The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help

Journal of Experimental Medicine

Volumn 183, Issue 5, 1996, Pages 2313-2328

  Fulcher, D A ^a,c   Lyons, A B ^b   Korn, S L ^a   Cook, M C ^a   Koleda, C ^c   Parish, C ^b   De Fazekas St Groth, B ^a   Basten, A ^a  

^a CENTENARY INSTITUTE   (Australia)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^c WESTMEAD HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; CD4 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; LYSOZYME; MAJOR HISTOCOMPATIBILITY ANTIGEN;

ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CONTROLLED STUDY; GENE REARRANGEMENT; IMMUNOGLOBULIN GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMALS; B-LYMPHOCYTES; BONE MARROW; BONE MARROW CELLS; CELL SURVIVAL; CHICKENS; CHIMERA; CROSSES, GENETIC; FLOW CYTOMETRY; GENE REARRANGEMENT, B-LYMPHOCYTE; GENES, IMMUNOGLOBULIN; IMMUNOHISTOCHEMISTRY; IMMUNOTHERAPY, ADOPTIVE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MURAMIDASE; PEPTIDES; RECEPTORS, ANTIGEN, B-CELL; SPLEEN; T-LYMPHOCYTES; TIME FACTORS;

EID: 0030008694     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.5.2313     Document Type: Article

References (53)

1. Nemazee, D.A., and K. Bürki. 1989. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature (Lond.). 337:562-566.
2. Erikson, J., M.Z. Radic, S.A. Camper, R.R. Hardy, C. Carmack, and M. Weigert. 1991. Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature (Lond.). 349:331-334.
3. Okamoto, M., M. Murakami, A. Shimizu, S. Ozaki, T. Tsubata, S. Kumagai, and T. Honjo. 1992. A Transgenic model of autoimmune hemolytic anemia. J. Exp. Med. 175: 71-79.
4. Goodnow, C.C., J. Crosbie, S. Adelstein, T.B. Lavoie, S.J. Smith-Gill, R.A. Brink, H. Pritchard-Briscoe, J.S. Wotherspoon, R.H. Loblay, K. Raphael et al., 1988. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature (Lond.). 334:676-682.
5. Hartley, S.B., J. Crosbie, R. Brink, A.B. Kantor, A. Basten, and C.C. Goodnow. 1991. Elimination from peripheral lymphoid tissues of self-reactive B-lymphocytes recognising membrane-bound antigens. Nature (Lond.). 353:765-769.
6. Hartley, S.B., M.P. Cooke, D.A. Fulcher, A.W. Harris, S. Cory, A. Basten, and C.C. Goodnow. 1993. Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death. Cell. 72:325-335.
7. Fulcher, D.A., and A. Basten. 1994. Reduced life span of anergic self-reactive B cells in a double-transgenic model. J. Exp. Med. 179:125-134.
8. Fulcher, D.A., and A. Basten. 1994. Whither the anergic B cell? Autoimmunity. 19:135-140.
9. Cyster, J.G., S.B. Hartley, and C.C. Goodnow. 1994. Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire. Nature (Lond.). 371:389-395.
10. Lyons, A.B., and C.R. Parish. 1994. Determination of lymphocyte division by flow cytometry. J. Immunol. Methods. 171:131-137.
11. Mason, D.Y., M. Jones, and C.C. Goodnow. 1992. Development and follicular localization of tolerant B lymphocytes in lysozyme/anti-lysozyme IgM/IgD transgenic mice. Int. Immunol. 4:163-175.
12. Adelstein, S., H. Pritchard-Briscoe, T.A. Anderson, J. Crosbie, G. Gammon, R.H. Loblay, A. Basten, and C.C. Goodnow. 1991. Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self antigen. Science (Wash. DC). 251:1223-1225.
13. Fazekas de St. Groth, B., P.A. Patten, W.Y. Ho, E.P. Rock, and M.M. Davis. 1992. An analysis of T cell receptor-ligand interaction using a transgenic antigen model for T cell tolerance and T cell receptor mutagenesis. In Molecular Mechanisms of Immunological Self-Recognition. F.W. Alt and A.H. Vogel, editors. Academic Press, San Diego, CA. 123-127.
14. Arnheim, N., E.M. Prager, and A.C. Wilson. 1969. Immunological prediction of sequence differences among proteins. J. Biol. Chem. 244:2085-2094.
15. Smith-Gill, S.J., A.C. Wilson, M. Potter, R.J. Feldman, and C.R. Mainhart. 1982. Mapping the antigenic epitope for a monoclonal antibody against avian lysozyme. J. Immunol. 128:314-322.
16. Coffman, R. 1982. Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development. Immunol. Rev. 69:5-23.
17. Rao, M., W. Lee, and D. Conrad. 1987. Characterisation of a monoclonal antibody directed against the murine B lymphocyte receptor for IgE. J. Immunol. 138:1845-1851.
18. Schuppel, R., J. Wilke, and E. Weiler. 1987. Monoclonal anti-allotype antibody towards BALB/c IgM. Analysis of specificity and site of a V-C crossover in recombinant strain BALB/c-IgH-Va/IgH-Cb. Eur. J. Immunol. 17:739-741.
19. Stall, A., and M. Loken. 1984. Allotypic specificities of murine IgD and IgM recongnised by monoclonal antibodies. J. Immunol. 132:787-795.
20. Ceredig, R., M. Lowenthal, M. Nabholz, and H.K. MacDonald. 1985. Expression of interleukin 2 receptors as a differentiation marker in intrathymic stem cells. Nature (Lond.). 314:98-100.
21. Sarmiento, M., A.L. Glasebrook, and F.W. Fitch. 1980. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T-cell-mediated cytolysis in the absence of complement. J. Immunol. 125:2665-2672.
22. Marshak-Rothstein, A., P. Fink, T. Gridley, D.H. Raulet, M.J. Sevan, and M.L. Gefter. 1979. Properties and applications of monoclonal antibodies directed against determinants of the Thy-1 locus. J. Immunol. 122:2491-2497.
23. Liu, Y.-J., J. Zhang, P.J.L. Lane, E.Y.-T. Chan, and I.C.M. MacLennan. 1991. Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell independent antigens. Eur. J. Immunol. 21:2951-2962.
24. Nossal, G.J.V. 1983. Cellular mechanisms of immunological tolerance. Annu. Rev. Immunol. 1:33-62.
25. Klinman, N.R. 1991. Tolerance susceptibility of newly generating memory B cells. J. Immunol. 146:4099-4104.
26. Van-den-Eertwegh, A.J.M., R.J. Noelle, M. Roy, D.M. Shepherd, A. Aruffo, J.A. Ledbetter, W.J. Boersma, and E. Claassen. 1993. In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactions. J. Exp. Med. 178:1555-1565.
27. Van-Rooijen, N. 1992. The humoral immune response in the spleen. Res. Immunol. 142:328-330.
28. Jacob, J., R. Kassir, and G. Kelsoe. 1991. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations. J. Exp. Med. 173:1165-1175.
29. Nossal, G.J.V. 1992. Cellular and molecular mechanisms of B lymphocyte tolerance. Adv. Immunol. 52:283-331.
30. Hodgkin, P.D., and A. Basten. 1995. B-cell activation, tolerance and antigen-presenting function. Curr. Opin. Immunol. 7:121-129.
31. Finkelman, F.D., J.M. Holmes, O.I. Dukhanina, and S.C. Morris. 1995. Cross-linking of membrane IgD, in the absence of T cell help, kills mature B cells in vivo. J. Exp. Med. 181:515-525.
32. + T lymphocytes. Am. J. Anatomy. 187:355-373.
33. Jacob, J., and G. Kelsoe. 1992. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common origin for periarteriolar lymphoid sheath-associated foci and germinal centers. J. Exp. Med. 176:679-687.
34. Kelsoe, G. 1994. B cell diversification and differentiation in the periphery. J. Exp. Med. 180:5-6.
35. Jacob, J., G. Kelsoe, K. Rajewsky, and U. Weiss. 1991. Intraclonal generation of antibody mutants in germinal centres. Nature (Lond.). 354:389-392.
36. Russell, D.M., Z. Dembic, G. Morahan, J.F.A.P. Miller, K. Bürki, and D. Nemazee. 1991. Peripheral deletion of self-reactive B cells. Nature (Lond.). 308:308-311.
37. Goodnow, C.C., J. Crosbie, H. Jorgensen, R.A. Brink, and A. Basten. 1989. Induction of self-tolerance in mature peripheral B lymphocytes. Nature (Lond.). 342:385-391.
38. Mörsky, P. 1988. Detection of lysozyme and alpha-2-macroglobulin-lysozyme complexes by immunoblotting. Clin. Chim. Acta. 178:327-336.
39. Cooke, M.P., A.W. Heath, K.M. Shokat, Y. Zeng, F.D. Finkelman, P.S. Linsley, M. Howard, and C.C. Goodnow. 1994. Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cell. J. Exp. Med. 179:425-438.
40. Eris, J.M., A. Basten, R. Brink, K. Doherty, M.R. Kehry, and P.D. Hodgkin. 1994. Anergic self-reactive B cells present antigen and respond normally to CD40 dependent signals but are defective in antigen receptor mediated functions. Proc. Natl. Acad. Sci. USA. 91:4392-4396.
41. Mitchison, N.A. 1971. The carrier effect in the secondary response to hapten-carrier conjugates. II. Cellular cooperation. Eur. J. Immunol. 1:18-27.
42. Britton, S., N.A. Mitchison, and K. Rajewsky. 1971. The carrier effect in the secondary response to hapten-protein conjugates. IV. Uptake of antigen in vitro and failure to obtain cooperative induction in vitro. Eur. J. Immunol. 1:65-68.
43. Miller, J.F.A.P., A. Basten, J. Sprent, and C. Cheers. 1971. Interaction between T and B lymphocytes. Cell. Immunol. 2: 469-495.
44. Rajewsky, K., V. Schirrmacher, S. Nase, and N.K. Jerne. 1969. The requirement of more than one antigenic determinant for immunogenicity. J. Exp. Med. 129:1131-1143.
45. Rock, K.L., B. Benacerraf, and A.K. Abbas. 1984. Antigen presentation by hapten-specific B lymphocytes. J. Exp. Med. 160:1102-1113.
46. Lanzavecchia, A. 1987. Antigen uptake and accumulation in antigen-specific B cells. Immunol. Rev. 99:39-51.
47. Tony, H.-P., and D.C. Parker. 1985. Major histocompatibility complex-restricted, polyclonal B cell responses resulting from helper T cell recognition of antiimmunoglobulin presented by small B lymphocytes. J. Exp. Med. 161:223-241.
48. Pulendran, B., G. Kannourakis, S. Nouri, K.G.C. Smith, and G.J.V. Nossal. 1995. Soluble antigen can cause enhanced apoptosis of germinal-centre B cells. Nature (Lond.). 375:281.
49. Shokat, K.M., and C.C. Goodnow. 1995. Antigen-induced B-cell death and elimination during germinal centre immune responses. Nature (Lond.). 375:334-338.
50. Han, S., B. Zheng, J. Dal-Porto, and G. Kelsoe. 1995. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl IV. Affinity-dependent antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self tolerance. J. Exp. Med. 182:1635-44.
51. Parry, S.L., J. Hasbold, M. Holman, and G.G. Klaus. 1994. Hypercross-linking surface IgM or IgD receptors on mature B cells induces apoptosis that is reversed by costimulation with IL-4 and anti-CD40. J. Immunol. 156:2821-2829.
52. Dong, X., K.J. Hamilton, M. Satoh, J. Wang, and W.H. Reeves. 1994. Initiation of autoimmunity to the p53 tumor suppressor protein by complexes of p53 and SV40 large T antigen. J. Exp. Med. 179:1243-1252.
53. Steinhoff, U., C. Burkhart, H. Arnheiter, H. Hengartner, and R. Zinkernagel. 1994. Virus or a hapten-carrier complex can activate autoreactive B cells by providing linked T help. Eur. J. Immunol. 24:773-776.