Stage-specific alterations in murine B lymphopoiesis with age

International Immunology

Volumn 8, Issue 4, 1996, Pages 509-518

  Stephan, Robert P ^a   Sanders, Virginia M ^a   Witte, Pamela L ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Ageing; B lymphopoiesis; Cell surface phenotype; Flow cytometry; LTBMC B; pro B pre B transition; Stromal cells

Indexed keywords

IMMUNOGLOBULIN M;

AGING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; CELL PROLIFERATION; FEMALE; FLOW CYTOMETRY; HUMORAL IMMUNITY; LYMPHOCYTE COUNT; LYMPHOPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROLYMPHOCYTE; STROMA CELL;

AGING; ANIMALS; B-LYMPHOCYTES; BONE MARROW; BONE MARROW CELLS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HEMATOPOIESIS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; SPLEEN; STROMAL CELLS;

EID: 0029966724     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/8.4.509     Document Type: Article

References (46)

1. Zharhary, D 1994. Age-related decline in B and T Cell Immunity in Snow, E. C., ed , Handbook of B and T Lymphocytes, p. 91 Academic Press, New York.
2. Kay, M. M. B and Makinodan, T 1981 Relationship between aging and the immune system Prog Allergy 29:134
3. Thoman, M. L. and Weigle, W. O. 1989. The cellular and subcellular bases of immunosenescence Adv. Immunol 46:221
4. Whisler, R. L , Newhouse, Y G , Ennist, D and Lachman, L B. 1985. Human B-lymphocyte colony responses suboptimal colony responsiveness in aged humans associated with defective function of B cells and monocytes Cell. Immunol. 94 133
5. Yang, X., Stedra, J. and Cerny, J. 1994 Repertoire diversity of antibody response to bacterial antigens in aged mice. IV Study of VH and VL gene utilization in splenic antibody foci by in situ hybridization. J Immunol 152:2214.
6. Viale, A.-C., Chies, J. A. B., Huetz, F., Malenchere, E., Weksler, M E., Freitas, A. A and Coutinho, A. 1994. Vh-gene family dominance in ageing mice Scand. J Immunol. 39.184.
7. Woda, B. A. and Feldman, J D 1979. Density of surface immunoglobulin and capping on rat lymphocytes. I Changes with aging. J. Exp. Med 149.416.
8. Zhao, K -S., Wang, Y-F., Gueret, R and Weksler, M E. 1995. Dysregulation of the humoral immune response in old mice Int. Immunol 7 929
9. + B cell precursors from bone marrow decreases in aging mice. Cell. Immunol. 147:267
10. Rolink, A , Haasner, D., Nishikawa, S -I. and Melchers, F. 1993. Changes in frequencies of cionable pre B cells during life in different lymphoid organs of mice. Blood 81:2290.
11. Ben-Yehuda, A., Szabo, P , Dyall, R. and Weksler, M. E. 1994. Bone marrow decline as a site of B-cell precursor differentiation with age: relationship to thymus involution. Proc Natl Acad. Sci. USA 91:11988
12. Riley, R. L., Kruger, M. G. and Elia, J 1991 B cell precursors are decreased in senescent BALB/c mice, but retain normal mitotic activity in vivo and in vitro Clin. Immunol. Immunopathol. 59:301.
13. Zharhary, D 1988 Age-related changes in the capability of the bone marrow to generate B cells. J Immunol. 141:1863.
14. Hardy, R R , Carmack, C E., Shinton, S. A., Kemp, J. D and Hayakawa, K. 1991. Resolution and characterization of pro-B and pre-pro B cell stages in normal mouse bone marrow. J. Exp. Med 173.1213
15. Osmond, D. G 1991 Proliferation kinetics and the lifespan of B cells in central and peripheral lymphoid organs Curr. Opin. Immunol 3:179.
16. Rolink, A and Melchers, F 1993 Generation and regeneration of cells of the B-lymphocyte lineage Curr Opin Immunol. 5.207.
17. Nishikawa, S., Ogawa, M , Nishikawa, S., Kunisada, T and Kodama, H 1988. B lymphopoiesis on stromal cell clone stromal cell clones acting on different stages of B cell differentiation. Eur. J. Immunol. 18 1767
18. Miyake, K., Medina, K Ishihara, K , Kimoto, M , Auerbach, R. and Kincade, P W 1991 A VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture J Cell Biol 114:557.
19. Witte, P L , Frantsve, L M., Hergott, M and Rahbe, S. M. 1993. Cytokine production and heterogeneity of primary stromal cells that support B lymphopoiesis Eur J Immunol 23 1809.
20. Kincade, P W Lee G , Paige C J and Scheid, M. P. 1981. Cellular interactions affecting the maturation of murine B lymphocyte precursors in vitro J Immunol 127 255
21. Billips, L. G , Petitte, D , Dorshkind, K , Narayanan, R., Chiu, C -P. and Landreth, K S. 1992 Differential roles of stromal cells. interleukin-7 and kit-ligand in the regulation of B lymphopoiesis Blood, 79.1185.
22. Namen, A. E , Lupton, S , Hjerrild, K., Wignall, J , Mochizuki, D Y , Schmierer, A , Mosley, B , March, C J , Urdal, D., Gillis, S , Cosman, D. and Goodwin, R G 1988 Stimulation of B-cell progenitors by cloned murine interleukin-7 Nature 333.571.
23. Kierney, P C and Dorshkind, K 1987 B lymphocyte precursors and myeloid progenitors survive in diffusion chamber culture but B cell differentiation requires close contact with stromal cells. Blood 80.1418.
24. Schofield, R , Dexter, T M., Lord, B I and Testa, N G 1986. Comparison of haemopoiesis in young and old mice Mech. Ageing Dev. 34:1
25. Sharp, A., Zipori, D., Toledo, J , Tal, S. and Resnitzky, P 1989 Age related changes in hemopoietic capacity of bone marrow cells. Mech. Ageing Dev. 48 91
26. Lipschitz, D A., Udupa, K. B , Milton, K. Y and Thompson, C. O 1984 Effect of age on hematopoiesis in man Blood 63 502.
27. Williams, L H., Udupa, K B. and Lipschitz, D A 1986 Evaluation of the effect of age on hematopoiesis in the C57BL/6 mouse Exp. Hematol 14.827
28. Harrison, D E. 1973. Normal production of erythrocytes by mouse marrow continuous for 73 months. Proc. Natl Acad Sci USA 70.3184.
29. Allman, D M , Ferguson, S. E and Cancro M P. 1992 Peripheral B cell maturation I Immature peripheral B cells in adults are heat-stable antigen hi and exhibit unique signaling characteristics. J. Immunol 149:2533.
30. Allman, D. M , Ferguson, S. E , Lentz V. M and Cancro, M P 1993 Peripheral B cell maturation II Heat-stable antigen hi splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells. J Immunol. 151:4431
31. Whitlock, C. A and Witte, O N. 1982 Long-term culture of B lymphocytes and their precursors from murine bone marrow. Proc Natl Acad. Sci USA 79.3608.
32. Whitlock, C. A., Robertson, D. and Witte, O. N. 1984. Murine B cell lymphopoiesis in long term culture J Immunol. Methods 67:353
33. Li, Y-S, Hayakawa, K and Hardy, R R 1993. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp Med 178:951
34. Kincade, P W 1994 B lymphopoiesis: global factors, local control Proc. Natl Acad. Sci USA 91 2888
35. Kincade, P. W., Medina, K L. and Smithson, G. 1994. Sex hormones as negative regulators of lymphopoiesis. Immunol Rev 137.119
36. Funk, P E , Kincade, P W. and Witte, P L 1994 Native associations of early hematopoietic stem cells and stromal cells isolated in bone marrow cell aggregates. Blood 83:361
37. Funk, P E. and Witte, P L 1992. Enrichment of primary lymphocyte-supporting stromal cells and characterization of associated B lymphocyte progenitors. Eur J Immunol 22:1305
38. von Freeden-Jeffry, U , Vieira, P., Lucian, L A , McNeil, T , Burdach, S. E G. and Murry, R 1995. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine J. Exp. Med 181:1519
39. Updyke, L W., Cocke, K. S and Wierda, D. 1993 Age-related changes in production of interleukin-7 IL-7, by murine long-term bone marrow cultures (LTBMC). Mech. Ageing Dev. 469 109
40. Funk, P E., Stephan, R. P. and Witte, P L 1995. VCAM1-positive reticular cells express interleukin-7 and stem cell factor in the bone marrow. Blood 86.2661
41. Opstelten, D. and Osmond, D. G. 1983. Pre-B cells in mouse bone marrow, immunofluorescence stathmokinetic studies of the proliferation of cytoplasmic μ-chain-bearing cells in normal mice. J Immunol 131.2635
42. ten Boekel, E., Melchers, F. and Relink, A 1995 The status of Ig loci rearrangements in single cells from different stages of B cell development. Int Immunol. 7 1013
43. H element reading frames. Cell 65.47
44. Chen, C , Nagy, Z , Radic, M. Z , Hardy, R. R., Huszar, D., Camper, S A and Weigert, M. 1995 The site and stage of anti-DNA B-cell deletion Nature 373 252
45. Hartley, S B , Cooke, M. P , Fulcher, D. A , Harris, A W , Cory, S , Basten, A. and Goodnow, C C. 1993. Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death Cell 72:325
46. Aroeira, L S., Williams, O , Lozano, E. G and Martinez-A., C 1994 Age-dependent changes in the response to staphylococcal enterotoxin B Int Immunol. 6 1555