Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire

Journal of Immunology

Volumn 168, Issue 10, 2002, Pages 5014-5023

  Johnson, Sara A ^a   Rozzo, Stephen J ^a   Cambier, John C ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; CD23 ANTIGEN; CD5 ANTIGEN; COMPLEMENT COMPONENT C3D RECEPTOR; DOUBLE STRANDED DNA; HISTONE; IMMUNOGLOBULIN M; SINGLE STRANDED DNA;

AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY DETECTION; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GAMMA IRRADIATION; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; TRANSGENIC MOUSE;

EID: 0037094083     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.10.5014     Document Type: Article

References (80)

1. Molecular alterations in the aging immune system
2. Immunosenescence
3. Ageing of lymphocytes and lymphocytes in the aged
4. + T cells from aged mice display functional and phenotypic characteristics of memory cells
5. hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A
6. + T cells
7. + lymphocytes in the aged microenvironment results in a memory-enriched population
8. Age-related changes of expression of IL-2 receptor subunits and kinetics of IL-2 internalization in T cells after mitogenic stimulation
9. Interleukin 2 receptor expression by T cells in human aging
10. Defective expression of high affinity IL-2 receptors on activated T cells from aged humans
11. + T cells from young and aged mice
12. + T cells from young and old mice
13. Cytokine production by T lymphocytes from young and aged mice
14. Age-associated decline in IL-4 production by murine T lymphocytes in extended culture
15. Lineagespecific telomere shortening and unaltered capacity for telomerase expression in human T and B lymphocytes with age
16. Tales of tails: Regulation of telomere length and telomerase activity during lymphocyte development, differentiation activation, and aging
17. Early activation defects in T lymphocytes from aged mice
18. Effect of aging on T lymphocyte activation
19. Effect of age on humoral immunity, selection of the B-cell repertoire and B-cell development
20. + B cells
21. Clonal expansions of B lymphocytes in old mice
22. VH-gene family dominance in ageing mice
23. Altered VH gene segment utilization in the response to phosphorylcholine by aged mice
24. Effect of age on the expressed B cell repertoire: Role of B cell subsets
25. Cellular basis of B cell clonal populations in old mice
26. Immunosenescence and germinal center reaction
27. Signal transduction in human B cells during aging: Alterations in stimulus-induced phosphorylations of tyrosine and serine/threonine substrates and in cytosolic calcium responsiveness
28. Age-related alterations in the activation and expression of phosphotyrosine kinases and protein kinase C (PKC) among human B cells
29. Stage-specific alterations in murine B lymphopoiesis with age
30. Age-related changes in the capability of the bone marrow to generate B cells
31. B cell precursors are decreased in senescent BALB/c mice, but retain normal mitotic activity in vivo and in vitro
32. Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice
33. B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation
34. "Cross-wiring" of the immune response in old mice: Increased autoantibody response despite reduced antibody response to nominal antigen
35. Similarities in B cell repertoire development between autoimmune and aging normal mice
36. A selective increase in the generation of phosphorylcholine-specific B cells associated with aging
37. Autoantibodies in highly aged humans
38. Autoantibodies to T-lineage cells in aged mice
39. Dysregulation of the humoral immune response in old mice
40. Peripheral deletion of self-reactive B cells
41. 1 mice
42. Autoimmunization in murine graft-vs-host disease I. Selective production of antibodies to histones and DNA
43. Control of multiple autoantibodies linked with a lupus nephritis susceptibility locus in New Zealand Black mice
44. Monoclonal anti-histone autoantibodies derived from murine models of lupus
45. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
46. CD19 expression levels regulate B lymphocyte development: Human CD19 restores normal function in mice lacking endogenous CD19
47. Antigen responsiveness of the mature and generative B cell populations of aged mice
48. Lifespan of lymphocytes
49. Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells
50. CD45 expression by B cells: Expression of different CD45 isoforms by subpopulations of activated B cells
51. - memory B cell compartment
52. Induction of CD45 isoform switch in murine B cells by antigen receptor stimulation and by phorbol myristate acetate and ionomycin
53. Immunological memory in T Cells
54. CD45: An emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development
55. CD45: A family of leukocytespecific cell surface glycoproteins
56. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals
57. high splenic B cells enriched in the marginal zone: Distinct phenotypes and functions
58. Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity
59. Alterations in splenic architecture and the localization of anti-double-stranded DNA B cells in aged mice
60. Changes in frequencies of clonable pre-B cells during life in different lymphoid organs of mice
61. Impaired ability of bone marrow stromal cells to support B-lymphopoiesis with age
62. Age-associated changes in the B-cell repertoire: Effect of age on RAG-1 gene expression in murine bone marrow
63. Age-associated defects in B lymphocyte development
64. The reduced expression of surrogate light chains in B cell precursors from senescent BALB/c mice is associated with decreased E2A proteins
65. Senescent BALB/c mice exhibit decreased expression of γ5 surrogate light chains and reduced development within the pre-B cell compartment
66. Surrogate or conventional light chains are required for membrane immunoglobulin μ to activate the precursor B cell transition
67. Development of B cells in aged mice: Decline in the ability of pro-B cells to respond to IL-7 but not to other growth factors
68. Autoantibodies inhibit interleukin-7-mediated proliferation and are associated with the age-dependent loss of pre-B cells in autoimmune New Zealand Black mice
69. Endogenous VH gene family expression in immunoglobulin-transgenic mice: Evidence for selection of antibody repertoires
70. Adhesive interactions in thymic development: Does selective expression of CD45 isoforms promote stage-specific microclustering in the assembly of functional adhesive complexes on differentiating T lineage lymphocytes?
71. + T cell subsets according to their expression of CD45 isotypes
72. B-cell homotypic adhesion through exon-A restricted epitopes of CD45 involves LFA-1/ICAM-1, ICAM-3 interactions, and induces coclustering of CD45 and LFA-1
73. Combinatorial effect of T-cell receptor ligation and CD45 isoform expression on the signaling contribution of the small GTPases ras and rapl
74. Specific CD45 isoforms differentially regulate T cell receptor signaling
75. B-cell subsets and the mature preimmune repertoire: Marginal zone and B1 B cells as part of a "natural immune memory."
76. The origin of marginal-zone cells
77. -/- mice
78. + B cells both in vivo and in vitro
79. B-1 cells are made, not born