메뉴 건너뛰기




Volumn 120, Issue 20, 2012, Pages 4143-4149

Aging and neoteny in the B lineage

Author keywords

[No Author keywords available]

Indexed keywords

AGING; B LYMPHOCYTE; CELL AGING; CELL MATURATION; CELL POPULATION; CELL SURVIVAL; GERIATRIC DISORDER; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC SYSTEM; HOMEOSTASIS; HUMAN; INFECTION; LYMPHOID CELL; LYMPHOPOIESIS; NEOTENY; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; TISSUE REGENERATION;

EID: 84869798045     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-07-444711     Document Type: Review
Times cited : (14)

References (100)
  • 1
    • 0026712810 scopus 로고
    • Changes in life expectancy 1900-1990
    • Kinsella KG. Changes in life expectancy 1900-1990. Am J Clin Nutr. 1992;55(6 Suppl):1196S-1202S.
    • (1992) Am J Clin Nutr , vol.55 , Issue.6 SUPPL.
    • Kinsella, K.G.1
  • 2
    • 13944262937 scopus 로고    scopus 로고
    • Understanding the odd science of aging
    • Thomas BL. Understanding the odd science of aging. Cell. 2005;120(4):437-447.
    • (2005) Cell , vol.120 , Issue.4 , pp. 437-447
    • Thomas, B.L.1
  • 3
    • 70350504881 scopus 로고    scopus 로고
    • Epidemiology and consequences of sarcopenia
    • Abellan van Kan G. Epidemiology and consequences of sarcopenia. J Nutr Health Aging. 2009;13(8):708-712.
    • (2009) J Nutr Health Aging , vol.13 , Issue.8 , pp. 708-712
    • Abellan Van Kan, G.1
  • 5
    • 77952312535 scopus 로고    scopus 로고
    • Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration
    • Jang YC, Lustgarten MS, Liu Y, et al. Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration. FASEB J. 2010;24(5):1376-1390.
    • (2010) FASEB J , vol.24 , Issue.5 , pp. 1376-1390
    • Jang, Y.C.1    Lustgarten, M.S.2    Liu, Y.3
  • 6
    • 70449519969 scopus 로고    scopus 로고
    • Contribution of hypoxia to Alzheimer's disease: Is HIF-1alpha a mediator of neurodegeneration?
    • Ogunshola OO, Antoniou X. Contribution of hypoxia to Alzheimer's disease: is HIF-1alpha a mediator of neurodegeneration? Cell Mol Life Sci. 2009;66(22):3555-3563.
    • (2009) Cell Mol Life Sci , vol.66 , Issue.22 , pp. 3555-3563
    • Ogunshola, O.O.1    Antoniou, X.2
  • 7
    • 79956365255 scopus 로고    scopus 로고
    • Morphological changes in nerve cells during normal aging
    • Pannese E. Morphological changes in nerve cells during normal aging. Brain Struct Funct. 2011;216(2):85-89.
    • (2011) Brain Struct Funct , vol.216 , Issue.2 , pp. 85-89
    • Pannese, E.1
  • 8
    • 79961076148 scopus 로고    scopus 로고
    • Consequences of sarcopenia
    • Visser M, Schaap LA. Consequences of sarcopenia. Clin Geriatr Med. 2011;27(3):387-399.
    • (2011) Clin Geriatr Med , vol.27 , Issue.3 , pp. 387-399
    • Visser, M.1    Schaap, L.A.2
  • 9
    • 48449090719 scopus 로고    scopus 로고
    • Functional and physiological characteristics of the aging skin
    • Farage MA, Miller KW, Elsner P, Maibach HI. Functional and physiological characteristics of the aging skin. Aging Clin Exp Res. 2008;20(3):195-200.
    • (2008) Aging Clin Exp Res , vol.20 , Issue.3 , pp. 195-200
    • Farage, M.A.1    Miller, K.W.2    Elsner, P.3    Maibach, H.I.4
  • 10
    • 0032526476 scopus 로고    scopus 로고
    • Age changes in stem cells of murine small intestinal crypts
    • DOI 10.1006/excr.1998.4001
    • Martin K, Kirkwood TBL, Potten CS. Age changes in stem cells of murine small intestinal crypts. Exp Cell Res. 1998;241(2):316-323. (Pubitemid 28366557)
    • (1998) Experimental Cell Research , vol.241 , Issue.2 , pp. 316-323
    • Martin, K.1    Kirkwood, T.B.L.2    Potten, C.S.3
  • 12
    • 84860343741 scopus 로고    scopus 로고
    • Stem cell heterogeneity: Implications for aging and regenerative medicine
    • Muller-Sieburg CE, Sieburg HB, Bernitz JM, Cattarossi G. Stem cell heterogeneity: implications for aging and regenerative medicine. Blood. 2012;119(17):3900-3907.
    • (2012) Blood , vol.119 , Issue.17 , pp. 3900-3907
    • Muller-Sieburg, C.E.1    Sieburg, H.B.2    Bernitz, J.M.3    Cattarossi, G.4
  • 13
    • 84862532139 scopus 로고    scopus 로고
    • Hematopoietic stem cell heterogeneity takes center stage
    • Copley MR, Beer PA, Eaves CJ. Hematopoietic stem cell heterogeneity takes center stage. Cell Stem Cell. 2012;10(6):690-697.
    • (2012) Cell Stem Cell , vol.10 , Issue.6 , pp. 690-697
    • Copley, M.R.1    Beer, P.A.2    Eaves, C.J.3
  • 14
    • 65349134226 scopus 로고    scopus 로고
    • Dendritic cell homeostasis
    • Merad M, Manz MG. Dendritic cell homeostasis. Blood. 2009;113(15):3418- 3427.
    • (2009) Blood , vol.113 , Issue.15 , pp. 3418-3427
    • Merad, M.1    Manz, M.G.2
  • 15
  • 16
    • 33750530369 scopus 로고    scopus 로고
    • Acute myeloid leukemia: Epidemiology and etiology
    • DOI 10.1002/cncr.22233
    • Deschler B, Lübbert M. Acute myeloid leukemia: epidemiology and etiology. Cancer. 2006;107(9):2099-2107. (Pubitemid 44665642)
    • (2006) Cancer , vol.107 , Issue.9 , pp. 2099-2107
    • Deschler, B.1    Lubbert, M.2
  • 17
    • 4944261763 scopus 로고    scopus 로고
    • Prevalence of anemia in persons 65 years and older in the United States: Evidence for a high rate of unexplained anemia
    • DOI 10.1182/blood-2004-05-1812
    • Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood. 2004;104(8):2263-2268. (Pubitemid 39331821)
    • (2004) Blood , vol.104 , Issue.8 , pp. 2263-2268
    • Guralnik, J.M.1    Eisenstaedt, R.S.2    Ferrucci, L.3    Klein, H.G.4    Woodman, R.C.5
  • 18
    • 77950418688 scopus 로고    scopus 로고
    • Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion
    • Beerman I, Bhattacharya D, Zandi S, et al. Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion. Proc Natl Acad Sci U S A. 2010;107(12):5465-5470.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.12 , pp. 5465-5470
    • Beerman, I.1    Bhattacharya, D.2    Zandi, S.3
  • 19
    • 47049099198 scopus 로고    scopus 로고
    • A new mechanism for the aging of hematopoietic stem cells: Aging changes the clonal composition of the stem cell compartment but not individual stem cells
    • Cho RH, Sieburg HB, Muller-Sieburg CE. A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells. Blood. 2008;111(12):5553-5561.
    • (2008) Blood , vol.111 , Issue.12 , pp. 5553-5561
    • Cho, R.H.1    Sieburg, H.B.2    Muller-Sieburg, C.E.3
  • 22
    • 84055200841 scopus 로고    scopus 로고
    • Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age
    • Pang WW, Price EA, Sahoo D, et al. Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age. Proc Natl Acad Sci U S A. 2011;108(50):20012-20017.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.50 , pp. 20012-20017
    • Pang, W.W.1    Price, E.A.2    Sahoo, D.3
  • 24
    • 33747789572 scopus 로고    scopus 로고
    • + T cell clonal expansions express elevated levels of CD122 and CD127 and display defects in perceiving homeostatic signals
    • Messaoudi I, Warner J, Nikolich-Zugich J. Age-related CD8+ T cell clonal expansions express elevated levels of CD122 and CD127 and display defects in perceiving homeostatic signals. J Immunol. 2006;177(5):2784-2792. (Pubitemid 44277793)
    • (2006) Journal of Immunology , vol.177 , Issue.5 , pp. 2784-2792
    • Messaoudi, I.1    Warner, J.2    Nikolich-Zugich, J.3
  • 25
    • 4444320808 scopus 로고    scopus 로고
    • Ageing, autoimmunity and arthritis: Senescence of the B cell compartment - Implications for humoral immunity
    • Johnson SA, Cambier JC. Ageing, autoimmunity and arthritis. Senescence of the B cell compartment: implications for humoral immunity. Arthritis Res Ther. 2004;6(4):131-139. (Pubitemid 39162373)
    • (2004) Arthritis Research and Therapy , vol.6 , Issue.4 , pp. 131-139
    • Johnson, S.A.1    Cambier, J.C.2
  • 26
    • 0037094083 scopus 로고    scopus 로고
    • Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire
    • Johnson SA, Rozzo SJ, Cambier JC. Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire. J Immunol. 2002;168(10):5014-5023. (Pubitemid 34495964)
    • (2002) Journal of Immunology , vol.168 , Issue.10 , pp. 5014-5023
    • Johnson, S.A.1    Rozzo, S.J.2    Cambier, J.C.3
  • 27
    • 0033559509 scopus 로고    scopus 로고
    • B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation
    • Kline GH, Hayden TA, Klinman NR. B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation. J Immunol. 1999;162(6):3342-3349. (Pubitemid 29313583)
    • (1999) Journal of Immunology , vol.162 , Issue.6 , pp. 3342-3349
    • Kline, G.H.1    Hayden, T.A.2    Klinman, N.R.3
  • 28
    • 77955720671 scopus 로고    scopus 로고
    • Tracing thymic output in older individuals
    • Mitchell WA, Lang PO, Aspinall R. Tracing thymic output in older individuals. Clin Exp Immunol. 2010;161(3):497-503.
    • (2010) Clin Exp Immunol , vol.161 , Issue.3 , pp. 497-503
    • Mitchell, W.A.1    Lang, P.O.2    Aspinall, R.3
  • 30
    • 38449108084 scopus 로고    scopus 로고
    • Deaths: Leading causes for 2003
    • Heron MP, Smith BL. Deaths: leading causes for 2003. Natl Vital Stat Rep. 2007;55(10):1-92.
    • (2007) Natl Vital Stat Rep , vol.55 , Issue.10 , pp. 1-92
    • Heron, M.P.1    Smith, B.L.2
  • 31
    • 32044453088 scopus 로고    scopus 로고
    • Antibody response to influenza vaccination in the elderly: A quantitative review
    • DOI 10.1016/j.vaccine.2005.08.105, PII S0264410X05009552
    • Goodwin K, Viboud C, Simonsen L. Antibody response to influenza vaccination in the elderly: a quantitative review. Vaccine. 2006;24(8):1159- 1169. (Pubitemid 43202262)
    • (2006) Vaccine , vol.24 , Issue.8 , pp. 1159-1169
    • Goodwin, K.1    Viboud, C.2    Simonsen, L.3
  • 33
    • 79955949208 scopus 로고    scopus 로고
    • Vaccine effectiveness in older individuals: What has been learned from the influenza-vaccine experience
    • Lang P-O, Govind S, Mitchell WA, Siegrist C-A, Aspinall R. Vaccine effectiveness in older individuals: what has been learned from the influenza-vaccine experience. Ageing Res Rev. 2011;10(3):389-395.
    • (2011) Ageing Res Rev , vol.10 , Issue.3 , pp. 389-395
    • Lang, P.-O.1    Govind, S.2    Mitchell, W.A.3    Siegrist, C.-A.4    Aspinall, R.5
  • 34
    • 0033486848 scopus 로고    scopus 로고
    • Immunoglobulin transgenes in B lymphocyte development, tolerance, and autoimmunity
    • Melamed D, Nemazee D. Immunoglobulin transgenes in B lymphocyte development, tolerance, and autoimmunity. Curr Dir Autoimmun. 1999;11-30.
    • (1999) Curr Dir Autoimmun , pp. 11-30
    • Melamed, D.1    Nemazee, D.2
  • 35
    • 0030006070 scopus 로고    scopus 로고
    • Clonal selection and learning in the antibody system
    • DOI 10.1038/381751a0
    • Rajewsky K. Clonal selection and learning in the antibody system. Nature. 1996;381:751-758. (Pubitemid 26243107)
    • (1996) Nature , vol.381 , Issue.6585 , pp. 751-758
    • Rajewsky, K.1
  • 36
    • 11144348754 scopus 로고    scopus 로고
    • Antigen receptor signaling competence and the determination of B cell fate in B-lymphopoiesis
    • Keren Z, Melamed D. Antigen receptor signaling competence and the determination of B cell fate in B-lymphopoiesis. Histol Histopathol. 2005;20(1):187-196. (Pubitemid 40028997)
    • (2005) Histology and Histopathology , vol.20 , Issue.1 , pp. 187-196
    • Keren, Z.1    Melamed, D.2
  • 37
    • 17044372889 scopus 로고    scopus 로고
    • CD19 regulates positive selection and maturation in B lymphopoiesis: Lack of CD19 imposes developmental arrest of immature B cells and consequential stimulation of receptor editing
    • Diamant E, Keren Z, Melamed D. CD19 regulates positive selection and maturation in B lymphopoiesis: lack of CD19 imposes developmental arrest of immature B cells and consequential stimulation of receptor editing. Blood. 2005;105(8):3247-3254.
    • (2005) Blood , vol.105 , Issue.8 , pp. 3247-3254
    • Diamant, E.1    Keren, Z.2    Melamed, D.3
  • 38
    • 4644229948 scopus 로고    scopus 로고
    • Receptor editing in positive and negative selection of B lymphopoiesis
    • Edry E, Melamed D. Receptor editing in positive and negative selection of B lymphopoiesis. J Immunol. 2004;173(7):4265-4271. (Pubitemid 39280653)
    • (2004) Journal of Immunology , vol.173 , Issue.7 , pp. 4265-4271
    • Edry, E.1    Melamed, D.2
  • 39
    • 1842640538 scopus 로고    scopus 로고
    • Modification of Ligand-independent B Cell Receptor Tonic Signals Activates Receptor Editing in Immature B Lymphocytes
    • DOI 10.1074/jbc.M311970200
    • Keren Z, Diamant E, Ostrovsky O, Bengal E, Melamed D. Modification of ligand-independent B cell receptor tonic signals activates receptor editing in immature B lymphocytes. J Biol Chem. 2004;279(14):13418-13424. (Pubitemid 38468865)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.14 , pp. 13418-13424
    • Keren, Z.1    Diamant, E.2    Ostrovsky, O.3    Bengal, E.4    Melamed, D.5
  • 40
    • 0032559223 scopus 로고    scopus 로고
    • Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection
    • DOI 10.1016/S0092-8674(00)80912-5
    • Melamed D, Benschop RJ, Cambier JC, Nemazee D. Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection. Cell. 1998;92(2):173-182. (Pubitemid 28073041)
    • (1998) Cell , vol.92 , Issue.2 , pp. 173-182
    • Melamed, D.1    Benschop, R.J.2    Cambier, J.C.3    Nemazee, D.4
  • 41
    • 34147122646 scopus 로고    scopus 로고
    • B cells and aging: Balancing the homeostatic equation
    • DOI 10.1016/j.exger.2007.01.010, PII S0531556507000277
    • Miller JP, Cancro MP. B cells and aging: balancing the homeostatic equation. Exp Gerontol. 2007;42(5):396-399. (Pubitemid 46562556)
    • (2007) Experimental Gerontology , vol.42 , Issue.5 SPEC. ISS. , pp. 396-399
    • Miller, J.P.1    Cancro, M.P.2
  • 42
    • 34250007142 scopus 로고    scopus 로고
    • Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
    • DOI 10.1038/nature05862, PII NATURE05862
    • Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature. 2007;447(7145):725-729. (Pubitemid 46889729)
    • (2007) Nature , vol.447 , Issue.7145 , pp. 725-729
    • Rossi, D.J.1    Bryder, D.2    Seita, J.3    Nussenzweig, A.4    Hoeijmakers, J.5    Weissman, I.L.6
  • 43
    • 79952338609 scopus 로고    scopus 로고
    • Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging
    • Rübe CE, Fricke A, Widmann TA, et al. Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging. PLoS One. 2011;6(3).
    • (2011) PLoS One , vol.6 , Issue.3
    • Rübe, C.E.1    Fricke, A.2    Widmann, T.A.3
  • 44
    • 66449086247 scopus 로고    scopus 로고
    • Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation
    • Inomata K, Aoto T, Binh NT, et al. Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation. Cell. 2009;137(6):1088-1099.
    • (2009) Cell , vol.137 , Issue.6 , pp. 1088-1099
    • Inomata, K.1    Aoto, T.2    Binh, N.T.3
  • 45
    • 77953512588 scopus 로고    scopus 로고
    • Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment
    • Morita Y, Ema H, Nakauchi H. Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment. J Exp Med. 2010;207(6):1173-1182.
    • (2010) J Exp Med , vol.207 , Issue.6 , pp. 1173-1182
    • Morita, Y.1    Ema, H.2    Nakauchi, H.3
  • 46
    • 77956685007 scopus 로고    scopus 로고
    • Reduced EBF expression underlies loss of B cell potential of hematopoietic progenitors with age
    • Lescale C, Dias S, Maes J, et al. Reduced EBF expression underlies loss of B cell potential of hematopoietic progenitors with age. Aging Cell. 2010;9(3):410-419.
    • (2010) Aging Cell , vol.9 , Issue.3 , pp. 410-419
    • Lescale, C.1    Dias, S.2    Maes, J.3
  • 47
    • 80052687220 scopus 로고    scopus 로고
    • Chronic B cell deficiency from birth prevents age-related alterations in the B lineage
    • Keren Z, Averbuch D, Shahaf G, et al. Chronic B cell deficiency from birth prevents age-related alterations in the B lineage. J Immunol. 2011;187(5):2140-2147.
    • (2011) J Immunol , vol.187 , Issue.5 , pp. 2140-2147
    • Keren, Z.1    Averbuch, D.2    Shahaf, G.3
  • 48
    • 79953097625 scopus 로고    scopus 로고
    • B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging
    • Keren Z, Naor S, Nussbaum S, et al. B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging. Blood. 2011;117(11):3104-3112.
    • (2011) Blood , vol.117 , Issue.11 , pp. 3104-3112
    • Keren, Z.1    Naor, S.2    Nussbaum, S.3
  • 49
    • 0042931219 scopus 로고    scopus 로고
    • The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors
    • Miller JP, Allman D. The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors. J Immunol. 2003;171(5):2326-2330. (Pubitemid 37025538)
    • (2003) Journal of Immunology , vol.171 , Issue.5 , pp. 2326-2330
    • Miller, J.P.1    Allman, D.2
  • 50
    • 30744451406 scopus 로고    scopus 로고
    • Effects of aging on the common lymphoid progenitor to pro-B cell transition
    • Min H, Montecino-Rodriguez E, Dorshkind K. Effects of aging on the common lymphoid progenitor to pro-B cell transition. J Immunol. 2006;176(2):1007-1012. (Pubitemid 43099700)
    • (2006) Journal of Immunology , vol.176 , Issue.2 , pp. 1007-1012
    • Min, H.1    Montecino-Rodriguez, E.2    Dorshkind, K.3
  • 51
    • 84863229585 scopus 로고    scopus 로고
    • A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage
    • Wang J, Sun Q, Morita Y, et al. A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage. Cell. 2012;148(5):1001-1014.
    • (2012) Cell , vol.148 , Issue.5 , pp. 1001-1014
    • Wang, J.1    Sun, Q.2    Morita, Y.3
  • 53
    • 20344371900 scopus 로고    scopus 로고
    • Insights into thymic aging and regeneration
    • DOI 10.1111/j.0105-2896.2005.00275.x
    • Taub DD, Longo DL. Insights into thymic aging and regeneration. Immunol Rev. 2005;205(1):72-93. (Pubitemid 40780178)
    • (2005) Immunological Reviews , vol.205 , pp. 72-93
    • Taub, D.D.1    Longo, D.L.2
  • 55
    • 84857728231 scopus 로고    scopus 로고
    • Regenerative capacity of adult cortical thymic epithelial cells
    • Rode I, Boehm T. Regenerative capacity of adult cortical thymic epithelial cells. Proc Natl Acad Sci U S A. 2012;109(9):3463-3468.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.9 , pp. 3463-3468
    • Rode, I.1    Boehm, T.2
  • 56
    • 0025801026 scopus 로고
    • Proliferation kinetics and the lifespan of B cells in central and peripheral lymphoid organs
    • Osmond DG. Proliferation kinetics and the lifespan of B cells in central and peripheral lymphoid organs. Curr Opin Immunol. 1991;3(2):179-185.
    • (1991) Curr Opin Immunol , vol.3 , Issue.2 , pp. 179-185
    • Osmond, D.G.1
  • 57
    • 0035887189 scopus 로고    scopus 로고
    • Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow
    • Hao Z, Rajewsky K. Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow. J Exp Med. 2001;194(8):1151-1164.
    • (2001) J Exp Med , vol.194 , Issue.8 , pp. 1151-1164
    • Hao, Z.1    Rajewsky, K.2
  • 58
    • 30344455329 scopus 로고    scopus 로고
    • B cell development in aging mice: Lessons from mathematical modeling
    • DOI 10.1093/intimm/dxh346
    • Shahaf G, Johnson K, Mehr R. B cell development in aging mice: lessons from mathematical modeling. Int Immunol. 2006;18(1):31-39. (Pubitemid 43057034)
    • (2006) International Immunology , vol.18 , Issue.1 , pp. 31-39
    • Shahaf, G.1    Johnson, K.2    Mehr, R.3
  • 59
    • 2942590824 scopus 로고    scopus 로고
    • Senescent B lymphopoiesis is balanced in suppressive homeostasis: Decrease in interleukin-7 and transforming growth factor-beta levels in stromal cells of senescence-accelerated mice
    • Tsuboi I, Morimoto K, Hirabayashi Y, et al. Senescent B lymphopoiesis is balanced in suppressive homeostasis: decrease in interleukin-7 and transforming growth factor-beta levels in stromal cells of senescence-accelerated mice. Exp Biol Med (Maywood). 2004;229(6):494-502. (Pubitemid 38736318)
    • (2004) Experimental Biology and Medicine , vol.229 , Issue.6 , pp. 494-502
    • Tsuboi, I.1    Morimoto, K.2    Hirabayashi, Y.3    Li, G.-X.4    Aizawa, S.5    Mori, K.J.6    Kanno, J.7    Inoue, T.8
  • 60
    • 0038206973 scopus 로고    scopus 로고
    • Impaired rearrangement of IgH V to DJ segments in bone marrow Pro-B cells from old mice
    • DOI 10.1016/S0008-8749(03)00084-4
    • Szabo P, Shen S, Telford W, Weksler ME. Impaired rearrangement of IgH V to DJ segments in bone marrow Pro-B cells from old mice. Cell Immunol. 2003;222(1):78-87. (Pubitemid 36683127)
    • (2003) Cellular Immunology , vol.222 , Issue.1 , pp. 78-87
    • Szabo, P.1    Shen, S.2    Telford, W.3    Weksler, M.E.4
  • 61
    • 0037438596 scopus 로고    scopus 로고
    • Decreased E12 and/or E47 transcription factor activity in the bone marrow as well as in the spleen of aged mice
    • Frasca D, Nguyen D, Riley RL, Blomberg BB. Decreased E12 and/or E47 transcription factor activity in the bone marrow as well as in the spleen of aged mice. J Immunol. 2003;170(2):719-726. (Pubitemid 36070521)
    • (2003) Journal of Immunology , vol.170 , Issue.2 , pp. 719-726
    • Frasca, D.1    Nguyen, D.2    Riley, R.L.3    Blomberg, B.B.4
  • 62
    • 50149099346 scopus 로고    scopus 로고
    • Acquired hematopoietic stem cell defects determine B-cell repertoire changes associated with aging
    • Guerrettaz LM, Johnson SA, Cambier JC. Acquired hematopoietic stem cell defects determine B-cell repertoire changes associated with aging. Proc Natl Acad Sci U S A. 2008;105(33):11898-11902.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.33 , pp. 11898-11902
    • Guerrettaz, L.M.1    Johnson, S.A.2    Cambier, J.C.3
  • 63
    • 0031035896 scopus 로고    scopus 로고
    • Phenotype of lymphocyte subsets after autologous peripheral blood stem cell transplantation
    • Koehne G, Zeller W, Stockschlaeder M, Zander AR. Phenotype of lymphocyte subsets after autologous peripheral blood stem cell transplantation. Bone Marrow Transplant. 1997;19(2):149-156. (Pubitemid 27068251)
    • (1997) Bone Marrow Transplantation , vol.19 , Issue.2 , pp. 149-156
    • Koehne, G.1    Zeller, W.2    Stockschlaeder, M.3    Zander, A.R.4
  • 65
    • 67349143418 scopus 로고    scopus 로고
    • Old mice retain bone marrow B1 progenitors, but lose B2 precursors, and exhibit altered immature B cell phenotype and light chain usage
    • Alter-Wolf S, Blomberg BB, Riley RL. Old mice retain bone marrow B1 progenitors, but lose B2 precursors, and exhibit altered immature B cell phenotype and light chain usage. Mech Ageing Dev. 2009;130(6):401-408.
    • (2009) Mech Ageing Dev , vol.130 , Issue.6 , pp. 401-408
    • Alter-Wolf, S.1    Blomberg, B.B.2    Riley, R.L.3
  • 66
    • 61349097791 scopus 로고    scopus 로고
    • B-cell responses to vaccination at the extremes of age
    • Siegrist CA, Aspinall R. B-cell responses to vaccination at the extremes of age. Nat Rev Immunol. 2009;9(3):185-194.
    • (2009) Nat Rev Immunol , vol.9 , Issue.3 , pp. 185-194
    • Siegrist, C.A.1    Aspinall, R.2
  • 67
    • 0033854211 scopus 로고    scopus 로고
    • The effect of age on the B-cell repertoire
    • DOI 10.1023/A:1006659401385
    • Weksler ME, Szabo P. The effect of age on the B-cell repertoire. J Clin Immunol. 2000;20(4):240-249. (Pubitemid 30619395)
    • (2000) Journal of Clinical Immunology , vol.20 , Issue.4 , pp. 240-249
    • Weksler, M.E.1    Szabo, P.2
  • 68
    • 59049088629 scopus 로고    scopus 로고
    • B-cell diversity decreases in old age and is correlated with poor health status
    • Gibson KL, Wu YC, Barnett Y, et al. B-cell diversity decreases in old age and is correlated with poor health status. Aging Cell. 2009;8(1):18-25.
    • (2009) Aging Cell , vol.8 , Issue.1 , pp. 18-25
    • Gibson, K.L.1    Wu, Y.C.2    Barnett, Y.3
  • 69
    • 79960997012 scopus 로고    scopus 로고
    • Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies
    • Sasaki S, Sullivan M, Narvaez CF, et al. Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies. J Clin Invest. 2011;121(8):3109-3119.
    • (2011) J Clin Invest , vol.121 , Issue.8 , pp. 3109-3119
    • Sasaki, S.1    Sullivan, M.2    Narvaez, C.F.3
  • 70
    • 0031859903 scopus 로고    scopus 로고
    • Altered antibody response to influenza H1N1 vaccine in healthy elderly people as determined by HI, ELISA, and neutralization assay
    • DOI 10.1002/(SICI)1096-9071(199805)55:1<82::AID-JMV13>3.0.CO;2-1
    • Remarque EJ, de Bruijn IA, Boersma WJ, Masurel N, Ligthart GJ. Altered antibody response to influenza H1N1 vaccine in healthy elderly people as determined by HI, ELISA, and neutralization assay. J Med Virol. 1998;55(1):82-87. (Pubitemid 28234217)
    • (1998) Journal of Medical Virology , vol.55 , Issue.1 , pp. 82-87
    • Remarque, E.J.1    De Bruijn, I.A.2    Boersma, W.J.A.3    Masurel, N.4    Ligthart, G.J.5
  • 71
    • 84863094641 scopus 로고    scopus 로고
    • Age-dependent increase of memory B cell response to cytomegalovirus in healthy adults
    • Aberle JH, Puchhammer-Stöckl E. Age-dependent increase of memory B cell response to cytomegalovirus in healthy adults. Exp Gerontol. 2012;47(8):654-657.
    • (2012) Exp Gerontol , vol.47 , Issue.8 , pp. 654-657
    • Aberle, J.H.1    Puchhammer-Stöckl, E.2
  • 72
    • 45949103917 scopus 로고    scopus 로고
    • Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells
    • Frasca D, Landin AM, Lechner SC, et al. Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells. J Immunol. 2008;180(8):5283-5290.
    • (2008) J Immunol , vol.180 , Issue.8 , pp. 5283-5290
    • Frasca, D.1    Landin, A.M.2    Lechner, S.C.3
  • 74
    • 80051568169 scopus 로고    scopus 로고
    • Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c(+) B-cell population is important for the development of autoimmunity
    • Rubtsov AV, Rubtsova K, Fischer A, et al. Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c(+) B-cell population is important for the development of autoimmunity. Blood. 2011;118(5):1305-1315.
    • (2011) Blood , vol.118 , Issue.5 , pp. 1305-1315
    • Rubtsov, A.V.1    Rubtsova, K.2    Fischer, A.3
  • 75
    • 80051569441 scopus 로고    scopus 로고
    • A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice
    • Hao Y, O'Neill P, Naradikian MS, Scholz JL, Cancro MP. A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice. Blood. 2011;118(5):1294-1304.
    • (2011) Blood , vol.118 , Issue.5 , pp. 1294-1304
    • Hao, Y.1    O'Neill, P.2    Naradikian, M.S.3    Scholz, J.L.4    Cancro, M.P.5
  • 76
    • 84880571140 scopus 로고    scopus 로고
    • Reversing T cell immunosenescence: Why, who, and how
    • [published online ahead of print February 26, 2012]. doi:10.1007/s11357- 012-9393-y
    • Lang PO, Govind S, Aspinall R. Reversing T cell immunosenescence: why, who, and how [published online ahead of print February 26, 2012]. Age (Dordr). doi:10.1007/s11357-012-9393-y.
    • Age (Dordr)
    • Lang, P.O.1    Govind, S.2    Aspinall, R.3
  • 77
    • 0035104210 scopus 로고    scopus 로고
    • Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice
    • DOI 10.1002/1521-4141(200102)31:2<500::AID-IMMU500>3.0.CO;2-C
    • Li F, Jin F, Freitas A, Szabo P, Weksler ME. Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice. Eur J Immunol. 2001;31(2):500-505. (Pubitemid 32166605)
    • (2001) European Journal of Immunology , vol.31 , Issue.2 , pp. 500-505
    • Li, F.1    Jin, F.2    Freitas, A.3    Szabo, P.4    Weksler, M.E.5
  • 78
    • 4043075603 scopus 로고    scopus 로고
    • TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology
    • Sasaki Y, Casola S, Kutok JL, Rajewsky K, Schmidt-Supprian M. TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology. J Immunol. 2004;173(4):2245-2252. (Pubitemid 39063079)
    • (2004) Journal of Immunology , vol.173 , Issue.4 , pp. 2245-2252
    • Sasaki, Y.1    Casola, S.2    Kutok, J.L.3    Rajewsky, K.4    Schmidt-Supprian, M.5
  • 79
    • 0029742201 scopus 로고    scopus 로고
    • Requirement for invariant chain in B cell maturation and function
    • DOI 10.1126/science.274.5284.106
    • Shachar I, Flavell RA. Requirement for invariant chain in B cell maturation and function. Science. 1996;274(5284):106-108. (Pubitemid 26332735)
    • (1996) Science , vol.274 , Issue.5284 , pp. 106-108
    • Shachar, I.1    Flavell, R.A.2
  • 80
    • 0036604452 scopus 로고    scopus 로고
    • Impaired light chain allelic exclusion and lack of positive selection in immature B cells expressing incompetent receptor deficient of CD19
    • Shivtiel S, Leider N, Sadeh O, Kraiem Z, Melamed D. Impaired light chain allelic exclusion and lack of positive selection in immature B cells expressing incompetent receptor deficient of CD19. J Immunol. 2002;168(11):5596-5604. (Pubitemid 34556140)
    • (2002) Journal of Immunology , vol.168 , Issue.11 , pp. 5596-5604
    • Shivtiel, S.1    Leider, N.2    Sadeh, O.3    Kraiem, Z.4    Melamed, D.5
  • 81
    • 84869839641 scopus 로고
    • Regulation and localization of lymphocyte production in the bone marrow
    • Osmond DG, Fahlman MT, Fulop GM, Rahal DM. Regulation and localization of lymphocyte production in the bone marrow. Ciba Found Symp. 1981;8468-86.
    • (1981) Ciba Found Symp , pp. 8468-8486
    • Osmond, D.G.1    Fahlman, M.T.2    Fulop, G.M.3    Rahal, D.M.4
  • 82
    • 0024547713 scopus 로고
    • Post-irradiation regeneration of early B-lymphocyte precursor cells in mouse bone marrow
    • Park YH, Osmond DG. Post-irradiation regeneration of early B-lymphocyte precursor cells in mouse bone marrow. Immunology. 1989;66(3):343-347. (Pubitemid 19092822)
    • (1989) Immunology , vol.66 , Issue.3 , pp. 343-347
    • Park, Y.-H.1    Osmond, D.G.2
  • 84
    • 0030769486 scopus 로고    scopus 로고
    • Independent homeostatic regulation of B cell compartments
    • DOI 10.1002/eji.1830270731
    • Agenes F, Rosado MM, Freitas AA. Independent homeostatic regulation of B cell compartments. Eur J Immunol. 1997;27(7):1801-1807. (Pubitemid 27302867)
    • (1997) European Journal of Immunology , vol.27 , Issue.7 , pp. 1801-1807
    • Agenes, F.1    Rosado, M.M.2    Freitas, A.A.3
  • 85
    • 13944261231 scopus 로고    scopus 로고
    • Rejuvenation of aged progenitor cells by exposure to a young systemic environment
    • DOI 10.1038/nature03260
    • Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature. 2005;433(7027):760-764. (Pubitemid 40292986)
    • (2005) Nature , vol.433 , Issue.7027 , pp. 760-764
    • Conboy, I.M.1    Conboy, M.J.2    Wagers, A.J.3    Girma, E.R.4    Weismann, I.L.5    Rando, T.A.6
  • 86
    • 84862908705 scopus 로고    scopus 로고
    • Rejuvenation of regeneration in the aging central nervous system
    • Ruckh JM, Zhao JW, Shadrach JL, et al. Rejuvenation of regeneration in the aging central nervous system. Cell Stem Cell. 2012;10(1):96-103.
    • (2012) Cell Stem Cell , vol.10 , Issue.1 , pp. 96-103
    • Ruckh, J.M.1    Zhao, J.W.2    Shadrach, J.L.3
  • 87
    • 84869750763 scopus 로고    scopus 로고
    • Aging impairs murine B cell differentiation and function in primary and secondary lymphoid tissues
    • Frasca D, Blomberg BB. Aging impairs murine B cell differentiation and function in primary and secondary lymphoid tissues. Aging Dis. 2011;2(5):361-373.
    • (2011) Aging Dis , vol.2 , Issue.5 , pp. 361-373
    • Frasca, D.1    Blomberg, B.B.2
  • 88
    • 33646362290 scopus 로고    scopus 로고
    • B-cell targeting in rheumatoid arthritis and other autoimmune diseases
    • Edwards JC, Cambridge G. B-cell targeting in rheumatoid arthritis and other autoimmune diseases. Nat Rev Immunol. 2006;6(5):394-403.
    • (2006) Nat Rev Immunol , vol.6 , Issue.5 , pp. 394-403
    • Edwards, J.C.1    Cambridge, G.2
  • 89
    • 25144477335 scopus 로고    scopus 로고
    • Regeneration of the immunoglobulin heavy-chain repertoire after transient B-cell depletion with an anti-CD20 antibody
    • Rouziere AS, Kneitz C, Palanichamy A, Dorner T, Tony HP. Regeneration of the immunoglobulin heavy-chain repertoire after transient B-cell depletion with an anti-CD20 antibody. Arthritis Res Ther. 2005;7(4):R714-R724.
    • (2005) Arthritis Res Ther , vol.7 , Issue.4
    • Rouziere, A.S.1    Kneitz, C.2    Palanichamy, A.3    Dorner, T.4    Tony, H.P.5
  • 93
    • 59449092041 scopus 로고    scopus 로고
    • Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system
    • Alexander T, Thiel A, Rosen O, et al. Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system. Blood. 2009;113(1):214-223.
    • (2009) Blood , vol.113 , Issue.1 , pp. 214-223
    • Alexander, T.1    Thiel, A.2    Rosen, O.3
  • 95
    • 80052098835 scopus 로고    scopus 로고
    • Reversing B cell aging
    • Mehr R, Melamed D. Reversing B cell aging. Aging (Albany NY). 2011;3(4):438-443.
    • (2011) Aging (Albany NY) , vol.3 , Issue.4 , pp. 438-443
    • Mehr, R.1    Melamed, D.2
  • 96
    • 80855138775 scopus 로고    scopus 로고
    • Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
    • Baker DJ, Wijshake T, Tchkonia T, et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature. 2011;479(7372):232- 236.
    • (2011) Nature , vol.479 , Issue.7372 , pp. 232-236
    • Baker, D.J.1    Wijshake, T.2    Tchkonia, T.3
  • 99
    • 0030619342 scopus 로고    scopus 로고
    • Doubling of world population unlikely
    • Lutz W, Sanderson W, Scherbov S. Doubling of world population unlikely. Nature. 1997;387(6635):803-805.
    • (1997) Nature , vol.387 , Issue.6635 , pp. 803-805
    • Lutz, W.1    Sanderson, W.2    Scherbov, S.3
  • 100
    • 84862971128 scopus 로고    scopus 로고
    • Aging and impaired immunity to influenza viruses: Implications for vaccine development
    • Liu WM, van der Zeijst BA, Boog CJ, Soethout EC. Aging and impaired immunity to influenza viruses: implications for vaccine development. Hum Vaccin. 2011;7(Suppl):94-98.
    • (2011) Hum Vaccin , vol.7 , Issue.SUPPL. , pp. 94-98
    • Liu, W.M.1    Van Der Zeijst, B.A.2    Boog, C.J.3    Soethout, E.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.