 28:396-408.
    • (2014) Genes Dev. , vol.28 , pp. 396-408
    • Hu, Z.1
  • 55
    • 26444573127 scopus 로고    scopus 로고
    • Towards the human cancer epigenome: a first draft of histone modifications
    • Fraga M.F., Esteller M. Towards the human cancer epigenome: a first draft of histone modifications. Cell Cycle 2005, 4:1377-1381.
    • (2005) Cell Cycle , vol.4 , pp. 1377-1381
    • Fraga, M.F.1    Esteller, M.2
  • 56
    • 32444434989 scopus 로고    scopus 로고
    • Histone H4-K16 acetylation controls chromatin structure and protein interactions
    • Shogren-Knaak M., et al. Histone H4-K16 acetylation controls chromatin structure and protein interactions. Science 2006, 311:844-847.
    • (2006) Science , vol.311 , pp. 844-847
    • Shogren-Knaak, M.1
  • 57
    • 84863507774 scopus 로고    scopus 로고
    • Histone H4 K16Q mutation, an acetylation mimic, causes structural disorder of its N-terminal basic patch in the nucleosome
    • Zhou B.R., et al. Histone H4 K16Q mutation, an acetylation mimic, causes structural disorder of its N-terminal basic patch in the nucleosome. J. Mol. Biol. 2012, 421:30-37.
    • (2012) J. Mol. Biol. , vol.421 , pp. 30-37
    • Zhou, B.R.1
  • 58
    • 77954360144 scopus 로고    scopus 로고
    • MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair
    • Sharma G.G., et al. MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair. Mol. Cell. Biol. 2010, 30:3582-3595.
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 3582-3595
    • Sharma, G.G.1
  • 59
    • 78649533191 scopus 로고    scopus 로고
    • MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1
    • Li X., et al. MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1. Mol. Cell. Biol. 2010, 30:5335-5347.
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 5335-5347
    • Li, X.1
  • 60
    • 84855200286 scopus 로고    scopus 로고
    • DNA damage in the presence of chemical genotoxic agents induce acetylation of H3K56 and H4K16 but not H3K9 in mammalian cells
    • Vempati R.K., Haldar D. DNA damage in the presence of chemical genotoxic agents induce acetylation of H3K56 and H4K16 but not H3K9 in mammalian cells. Mol. Biol. Rep. 2012, 39:303-308.
    • (2012) Mol. Biol. Rep. , vol.39 , pp. 303-308
    • Vempati, R.K.1    Haldar, D.2
  • 61
    • 4944245398 scopus 로고    scopus 로고
    • Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin
    • Vaquero A., et al. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol. Cell 2004, 16:93-105.
    • (2004) Mol. Cell , vol.16 , pp. 93-105
    • Vaquero, A.1
  • 62
    • 33645768490 scopus 로고    scopus 로고
    • Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation
    • Pruitt K., et al. Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet. 2006, 2:e40.
    • (2006) PLoS Genet. , vol.2
    • Pruitt, K.1
  • 63
    • 0031459980 scopus 로고    scopus 로고
    • Extrachromosomal rDNA circles - a cause of aging in yeast
    • Sinclair D.A., Guarente L. Extrachromosomal rDNA circles - a cause of aging in yeast. Cell 1997, 91:1033-1042.
    • (1997) Cell , vol.91 , pp. 1033-1042
    • Sinclair, D.A.1    Guarente, L.2
  • 64
    • 8644224064 scopus 로고    scopus 로고
    • Sir2 mediates longevity in the fly through a pathway related to calorie restriction
    • Rogina B., Helfand S.L. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:15998-16003.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 15998-16003
    • Rogina, B.1    Helfand, S.L.2
  • 65
    • 0035826271 scopus 로고    scopus 로고
    • Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
    • Tissenbaum H.A., Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 2001, 410:227-230.
    • (2001) Nature , vol.410 , pp. 227-230
    • Tissenbaum, H.A.1    Guarente, L.2
  • 66
    • 78649482634 scopus 로고    scopus 로고
    • SIRT1: recent lessons from mouse models
    • Herranz D., Serrano M. SIRT1: recent lessons from mouse models. Nat. Rev. Cancer 2010, 10:819-823.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 819-823
    • Herranz, D.1    Serrano, M.2
  • 67
    • 56749156405 scopus 로고    scopus 로고
    • SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
    • Oberdoerffer P., et al. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell 2008, 135:907-918.
    • (2008) Cell , vol.135 , pp. 907-918
    • Oberdoerffer, P.1
  • 68
    • 84886904734 scopus 로고    scopus 로고
    • The emerging and diverse roles of sirtuins in cancer: a clinical perspective
    • Yuan H., et al. The emerging and diverse roles of sirtuins in cancer: a clinical perspective. Onco Targets Ther. 2013, 6:1399-1416.
    • (2013) Onco Targets Ther. , vol.6 , pp. 1399-1416
    • Yuan, H.1
  • 69
    • 68149100569 scopus 로고    scopus 로고
    • The role of epigenetics in aging and age-related diseases
    • Calvanese V., et al. The role of epigenetics in aging and age-related diseases. Ageing Res. Rev. 2009, 8:268-276.
    • (2009) Ageing Res. Rev. , vol.8 , pp. 268-276
    • Calvanese, V.1
  • 70
    • 2642542643 scopus 로고    scopus 로고
    • A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin
    • Schotta G., et al. A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev. 2004, 18:1251-1262.
    • (2004) Genes Dev. , vol.18 , pp. 1251-1262
    • Schotta, G.1
  • 71
    • 34547400458 scopus 로고    scopus 로고
    • Active and repressive chromatin are interspersed without spreading in an imprinted gene cluster in the mammalian genome
    • Regha K., et al. Active and repressive chromatin are interspersed without spreading in an imprinted gene cluster in the mammalian genome. Mol. Cell 2007, 27:353-366.
    • (2007) Mol. Cell , vol.27 , pp. 353-366
    • Regha, K.1
  • 72
    • 20144388146 scopus 로고    scopus 로고
    • Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
    • Fraga M.F., et al. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat. Genet. 2005, 37:391-400.
    • (2005) Nat. Genet. , vol.37 , pp. 391-400
    • Fraga, M.F.1
  • 73
    • 33646142159 scopus 로고    scopus 로고
    • Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats
    • Pogribny I.P., et al. Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats. Carcinogenesis 2006, 27:1180-1186.
    • (2006) Carcinogenesis , vol.27 , pp. 1180-1186
    • Pogribny, I.P.1
  • 74
    • 32544452237 scopus 로고    scopus 로고
    • Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins
    • Tryndyak V.P., et al. Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins. Cancer Biol. Ther. 2006, 5:65-70.
    • (2006) Cancer Biol. Ther. , vol.5 , pp. 65-70
    • Tryndyak, V.P.1
  • 75
    • 84875754667 scopus 로고    scopus 로고
    • Histone H4 lysine 20 methylation: key player in epigenetic regulation of genomic integrity
    • Jorgensen S., et al. Histone H4 lysine 20 methylation: key player in epigenetic regulation of genomic integrity. Nucleic Acids Res. 2013, 41:2797-2806.
    • (2013) Nucleic Acids Res. , vol.41 , pp. 2797-2806
    • Jorgensen, S.1
  • 76
    • 48749102722 scopus 로고    scopus 로고
    • A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse
    • Schotta G., et al. A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev. 2008, 22:2048-2061.
    • (2008) Genes Dev. , vol.22 , pp. 2048-2061
    • Schotta, G.1
  • 77
    • 33745016642 scopus 로고    scopus 로고
    • Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging
    • Shumaker D.K., et al. Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:8703-8708.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 8703-8708
    • Shumaker, D.K.1
  • 78
    • 0037131426 scopus 로고    scopus 로고
    • Postsynthetic trimethylation of histone H4 at lysine 20 in mammalian tissues is associated with aging
    • Sarg B., et al. Postsynthetic trimethylation of histone H4 at lysine 20 in mammalian tissues is associated with aging. J. Biol. Chem. 2002, 277:39195-39201.
    • (2002) J. Biol. Chem. , vol.277 , pp. 39195-39201
    • Sarg, B.1
  • 79
    • 84861868041 scopus 로고    scopus 로고
    • H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence
    • Chicas A., et al. H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:8971-8976.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 8971-8976
    • Chicas, A.1
  • 80
    • 65949086183 scopus 로고    scopus 로고
    • Global histone modifications in breast cancer correlate with tumor phenotypes, prognostic factors, and patient outcome
    • Elsheikh S.E., et al. Global histone modifications in breast cancer correlate with tumor phenotypes, prognostic factors, and patient outcome. Cancer Res. 2009, 69:3802-3809.
    • (2009) Cancer Res. , vol.69 , pp. 3802-3809
    • Elsheikh, S.E.1
  • 81
    • 35348862421 scopus 로고    scopus 로고
    • Global histone modifications predict prognosis of resected non small-cell lung cancer
    • Barlesi F., et al. Global histone modifications predict prognosis of resected non small-cell lung cancer. J. Clin. Oncol. 2007, 25:4358-4364.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 4358-4364
    • Barlesi, F.1
  • 82
    • 41349090663 scopus 로고    scopus 로고
    • SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
    • Michishita E., et al. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 2008, 452:492-496.
    • (2008) Nature , vol.452 , pp. 492-496
    • Michishita, E.1
  • 83
    • 31044445366 scopus 로고    scopus 로고
    • Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
    • Mostoslavsky R., et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 2006, 124:315-329.
    • (2006) Cell , vol.124 , pp. 315-329
    • Mostoslavsky, R.1
  • 84
    • 84858000209 scopus 로고    scopus 로고
    • The sirtuin SIRT6 regulates lifespan in male mice
    • Kanfi Y., et al. The sirtuin SIRT6 regulates lifespan in male mice. Nature 2012, 483:218-221.
    • (2012) Nature , vol.483 , pp. 218-221
    • Kanfi, Y.1
  • 85
    • 84890570698 scopus 로고    scopus 로고
    • Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics
    • Liu Y., et al. Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics. Protein Cell 2013, 4:702-710.
    • (2013) Protein Cell , vol.4 , pp. 702-710
    • Liu, Y.1
  • 86
    • 58149090925 scopus 로고    scopus 로고
    • SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span
    • Kawahara T.L., et al. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell 2009, 136:62-74.
    • (2009) Cell , vol.136 , pp. 62-74
    • Kawahara, T.L.1
  • 87
    • 84864297655 scopus 로고    scopus 로고
    • Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation
    • Chandra T., et al. Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Mol. Cell 2012, 47:203-214.
    • (2012) Mol. Cell , vol.47 , pp. 203-214
    • Chandra, T.1
  • 88
    • 84882642434 scopus 로고    scopus 로고
    • Redistribution of the lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence
    • Sadaie M., et al. Redistribution of the lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence. Genes Dev. 2013, 27:1800-1808.
    • (2013) Genes Dev. , vol.27 , pp. 1800-1808
    • Sadaie, M.1
  • 89
    • 78149356747 scopus 로고    scopus 로고
    • Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia
    • Muller-Tidow C., et al. Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia. Blood 2010, 116:3564-3571.
    • (2010) Blood , vol.116 , pp. 3564-3571
    • Muller-Tidow, C.1
  • 90
    • 84892747115 scopus 로고    scopus 로고
    • High expression of H3K9me3 is a strong predictor of poor survival in patients with salivary adenoid cystic carcinoma
    • Xia R., et al. High expression of H3K9me3 is a strong predictor of poor survival in patients with salivary adenoid cystic carcinoma. Arch. Pathol. Lab. Med. 2013, 137:1761-1769.
    • (2013) Arch. Pathol. Lab. Med. , vol.137 , pp. 1761-1769
    • Xia, R.1
  • 91
    • 46149100720 scopus 로고    scopus 로고
    • The global histone modification pattern correlates with cancer recurrence and overall survival in gastric adenocarcinoma
    • Park Y.S., et al. The global histone modification pattern correlates with cancer recurrence and overall survival in gastric adenocarcinoma. Ann. Surg. Oncol. 2008, 15:1968-1976.
    • (2008) Ann. Surg. Oncol. , vol.15 , pp. 1968-1976
    • Park, Y.S.1
  • 92
    • 33748178469 scopus 로고    scopus 로고
    • Chromosomal translocations involving the MLL gene: molecular mechanisms
    • Aplan P.D. Chromosomal translocations involving the MLL gene: molecular mechanisms. DNA Repair 2006, 5:1265-1272.
    • (2006) DNA Repair , vol.5 , pp. 1265-1272
    • Aplan, P.D.1
  • 93
    • 77954660029 scopus 로고    scopus 로고
    • Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans
    • Greer E.L., et al. Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Nature 2010, 466:383-387.
    • (2010) Nature , vol.466 , pp. 383-387
    • Greer, E.L.1
  • 94
    • 33646070846 scopus 로고    scopus 로고
    • A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    • Bernstein B.E., et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006, 125:315-326.
    • (2006) Cell , vol.125 , pp. 315-326
    • Bernstein, B.E.1
  • 95
    • 33746324216 scopus 로고    scopus 로고
    • Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression
    • Shilatifard A. Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression. Annu. Rev. Biochem. 2006, 75:243-269.
    • (2006) Annu. Rev. Biochem. , vol.75 , pp. 243-269
    • Shilatifard, A.1
  • 96
    • 84861982240 scopus 로고    scopus 로고
    • Bivalent histone modifications in early embryogenesis
    • Vastenhouw N.L., Schier A.F. Bivalent histone modifications in early embryogenesis. Curr. Opin. Cell Biol. 2012, 24:374-386.
    • (2012) Curr. Opin. Cell Biol. , vol.24 , pp. 374-386
    • Vastenhouw, N.L.1    Schier, A.F.2
  • 97
    • 84882682843 scopus 로고    scopus 로고
    • Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape
    • Shah P.P., et al. Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape. Genes Dev. 2013, 27:1787-1799.
    • (2013) Genes Dev. , vol.27 , pp. 1787-1799
    • Shah, P.P.1
  • 98
    • 79960927422 scopus 로고    scopus 로고
    • Increased methylation variation in epigenetic domains across cancer types
    • Hansen K.D., et al. Increased methylation variation in epigenetic domains across cancer types. Nat. Genet. 2011, 43:768-775.
    • (2011) Nat. Genet. , vol.43 , pp. 768-775
    • Hansen, K.D.1
  • 99
    • 33947134834 scopus 로고    scopus 로고
    • The polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
    • Bracken A.P., et al. The polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev. 2007, 21:525-530.
    • (2007) Genes Dev. , vol.21 , pp. 525-530
    • Bracken, A.P.1
  • 100
    • 0141816752 scopus 로고    scopus 로고
    • EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
    • Kleer C.G., et al. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:11606-11611.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 11606-11611
    • Kleer, C.G.1
  • 101
    • 33644822360 scopus 로고    scopus 로고
    • EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast
    • Bachmann I.M., et al. EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. J. Clin. Oncol. 2006, 24:268-273.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 268-273
    • Bachmann, I.M.1
  • 102
    • 84887617868 scopus 로고    scopus 로고
    • Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas
    • Bender S., et al. Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell 2013, 24:660-672.
    • (2013) Cancer Cell , vol.24 , pp. 660-672
    • Bender, S.1
  • 103
    • 32844459336 scopus 로고    scopus 로고
    • The polycomb group protein EZH2 directly controls DNA methylation
    • Vire E., et al. The polycomb group protein EZH2 directly controls DNA methylation. Nature 2006, 439:871-874.
    • (2006) Nature , vol.439 , pp. 871-874
    • Vire, E.1
  • 104
    • 44349131472 scopus 로고    scopus 로고
    • Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
    • Kondo Y., et al. Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. Nat. Genet. 2008, 40:741-750.
    • (2008) Nat. Genet. , vol.40 , pp. 741-750
    • Kondo, Y.1
  • 105
    • 84871932584 scopus 로고    scopus 로고
    • DNA damage, chromatin, and transcription: the trinity of aging
    • Burgess R.C., et al. DNA damage, chromatin, and transcription: the trinity of aging. Curr. Opin. Cell Biol. 2012, 24:724-730.
    • (2012) Curr. Opin. Cell Biol. , vol.24 , pp. 724-730
    • Burgess, R.C.1
  • 106
    • 84872533627 scopus 로고    scopus 로고
    • RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond
    • Castel S.E., Martienssen R.A. RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond. Nat. Rev. Genet. 2013, 14:100-112.
    • (2013) Nat. Rev. Genet. , vol.14 , pp. 100-112
    • Castel, S.E.1    Martienssen, R.A.2
  • 107
    • 84861904178 scopus 로고    scopus 로고
    • Genome regulation by long noncoding RNAs
    • Rinn J.L., Chang H.Y. Genome regulation by long noncoding RNAs. Annu. Rev. Biochem. 2012, 81:145-166.
    • (2012) Annu. Rev. Biochem. , vol.81 , pp. 145-166
    • Rinn, J.L.1    Chang, H.Y.2
  • 108
    • 19944376457 scopus 로고    scopus 로고
    • Global identification of human transcribed sequences with genome tiling arrays
    • Bertone P., et al. Global identification of human transcribed sequences with genome tiling arrays. Science 2004, 306:2242-2246.
    • (2004) Science , vol.306 , pp. 2242-2246
    • Bertone, P.1
  • 109
    • 80052978224 scopus 로고    scopus 로고
    • Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses
    • Cabili M.N., et al. Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses. Genes Dev. 2011, 25:1915-1927.
    • (2011) Genes Dev. , vol.25 , pp. 1915-1927
    • Cabili, M.N.1
  • 110
    • 84879671055 scopus 로고    scopus 로고
    • Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs
    • Hangauer M.J., et al. Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs. PLoS Genet. 2013, 9:e1003569.
    • (2013) PLoS Genet. , vol.9
    • Hangauer, M.J.1
  • 111
    • 84865379361 scopus 로고    scopus 로고
    • LincRNA-p21 suppresses target mRNA translation
    • Yoon J.H., et al. LincRNA-p21 suppresses target mRNA translation. Mol. Cell 2012, 47:648-655.
    • (2012) Mol. Cell , vol.47 , pp. 648-655
    • Yoon, J.H.1
  • 112
    • 81855166810 scopus 로고    scopus 로고
    • RNA: a new layer of regulation
    • David R. RNA: a new layer of regulation. Nat. Rev. Mol. Cell Biol. 2011, 12:766.
    • (2011) Nat. Rev. Mol. Cell Biol. , vol.12 , pp. 766
    • David, R.1
  • 113
    • 84898432405 scopus 로고    scopus 로고
    • Long non-coding RNA in health and disease
    • Maass P.G., et al. Long non-coding RNA in health and disease. J. Mol. Med. (Berl.) 2014, 92:337-346.
    • (2014) J. Mol. Med. (Berl.) , vol.92 , pp. 337-346
    • Maass, P.G.1
  • 114
    • 77951118936 scopus 로고    scopus 로고
    • Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
    • Gupta R.A., et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 2010, 464:1071-1076.
    • (2010) Nature , vol.464 , pp. 1071-1076
    • Gupta, R.A.1
  • 115
    • 77954572735 scopus 로고    scopus 로고
    • Long noncoding RNA as modular scaffold of histone modification complexes
    • Tsai M.C., et al. Long noncoding RNA as modular scaffold of histone modification complexes. Science 2010, 329:689-693.
    • (2010) Science , vol.329 , pp. 689-693
    • Tsai, M.C.1
  • 116
    • 84896710254 scopus 로고    scopus 로고
    • Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients
    • Quagliata L., et al. Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients. Hepatology 2014, 59:911-923.
    • (2014) Hepatology , vol.59 , pp. 911-923
    • Quagliata, L.1
  • 117
    • 79953748673 scopus 로고    scopus 로고
    • A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression
    • Wang K.C., et al. A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Nature 2011, 472:120-124.
    • (2011) Nature , vol.472 , pp. 120-124
    • Wang, K.C.1
  • 118
    • 84879462680 scopus 로고    scopus 로고
    • Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer
    • Takayama K., et al. Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer. EMBO J. 2013, 32:1665-1680.
    • (2013) EMBO J. , vol.32 , pp. 1665-1680
    • Takayama, K.1
  • 119
    • 84884618929 scopus 로고    scopus 로고
    • The intronic long noncoding RNA ANRASSF1 recruits PRC2 to the RASSF1A promoter, reducing the expression of RASSF1A and increasing cell proliferation
    • Beckedorff F.C., et al. The intronic long noncoding RNA ANRASSF1 recruits PRC2 to the RASSF1A promoter, reducing the expression of RASSF1A and increasing cell proliferation. PLoS Genet. 2013, 9:e1003705.
    • (2013) PLoS Genet. , vol.9
    • Beckedorff, F.C.1
  • 120
    • 84875177348 scopus 로고    scopus 로고
    • X-inactivation, imprinting, and long noncoding RNAs in health and disease
    • Lee J.T., Bartolomei M.S. X-inactivation, imprinting, and long noncoding RNAs in health and disease. Cell 2013, 152:1308-1323.
    • (2013) Cell , vol.152 , pp. 1308-1323
    • Lee, J.T.1    Bartolomei, M.S.2
  • 121
    • 84874053510 scopus 로고    scopus 로고
    • Xist RNA is a potent suppressor of hematologic cancer in mice
    • Yildirim E., et al. Xist RNA is a potent suppressor of hematologic cancer in mice. Cell 2013, 152:727-742.
    • (2013) Cell , vol.152 , pp. 727-742
    • Yildirim, E.1
  • 122
    • 84883794528 scopus 로고    scopus 로고
    • Senescence-associated lncRNAs: senescence-associated long noncoding RNAs
    • Abdelmohsen K., et al. Senescence-associated lncRNAs: senescence-associated long noncoding RNAs. Aging Cell 2013, 12:890-900.
    • (2013) Aging Cell , vol.12 , pp. 890-900
    • Abdelmohsen, K.1
  • 123
    • 33750030758 scopus 로고    scopus 로고
    • The regulation of INK4/ARF in cancer and aging
    • Kim W.Y., Sharpless N.E. The regulation of INK4/ARF in cancer and aging. Cell 2006, 127:265-275.
    • (2006) Cell , vol.127 , pp. 265-275
    • Kim, W.Y.1    Sharpless, N.E.2
  • 124
    • 63549095397 scopus 로고    scopus 로고
    • Anti-aging activity of the Ink4/Arf locus
    • Matheu A., et al. Anti-aging activity of the Ink4/Arf locus. Aging Cell 2009, 8:152-161.
    • (2009) Aging Cell , vol.8 , pp. 152-161
    • Matheu, A.1
  • 125
    • 79955468280 scopus 로고    scopus 로고
    • INK4B tumor suppressor gene
    • INK4B tumor suppressor gene. Oncogene 2011, 30:1956-1962.
    • (2011) Oncogene , vol.30 , pp. 1956-1962
    • Kotake, Y.1
  • 126
    • 77953096072 scopus 로고    scopus 로고
    • Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a
    • Yap K.L., et al. Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol. Cell 2010, 38:662-674.
    • (2010) Mol. Cell , vol.38 , pp. 662-674
    • Yap, K.L.1
  • 127
    • 38049155825 scopus 로고    scopus 로고
    • Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
    • Yu W., et al. Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA. Nature 2008, 451:202-206.
    • (2008) Nature , vol.451 , pp. 202-206
    • Yu, W.1
  • 128
    • 79551623370 scopus 로고    scopus 로고
    • ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS
    • Pasmant E., et al. ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS. FASEB J. 2011, 25:444-448.
    • (2011) FASEB J. , vol.25 , pp. 444-448
    • Pasmant, E.1
  • 129
    • 84878919248 scopus 로고    scopus 로고
    • Non-coding RNAs in DNA damage and repair
    • Sharma V., Misteli T. Non-coding RNAs in DNA damage and repair. FEBS Lett. 2013, 587:1832-1839.
    • (2013) FEBS Lett. , vol.587 , pp. 1832-1839
    • Sharma, V.1    Misteli, T.2
  • 130
    • 84874969813 scopus 로고    scopus 로고
    • Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway
    • Wan G., et al. Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway. Cell. Signal. 2013, 25:1086-1095.
    • (2013) Cell. Signal. , vol.25 , pp. 1086-1095
    • Wan, G.1
  • 131
    • 84887033381 scopus 로고    scopus 로고
    • A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation
    • Wan G., et al. A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation. EMBO J. 2013, 32:2833-2847.
    • (2013) EMBO J. , vol.32 , pp. 2833-2847
    • Wan, G.1
  • 132
    • 80052431169 scopus 로고    scopus 로고
    • In vitro generation of human cells with cancer stem cell properties
    • Scaffidi P., Misteli T. In vitro generation of human cells with cancer stem cell properties. Nat. Cell Biol. 2011, 13:1051-1061.
    • (2011) Nat. Cell Biol. , vol.13 , pp. 1051-1061
    • Scaffidi, P.1    Misteli, T.2
  • 133
    • 84879242423 scopus 로고    scopus 로고
    • The cellular etiology of chromosome translocations
    • Roukos V., et al. The cellular etiology of chromosome translocations. Curr. Opin. Cell Biol. 2013, 25:357-364.
    • (2013) Curr. Opin. Cell Biol. , vol.25 , pp. 357-364
    • Roukos, V.1
  • 134
    • 80052404953 scopus 로고    scopus 로고
    • Cancer epigenetics: from disruption of differentiation programs to the emergence of cancer stem cells
    • Scaffidi P., Misteli T. Cancer epigenetics: from disruption of differentiation programs to the emergence of cancer stem cells. Cold Spring Harb. Symp. Quant. Biol. 2010, 75:251-258.
    • (2010) Cold Spring Harb. Symp. Quant. Biol. , vol.75 , pp. 251-258
    • Scaffidi, P.1    Misteli, T.2
  • 135
    • 78649449767 scopus 로고    scopus 로고
    • The influence of heterochromatin on DNA double strand break repair: getting the strong, silent type to relax
    • Goodarzi A.A., et al. The influence of heterochromatin on DNA double strand break repair: getting the strong, silent type to relax. DNA Repair 2010, 9:1273-1282.
    • (2010) DNA Repair , vol.9 , pp. 1273-1282
    • Goodarzi, A.A.1
  • 136
    • 84899893679 scopus 로고    scopus 로고
    • Recurrent epimutations activate gene body promoters in primary glioblastoma
    • Nagarajan R.P., et al. Recurrent epimutations activate gene body promoters in primary glioblastoma. Genome Res. 2014, 24:761-774.
    • (2014) Genome Res. , vol.24 , pp. 761-774
    • Nagarajan, R.P.1
  • 137
    • 78049518884 scopus 로고    scopus 로고
    • Prognostic relevance of global histone H3 lysine 4 (H3K4) methylation in renal cell carcinoma
    • Ellinger J., et al. Prognostic relevance of global histone H3 lysine 4 (H3K4) methylation in renal cell carcinoma. Int. J. Cancer 2010, 127:2360-2366.
    • (2010) Int. J. Cancer , vol.127 , pp. 2360-2366
    • Ellinger, J.1
  • 138
    • 77950510166 scopus 로고    scopus 로고
    • Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: results from RTOG 9704
    • Manuyakorn A., et al. Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: results from RTOG 9704. J. Clin. Oncol. 2010, 28:1358-1365.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 1358-1365
    • Manuyakorn, A.1
  • 139
    • 74249098871 scopus 로고    scopus 로고
    • Prognostic impact of H3K27me3 expression on locoregional progression after chemoradiotherapy in esophageal squamous cell carcinoma
    • He L.R., et al. Prognostic impact of H3K27me3 expression on locoregional progression after chemoradiotherapy in esophageal squamous cell carcinoma. BMC Cancer 2009, 9:461.
    • (2009) BMC Cancer , vol.9 , pp. 461
    • He, L.R.1
  • 140
    • 80053445408 scopus 로고    scopus 로고
    • Human cancer long non-coding RNA transcriptomes
    • Gibb E.A., et al. Human cancer long non-coding RNA transcriptomes. PLoS ONE 2011, 6:e25915.
    • (2011) PLoS ONE , vol.6
    • Gibb, E.A.1
  • 141
    • 84862828921 scopus 로고    scopus 로고
    • Functional elements demarcated by histone modifications in breast cancer cells
    • Choe M.K., et al. Functional elements demarcated by histone modifications in breast cancer cells. Biochem. Biophys. Res. Commun. 2012, 418:475-482.
    • (2012) Biochem. Biophys. Res. Commun. , vol.418 , pp. 475-482
    • Choe, M.K.1


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