Reversing B cell aging

Aging

Volumn 3, Issue 4, 2011, Pages 438-443

  Mehr, Ramit ^a   Melamed, Doron ^b  

^a BAR ILAN UNIVERSITY   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Aging; B cells; Immunosenescence; Rejuvenation

Indexed keywords

AGING; ANIMAL; ARTICLE; B LYMPHOCYTE; CELL AGING; HOMEOSTASIS; HUMAN; IMMUNOLOGY; LYMPHOPOIESIS; PHYSIOLOGY;

AGING; ANIMALS; B-LYMPHOCYTES; CELL AGING; HOMEOSTASIS; HUMANS; LYMPHOPOIESIS;

EID: 80052098835     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100313     Document Type: Article

References (67)

1. Lutz W, Sanderson W, Scherbov S. Doubling of world population unlikely. Nature. 1997; 387: 803-805.
2. Heron MP, Smith BL. Deaths: leading causes for 2003. Natl Vital Stat Rep. 2007; 55: 1-92.
3. Weinberger B, Herndler-Brandstetter D, Schwanninger A, Weiskopf D, Grubeck-Loebenstein B. Biology of immune responses to vaccines in elderly persons. Clin Infect Dis. 2008; 46: 1078-1084.
4. Zheng B, Switzer K, Marinova E, Wansley D, Han S. Correction of age-associated deficiency in germinal center response by immunization with immune complexes. Clin Immunol. 2007; 124: 131-137.
5. Weng NP. Aging of the immune system: how much can the adaptive immune system adapt? Immunity. 2006; 24: 495-499.
6. Dorshkind K, Montecino-Rodriguez E, Signer RA. The ageing immune system: is it ever too old to become young again? Nat Rev Immunol. 2009; 9: 57-62.
7. Weksler ME. Changes in the B-cell repertoire with age. Vaccine. 2000; 18: 1624-1628.
8. Johnson SA, Rozzo SJ, Cambier JC. Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire. J Immunol. 2002; 168: 5014-5023.
9. Weksler ME, Szabo P. The effect of age on the B-cell repertoire. J Clin Immunol. 2000; 20: 240-249.
10. LeMaoult J, Delassus S, Dyall R, Nikolic-Zugic J, Kourilsky P, Weksler ME. Clonal expansions of B lymphocytes in old mice. J Immunol. 1997; 159: 3866-3874.
11. Gibson KL, Wu YC, Barnett Y, Duggan O, Vaughan R, Kondeatis E, Nilsson BO, Wikby A, Kipling D, Dunn-Walters DK. Bcell diversity decreases in old age and is correlated with poor health status. Aging Cell. 2009; 8: 18-25.
12. Kline GH, Hayden TA, Klinman NR. B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation. J Immunol. 1999; 162: 3342-3349.
13. Miller JP, Allman D. The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors. J Immunol. 2003; 171: 2326-2330.
14. Shahaf G, Johnson K, Mehr R. B cell development in aging mice: lessons from mathematical modeling. Int Immunol. 2006; 18: 31-39.
15. Tsuboi I, Morimoto K, Hirabayashi Y, Li GX, Aizawa S, Mori KJ, Kanno J, Inoue T. Senescent B lymphopoiesis is balanced in suppressive homeostasis: decrease in interleukin-7 and transforming growth factor-beta levels in stromal cells of senescence-accelerated mice. Exp Biol Med (Maywood). 2004; 229: 494-502.
16. Szabo P, Shen S, Telford W, Weksler ME. Impaired rearrangement of IgH V to DJ segments in bone marrow Pro-B cells from old mice. Cell Immunol. 2003; 222: 78-87.
17. Frasca D, Nguyen D, Riley RL, Blomberg BB. Decreased E12 and/or E47 transcription factor activity in the bone marrow as well as in the spleen of aged mice. J Immunol. 2003; 170: 719-726.
18. Warren LA, Rossi DJ. Stem cells and aging in the hematopoietic system. Mech Ageing Dev. 2008.
19. Rossi DJ, Jamieson CH, Weissman IL. Stems cells and the pathways to aging and cancer. Cell. 2008; 132: 681-696.
20. Weng NP. Telomere and adaptive immunity. Mech Ageing Dev. 2008; 129: 60-66.
21. Issa JP. Age-related epigenetic changes and the immune system. Clin Immunol. 2003; 109: 103-108.
22. Kim M, Moon HB, Spangrude GJ. Major age-related changes of mouse hematopoietic stem/progenitor cells. Ann N Y Acad Sci. 2003; 996: 195-208.
23. Rossi DJ, Bryder D, Zahn JM, Ahlenius H, Sonu R, Wagers AJ, Weissman IL. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci U S A. 2005; 102: 9194-9199.
24. Cho RH, Sieburg HB, Muller-Sieburg CE. A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells. Blood. 2008; 111: 5553-5561.
25. Mehr R, Shahaf G, Sah A, Cancro M. Asynchronous differentiation models explain bone marrow labeling kinetics and predict reflux between the pre- and immature B cell pools. Int Immunol. 2003; 15: 301-312.
26. Guerrettaz LM, Johnson SA, Cambier JC. Acquired hematopoietic stem cell defects determine B-cell repertoire changes associated with aging. Proc Natl Acad Sci U S A. 2008; 105: 11898-11902.
27. Miller JP, Cancro MP. B cells and aging: balancing the homeostatic equation. Exp Gerontol. 2007; 42: 396-399.
28. Linton PJ, Dorshkind K. Age-related changes in lymphocyte development and function. Nat Immunol. 2004; 5: 133-139.
29. Johnson SA, Cambier JC. Ageing, autoimmunity and arthritis: senescence of the B cell compartment - implications for humoral immunity. Arthritis Res Ther. 2004; 6: 131-139.
30. Kumar R, Burns EA. Age-related decline in immunity: implications for vaccine responsiveness. Expert Rev Vaccines. 2008; 7: 467-479.
31. Frasca D, Van der Put E, Riley RL, Blomberg BB. Reduced Ig class switch in aged mice correlates with decreased E47 and activation-induced cytidine deaminase. J Immunol. 2004; 172: 2155-2162.
32. Whisler RL, Grants IS. Age-related alterations in the activation and expression of phosphotyrosine kinases and protein kinase C (PKC) among human B cells. Mech Ageing Dev. 1993; 71: 31-46.
33. Dailey RW, Eun SY, Russell CE, Vogel LA. B cells of aged mice show decreased expansion in response to antigen, but are normal in effector function. Cell Immunol. 2001; 214: 99-109.
34. Zheng B, Han S, Takahashi Y, Kelsoe G. Immunosenescence and germinal center reaction. Immunol Rev. 1997; 160: 63-77.
35. Banerjee M, Mehr R, Belelovsky A, Spencer J, Dunn-Walters DK. Age- and tissue-specific differences in human germinal center B cell selection revealed by analysis of IgVH gene hypermutation and lineage trees. Eur J Immunol. 2002; 32: 1947-1957.
36. Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al- Regaiey K, Su L, Sharpless NE. Ink4a/Arf expression is a biomarker of aging. J Clin Invest. 2004; 114: 1299-1307.
37. Signer RA, Montecino-Rodriguez E, Witte ON, Dorshkind K. Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf. Genes Dev. 2008; 22: 3115-3120.
38. Merad M, Manz MG. Dendritic cell homeostasis. Blood. 2009; 113: 3418-3427.
39. Peter Klinken S. Red blood cells. Int J Biochem Cell Biol. 2002; 34: 1513-1518.
40. Min H, Montecino-Rodriguez E, Dorshkind K. Effects of aging on the common lymphoid progenitor to pro-B cell transition. J Immunol. 2006; 176: 1007-1012.
41. de La Rubia J, Diaz MA, Verdeguer A, Pascual MJ, Arbona C, Arrieta R, Brunet S, Bargay J, Martinez C, Espigado I, Serrano D, Alegre A, de Arriba F, de La Serna J, Zamora C, Benlloch L, Sanz MA. Donor age-related differences in PBPC mobilization with rHuG-CSF. Transfusion. 2001; 41: 201-205.
42. Eaton SM, Maue AC, Swain SL, Haynes L. Bone marrow precursor cells from aged mice generate CD4 T cells that function well in primary and memory responses. J Immunol. 2008; 181: 4825-4831.
43. Borghans JA, de Boer RJ. Quantification of T-cell dynamics: from telomeres to DNA labeling. Immunol Rev. 2007; 216: 35-47.
44. Mehr R, Segel L, Sharp A, Globerson A. Colonization of the Thymus by T Cell Progenitors: Models for Cell-Cell Interactions. Journal of Theoretical Biology. 1994; 170: 247-257.
45. Mehr R, Fridkis-Hareli M, Abel L, Segel L, Globerson A. Lymphocyte Development in Irradiated Thymuses: Dynamics of Colonization by Progenitor Cells and Regeneration of Resident Cells. Journal of Theoretical Biology. 1995; 177: 181-192.
46. Shahaf G, Allman D, Cancro MP, Mehr R. Screening of alternative models for transitional B cell maturation. Int Immunol. 2004; 16: 1081-1090.
47. Mehr R, Perelson AS, Fridkis-Hareli M, Globerson A. Feedback regulation of T cell development: manifestations in aging. Mechanisms of Ageing and Development. 1996; 91: 195- 210.
48. Mehr R, Perelson AS. Blind T-cell homeostasis and the CD4/CD8 ratio in the thymus and peripheral blood. J Acquir Immune Defic Syndr Hum Retrovirol. 1997; 14: 387-398.
49. Osmond DG. Proliferation kinetics and the lifespan of B cells in central and peripheral lymphoid organs. Curr Opin Immunol. 1991; 3: 179-185.
50. Allman DM, Ferguson SE, Lentz VM, Cancro MP. Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells. J Immunol. 1993; 151: 4431- 4444.
51. Freitas AA, Rocha B, Forni L, Coutinho A. Population dynamics of B lymphocytes and their precursors: demonstration of high turnover in the central and peripheral lymphoid organs. J Immunol. 1982; 128: 54-60.
52. Grabstein KH, Waldschmidt TJ, Finkelman FD, Hess BW, Alpert AR, Boiani NE, Namen AE, Morrissey PJ. Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody. J Exp Med. 1993; 178: 257-264.
53. Sudo T, Nishikawa S, Ohno N, Akiyama N, Tamakoshi M, Yoshida H, Nishikawa S-I. Expression and function of interleukin 7 receptor in murine lymphocytes. Proc. Natl. Acad. Sci. USA. 1993; 90: 9125-9129.
54. Hao Z, Rajewsky K. Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow. J Exp Med. 2001; 194: 1151-1164.
55. Cyster JG, Goodnow CC. Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate. Immunity. 1995; 3: 691-701.
56. Park YH, Osmond DG. Post-irradiation regeneration of early B-lymphocyte precursor cells in mouse bone marrow. Immunology. 1989; 66: 343-347.
57. Osmond DG, Fahlman MT, Fulop GM, Rahal DM. Regulation and localization of lymphocyte production in the bone marrow. Ciba Found Symp. 1981; 84: 68-86.
58. Cancro MP, Allman DM, Hayes CE, Lentz VM, Fields RG, Sah AP, Tomayko M. B cell maturation and selection at the marrowperiphery interface. Immunol Res. 1998; 17: 3-11.
59. Agenes F, Rosado MM, Freitas AA. Independent homeostatic regulation of B cell compartments. Eur J Immunol. 1997; 27: 1801-1807.
60. Li F, Jin F, Freitas A, Szabo P, Weksler ME. Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice. Eur J Immunol. 2001; 31: 500-505.
61. Beerman I, Bhattacharya D, Zandi S, Sigvardsson M, Weissman IL, Bryder D, Rossi DJ. Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion. Proc Natl Acad Sci U S A. 2010; 107: 5465-5470.
62. Mehr R, Abel L, Ubezio P, Globerson A, Agur Z. A mathematical model of the effect of aging on bone marrow cells colonizing the thymus. Mechanisms of Ageing and Development. 1993; 67: 159-172.
63. Sasaki Y, Casola S, Kutok JL, Rajewsky K, Schmidt-Supprian M. TNF family member B cell-activating factor (BAFF) receptordependent and -independent roles for BAFF in B cell physiology. J Immunol. 2004; 173: 2245-2252.
64. Edwards JC, Cambridge G. B-cell targeting in rheumatoid arthritis and other autoimmune diseases. Nat Rev Immunol. 2006; 6: 394-403.
65. Keren Z, Naor S, Nussbaum S, Golan K, Itkin T, Sasaki Y, Schmidt-Supprian M, Lapidot T, Melamed D. B cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging. Blood. 2011; In press.
66. Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature. 2005; 433: 760-764.
67. Rouziere AS, Kneitz C, Palanichamy A, Dorner T, Tony HP. Regeneration of the immunoglobulin heavy-chain repertoire after transient B-cell depletion with an anti-CD20 antibody. Arthritis Res Ther. 2005; 7: R714-724.