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Volumn 269, Issue 1, 2016, Pages 118-129

Age-associated B cells: Key mediators of both protective and autoreactive humoral responses

Author keywords

Age associated B cell; Autoimmunity; CD11c; T BET; TLR7; TLR9

Indexed keywords

AUTOANTIGEN; CELL MARKER; IMMUNOGLOBULIN G2A; NUCLEIC ACID; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TRANSCRIPTION FACTOR T BET; CYTOKINE; IMMUNOGLOBULIN G; T BOX TRANSCRIPTION FACTOR; T-BOX TRANSCRIPTION FACTOR TBX21;

EID: 84950153720     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12380     Document Type: Article
Times cited : (110)

References (176)
  • 1
    • 79955746123 scopus 로고    scopus 로고
    • The control of adaptive immune responses by the innate immune system
    • Schenten D, Medzhitov R. The control of adaptive immune responses by the innate immune system. Adv Immunol 2011;109:87-124.
    • (2011) Adv Immunol , vol.109 , pp. 87-124
    • Schenten, D.1    Medzhitov, R.2
  • 3
    • 84904443484 scopus 로고    scopus 로고
    • T-cell-receptor-dependent signal intensity dominantly controls CD4(+) T cell polarization in vivo
    • van Panhuys N, Klauschen F, Germain RN. T-cell-receptor-dependent signal intensity dominantly controls CD4(+) T cell polarization in vivo. Immunity 2014;41:63-74.
    • (2014) Immunity , vol.41 , pp. 63-74
    • van Panhuys, N.1    Klauschen, F.2    Germain, R.N.3
  • 5
    • 65349104572 scopus 로고    scopus 로고
    • Mechanisms of costimulation
    • Sharpe AH. Mechanisms of costimulation. Immunol Rev 2009;229:5-11.
    • (2009) Immunol Rev , vol.229 , pp. 5-11
    • Sharpe, A.H.1
  • 6
    • 0036233983 scopus 로고    scopus 로고
    • Transcription: tantalizing times for T cells
    • Ho IC, Glimcher LH. Transcription: tantalizing times for T cells. Cell 2002;109(Suppl):S109-S120.
    • (2002) Cell , vol.109 , pp. S109-S120
    • Ho, I.C.1    Glimcher, L.H.2
  • 7
    • 0036885067 scopus 로고    scopus 로고
    • The lineage decisions of helper T cells
    • Murphy KM, Reiner SL. The lineage decisions of helper T cells. Nat Rev Immunol 2002;2:933-944.
    • (2002) Nat Rev Immunol , vol.2 , pp. 933-944
    • Murphy, K.M.1    Reiner, S.L.2
  • 9
    • 37549036732 scopus 로고    scopus 로고
    • Fcgamma receptors as regulators of immune responses
    • Nimmerjahn F, Ravetch JV. Fcgamma receptors as regulators of immune responses. Nat Rev Immunol 2008;8:34-47.
    • (2008) Nat Rev Immunol , vol.8 , pp. 34-47
    • Nimmerjahn, F.1    Ravetch, J.V.2
  • 10
    • 80051569441 scopus 로고    scopus 로고
    • A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice
    • Hao Y, O'Neill PJ, Naradikian MS, Scholz JL, Cancro MP. A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice. Blood 2011;118:1294-1304.
    • (2011) Blood , vol.118 , pp. 1294-1304
    • Hao, Y.1    O'Neill, P.J.2    Naradikian, M.S.3    Scholz, J.L.4    Cancro, M.P.5
  • 11
    • 80051568169 scopus 로고    scopus 로고
    • + B-cell population is important for the development of autoimmunity
    • + B-cell population is important for the development of autoimmunity. Blood 2011;118:1305-1315.
    • (2011) Blood , vol.118 , pp. 1305-1315
    • Rubtsov, A.V.1
  • 12
    • 84940118728 scopus 로고    scopus 로고
    • Age-associated B cells: a T-bet-dependent effector with roles in protective and pathogenic immunity
    • Rubtsova K, Rubtsov AV, Cancro MP, Marrack P. Age-associated B cells: a T-bet-dependent effector with roles in protective and pathogenic immunity. J Immunol 2015;195:1933-1937.
    • (2015) J Immunol , vol.195 , pp. 1933-1937
    • Rubtsova, K.1    Rubtsov, A.V.2    Cancro, M.P.3    Marrack, P.4
  • 13
    • 0025868702 scopus 로고
    • Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
    • Hardy RRCC, Shinton SA, Kemp JD, Hayakawa K. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J Exp Med 1991;173:1213-1225.
    • (1991) J Exp Med , vol.173 , pp. 1213-1225
    • Hardy, R.R.C.C.1    Shinton, S.A.2    Kemp, J.D.3    Hayakawa, K.4
  • 14
    • 0025801026 scopus 로고
    • Proliferation kinetics and the lifespan of B cells in central and peripheral lymphoid organs
    • Osmond DG. Proliferation kinetics and the lifespan of B cells in central and peripheral lymphoid organs. Curr Opin Immunol 1991;3:179-185.
    • (1991) Curr Opin Immunol , vol.3 , pp. 179-185
    • Osmond, D.G.1
  • 16
    • 61849159361 scopus 로고    scopus 로고
    • Transcriptional regulation of early B cell development
    • Northrup DL, Allman D. Transcriptional regulation of early B cell development. Immunol Res 2008;42:106-117.
    • (2008) Immunol Res , vol.42 , pp. 106-117
    • Northrup, D.L.1    Allman, D.2
  • 17
    • 0027997502 scopus 로고
    • Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP
    • Urbanek P, Wang ZQ, Fetka I, Wagner EF, Busslinger M. Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell 1994;79:901-912.
    • (1994) Cell , vol.79 , pp. 901-912
    • Urbanek, P.1    Wang, Z.Q.2    Fetka, I.3    Wagner, E.F.4    Busslinger, M.5
  • 18
    • 0037025198 scopus 로고    scopus 로고
    • Reversion of B cell commitment upon loss of Pax5 expression
    • Mikkola I, Heavey B, Horcher M, Busslinger M. Reversion of B cell commitment upon loss of Pax5 expression. Science 2002;297:110-113.
    • (2002) Science , vol.297 , pp. 110-113
    • Mikkola, I.1    Heavey, B.2    Horcher, M.3    Busslinger, M.4
  • 19
    • 0033533891 scopus 로고    scopus 로고
    • Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
    • Nutt SL, Heavey B, Rolink AG, Busslinger M. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature 1999;401:556-562.
    • (1999) Nature , vol.401 , pp. 556-562
    • Nutt, S.L.1    Heavey, B.2    Rolink, A.G.3    Busslinger, M.4
  • 20
    • 0032541471 scopus 로고    scopus 로고
    • Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12
    • Kee BL, Murre C. Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12. J Exp Med 1998;188:699-713.
    • (1998) J Exp Med , vol.188 , pp. 699-713
    • Kee, B.L.1    Murre, C.2
  • 21
    • 33846141460 scopus 로고    scopus 로고
    • Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5
    • Roessler S, et al. Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5. Mol Cell Biol 2007;27:579-594.
    • (2007) Mol Cell Biol , vol.27 , pp. 579-594
    • Roessler, S.1
  • 22
    • 3042693975 scopus 로고    scopus 로고
    • Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A
    • Seet CS, Brumbaugh RL, Kee BL. Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A. J Exp Med 2004;199:1689-1700.
    • (2004) J Exp Med , vol.199 , pp. 1689-1700
    • Seet, C.S.1    Brumbaugh, R.L.2    Kee, B.L.3
  • 23
    • 38449102306 scopus 로고    scopus 로고
    • Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5
    • Pongubala JM, et al. Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5. Nat Immunol 2008;9:203-215.
    • (2008) Nat Immunol , vol.9 , pp. 203-215
    • Pongubala, J.M.1
  • 24
    • 0027992622 scopus 로고
    • E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
    • Bain G, et al. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell 1994;79:885-892.
    • (1994) Cell , vol.79 , pp. 885-892
    • Bain, G.1
  • 25
    • 0028148938 scopus 로고
    • The helix-loop-helix gene E2A is required for B cell formation
    • Zhuang Y, Soriano P, Weintraub H. The helix-loop-helix gene E2A is required for B cell formation. Cell 1994;79:875-884.
    • (1994) Cell , vol.79 , pp. 875-884
    • Zhuang, Y.1    Soriano, P.2    Weintraub, H.3
  • 26
    • 84878203280 scopus 로고    scopus 로고
    • Transcriptional repression of Gata3 is essential for early B cell commitment
    • Banerjee A, Northrup D, Boukarabila H, Jacobsen SE, Allman D. Transcriptional repression of Gata3 is essential for early B cell commitment. Immunity 2013;38:930-942.
    • (2013) Immunity , vol.38 , pp. 930-942
    • Banerjee, A.1    Northrup, D.2    Boukarabila, H.3    Jacobsen, S.E.4    Allman, D.5
  • 27
    • 0026644137 scopus 로고
    • Peripheral B cell maturation. I. Immature peripheral B cells in adults are heat-stable antigenhi and exhibit unique signaling characteristics
    • Allman DM, Ferguson SE, Cancro MP. Peripheral B cell maturation. I. Immature peripheral B cells in adults are heat-stable antigenhi and exhibit unique signaling characteristics. J Immunol 1992;149:2533-2540.
    • (1992) J Immunol , vol.149 , pp. 2533-2540
    • Allman, D.M.1    Ferguson, S.E.2    Cancro, M.P.3
  • 28
    • 0027379716 scopus 로고
    • Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells
    • Allman DM, Ferguson SE, Lentz VM, Cancro MP. Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells. J Immunol 1993;151:4431-4444.
    • (1993) J Immunol , vol.151 , pp. 4431-4444
    • Allman, D.M.1    Ferguson, S.E.2    Lentz, V.M.3    Cancro, M.P.4
  • 29
    • 0029003671 scopus 로고
    • Transitional B cells are the target of negative selection in the B cell compartment
    • Carsetti R, Kohler G, Lamers MC. Transitional B cells are the target of negative selection in the B cell compartment. J Exp Med 1995;181:2129-2140.
    • (1995) J Exp Med , vol.181 , pp. 2129-2140
    • Carsetti, R.1    Kohler, G.2    Lamers, M.C.3
  • 30
    • 0035892228 scopus 로고    scopus 로고
    • Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation
    • Allman D, Lindsley RC, DeMuth W, Rudd K, Shinton SA, Hardy RR. Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation. J Immunol 2001;167:6834-6840.
    • (2001) J Immunol , vol.167 , pp. 6834-6840
    • Allman, D.1    Lindsley, R.C.2    DeMuth, W.3    Rudd, K.4    Shinton, S.A.5    Hardy, R.R.6
  • 31
    • 0942268734 scopus 로고    scopus 로고
    • Peripheral B-cell maturation: the intersection of selection and homeostasis
    • Cancro MP. Peripheral B-cell maturation: the intersection of selection and homeostasis. Immunol Rev 2004;197:89-101.
    • (2004) Immunol Rev , vol.197 , pp. 89-101
    • Cancro, M.P.1
  • 32
    • 0942290440 scopus 로고    scopus 로고
    • Peripheral development of B cells in mouse and man
    • Carsetti R, Rosado MM, Wardmann H. Peripheral development of B cells in mouse and man. Immunol Rev 2004;197:179-191.
    • (2004) Immunol Rev , vol.197 , pp. 179-191
    • Carsetti, R.1    Rosado, M.M.2    Wardmann, H.3
  • 33
    • 0038742790 scopus 로고    scopus 로고
    • Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development
    • Saito T, et al. Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity 2003;18:675-685.
    • (2003) Immunity , vol.18 , pp. 675-685
    • Saito, T.1
  • 34
    • 2942659675 scopus 로고    scopus 로고
    • Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo
    • Hozumi K, et al. Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo. Nat Immunol 2004;5:638-644.
    • (2004) Nat Immunol , vol.5 , pp. 638-644
    • Hozumi, K.1
  • 35
    • 60149102638 scopus 로고    scopus 로고
    • Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches
    • Tan JB, et al. Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches. Immunity 2009;30:254-263.
    • (2009) Immunity , vol.30 , pp. 254-263
    • Tan, J.B.1
  • 36
    • 70350515662 scopus 로고    scopus 로고
    • The follicular versus marginal zone B lymphocyte cell fate decision
    • Pillai S, Cariappa A. The follicular versus marginal zone B lymphocyte cell fate decision. Nat Rev Immunol 2009;9:767-777.
    • (2009) Nat Rev Immunol , vol.9 , pp. 767-777
    • Pillai, S.1    Cariappa, A.2
  • 37
    • 0023729241 scopus 로고
    • Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice
    • Goodnow CC, et al. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 1988;334:676-682.
    • (1988) Nature , vol.334 , pp. 676-682
    • Goodnow, C.C.1
  • 38
    • 0024529870 scopus 로고
    • Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes
    • Nemazee DA, Burki K. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature 1989;337:562-566.
    • (1989) Nature , vol.337 , pp. 562-566
    • Nemazee, D.A.1    Burki, K.2
  • 40
    • 0025948793 scopus 로고
    • Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens
    • Hartley SB, Crosbie J, Brink R, Kantor AB, Basten A, Goodnow CC. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature 1991;353:765-769.
    • (1991) Nature , vol.353 , pp. 765-769
    • Hartley, S.B.1    Crosbie, J.2    Brink, R.3    Kantor, A.B.4    Basten, A.5    Goodnow, C.C.6
  • 41
    • 0027532192 scopus 로고
    • B lymphocytes may escape tolerance by revising their antigen receptors
    • Radic MZ, Erikson J, Litwin S, Weigert M. B lymphocytes may escape tolerance by revising their antigen receptors. J Exp Med 1993;177:1165-1173.
    • (1993) J Exp Med , vol.177 , pp. 1165-1173
    • Radic, M.Z.1    Erikson, J.2    Litwin, S.3    Weigert, M.4
  • 42
    • 0030008694 scopus 로고    scopus 로고
    • The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help
    • Fulcher DA, et al. The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help. J Exp Med 1996;183:2313-2328.
    • (1996) J Exp Med , vol.183 , pp. 2313-2328
    • Fulcher, D.A.1
  • 43
    • 0342711256 scopus 로고    scopus 로고
    • In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
    • Lam KP, Kuhn R, Rajewsky K. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 1997;90:1073-1083.
    • (1997) Cell , vol.90 , pp. 1073-1083
    • Lam, K.P.1    Kuhn, R.2    Rajewsky, K.3
  • 44
    • 0016653937 scopus 로고
    • Evidence for the clonal abortion theory of B-lymphocyte tolerance
    • Nossal GJ, Pike BL. Evidence for the clonal abortion theory of B-lymphocyte tolerance. J Exp Med 1975;141:904-917.
    • (1975) J Exp Med , vol.141 , pp. 904-917
    • Nossal, G.J.1    Pike, B.L.2
  • 45
    • 0034646356 scopus 로고    scopus 로고
    • A B-cell receptor-specific selection step governs immature to mature B cell differentiation
    • Levine MH, et al. A B-cell receptor-specific selection step governs immature to mature B cell differentiation. Proc Natl Acad Sci USA 2000;97:2743-2748.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 2743-2748
    • Levine, M.H.1
  • 46
    • 2942729834 scopus 로고    scopus 로고
    • B cell positive selection: road map to the primary repertoire?
    • Cancro MP, Kearney JF. B cell positive selection: road map to the primary repertoire? J Immunol 2004;173:15-19.
    • (2004) J Immunol , vol.173 , pp. 15-19
    • Cancro, M.P.1    Kearney, J.F.2
  • 47
    • 15444365480 scopus 로고    scopus 로고
    • Defective B cell tolerance checkpoints in systemic lupus erythematosus
    • Yurasov S, et al. Defective B cell tolerance checkpoints in systemic lupus erythematosus. J Exp Med 2005;201:703-711.
    • (2005) J Exp Med , vol.201 , pp. 703-711
    • Yurasov, S.1
  • 48
    • 34047134533 scopus 로고    scopus 로고
    • The role of BLyS/BLyS receptors in anti-chromatin B cell regulation
    • Hondowicz BD, et al. The role of BLyS/BLyS receptors in anti-chromatin B cell regulation. Int Immunol 2007;19:465-475.
    • (2007) Int Immunol , vol.19 , pp. 465-475
    • Hondowicz, B.D.1
  • 50
    • 0033532634 scopus 로고    scopus 로고
    • BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
    • Schneider P, et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med 1999;189:1747-1756.
    • (1999) J Exp Med , vol.189 , pp. 1747-1756
    • Schneider, P.1
  • 51
    • 0033538468 scopus 로고    scopus 로고
    • BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator
    • Moore PA, et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999;285:260-263.
    • (1999) Science , vol.285 , pp. 260-263
    • Moore, P.A.1
  • 52
    • 9644266695 scopus 로고    scopus 로고
    • The BLyS family of ligands and receptors: an archetype for niche-specific homeostatic regulation
    • Cancro MP. The BLyS family of ligands and receptors: an archetype for niche-specific homeostatic regulation. Immunol Rev 2004;202:237-249.
    • (2004) Immunol Rev , vol.202 , pp. 237-249
    • Cancro, M.P.1
  • 53
    • 0035797908 scopus 로고    scopus 로고
    • Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency
    • Yan M, et al. Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency. Curr Biol 2001;11:1547-1552.
    • (2001) Curr Biol , vol.11 , pp. 1547-1552
    • Yan, M.1
  • 54
    • 0035860559 scopus 로고    scopus 로고
    • An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
    • Schiemann B, et al. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 2001;293:2111-2114.
    • (2001) Science , vol.293 , pp. 2111-2114
    • Schiemann, B.1
  • 55
    • 0035846593 scopus 로고    scopus 로고
    • Competition for BLyS-mediated signaling through Bcmd/BR3 regulates peripheral B lymphocyte numbers
    • Harless SM, et al. Competition for BLyS-mediated signaling through Bcmd/BR3 regulates peripheral B lymphocyte numbers. Curr Biol 2001;11:1986-1989.
    • (2001) Curr Biol , vol.11 , pp. 1986-1989
    • Harless, S.M.1
  • 56
    • 0032522626 scopus 로고    scopus 로고
    • Bcmd decreases the life span of B-2 but not B-1 cells in A/WySnJ mice
    • Lentz VM, Hayes CE, Cancro MP. Bcmd decreases the life span of B-2 but not B-1 cells in A/WySnJ mice. J Immunol 1998;160:3743-3747.
    • (1998) J Immunol , vol.160 , pp. 3743-3747
    • Lentz, V.M.1    Hayes, C.E.2    Cancro, M.P.3
  • 57
    • 0030014518 scopus 로고    scopus 로고
    • Bcmd governs recruitment of new B cells into the stable peripheral B cell pool in the A/WySnJ mouse
    • Lentz VM, Cancro MP, Nashold FE, Hayes CE. Bcmd governs recruitment of new B cells into the stable peripheral B cell pool in the A/WySnJ mouse. J Immunol 1996;157:598-606.
    • (1996) J Immunol , vol.157 , pp. 598-606
    • Lentz, V.M.1    Cancro, M.P.2    Nashold, F.E.3    Hayes, C.E.4
  • 58
    • 56349091862 scopus 로고    scopus 로고
    • Tonic B cell antigen receptor signals supply an NF-kappaB substrate for prosurvival BLyS signaling
    • Stadanlick JE, et al. Tonic B cell antigen receptor signals supply an NF-kappaB substrate for prosurvival BLyS signaling. Nat Immunol 2008;9:1379-1387.
    • (2008) Nat Immunol , vol.9 , pp. 1379-1387
    • Stadanlick, J.E.1
  • 59
    • 0037097665 scopus 로고    scopus 로고
    • Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators
    • Hsu BL, Harless SM, Lindsley RC, Hilbert DM, Cancro MP. Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators. J Immunol 2002;168:5993-5996.
    • (2002) J Immunol , vol.168 , pp. 5993-5996
    • Hsu, B.L.1    Harless, S.M.2    Lindsley, R.C.3    Hilbert, D.M.4    Cancro, M.P.5
  • 60
    • 33646891951 scopus 로고    scopus 로고
    • Space, selection, and surveillance: setting boundaries with BLyS
    • Miller JP, Stadanlick JE, Cancro MP. Space, selection, and surveillance: setting boundaries with BLyS. J Immunol 2006;176:6405-6410.
    • (2006) J Immunol , vol.176 , pp. 6405-6410
    • Miller, J.P.1    Stadanlick, J.E.2    Cancro, M.P.3
  • 61
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000;102:553-563.
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5    Honjo, T.6
  • 62
    • 33746574474 scopus 로고    scopus 로고
    • Targeting of somatic hypermutation
    • Odegard VH, Schatz DG. Targeting of somatic hypermutation. Nat Rev Immunol 2006;6:573-583.
    • (2006) Nat Rev Immunol , vol.6 , pp. 573-583
    • Odegard, V.H.1    Schatz, D.G.2
  • 64
    • 84937692071 scopus 로고    scopus 로고
    • Salmonella infection drives promiscuous B cell activation followed by extrafollicular affinity maturation
    • Di Niro R, et al. Salmonella infection drives promiscuous B cell activation followed by extrafollicular affinity maturation. Immunity 2015;43:120-131.
    • (2015) Immunity , vol.43 , pp. 120-131
    • Di Niro, R.1
  • 65
    • 1842405362 scopus 로고    scopus 로고
    • Lifetime of plasma cells in the bone marrow
    • Manz RA, Thiel A, Radbruch A. Lifetime of plasma cells in the bone marrow. Nature 1997;388:133-134.
    • (1997) Nature , vol.388 , pp. 133-134
    • Manz, R.A.1    Thiel, A.2    Radbruch, A.3
  • 66
  • 67
    • 35848969753 scopus 로고    scopus 로고
    • Duration of humoral immunity to common viral and vaccine antigens
    • Amanna IJ, Carlson NE, Slifka MK. Duration of humoral immunity to common viral and vaccine antigens. N Engl J Med 2007;357:1903-1915.
    • (2007) N Engl J Med , vol.357 , pp. 1903-1915
    • Amanna, I.J.1    Carlson, N.E.2    Slifka, M.K.3
  • 68
    • 0029045421 scopus 로고
    • BCL-6 protein is expressed in germinal-center B cells
    • Cattoretti G, et al. BCL-6 protein is expressed in germinal-center B cells. Blood 1995;86:45-53.
    • (1995) Blood , vol.86 , pp. 45-53
    • Cattoretti, G.1
  • 69
    • 0029904294 scopus 로고    scopus 로고
    • BCL-6 expression during B-cell activation
    • Allman D, et al. BCL-6 expression during B-cell activation. Blood 1996;87:5257-5268.
    • (1996) Blood , vol.87 , pp. 5257-5268
    • Allman, D.1
  • 70
    • 0030901289 scopus 로고    scopus 로고
    • Control of inflammation, cytokine expression, and germinal center formation by BCL-6
    • Dent AL, Shaffer AL, Yu X, Allman D, Staudt LM. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 1997;276:589-592.
    • (1997) Science , vol.276 , pp. 589-592
    • Dent, A.L.1    Shaffer, A.L.2    Yu, X.3    Allman, D.4    Staudt, L.M.5
  • 71
    • 10344247666 scopus 로고    scopus 로고
    • The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells
    • Phan RT, Dalla-Favera R. The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells. Nature 2004;432:635-639.
    • (2004) Nature , vol.432 , pp. 635-639
    • Phan, R.T.1    Dalla-Favera, R.2
  • 73
    • 34248543774 scopus 로고    scopus 로고
    • Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1
    • Kallies A, et al. Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1. Immunity 2007;26:555-566.
    • (2007) Immunity , vol.26 , pp. 555-566
    • Kallies, A.1
  • 74
    • 0036272784 scopus 로고    scopus 로고
    • Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells
    • Lin KI, Angelin-Duclos C, Kuo TC, Calame K. Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells. Mol Cell Biol 2002;22:4771-4780.
    • (2002) Mol Cell Biol , vol.22 , pp. 4771-4780
    • Lin, K.I.1    Angelin-Duclos, C.2    Kuo, T.C.3    Calame, K.4
  • 75
    • 18444395232 scopus 로고    scopus 로고
    • Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program
    • Shaffer AL, et al. Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity 2002;17:51-62.
    • (2002) Immunity , vol.17 , pp. 51-62
    • Shaffer, A.L.1
  • 77
    • 84862068507 scopus 로고    scopus 로고
    • Long-lived bone marrow plasma cells are induced early in response to T cell-independent or T cell-dependent antigens
    • Bortnick A, Chernova I, Quinn WJ 3rd, Mugnier M, Cancro MP, Allman D. Long-lived bone marrow plasma cells are induced early in response to T cell-independent or T cell-dependent antigens. J Immunol 2012;188:5389-5396.
    • (2012) J Immunol , vol.188 , pp. 5389-5396
    • Bortnick, A.1    Chernova, I.2    Quinn 3rd, W.J.3    Mugnier, M.4    Cancro, M.P.5    Allman, D.6
  • 78
    • 84910115884 scopus 로고    scopus 로고
    • Lasting antibody responses are mediated by a combination of newly formed and established bone marrow plasma cells drawn from clonally distinct precursors
    • Chernova I, et al. Lasting antibody responses are mediated by a combination of newly formed and established bone marrow plasma cells drawn from clonally distinct precursors. J Immunol 2014;193:4971-4979.
    • (2014) J Immunol , vol.193 , pp. 4971-4979
    • Chernova, I.1
  • 79
    • 84937714861 scopus 로고    scopus 로고
    • Long-lived plasma cells are contained within the CD19(-)CD38(hi)CD138(+) subset in human bone marrow
    • Halliley JL, et al. Long-lived plasma cells are contained within the CD19(-)CD38(hi)CD138(+) subset in human bone marrow. Immunity 2015;43:132-145.
    • (2015) Immunity , vol.43 , pp. 132-145
    • Halliley, J.L.1
  • 80
    • 84855796468 scopus 로고    scopus 로고
    • + plasma cell phenotype in the gut
    • + plasma cell phenotype in the gut. Nature 2012;481:199-203.
    • (2012) Nature , vol.481 , pp. 199-203
    • Fritz, J.H.1
  • 81
    • 0347285357 scopus 로고    scopus 로고
    • BCMA is essential for the survival of long-lived bone marrow plasma cells
    • O'Connor BP, et al. BCMA is essential for the survival of long-lived bone marrow plasma cells. J Exp Med 2004;199:91-98.
    • (2004) J Exp Med , vol.199 , pp. 91-98
    • O'Connor, B.P.1
  • 82
    • 85027921645 scopus 로고    scopus 로고
    • Mcl-1 is essential for the survival of plasma cells
    • Peperzak V, et al. Mcl-1 is essential for the survival of plasma cells. Nat Immunol 2013;14:290-297.
    • (2013) Nat Immunol , vol.14 , pp. 290-297
    • Peperzak, V.1
  • 83
    • 33749018225 scopus 로고    scopus 로고
    • Competence and competition: the challenge of becoming a long-lived plasma cell
    • Radbruch A, et al. Competence and competition: the challenge of becoming a long-lived plasma cell. Nat Rev Immunol 2006;6:741-750.
    • (2006) Nat Rev Immunol , vol.6 , pp. 741-750
    • Radbruch, A.1
  • 84
    • 84855512128 scopus 로고    scopus 로고
    • Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutants
    • Purtha WE, Tedder TF, Johnson S, Bhattacharya D, Diamond MS. Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutants. J Exp Med 2011;208:2599-2606.
    • (2011) J Exp Med , vol.208 , pp. 2599-2606
    • Purtha, W.E.1    Tedder, T.F.2    Johnson, S.3    Bhattacharya, D.4    Diamond, M.S.5
  • 85
    • 70449722777 scopus 로고    scopus 로고
    • Multiple layers of B cell memory with different effector functions
    • Dogan I, et al. Multiple layers of B cell memory with different effector functions. Nat Immunol 2009;10:1292-1299.
    • (2009) Nat Immunol , vol.10 , pp. 1292-1299
    • Dogan, I.1
  • 86
    • 79952282195 scopus 로고    scopus 로고
    • Different B cell populations mediate early and late memory during an endogenous immune response
    • Pape KA, Taylor JJ, Maul RW, Gearhart PJ, Jenkins MK. Different B cell populations mediate early and late memory during an endogenous immune response. Science 2011;331:1203-1207.
    • (2011) Science , vol.331 , pp. 1203-1207
    • Pape, K.A.1    Taylor, J.J.2    Maul, R.W.3    Gearhart, P.J.4    Jenkins, M.K.5
  • 87
    • 84903646784 scopus 로고    scopus 로고
    • CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype
    • Zuccarino-Catania GV, et al. CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype. Nat Immunol 2014;15:631-637.
    • (2014) Nat Immunol , vol.15 , pp. 631-637
    • Zuccarino-Catania, G.V.1
  • 88
    • 55749115444 scopus 로고    scopus 로고
    • BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact
    • Scholz JL, et al. BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact. Proc Natl Acad Sci USA 2008;105:15517-15522.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 15517-15522
    • Scholz, J.L.1
  • 89
    • 0034609775 scopus 로고    scopus 로고
    • Memory B-cell persistence is independent of persisting immunizing antigen
    • Maruyama M, Lam KP, Rajewsky K. Memory B-cell persistence is independent of persisting immunizing antigen. Nature 2000;407:636-642.
    • (2000) Nature , vol.407 , pp. 636-642
    • Maruyama, M.1    Lam, K.P.2    Rajewsky, K.3
  • 90
    • 0025370195 scopus 로고
    • Persistence of memory B cells in mice deprived of T cell help
    • Vieira P, Rajewsky K. Persistence of memory B cells in mice deprived of T cell help. Int Immunol 1990;2:487-494.
    • (1990) Int Immunol , vol.2 , pp. 487-494
    • Vieira, P.1    Rajewsky, K.2
  • 91
    • 0042931219 scopus 로고    scopus 로고
    • The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors
    • Miller JP, Allman D. The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors. J Immunol 2003;171:2326-2330.
    • (2003) J Immunol , vol.171 , pp. 2326-2330
    • Miller, J.P.1    Allman, D.2
  • 92
    • 34548030239 scopus 로고    scopus 로고
    • Multiple prethymic defects underlie age-related loss of T progenitor competence
    • Zediak VP, Maillard I, Bhandoola A. Multiple prethymic defects underlie age-related loss of T progenitor competence. Blood 2007;110:1161-1167.
    • (2007) Blood , vol.110 , pp. 1161-1167
    • Zediak, V.P.1    Maillard, I.2    Bhandoola, A.3
  • 93
    • 0025762004 scopus 로고
    • B cell precursors are decreased in senescent BALB/c mice, but retain normal mitotic activity in vivo and in vitro
    • Riley RL, Kruger MG, Elia J. B cell precursors are decreased in senescent BALB/c mice, but retain normal mitotic activity in vivo and in vitro. Clin Immunol Immunopathol 1991;59:301-313.
    • (1991) Clin Immunol Immunopathol , vol.59 , pp. 301-313
    • Riley, R.L.1    Kruger, M.G.2    Elia, J.3
  • 94
    • 0029966724 scopus 로고    scopus 로고
    • Stage-specific alterations in murine B lymphopoiesis with age
    • Stephan RP, Sanders VM, Witte PL. Stage-specific alterations in murine B lymphopoiesis with age. Int Immunol 1996;8:509-518.
    • (1996) Int Immunol , vol.8 , pp. 509-518
    • Stephan, R.P.1    Sanders, V.M.2    Witte, P.L.3
  • 95
    • 0017167094 scopus 로고
    • Immunological studies of aging. II. Loss of IgG and high avidity plaque-forming cells and increased suppressor cell activity in aging mice
    • Goidl EA, Innes JB, Weksler ME. Immunological studies of aging. II. Loss of IgG and high avidity plaque-forming cells and increased suppressor cell activity in aging mice. J Exp Med 1976;144:1037-1048.
    • (1976) J Exp Med , vol.144 , pp. 1037-1048
    • Goidl, E.A.1    Innes, J.B.2    Weksler, M.E.3
  • 96
    • 0020614457 scopus 로고
    • Antigen responsiveness of the mature and generative B cell populations of aged mice
    • Zharhary D, Klinman NR. Antigen responsiveness of the mature and generative B cell populations of aged mice. J Exp Med 1983;157:1300-1308.
    • (1983) J Exp Med , vol.157 , pp. 1300-1308
    • Zharhary, D.1    Klinman, N.R.2
  • 97
    • 0021244845 scopus 로고
    • T-cell cytotoxicity and aging: differing causes of reduced response in individual mice
    • Zharhary D, Segev Y, Gershon HE. T-cell cytotoxicity and aging: differing causes of reduced response in individual mice. Mech Ageing Dev 1984;25:129-140.
    • (1984) Mech Ageing Dev , vol.25 , pp. 129-140
    • Zharhary, D.1    Segev, Y.2    Gershon, H.E.3
  • 98
    • 0022444347 scopus 로고
    • T cell involvement in the decrease of antigen-responsive B cells in aged mice
    • Zharhary D. T cell involvement in the decrease of antigen-responsive B cells in aged mice. Eur J Immunol 1986;16:1175-1178.
    • (1986) Eur J Immunol , vol.16 , pp. 1175-1178
    • Zharhary, D.1
  • 99
    • 0026059308 scopus 로고
    • Repertoire diversity of antibody response to bacterial antigens in aged mice. II. Phosphorylcholine-antibody in young and aged mice differ in both VH/VL gene repertoire and in specificity
    • Nicoletti C, Borghesi-Nicoletti C, Yang XH, Schulze DH, Cerny J. Repertoire diversity of antibody response to bacterial antigens in aged mice. II. Phosphorylcholine-antibody in young and aged mice differ in both VH/VL gene repertoire and in specificity. J Immunol 1991;147:2750-2755.
    • (1991) J Immunol , vol.147 , pp. 2750-2755
    • Nicoletti, C.1    Borghesi-Nicoletti, C.2    Yang, X.H.3    Schulze, D.H.4    Cerny, J.5
  • 100
    • 0027252520 scopus 로고
    • Repertoire diversity of antibody response to bacterial antigens in aged mice. III. Phosphorylcholine antibody from young and aged mice differ in structure and protective activity against infection with Streptococcus pneumoniae
    • Nicoletti C, Yang X, Cerny J. Repertoire diversity of antibody response to bacterial antigens in aged mice. III. Phosphorylcholine antibody from young and aged mice differ in structure and protective activity against infection with Streptococcus pneumoniae. J Immunol 1993;150:543-549.
    • (1993) J Immunol , vol.150 , pp. 543-549
    • Nicoletti, C.1    Yang, X.2    Cerny, J.3
  • 101
    • 0033962638 scopus 로고    scopus 로고
    • Changes in the B-cell repertoire with age
    • Weksler ME. Changes in the B-cell repertoire with age. Vaccine 2000;18:1624-1628.
    • (2000) Vaccine , vol.18 , pp. 1624-1628
    • Weksler, M.E.1
  • 103
    • 0037094083 scopus 로고    scopus 로고
    • Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire
    • Johnson SA, Rozzo SJ, Cambier JC. Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire. J Immunol 2002;168:5014-5023.
    • (2002) J Immunol , vol.168 , pp. 5014-5023
    • Johnson, S.A.1    Rozzo, S.J.2    Cambier, J.C.3
  • 104
    • 0037310619 scopus 로고    scopus 로고
    • Enhanced differentiation of splenic plasma cells but diminished long-lived high-affinity bone marrow plasma cells in aged mice
    • Han S, et al. Enhanced differentiation of splenic plasma cells but diminished long-lived high-affinity bone marrow plasma cells in aged mice. J Immunol 2003;170:1267-1273.
    • (2003) J Immunol , vol.170 , pp. 1267-1273
    • Han, S.1
  • 105
    • 0344304396 scopus 로고    scopus 로고
    • CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly
    • Haynes L, Eaton SM, Burns EM, Randall TD, Swain SL. CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly. Proc Natl Acad Sci USA 2003;100:15053-15058.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15053-15058
    • Haynes, L.1    Eaton, S.M.2    Burns, E.M.3    Randall, T.D.4    Swain, S.L.5
  • 106
    • 23044456776 scopus 로고    scopus 로고
    • Humoral immune response and B-cell functions including immunoglobulin class switch are downregulated in aged mice and humans
    • Frasca D, Riley RL, Blomberg BB. Humoral immune response and B-cell functions including immunoglobulin class switch are downregulated in aged mice and humans. Semin Immunol 2005;17:378-384.
    • (2005) Semin Immunol , vol.17 , pp. 378-384
    • Frasca, D.1    Riley, R.L.2    Blomberg, B.B.3
  • 107
    • 34547132777 scopus 로고    scopus 로고
    • Immunosenescence: deficits in adaptive immunity in the elderly
    • Hakim FT, Gress RE. Immunosenescence: deficits in adaptive immunity in the elderly. Tissue Antigens 2007;70:179-189.
    • (2007) Tissue Antigens , vol.70 , pp. 179-189
    • Hakim, F.T.1    Gress, R.E.2
  • 109
    • 73549112692 scopus 로고    scopus 로고
    • Immunosenescence and vaccination of the elderly. I. Age-related immune impairment
    • Ongradi J, Stercz B, Kovesdi V, Vertes L. Immunosenescence and vaccination of the elderly. I. Age-related immune impairment. Acta Microbiol Immunol Hung 2009;56:199-210.
    • (2009) Acta Microbiol Immunol Hung , vol.56 , pp. 199-210
    • Ongradi, J.1    Stercz, B.2    Kovesdi, V.3    Vertes, L.4
  • 110
  • 111
    • 0014404849 scopus 로고
    • Reciprocal change with age in antibody to extrinsic and intrinsic antigens
    • Rowley MJ, Buchanan H, Mackay IR. Reciprocal change with age in antibody to extrinsic and intrinsic antigens. Lancet 1968;2:24-26.
    • (1968) Lancet , vol.2 , pp. 24-26
    • Rowley, M.J.1    Buchanan, H.2    Mackay, I.R.3
  • 112
    • 0028243373 scopus 로고
    • Increase of cross(auto)-reactive antibodies after immunization in aged mice: a cellular and molecular study
    • Borghesi C, Nicoletti C. Increase of cross(auto)-reactive antibodies after immunization in aged mice: a cellular and molecular study. Int J Exp Pathol 1994;75:123-130.
    • (1994) Int J Exp Pathol , vol.75 , pp. 123-130
    • Borghesi, C.1    Nicoletti, C.2
  • 114
    • 0034051359 scopus 로고    scopus 로고
    • Alterations in splenic architecture and the localization of anti-double-stranded DNA B cells in aged mice
    • Eaton-Bassiri AS, Mandik-Nayak L, Seo SJ, Madaio MP, Cancro MP, Erikson J. Alterations in splenic architecture and the localization of anti-double-stranded DNA B cells in aged mice. Int Immunol 2000;12:915-926.
    • (2000) Int Immunol , vol.12 , pp. 915-926
    • Eaton-Bassiri, A.S.1    Mandik-Nayak, L.2    Seo, S.J.3    Madaio, M.P.4    Cancro, M.P.5    Erikson, J.6
  • 115
    • 0033975581 scopus 로고    scopus 로고
    • Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space
    • Franceschi C, Bonafe M, Valensin S. Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine 2000;18:1717-1720.
    • (2000) Vaccine , vol.18 , pp. 1717-1720
    • Franceschi, C.1    Bonafe, M.2    Valensin, S.3
  • 116
    • 12144278834 scopus 로고    scopus 로고
    • Impaired hematopoietic stem cell functioning after serial transplantation and during normal aging
    • Kamminga LM, et al. Impaired hematopoietic stem cell functioning after serial transplantation and during normal aging. Stem Cells 2005;23:82-92.
    • (2005) Stem Cells , vol.23 , pp. 82-92
    • Kamminga, L.M.1
  • 117
    • 4444320808 scopus 로고    scopus 로고
    • Ageing, autoimmunity and arthritis: senescence of the B cell compartment - implications for humoral immunity
    • Johnson SA, Cambier JC. Ageing, autoimmunity and arthritis: senescence of the B cell compartment - implications for humoral immunity. Arthritis Res Ther 2004;6:131-139.
    • (2004) Arthritis Res Ther , vol.6 , pp. 131-139
    • Johnson, S.A.1    Cambier, J.C.2
  • 120
    • 37449004696 scopus 로고    scopus 로고
    • Hematopoietic stem cell aging and self-renewal
    • Dykstra B, de Haan G. Hematopoietic stem cell aging and self-renewal. Cell Tissue Res 2008;331:91-101.
    • (2008) Cell Tissue Res , vol.331 , pp. 91-101
    • Dykstra, B.1    de Haan, G.2
  • 121
    • 49649117750 scopus 로고    scopus 로고
    • Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation
    • Lages CS, et al. Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J Immunol 2008;181:1835-1848.
    • (2008) J Immunol , vol.181 , pp. 1835-1848
    • Lages, C.S.1
  • 122
    • 60549106099 scopus 로고    scopus 로고
    • Clonal expansions and loss of receptor diversity in the naive CD8 T cell repertoire of aged mice
    • Ahmed M, Lanzer KG, Yager EJ, Adams PS, Johnson LL, Blackman MA. Clonal expansions and loss of receptor diversity in the naive CD8 T cell repertoire of aged mice. J Immunol 2009;182:784-792.
    • (2009) J Immunol , vol.182 , pp. 784-792
    • Ahmed, M.1    Lanzer, K.G.2    Yager, E.J.3    Adams, P.S.4    Johnson, L.L.5    Blackman, M.A.6
  • 123
    • 70849110194 scopus 로고    scopus 로고
    • Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects
    • Tsukamoto H, et al. Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects. Proc Natl Acad Sci USA 2009;106:18333-18338.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 18333-18338
    • Tsukamoto, H.1
  • 124
    • 68149168943 scopus 로고    scopus 로고
    • Effects of aging on hematopoietic stem and progenitor cells
    • Waterstrat A, Van Zant G. Effects of aging on hematopoietic stem and progenitor cells. Curr Opin Immunol 2009;21:408-413.
    • (2009) Curr Opin Immunol , vol.21 , pp. 408-413
    • Waterstrat, A.1    Van Zant, G.2
  • 125
  • 126
    • 0026090133 scopus 로고
    • The repertoire diversity and magnitude of antibody responses to bacterial antigens in aged mice: I. Age-associated changes in antibody responses differ according to the mouse strain
    • Nicoletti C, Cerny J. The repertoire diversity and magnitude of antibody responses to bacterial antigens in aged mice: I. Age-associated changes in antibody responses differ according to the mouse strain. Cell Immunol 1991;133:72-83.
    • (1991) Cell Immunol , vol.133 , pp. 72-83
    • Nicoletti, C.1    Cerny, J.2
  • 127
    • 0031568406 scopus 로고    scopus 로고
    • Development of B cells in aged mice: decline in the ability of pro-B cells to respond to IL-7 but not to other growth factors
    • Stephan RP, Lill-Elghanian DA, Witte PL. Development of B cells in aged mice: decline in the ability of pro-B cells to respond to IL-7 but not to other growth factors. J Immunol 1997;158:1598-1609.
    • (1997) J Immunol , vol.158 , pp. 1598-1609
    • Stephan, R.P.1    Lill-Elghanian, D.A.2    Witte, P.L.3
  • 128
    • 0031985281 scopus 로고    scopus 로고
    • Impaired ability of bone marrow stromal cells to support B-lymphopoiesis with age
    • Stephan RP, Reilly CR, Witte PL. Impaired ability of bone marrow stromal cells to support B-lymphopoiesis with age. Blood 1998;91:75-88.
    • (1998) Blood , vol.91 , pp. 75-88
    • Stephan, R.P.1    Reilly, C.R.2    Witte, P.L.3
  • 129
    • 0033559509 scopus 로고    scopus 로고
    • B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation
    • Kline GH, Hayden TA, Klinman NR. B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation. J Immunol 1999;162:3342-3349.
    • (1999) J Immunol , vol.162 , pp. 3342-3349
    • Kline, G.H.1    Hayden, T.A.2    Klinman, N.R.3
  • 130
    • 0037438596 scopus 로고    scopus 로고
    • Decreased E12 and/or E47 transcription factor activity in the bone marrow as well as in the spleen of aged mice
    • Frasca D, Nguyen D, Riley RL, Blomberg BB. Decreased E12 and/or E47 transcription factor activity in the bone marrow as well as in the spleen of aged mice. J Immunol 2003;170:719-726.
    • (2003) J Immunol , vol.170 , pp. 719-726
    • Frasca, D.1    Nguyen, D.2    Riley, R.L.3    Blomberg, B.B.4
  • 131
    • 19944430840 scopus 로고    scopus 로고
    • Effect of age on the immunoglobulin class switch
    • Frasca D, Riley RL, Blomberg BB. Effect of age on the immunoglobulin class switch. Crit Rev Immunol 2004;24:297-320.
    • (2004) Crit Rev Immunol , vol.24 , pp. 297-320
    • Frasca, D.1    Riley, R.L.2    Blomberg, B.B.3
  • 132
    • 0842321787 scopus 로고    scopus 로고
    • Reduced Ig class switch in aged mice correlates with decreased E47 and activation-induced cytidine deaminase
    • Frasca D, Van der Put E, Riley RL, Blomberg BB. Reduced Ig class switch in aged mice correlates with decreased E47 and activation-induced cytidine deaminase. J Immunol 2004;172:2155-2162.
    • (2004) J Immunol , vol.172 , pp. 2155-2162
    • Frasca, D.1    Van der Put, E.2    Riley, R.L.3    Blomberg, B.B.4
  • 133
    • 34548754592 scopus 로고    scopus 로고
    • Tristetraprolin, a negative regulator of mRNA stability, is increased in old B cells and is involved in the degradation of E47 mRNA
    • Frasca D, Landin AM, Alvarez JP, Blackshear PJ, Riley RL, Blomberg BB. Tristetraprolin, a negative regulator of mRNA stability, is increased in old B cells and is involved in the degradation of E47 mRNA. J Immunol 2007;179:918-927.
    • (2007) J Immunol , vol.179 , pp. 918-927
    • Frasca, D.1    Landin, A.M.2    Alvarez, J.P.3    Blackshear, P.J.4    Riley, R.L.5    Blomberg, B.B.6
  • 134
    • 45949103917 scopus 로고    scopus 로고
    • Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells
    • Frasca D, et al. Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells. J Immunol 2008;180:5283-5290.
    • (2008) J Immunol , vol.180 , pp. 5283-5290
    • Frasca, D.1
  • 135
    • 84878945504 scopus 로고    scopus 로고
    • In senescence, age-associated B cells secrete TNFalpha and inhibit survival of B-cell precursors
    • Ratliff M, Alter S, Frasca D, Blomberg BB, Riley RL. In senescence, age-associated B cells secrete TNFalpha and inhibit survival of B-cell precursors. Aging Cell 2013;12:303-311.
    • (2013) Aging Cell , vol.12 , pp. 303-311
    • Ratliff, M.1    Alter, S.2    Frasca, D.3    Blomberg, B.B.4    Riley, R.L.5
  • 136
  • 137
    • 79953225865 scopus 로고    scopus 로고
    • Alterations in marginal zone macrophages and marginal zone B cells in old mice
    • Birjandi SZ, Ippolito JA, Ramadorai AK, Witte PL. Alterations in marginal zone macrophages and marginal zone B cells in old mice. J Immunol 2011;186:3441-3451.
    • (2011) J Immunol , vol.186 , pp. 3441-3451
    • Birjandi, S.Z.1    Ippolito, J.A.2    Ramadorai, A.K.3    Witte, P.L.4
  • 138
    • 44849097480 scopus 로고    scopus 로고
    • Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL
    • Benson MJ, et al. Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL. J Immunol 2008;180:3655-3659.
    • (2008) J Immunol , vol.180 , pp. 3655-3659
    • Benson, M.J.1
  • 139
    • 78650647005 scopus 로고    scopus 로고
    • Cutting edge: hierarchy of maturity of murine memory B cell subsets
    • Tomayko MM, Steinel NC, Anderson SM, Shlomchik MJ. Cutting edge: hierarchy of maturity of murine memory B cell subsets. J Immunol 2010;185:7146-7150.
    • (2010) J Immunol , vol.185 , pp. 7146-7150
    • Tomayko, M.M.1    Steinel, N.C.2    Anderson, S.M.3    Shlomchik, M.J.4
  • 140
    • 84882759383 scopus 로고    scopus 로고
    • T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance
    • Rubtsova K, Rubtsov AV, van Dyk LF, Kappler JW, Marrack P. T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance. Proc Natl Acad Sci USA 2013;110:E3216-E3224.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. E3216-E3224
    • Rubtsova, K.1    Rubtsov, A.V.2    van Dyk, L.F.3    Kappler, J.W.4    Marrack, P.5
  • 141
    • 84875076234 scopus 로고    scopus 로고
    • Homeostatic regulation of aging and rejuvenation in the B lineage cells
    • Melamed D. Homeostatic regulation of aging and rejuvenation in the B lineage cells. Crit Rev Immunol 2013;33:41-56.
    • (2013) Crit Rev Immunol , vol.33 , pp. 41-56
    • Melamed, D.1
  • 142
    • 84869798045 scopus 로고    scopus 로고
    • Aging and neoteny in the B lineage
    • Melamed D, Scott DW. Aging and neoteny in the B lineage. Blood 2012;120:4143-4149.
    • (2012) Blood , vol.120 , pp. 4143-4149
    • Melamed, D.1    Scott, D.W.2
  • 144
    • 79953097625 scopus 로고    scopus 로고
    • B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging
    • Keren Z, et al. B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging. Blood 2011;117:3104-3112.
    • (2011) Blood , vol.117 , pp. 3104-3112
    • Keren, Z.1
  • 145
    • 80052687220 scopus 로고    scopus 로고
    • Chronic B cell deficiency from birth prevents age-related alterations in the B lineage
    • Keren Z, et al. Chronic B cell deficiency from birth prevents age-related alterations in the B lineage. J Immunol 2011;187:2140-2147.
    • (2011) J Immunol , vol.187 , pp. 2140-2147
    • Keren, Z.1
  • 146
    • 80051618656 scopus 로고    scopus 로고
    • Cutting edge: dendritic cell-restricted antigen presentation initiates the follicular helper T cell program but cannot complete ultimate effector differentiation
    • Goenka R, et al. Cutting edge: dendritic cell-restricted antigen presentation initiates the follicular helper T cell program but cannot complete ultimate effector differentiation. J Immunol 2011;187:1091-1095.
    • (2011) J Immunol , vol.187 , pp. 1091-1095
    • Goenka, R.1
  • 147
    • 79959342619 scopus 로고    scopus 로고
    • Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone
    • Kerfoot SM, et al. Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone. Immunity 2011;34:947-960.
    • (2011) Immunity , vol.34 , pp. 947-960
    • Kerfoot, S.M.1
  • 148
    • 79959328032 scopus 로고    scopus 로고
    • ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6
    • Choi YS, et al. ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity 2011;34:932-946.
    • (2011) Immunity , vol.34 , pp. 932-946
    • Choi, Y.S.1
  • 149
    • 84898790799 scopus 로고    scopus 로고
    • Memory B cells form in aged mice despite impaired affinity maturation and germinal center kinetics
    • Goenka R, Scholz JL, Naradikian MS, Cancro MP. Memory B cells form in aged mice despite impaired affinity maturation and germinal center kinetics. Exp Gerontol 2014;54:109-115.
    • (2014) Exp Gerontol , vol.54 , pp. 109-115
    • Goenka, R.1    Scholz, J.L.2    Naradikian, M.S.3    Cancro, M.P.4
  • 150
    • 0014340541 scopus 로고
    • Anti-nuclear antibodies in mice. I. Influence of age and possible genetic factors on spontaneous and induced responses
    • Teague PO, Friou GJ, Myers LL. Anti-nuclear antibodies in mice. I. Influence of age and possible genetic factors on spontaneous and induced responses. J Immunol 1968;101:791-798.
    • (1968) J Immunol , vol.101 , pp. 791-798
    • Teague, P.O.1    Friou, G.J.2    Myers, L.L.3
  • 151
    • 0015821513 scopus 로고
    • Lymphocyte phytohemagglutinin responsiveness, immunoglobulins and autoantibodies in aging humans
    • Hallgren HM, Buckley CE 3rd, Gilbertsen VA, Yunis EJ. Lymphocyte phytohemagglutinin responsiveness, immunoglobulins and autoantibodies in aging humans. J Immunol 1973;111:1101-1107.
    • (1973) J Immunol , vol.111 , pp. 1101-1107
    • Hallgren, H.M.1    Buckley 3rd, C.E.2    Gilbertsen, V.A.3    Yunis, E.J.4
  • 153
    • 84886790466 scopus 로고    scopus 로고
    • T-bet: a bridge between innate and adaptive immunity
    • Lazarevic V, Glimcher LH, Lord GM. T-bet: a bridge between innate and adaptive immunity. Nat Rev Immunol 2013;13:777-789.
    • (2013) Nat Rev Immunol , vol.13 , pp. 777-789
    • Lazarevic, V.1    Glimcher, L.H.2    Lord, G.M.3
  • 154
    • 0041522519 scopus 로고    scopus 로고
    • T-bet regulates T-independent IgG2a class switching
    • Gerth AJ, Lin L, Peng SL. T-bet regulates T-independent IgG2a class switching. Int Immunol 2003;15:937-944.
    • (2003) Int Immunol , vol.15 , pp. 937-944
    • Gerth, A.J.1    Lin, L.2    Peng, S.L.3
  • 155
    • 0038639600 scopus 로고    scopus 로고
    • CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells
    • Liu N, Ohnishi N, Ni L, Akira S, Bacon KB. CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells. Nat Immunol 2003;4:687-693.
    • (2003) Nat Immunol , vol.4 , pp. 687-693
    • Liu, N.1    Ohnishi, N.2    Ni, L.3    Akira, S.4    Bacon, K.B.5
  • 157
    • 0036133221 scopus 로고    scopus 로고
    • Increased efficacy of the immunoglobulin G2a subclass in antibody-mediated protection against lactate dehydrogenase-elevating virus-induced polioencephalomyelitis revealed with switch mutants
    • Markine-Goriaynoff D, Coutelier JP. Increased efficacy of the immunoglobulin G2a subclass in antibody-mediated protection against lactate dehydrogenase-elevating virus-induced polioencephalomyelitis revealed with switch mutants. J Virol 2002;76:432-435.
    • (2002) J Virol , vol.76 , pp. 432-435
    • Markine-Goriaynoff, D.1    Coutelier, J.P.2
  • 158
    • 0037117557 scopus 로고    scopus 로고
    • T-bet regulates IgG class switching and pathogenic autoantibody production
    • Peng SL, Szabo SJ, Glimcher LH. T-bet regulates IgG class switching and pathogenic autoantibody production. Proc Natl Acad Sci USA 2002;99:5545-5550.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 5545-5550
    • Peng, S.L.1    Szabo, S.J.2    Glimcher, L.H.3
  • 159
    • 28244472817 scopus 로고    scopus 로고
    • Stat1-dependent synergistic activation of T-bet for IgG2a production during early stage of B cell activation
    • Xu W, Zhang JJ. Stat1-dependent synergistic activation of T-bet for IgG2a production during early stage of B cell activation. J Immunol 2005;175:7419-7424.
    • (2005) J Immunol , vol.175 , pp. 7419-7424
    • Xu, W.1    Zhang, J.J.2
  • 160
    • 2942755979 scopus 로고    scopus 로고
    • T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells
    • Chtanova T, et al. T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J Immunol 2004;173:68-78.
    • (2004) J Immunol , vol.173 , pp. 68-78
    • Chtanova, T.1
  • 161
    • 84859897308 scopus 로고    scopus 로고
    • The development and fate of follicular helper T cells defined by an IL-21 reporter mouse
    • Luthje K, et al. The development and fate of follicular helper T cells defined by an IL-21 reporter mouse. Nat Immunol 2012;13:491-498.
    • (2012) Nat Immunol , vol.13 , pp. 491-498
    • Luthje, K.1
  • 162
    • 65549114338 scopus 로고    scopus 로고
    • + T cells in reactive lymph nodes during helminth infection are T follicular helper cells
    • + T cells in reactive lymph nodes during helminth infection are T follicular helper cells. J Exp Med 2009;206:1001-1007.
    • (2009) J Exp Med , vol.206 , pp. 1001-1007
    • King, I.L.1    Mohrs, M.2
  • 163
    • 62849090439 scopus 로고    scopus 로고
    • Cytokine-secreting follicular T cells shape the antibody repertoire
    • Reinhardt RL, Liang HE, Locksley RM. Cytokine-secreting follicular T cells shape the antibody repertoire. Nat Immunol 2009;10:385-393.
    • (2009) Nat Immunol , vol.10 , pp. 385-393
    • Reinhardt, R.L.1    Liang, H.E.2    Locksley, R.M.3
  • 164
    • 77149142640 scopus 로고    scopus 로고
    • IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
    • Zotos D, et al. IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med 2010;207:365-378.
    • (2010) J Exp Med , vol.207 , pp. 365-378
    • Zotos, D.1
  • 165
    • 77149122105 scopus 로고    scopus 로고
    • IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
    • Linterman MA, et al. IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J Exp Med 2010;207:353-363.
    • (2010) J Exp Med , vol.207 , pp. 353-363
    • Linterman, M.A.1
  • 166
    • 46049112339 scopus 로고    scopus 로고
    • Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals
    • Moir S, et al. Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals. J Exp Med 2008;205:1797-1805.
    • (2008) J Exp Med , vol.205 , pp. 1797-1805
    • Moir, S.1
  • 167
    • 69449083224 scopus 로고    scopus 로고
    • Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells
    • Rakhmanov M, et al. Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells. Proc Natl Acad Sci USA 2009;106:13451-13456.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 13451-13456
    • Rakhmanov, M.1
  • 168
    • 84875752691 scopus 로고    scopus 로고
    • Expansion of autoreactive unresponsive CD21-/low B cells in Sjogren's syndrome-associated lymphoproliferation
    • Saadoun D, et al. Expansion of autoreactive unresponsive CD21-/low B cells in Sjogren's syndrome-associated lymphoproliferation. Arthritis Rheum 2013;65:1085-1096.
    • (2013) Arthritis Rheum , vol.65 , pp. 1085-1096
    • Saadoun, D.1
  • 169
    • 84921779190 scopus 로고    scopus 로고
    • Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency
    • Stepensky P, et al. Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency. Blood 2015;125:753-761.
    • (2015) Blood , vol.125 , pp. 753-761
    • Stepensky, P.1
  • 171
    • 33748472865 scopus 로고    scopus 로고
    • Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus
    • Christensen SR, Shupe J, Nickerson K, Kashgarian M, Flavell RA, Shlomchik MJ. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 2006;25:417-428.
    • (2006) Immunity , vol.25 , pp. 417-428
    • Christensen, S.R.1    Shupe, J.2    Nickerson, K.3    Kashgarian, M.4    Flavell, R.A.5    Shlomchik, M.J.6
  • 174
    • 77949903821 scopus 로고    scopus 로고
    • TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus
    • Nickerson KM, et al. TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus. J Immunol 2010;184:1840-1848.
    • (2010) J Immunol , vol.184 , pp. 1840-1848
    • Nickerson, K.M.1
  • 175
    • 33645076274 scopus 로고    scopus 로고
    • TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE
    • Ehlers M, Fukuyama H, McGaha TL, Aderem A, Ravetch JV. TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. J Exp Med 2006;203:553-561.
    • (2006) J Exp Med , vol.203 , pp. 553-561
    • Ehlers, M.1    Fukuyama, H.2    McGaha, T.L.3    Aderem, A.4    Ravetch, J.V.5
  • 176
    • 84875986912 scopus 로고    scopus 로고
    • Exacerbated autoimmunity in the absence of TLR9 in MRL.Fas(lpr) mice depends on Ifnar1
    • Nickerson KM, Cullen JL, Kashgarian M, Shlomchik MJ. Exacerbated autoimmunity in the absence of TLR9 in MRL.Fas(lpr) mice depends on Ifnar1. J Immunol 2013;190:3889-3894.
    • (2013) J Immunol , vol.190 , pp. 3889-3894
    • Nickerson, K.M.1    Cullen, J.L.2    Kashgarian, M.3    Shlomchik, M.J.4


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