Effects of aging on hematopoietic stem and progenitor cells

Current Opinion in Immunology

Volumn 21, Issue 4, 2009, Pages 408-413

  Waterstrat, Amanda ^a   Van Zant, Gary ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE PROTEIN; DNA; REACTIVE OXYGEN METABOLITE;

AGING; BONE MARROW; CELL AGING; CELL FUNCTION; CELL HOMING; CELL LINEAGE; CELL METABOLISM; CELL RENEWAL; CELL SURFACE; DNA REPAIR; ENGRAFTMENT; EPIGENETICS; FLUORESCENCE ACTIVATED CELL SORTING; GENETIC TRANSCRIPTION; GENOME ANALYSIS; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC SYSTEM; HUMAN; MICROARRAY ANALYSIS; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; STEM CELL MOBILIZATION; TELOMERE;

AGING; ANIMALS; ANTIGENS, DIFFERENTIATION; CELL AGING; CELL LINEAGE; DNA REPAIR; HEMATOPOIETIC STEM CELLS; HUMANS; TRANSCRIPTIONAL ACTIVATION;

EID: 68149168943     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2009.05.002     Document Type: Review

References (62)

1. Hayflick L. How and why we age. Exp Gerontol 33 (1998) 639-653
2. Rando T. Stem cells, ageing and the quest for immortality. Nautre 441 (2006) 1080-1086
3. Sharpless N.E., and DePinho R.A. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 8 (2007) 703-713
4. Chen J., Astle C.M., and Harrison D.E. Genetic regulation of primitive hematopoietic stem cell senescence. Exp Hematol 28 (2000) 442-450
5. de Haan G., and Van Zant G. Dynamic changes in mouse hematopoietic stem cell numbers during aging. Blood 93 (1999) 3294-3301
6. Harrison D.E., Astle C.M., and Stone M. Numbers and functions of transplantable primitive immunohematopoietic stem cells. Effects of age. J Immunol 142 (1989) 3833-3840
7. Morrison S.J., Wandycz A., Akashi K., Globerson A., and Weissman I.L. The aging of hematopoietic stem cells. Nat Med 2 (1996) 1011-1016
8. Harrison D.E. Mouse erythropoietic stem cell lines function normally 100 months: loss related to number of transplantations. Mech Ageing Dev 9 (1979) 427-433
9. Harrison D.E., and Astle C.M. Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and transplantation procedure. J Exp Med 156 (1982) 1767-1779
10. Kamminga L.M., van Os R., Ausema A., Noach E.J., Weersing E., Dontje B., Vellenga E., and de Haan G. Impaired hematopoietic stem cell functioning after serial transplantation and during normal aging. Stem Cells 23 (2005) 82-92
11. Geiger H., True J.M., de Haan G., and Van Zant G. Age- and stage-specific regulation patterns in the hematopoietic stem cell hierarchy. Blood 98 (2001) 2966-2972
12. Waterstrat A., Oakley E.J., Miller A., Swiderski C., Liang Y., and Van Zant G. Mechanisms of stem cell aging. In: Rudolph K.L. (Ed). Telomeres and Telomerase in Ageing, Disease, and Cancer (2008), Springer 111-140
13. INK4a. Nature 443 (2006) 421-426
14. Siminovitch L., Till J., and McCulloch E. Decline in colony-forming ability of marrow cells subjected to serial transplantation into irradiated mice. J Cell Physiol 64 (1964) 23-31
15. Chambers S.M., Shaw C.A., Gatza C., Fisk J.C., Donehower L.A., and Goodell M.A. Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol 5 (2007) e201
16. Rossi D.J., Bryder D., Zahn J.M., Ahlenius H., Sonu R., Wagers A.J., and Weissman I.L. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci U S A 102 (2005) 9194-9199
17. Dykstra B., Kent D., Bowie M., McCaffrey L., Hamilton M., Lyons K., Lee S.-J., Brinkman R., and Eaves C. Long-term propagation of distinct hematopoietic differentiation programs in vivo. Cell Stem Cell 1 (2007) 218-229. This study revealed four distinct classes of transplantable HSCs associated with unique patterns of blood cell production and differences in self-renewal capacity.
18. Sieburg H.B., Cho R.H., Dykstra B., Uchida N., Eaves C.J., and Muller-Sieburg C.E. The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets. Blood 107 (2006) 2311-2316. This study revealed predictable heterogeneity in the hematopoietic compartment consisting of three distinct classes of HSCs that generate unique patterns of blood cell production.
19. Cho R.H., Sieburg H.B., and Muller-Sieburg C.E. A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells. Blood 111 (2008) 5553-5561. This paper describes a shift in the clonal composition of the HSC compartment in two mouse strains during aging revealing similar, yet genotype-influenced, expansion of a myeloid-biased HSC population.
20. Muller-Sieburg C.E., and Sieburg H.B. Stem cell aging: survival of the laziest. Cell Cycle 7 (2008) 3798-3804. This is an excellent review describing the implications of a model for stem cell aging in which a shift in the clone composition, rather than changes in individual HSCs, underlies age-associated changes in the hematopoietic system.
21. Dykstra B., and de Haan G. Hematopoietic stem cell aging and self-renewal. Cell Tissue Res 331 (2008) 91-101. This review provides an excellent summary of genotype-restricted patterns of HSC aging.
22. Van Zant G., and Liang Y. The role of stem cells in aging. Exp Hematol 31 (2003) 659-672
23. Warren L.A., and Rossi D.J. Stem cells and aging in the hematopoietic system. Mech Ageing Dev 130 (2009) 46-53
24. Harrison D.E. Long-term erythropoietic repopulating ability of old, young, and fetal stem cells. J Exp Med 157 (1983) 1496-1504
25. Yilmaz O.H., Kiel M.J., and Morrison S.J. SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity. Blood 107 (2006) 924-930
26. Liang Y., Van Zant G., and Szilvassy S.J. Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells. Blood 106 (2005) 1479-1487
27. Pearce D.J., Anjos-Afonso F., Ridler C.M., Eddaoudi A., and Bonnet D. Age-dependent increase in side population distribution within hematopoiesis: implications for our understanding of the mechanism of aging. Stem Cells 25 (2007) 828-835
28. Xing Z., Ryan M.A., Daria D., Nattamai K., Van Zant G., Wang L., Zheng Y., and Geiger H. Increased hematopoietic stem cell mobilization in aged mice. Blood 108 (2006) 2190-2197
29. Purton L.E., and Scadden D.T. Limiting factors in murine hematopoietic stem cell assays. Cell Stem Cell 1 (2007) 263-270
30. Wilson A., Laurenti E., Oser G., van der Wath R.C., Blanco-Bose W., Jaworski M., Offner S., Dunant C.F., Eshkind L., Bockamp E., et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 135 (2008) 1118-1129
31. Kiel M.J., Yilmaz O.H., Iwashita T., Yilmaz O.H., Terhorst C., and Morrison S.J. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121 (2005) 1109-1121
32. Morrison S.J., Wright D., and Weissman I.L. Cyclophosphamide/granulocyte colony-stimulating factor induces hematopoietic stem cell to proliferate prior to mobilization. Proc Natl Acad Sci U S A 94 (1997) 1908-1913
33. Uchida N., Dykstra B., Lyons K., Leung F., Kristiansen M., and Eaves C. ABC transporter activities of murine hematopoietic stem cells vary according to their developmental and activation status. Blood 103 (2004) 4487-4495
34. Nijnik A., Woodbine L., Marchetti C., Dawson S., Lambe T., Liu C., Rodrigues N.P., Crockford T.L., Cabuy E., Vindigni A., et al. DNA repair is limiting for haematopoietic stem cells during ageing. Nature 447 (2007) 686-690
35. -/- mice. EMBO J 24 (2005) 861-871
36. Rossi D.J., Bryder D., and Weissman I.L. Hematopoietic stem cell aging: mechanism and consequence. Exp Gerontol 42 (2007) 385-390
37. Passos J.F., Saretzki G., and von Zglinicki T. DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?. Nucleic Acids Res 35 (2007) 7505-7513
38. Raaijmakers M.H. ATP-binding-cassette transporters in hematopoietic stem cells and their utility as therapeutical targets in acute and chronic myeloid leukemia. Leukemia 21 (2007) 2094-2102
39. Allsopp R.C., Morin G.B., DePinho R.A., Harley C.B., and Weissman I.L. Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood 102 (2003) 517-520
40. Ito K., Hirao A., Arai F., Matsuoka S., Takubo K., Hamaguchi I., Nomiyama K., Hosokawa K., Sakurada K., Nakagata N., et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 431 (2004) 997-1002
41. Ito K., Hirao A., Arai F., Takubo K., Matsuoka S., Miyamoto K., Ohmura M., Naka K., Hosokawa K., Ikeda Y., et al. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med 12 (2006) 446-451
42. Miyamoto K., Araki K.Y., Naka K., Arai F., Takubo K., Yamazaki S., Matsuoka S., Miyamoto T., Ito K., Ohmura M., et al. Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell 1 (2007) 101-112
43. Tothova Z., Kollipara R., Huntly B.J., Lee B.H., Castrillon D.H., Cullen D.E., McDowell E.P., Lazo-Kallanian S., Williams I.R., Sears C., et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 128 (2007) 325-339
44. Parmar K., Mauch P., Vergilio J.-A., Sackstein R., and Down J.D. Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc Natl Acad Sci U S A 104 (2007) 5431-5436
45. Kim H.J., Jung K.J., Yu B.P., Cho C.G., Choi J.S., and Chung H.Y. Modulation of redox-sensitive transcription factors by calorie restriction during aging. Mech Ageing Dev 123 (2002) 1589-1595
46. Sohal R.S., and Weindruch R. Oxidative stress, caloric restriction, and aging. Science 273 (1996) 59-63
47. Ertl R.P., Chen J., Astle C.M., Duffy T.M., and Harrison D.E. Effects of dietary restriction on hematopoietic stem-cell aging are genetically regulated. Blood 111 (2008) 1709-1716
48. Larsson J., Ohishi M., Garrison B., Aspling M., Janzen V., Adams G.B., Curto M., McClatchey A.I., Schipani E., and Scadden D.T. Nf2/merlin regulates hematopoietic stem cell behavior by altering microenvironmental architecture. Cell Stem Cell 3 (2008) 221-227
49. Wagner W., Horn P., Bork S., and Ho A.D. Aging of hematopoietic stem cells is regulated by the stem cell niche. Exp Gerontol 43 (2008) 974-980
50. Labrie III J.E., Borghesi L., and Gerstein R.M. Bone marrow microenvironmental changes in aged mice compromise V(D)J recombinase activity and B cell generation. Semin Immunol 17 (2005) 347-355
51. Rosen C.J., and Bouxsein M.L. Mechanisms of disease: is osteoporosis the obesity of bone?. Nat Clin Pract Rheumatol 2 (2006) 34-43
52. + hematopoietic progenitor cells. Rejuvenation Res 10 (2007) 459-472
53. Ju Z., Jiang H., Jaworski M., Rathinam C., Gompf A., Klein C., Trumpp A., and Rudolph K.L. Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment. Nat Med 13 (2007) 742-747. This is an excellent study demonstrating that aging and telomere attrition in the bone marrow microenvironment influence HSC function.
54. Song Z., Ju Z., and Rudolph K.L. Cell intrinsic and extrinsic mechanisms of stem cell aging depend on telomere status. Exp Gerontol 44 (2009) 75-82
55. Celso C.L., Fleming H.E., Wu J.W., Zhao C.X., Miake-Lye S., Fujisaki J., Côté D., Rowe D.W., Lin C.P., and Scadden D.T. Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche. Nature 457 (2009) 92-96. This paper describes a novel method for HSC visualization and reveals differences in the localization of various subsets of hematopoietic cells based on differentiation status.
56. Xie Y., Ying T., Wiegraebe W., He X.C., Miller D., Stark D., Perko K., Alexander R., Schwartz J., Grindley J.C., et al. Detection of functional haematopoietic stem cell niche using real-time imaging. Nature 457 (2009) 97-101. This paper presents a novel method for visualizing transplanted HSCs in the long bones of mice and reveals distinct patterns of stem cell localization in irradiated verses nonirradiated recipients.
57. Méndez-Ferrer S., Lucas D., Battista M., and Frenette P.S. Haematopoietic stem cell release is regulated by circadian oscilations. Nature 452 (2008) 442-447. This paper provides the first demonstration of circadian regulation of HSC trafficking.
58. Massberg S., Schaerli P., Knezevic-Maramica I., Kollnberger M., Tubo N., Moseman E.A., Huff I.V., Junt T., Wagers A.J., Mazo I.B., et al. Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell Stem Cell 131 (2007) 994-1008
59. Thijssen D.H., Vos J.B., Versevden C., van Zonneveld A.J., Smits P., Sweep F.C., Hopman M.T., and de Boer H.C. Haematopoietic stem cells and endothelial progenitor cells in healthy men: effect of aging and training. Aging Cell 5 (2006) 495-503
60. Bhandoola A., von Boehmer H., Petrie H.T., and Zúñiga-Pflücker J.C. Commitment and developmental potential of extrathymic and intrathymic T-cell precursors: plenty to choose from. Immunity 26 (2007) 678-689
61. Min H., Montecino-Rodriques E., and Dorshkind K. Reduction in the developmental potential of intrathymic T cell progenitors with age. J Immunol 173 (2004) 245-250
62. Zhu X., Gui J., Cheng L., Barnes P., and Su D. Lymphohmatopoietic progenitors do not have a synchronized defect with age-related thymic involution. Aging Cell 6 (2007) 663-672