Decreased E12 and/or E47 transcription factor activity in the bone marrow as well as in the spleen of aged mice

Journal of Immunology

Volumn 170, Issue 2, 2003, Pages 719-726

  Frasca, Daniela ^a   Nguyen, Diep ^a   Riley, Richard L ^a   Blomberg, Bonnie B ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 7; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E12; TRANSCRIPTION FACTOR E47; UNCLASSIFIED DRUG;

AGED; AGING; ANIMAL CELL; ARTICLE; B LYMPHOCYTE ACTIVATION; BONE MARROW; CELL MATURATION; CONTROLLED STUDY; FEMALE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; REGULATORY MECHANISM; SPLEEN;

EID: 0037438596     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.2.719     Document Type: Article

References (56)

1. Quong, M. W., W. J. Romanow, and C. Murre. 2002. E protein function in lymphocyte development. Annu. Rev. Immunol. 20:301.
2. Murre, C., P. S. McCaw, and D. Baltimore. 1989. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 56:777.
3. Quong, M. W., D. P. Harris, S. L. Swain, and C. Murre. 1999. E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination. EMBO J. 18:6307.
4. Massari, M. E., P. A. Jennings, and C. Murre. 1996. The AD1 transactivation domain of E2A contains a highly conserved helix which is required for its activity in both Saccharomyces cerevisiae and mammalian cells. Mol. Cell. Biol. 16:121.
5. Henthorn, P., M. Kiledjian, and T. Kadesch. 1990. Two distinct transcription factors that bind the immunoglobulin enhancer μE5/κ2 motif. Science 247:467.
6. Nelson, C., L. P. Shen, A. Meister, E. Fodor, and W. J. Rutter. 1990. Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs. Genes Dev. 4:1035.
7. Murre, C., A. Voronova, and D. Baltimore. 1991. B-cell- and myocyte-specific E2-box-binding factors contain E12/E47-like subunits. Mol. Cell. Biol. 11:1156.
8. Sloan, S. R., C. P. Shen, R. McCarrick-Walmsley, and T. Kadesh. 1996. Phosphorylation of E47 as a potential determinant of B-cell-specific activity. Mol. Cell. Biol. 16:6900.
9. Chu, C., and D. S. Kohtz. 2001. Identification of the E2A gene products as regulatory targets of the G1 cyclin-dependent kinases. J. Biol. Chem. 276:8524.
10. Lassar, A. B., R. L. Davis, W. E. Wright, T. Kadesch, C. Murre, A. Voronova, D. Baltimore, and H. Weintraub. 1991. Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo. Cell 66:305.
11. Lee, J. E., S. M. Hollenberg, L. Snider, D. L. Turner, N. Lipnick, and H. Weintraub, H. 1995. Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science 268:836.
12. Herblot, S., P. D. Aplan, and T. Hoang. 2002. Gradient of E2A activity in B-cell development. Mol. Cell. Biol. 22:886.
13. Bain, G., E. C. Maandag, D. J. Izon, D. Amsen, A. M. Kruisbeek, B. C. Weintraub, I. Krop, M. S. Schlissel, A. J. Feeney, and M. van Roon. 1994. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell 79:885.
14. Zhuang, Y., P. Soriano, and H. Weintraub. 1994. The helix-loop-helix gene E2A is required for B cell formation. Cell 79:875.
15. Bain, G., E. C. Robanus Maandag, H. P. te Riele, A. J. Feeney, A. Sheehy, M. Schlissel, S. A. Shinton, R. R. Hardy, and C. Murre. 1997. Both E12 and E47 allow commitment to the B cell lineage. Immunity 6:145.
16. Schlissel, M., A. Voronova, and D. Baltimore. 1991. Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line. Genes Dev. 5:1376.
17. Choi, J. K., C. P. Shen, H. S. Radomska, L. A. Eckhardt, and T. Kadesch. 1996. E47 activates the Ig-heavy chain and TdT loci in non-B cells. EMBO J. 15:5014.
18. Sigvardsson, M., M. O'Riordan, and R. Grosschedl. 1997. EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes. Immunity 7:25.
19. Kee, B. L., and C. Murre. 1998. Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12. J. Exp. Med. 188:699.
20. Romanow, W. J., A. W. Langerak, P. Goebel, I. L. Wolvers-Tettero, J. J. van Dongen, A. J. Feeney, and C. Murre. 2000. E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells. Mol. Cell 5:343.
21. Goebel, P., N. Janney, J. R. Valenzuela, W. J. Romanow, C. Murre, and A. J. Feeney. 2001. Localized gene-specific induction of accessibility to V(D)J recombination induced by E2A and early B cell factor in nonlymphoid cells. J. Exp. Med. 194:645.
22. Riley. R. L., M. G. Kruger, and J. Elia. 1991. B cell precursors are decreased in senescent BALB/c mice, but retain normal mitotic activity in vivo and in vitro. Clin. Immunol. Immunopathol. 59:301.
23. Klinman, N. R., and G. H. Kline. 1997. The B-cell biology of aging. Immunol. Rev. 160:103.
24. Szabo, P., S. Shen, and M. E. Weksler. 1999. Age-associated defects in B lymphocyte development. Exp. Gerontol. 34:431.
25. Weksler, M. E., and P. Szabo. 2000. The effect of age on the B-cell repertoire. J. Clin. Immunol. 20:240.
26. Sherwood, E. M., W. Xu, A. M. King, B. B. Blomberg, and R. L. Riley. 2000. The reduced expression of surrogate light chains in B cell precursors from senescent BALB/c mice is associated with decreased E2A proteins. Mech. Ageing Dev. 118:45.
27. Li, F., F. Jin, A. Freitas, P. Szabo, and M. E. Weksler. 2001. Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice. Eur. J. Immunol. 31:500.
28. Kline, G. H., T. A. Hayden, and N. R. Klinman. 1999. B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation. J. Immunol. 162:3342.
29. Zheng, B., S. Han, Y. Takahashi, and G. Kelsoe. 1997. Immunosenescence and germinal center reaction. Immunol. Rev. 160:63.
30. Berek, G., A. Berger, and M. Apel. 1991. Mutation of the immune response in germinal centers. Cell 67:1121.
31. Jacob, J., G. Kelsoe, K. Rajewsky, and U. Weiss. 1991. Intracional generation of antibody mutants in germinal centers. Nature 354:389.
32. Lui, Y. J., F. Malisan, O. de Bouteiller, C. Guret, S. Lebecque, J. Banchereau, F. C. Mills, E. E. Max, and H. Martinez-Valdez. 1996. Within germinal centers, isotype switching of immunoglobulin genes occurs after the onset of somatic mutation. Immunol. 4:241.
33. Sherwood, E. M., B. B. Blomberg, W. Xu, C. A. Warner, and R. L. Riley. 1998. Senescent BALB/c mice exhibit decreased expression of λ5 surrogate light chains and reduced development within the pre-B cell compartment. J. Immunol. 161:4472.
34. Frasca, D., D. Nguyen, R. L. Riley, and B. B. Blomberg. Effects of aging on proliferation and E47 transcription factor activity induced by different stimuli in murine splenic B cells. Mech. Ageing Dev. In press.
35. Jacobs, Y., C. Vierra, and C, Nelson. 1993. E2A expression, nuclear localization, and in vivo formation of DNA- and non-DNA-binding species during B-cell development. Mol. Cell. Biol. 13:7321.
36. Bain, G., C. L. Cravatt, C. Loomans, J. Alberola-Ila, S. M. Hedrick, and C. Murre. 2001. Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade. Nat. Immunol. 2:165.
37. Yaneva, M., T. Kowalewski, and M. R. Lieber. 1997. Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies. EMBO J. 16:5098.
38. Frasca, D., B. Barattini, G. Tocchi, L. Guidi, L. Pierelli, and G, Doria. 2001. Role of DNA-dependent protein kinase in recognition of radiation-induced DNA damage in human peripheral blood mononuclear cells. Int. Immunol. 13:791.
39. Zhao, F., A. Vilardi, R. J. Neely, and J. C. Choi, 2001. Promotion of cell cycle progression by basic helix-loop-helix E2A. Mol. Cell. Biol. 21:6346.
40. Storb, U., N. Michael, N. Kim, H. Nguyen, and T. E. Martin. 2001. Molecular basis of somatic hyper mutation of immunoglobulin genes. In Keystone Symposia on B Lymphocytes, Snowbird, UT, April 17-22 (Abstr.).
41. Kitamura, D., J. Roes, R. Kuhn, and K. Rajewsky, 1991. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature 350:423.
42. Kitamura, D., A. Kudo, S. Schaal, W. Muller, F. Melchers, and K. Rajewsky. 1992. A critical role of protein in cell development. Cell 69:823.
43. Rolink, A., U. Grawunder, T. H. Winkler, H. Karasuyama, and F. Melchers. 1994, IL-2 receptor α chain (CD25, TAC) expression defines a crucial stage in pre-B cell development. Int. Immunol. 6:1257.
44. Williams, G. T., C. J. Jolly, J. Köhler, and M. S. Neuberger. 2000. The contribution of somatic hypermutation to the diversity of serum immunoglobulin: dramatic increase with age. Immunity 13:409.
45. Bovbjerg, B. J., Y. T. Kim, R. Schwab, K. Schmitt, T. De Blasio, and M. E. Weksler. 1991. Cross-wiring of the immune response in old mice: increased autoantibody response despite reduced antibody response to nominal antigens. Cell. Immunol. 135:519.
46. Klinman, N. R. 1992. Similarities in B cell repertoire development between autoimmune and aging normal mice. J. Immunol. 148:1353.
47. Zhao, K. S., Y. F. Wang, R. Gueret, and M. E. Weksler. 1995. Dysregulation of the humoral immune response in old mice. Int. Immunol. 7:929.
48. +B cells. Mech. Ageing Dev. 103:111.
49. Hu, A., D. Ehleiter, A. Ben-Yehuda, R. Schwab, C. Russo, P. Szabo, and M. E. Weksler. 1993. Effect of age on the expressed B cell repertoire: role of B cell subsets. Int. Immunol. 5:1035.
50. Whisler, R. L., Y. G. Newhouse, I. S. Grants, and K. V. Hackshaw. 1995. Differential expression of the α and β isoforms of protein kinase C in peripheral blood T and B cells from young and elderly adults. Mech. Ageing Dev. 77:197.
51. Johnson, S. A., S. J. Rozzo, and J. C. Cambier. 2002. Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire. J. Immunol. 168:5014.
52. Kline, G. H., T. A. Hayden, and N. R. Klinman. 1999. B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation. J. Immunol. 162:3342.
53. Aronheim, A., H. Ohlsson, C. W. Park, T. Edlund, and M. D. Walker. 1991. Distribution and characterization of helix-loop-helix enhancer-binding proteins from pancreatic β cells and lymphocytes. Nucleic Acids Res. 19:3893.
54. Shen, C. P., and T. Kadesch. 1995. B-cell-specific DNA binding by an E47 homodimer. Mol. Cell. Biol. 15:4518.
55. Sun, X. H., and D. Baltimore. 1991. An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers. [Published erratum appears in 1991 Cell 66:423]. Cell 64:459.
56. Benezra, R. 1994. An intermolecular disulfide bond stabilizes E2A homodimers and is required for DNA binding at physiological temperatures. Cell 79:1057.