메뉴 건너뛰기




Volumn 21, Issue 3, 2009, Pages 201-209

Immunosenescence and vaccine failure in the elderly

Author keywords

Adaptive immunity; Frailty; Immunosenescence; Innate immunity; Vaccination

Indexed keywords

CYTOKINE; DIPHTHERIA PERTUSSIS TETANUS VACCINE; INFLUENZA VACCINE; PNEUMOCOCCUS VACCINE; VARICELLA ZOSTER VACCINE;

EID: 67651151156     PISSN: 15940667     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03324904     Document Type: Review
Times cited : (225)

References (85)
  • 1
    • 0030619342 scopus 로고    scopus 로고
    • Doubling of world population unlikely
    • Lutz W, Sanderson W, Scherbov S. Doubling of world population unlikely. Nature 1997; 387: 803-805
    • (1997) Nature , vol.387 , pp. 803-805
    • Lutz, W.1    Sanderson, W.2    Scherbov, S.3
  • 4
    • 42449116960 scopus 로고    scopus 로고
    • Natural killer cells: Diversity in search of a niche
    • Di Santo JP. Natural killer cells: diversity in search of a niche. Nat Immunol 2008; 9: 473-475
    • (2008) Nat Immunol , vol.9 , pp. 473-475
    • Di Santo, J.P.1
  • 5
    • 0028299684 scopus 로고
    • Effects of aging on natural killer cell activity and activation by interleukin-2 and IFN-alpha
    • Kutza J, Murasako DM. Effects of aging on natural killer cell activity and activation by interleukin-2 and IFN-alpha. Cell Immunol 1994; 155: 195-204.
    • (1994) Cell Immunol , vol.155 , pp. 195-204
    • Kutza, J.1    Murasako, D.M.2
  • 6
    • 0030607135 scopus 로고    scopus 로고
    • Age-associated decline in IL-2 and IL-12 induction of LAK cell activity of human PBMC samples
    • Kutza J. Murasko DM. Age-associated decline in IL-2 and IL-12 induction of LAK cell activity of human PBMC samples. Mech Ageing Dev 1996; 90: 209-222
    • (1996) Mech Ageing Dev , vol.90 , pp. 209-222
    • Kutza, J.1    Murasko, D.M.2
  • 7
    • 0033951533 scopus 로고    scopus 로고
    • NK and NK/T cells in human senescence
    • Solana R, Mariani E. NK and NK/T cells in human senescence. Vaccine 2000; 18: 1613-1620
    • (2000) Vaccine , vol.18 , pp. 1613-1620
    • Solana, R.1    Mariani, E.2
  • 8
    • 0034916891 scopus 로고    scopus 로고
    • Association between natural killer cell activity and infection in immunologically normal elderly people
    • Ogata K, An E, Shioi Y et al. Association between natural killer cell activity and infection in immunologically normal elderly people. Clin Exp Immunol 2001; 124: 392-397
    • (2001) Clin Exp Immunol , vol.124 , pp. 392-397
    • Ogata, K.1    An, E.2    Shioi, Y.3
  • 9
    • 34447324973 scopus 로고    scopus 로고
    • Immunological biomarkers of ageing in man: Changes in both innate and adaptive immunity are associated with health and longevity
    • De la Rosa O, Pawelec G, Peralbo E et al. Immunological biomarkers of ageing in man: changes in both innate and adaptive immunity are associated with health and longevity. Biogerontology 2006; 7: 471-481
    • (2006) Biogerontology , vol.7 , pp. 471-481
    • De La Rosa, O.1    Pawelec, G.2    Peralbo, E.3
  • 10
    • 0031240062 scopus 로고    scopus 로고
    • Natural killer cells in the late decades of human life
    • Ogata K, Yokose N, Tamura H et al. Natural killer cells in the late decades of human life. Clin Immunol Immunopathol 1997; 84: 269-275
    • (1997) Clin Immunol Immunopathol , vol.84 , pp. 269-275
    • Ogata, K.1    Yokose, N.2    Tamura, H.3
  • 11
    • 0031920023 scopus 로고    scopus 로고
    • T cell immunosenescence and its clinical relevance in man
    • Remarque E, Pawelec G. T cell immunosenescence and its clinical relevance in man. Rev Clin Gerontol 1998; 8: 5-14.
    • (1998) Rev Clin Gerontol , vol.8 , pp. 5-14
    • Remarque, E.1    Pawelec, G.2
  • 13
    • 0027381336 scopus 로고
    • Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians
    • Sansoni P, Cossarizza A, Brianti V et al. Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians. Blood 1993; 82: 2767-2773
    • (1993) Blood , vol.82 , pp. 2767-2773
    • Sansoni, P.1    Cossarizza, A.2    Brianti, V.3
  • 14
    • 0028891555 scopus 로고
    • The immunology of exceptional individuals: The lesson of centenarians
    • Franceschi C, Monti D, Sansoni P, Cossarizza A. The immunology of exceptional individuals: the lesson of centenarians. Immunol Today 1995; 16: 12-16
    • (1995) Immunol Today , vol.16 , pp. 12-16
    • Franceschi, C.1    Monti, D.2    Sansoni, P.3    Cossarizza, A.4
  • 15
    • 33845898737 scopus 로고    scopus 로고
    • Steady-state and inflammatory dendritic-cell development
    • Shortman K, Naik SH, Steady-state and inflammatory dendritic-cell development. Nat Rev Immunol 2007; 7: 19-30.
    • (2007) Nat Rev Immunol , vol.7 , pp. 19-30
    • Shortman, K.1    Naik, S.H.2
  • 16
    • 34548544885 scopus 로고    scopus 로고
    • Dendritic cell subsets in health and disease
    • Ueno H, Klechevsky E, Morita R et al. Dendritic cell subsets in health and disease. Immunol Rev 2007; 219: 118-142
    • (2007) Immunol Rev , vol.219 , pp. 118-142
    • Ueno, H.1    Klechevsky, E.2    Morita, R.3
  • 17
    • 17644372733 scopus 로고    scopus 로고
    • IPC: Professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors
    • Liu YJ. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu Rev Immunol 2005; 23: 275-306.
    • (2005) Annu Rev Immunol , vol.23 , pp. 275-306
    • Liu, Y.J.1
  • 18
    • 33846046984 scopus 로고    scopus 로고
    • Peripheral blood dendritic cells and monocytes are differentially regulated in the elderly
    • Della Bella S, Bierti L, Presicce P et al. Peripheral blood dendritic cells and monocytes are differentially regulated in the elderly. Clin Immunol 2007; 122: 220-228
    • (2007) Clin Immunol , vol.122 , pp. 220-228
    • Della Bella, S.1    Bierti, L.2    Presicce, P.3
  • 19
    • 0344153742 scopus 로고    scopus 로고
    • Age-dependent changes in thymic macrophages and dendritic cells
    • Varas A, Sacédon R, Hernandez-López C et al. Age-dependent changes in thymic macrophages and dendritic cells. Microsc Res Tech 2003; 62: 501-507
    • (2003) Microsc Res Tech , vol.62 , pp. 501-507
    • Varas, A.1    Sacédon, R.2    Hernandez-López, C.3
  • 21
    • 84889251574 scopus 로고    scopus 로고
    • NK cells in human ageing
    • In Fülöp T, Hirokawa H, Pawelec G, Franceschi C, eds. Berlin: Springer Science (in press)
    • Tarazona R, Gayoso I, Alonso C et al. NK cells in human ageing. In Fülöp T, Hirokawa H, Pawelec G, Franceschi C, eds. Ageing, Immunity and Inflammation. Berlin: Springer Science 2009 (in press).
    • (2009) Ageing, Immunity and Inflammation
    • Tarazona, R.1    Gayoso, I.2    Alonso, C.3
  • 22
    • 0033911488 scopus 로고    scopus 로고
    • Inflamm-aging. An evolutionary perspective on immunosenescence
    • Franceschi C, Bonafè M, Valensin S et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann NY Acad Sci 2000; 908: 244-254
    • (2000) Ann NY Acad Sci , vol.908 , pp. 244-254
    • Franceschi, C.1    Bonafè, M.2    Valensin, S.3
  • 23
    • 0022377731 scopus 로고
    • The involution of the ageing human thymic epithelium is independent of puberty. a morphometric study
    • Steinmann GG, Klaus B, Müller-Hermelink HK. The involution of the ageing human thymic epithelium is independent of puberty. A morphometric study. Scand J Immunol 1985; 22: 563-575
    • (1985) Scand J Immunol , vol.22 , pp. 563-575
    • Steinmann, G.G.1    Klaus, B.2    Müller-Hermelink, H.K.3
  • 24
    • 11144267995 scopus 로고    scopus 로고
    • Age-related loss of naïve T cells and dysregulation of T-cell/B-cell interactions in human lymph nodes
    • Lazuardi L, Jenewein B, Wolf AM, Pfister G, Tzankov A, Grubeck-Loebenstein B. Age-related loss of naïve T cells and dysregulation of T-cell/B-cell interactions in human lymph nodes. Immunology 2005; 114: 37-43.
    • (2005) Immunology , vol.114 , pp. 37-43
    • Lazuardi, L.1    Jenewein, B.2    Wolf, A.M.3    Pfister, G.4    Tzankov, A.5    Grubeck-Loebenstein, B.6
  • 25
    • 33744477359 scopus 로고    scopus 로고
    • Naïve T cells in the elderly. Are they still there?
    • Pfister G, Weiskopf D, Lazuardi L et al. Naïve T cells in the elderly. Are they still there? Ann NY Acad Sci 2006; 1067: 152-157
    • (2006) Ann NY Acad Sci , vol.1067 , pp. 152-157
    • Pfister, G.1    Weiskopf, D.2    Lazuardi, L.3
  • 26
    • 0036604275 scopus 로고    scopus 로고
    • Lack of antibody production following immunization in old age: Association with CD8(+)CD28(-) T cell expansions and an imbalance in the production of Th1 and Th2 cytokines
    • Saurwein-Teissl M, Lung TL, Marx F et al. Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell expansions and an imbalance in the production of Th1 and Th2 cytokines. J Immunol 2002; 168: 5893-5899
    • (2002) J Immunol , vol.168 , pp. 5893-5899
    • Saurwein-Teissl, M.1    Lung, T.L.2    Marx, F.3
  • 27
    • 0037221256 scopus 로고    scopus 로고
    • IL-4 producing CD8+ T cells with a CD62L++(bright) phenotype accumulate in a subgroup of older adults and are associated with the maintenance of intact humoral immunity in old age
    • Schwaiger S, Wolf A-M, Robatscher P, Jenewein B, Grubeck-Loebenstein B. IL-4 producing CD8+ T cells with a CD62L++(bright) phenotype accumulate in a subgroup of older adults and are associated with the maintenance of intact humoral immunity in old age. J Immunol 2003; 170: 613-619
    • (2003) J Immunol , vol.170 , pp. 613-619
    • Schwaiger, S.1    Wolf, A.-M.2    Robatscher, P.3    Jenewein, B.4    Grubeck-Loebenstein, B.5
  • 28
    • 22544432524 scopus 로고    scopus 로고
    • CD25-expressing CD8+ T cells are potent memory cells in old age
    • Hemdler-Brandstetter D, Schwaiger S, Veel E et al. CD25-expressing CD8+ T cells are potent memory cells in old age. J Immunol 2005; 175: 1566-1574
    • (2005) J Immunol , vol.175 , pp. 1566-1574
    • Hemdler-Brandstetter, D.1    Schwaiger, S.2    Veel, E.3
  • 29
    • 34248139722 scopus 로고    scopus 로고
    • Subject classification obtained by cluster analysis and principal component analysis applied to flow cytometric data
    • Lugli E, Pinti M, Nasi M et al. Subject classification obtained by cluster analysis and principal component analysis applied to flow cytometric data. Cytometry A 2007; 71: 334-344
    • (2007) Cytometry a , vol.71 , pp. 334-344
    • Lugli, E.1    Pinti, M.2    Nasi, M.3
  • 30
    • 33646546302 scopus 로고    scopus 로고
    • Aging of the immune system: How much can the adaptive immune system adapt?
    • Weng N. Aging of the immune system: how much can the adaptive immune system adapt? Immunity 2006; 24: 495-499
    • (2006) Immunity , vol.24 , pp. 495-499
    • Weng, N.1
  • 31
    • 14744281718 scopus 로고    scopus 로고
    • Long term CMV infection leads to significant changes in the composition of the CD8+ T cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons
    • Almanzar G, Schwaiger S, Jenewein B et al. Long term CMV infection leads to significant changes in the composition of the CD8+ T cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons. J Virol 2005; 79: 3675-3683
    • (2005) J Virol , vol.79 , pp. 3675-3683
    • Almanzar, G.1    Schwaiger, S.2    Jenewein, B.3
  • 32
    • 0037103256 scopus 로고    scopus 로고
    • Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals
    • Khan N, Shariff N, Cobbold M et al. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J Immunol 2002; 169: 1984-1992
    • (2002) J Immunol , vol.169 , pp. 1984-1992
    • Khan, N.1    Shariff, N.2    Cobbold, M.3
  • 33
    • 0042206627 scopus 로고    scopus 로고
    • Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1)
    • Ouyang Q, Wagner WM, Voehringer D et al. Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1). Exp Gerontol 2003; 38: 911-920
    • (2003) Exp Gerontol , vol.38 , pp. 911-920
    • Ouyang, Q.1    Wagner, W.M.2    Voehringer, D.3
  • 34
    • 0035915757 scopus 로고    scopus 로고
    • Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: The Swedish longitudinal OCTO immune study
    • Olsson J, Wikby A, Johansson B, Lofgren S, Nilsson BO, Ferguson FG. Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech Ageing Dev 2000; 121: 187-201.
    • (2000) Mech Ageing Dev , vol.121 , pp. 187-201
    • Olsson, J.1    Wikby, A.2    Johansson, B.3    Lofgren, S.4    Nilsson, B.O.5    Ferguson, F.G.6
  • 36
    • 0037012021 scopus 로고    scopus 로고
    • Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: The Swedish NONA immune study
    • Wikby A, Johansson B, Olsson J, Lofgren S, Nilsson BO, Ferguson F. Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp Gerontol 2002; 37: 445-453
    • (2002) Exp Gerontol , vol.37 , pp. 445-453
    • Wikby, A.1    Johansson, B.2    Olsson, J.3    Lofgren, S.4    Nilsson, B.O.5    Ferguson, F.6
  • 37
    • 0032524932 scopus 로고    scopus 로고
    • Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: The Swedish longitudinal OCTO-immune study
    • Wikby A, Maxson P, Olsson J, Johansson B, Ferguson FG. Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study. Mech Ageing Dev 1998; 102: 187-198
    • (1998) Mech Ageing Dev , vol.102 , pp. 187-198
    • Wikby, A.1    Maxson, P.2    Olsson, J.3    Johansson, B.4    Ferguson, F.G.5
  • 38
    • 0028839467 scopus 로고
    • Immune parameters in a longitudinal study of a very old population of Swedish people: A comparison between survivors and nonsurvivors
    • Ferguson FG, Wikby A, Maxson P, Olsson J, Johansson B. Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and nonsurvivors. J Gerontol A Biol Sci Med Sci 1995; 50: B378-82.
    • (1995) J Gerontol a Biol Sci Med Sci , vol.50
    • Ferguson, F.G.1    Wikby, A.2    Maxson, P.3    Olsson, J.4    Johansson, B.5
  • 39
    • 32044433093 scopus 로고    scopus 로고
    • Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional CMV specific T cells in the very elderly
    • Hadrup SR, Strindhall J, Kollgaard T et al. Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional CMV specific T cells in the very elderly. J Immunol 2006; 176: 2645-2653
    • (2006) J Immunol , vol.176 , pp. 2645-2653
    • Hadrup, S.R.1    Strindhall, J.2    Kollgaard, T.3
  • 40
    • 33745451585 scopus 로고    scopus 로고
    • The immune risk phenotype is associated with IL-6 in the terminal decline stage: Findings from the Swedish NONA immune longitudinal study of very late functioning
    • Wikby A, Nilsson BO, Forsey R et al. The immune risk phenotype is associated with IL-6 in the terminal decline stage: findings from the Swedish NONA immune longitudinal study of very late functioning. Mech Ageing Dev 2006; 127: 695-704.
    • (2006) Mech Ageing Dev , vol.127 , pp. 695-704
    • Wikby, A.1    Nilsson, B.O.2    Forsey, R.3
  • 41
    • 23044433753 scopus 로고    scopus 로고
    • Homeostasis and the age-associated defect of CD4 T cells
    • Swain S, Clise-Dwyer K, Haynes L. Homeostasis and the age-associated defect of CD4 T cells. Semin Immunol 2005; 17: 370-377
    • (2005) Semin Immunol , vol.17 , pp. 370-377
    • Swain, S.1    Clise-Dwyer, K.2    Haynes, L.3
  • 42
    • 27144529078 scopus 로고    scopus 로고
    • Age-related differences in phenotype and function of CD4+ T cells are due to a phenoytypic shift from naïve to memory effector CD4+ T cells
    • Kovaiou RD, Weiskirchner I, Keller M, Pfister G, Cioca DP, Grubeck-Loebenstein B. Age-related differences in phenotype and function of CD4+ T cells are due to a phenoytypic shift from naïve to memory effector CD4+ T cells. Int Immunol 2005; 17: 1359-1366
    • (2005) Int Immunol , vol.17 , pp. 1359-1366
    • Kovaiou, R.D.1    Weiskirchner, I.2    Keller, M.3    Pfister, G.4    Cioca, D.P.5    Grubeck-Loebenstein, B.6
  • 43
    • 2942746461 scopus 로고    scopus 로고
    • Age-associated change in the frequency of memory CD4+ T cells impair long term CD4+ T cell responses to influenza vaccine
    • Kang I, Hong MS, Nolasco H et al. Age-associated change in the frequency of memory CD4+ T cells impair long term CD4+ T cell responses to influenza vaccine. J Immunol 2004; 173: 673-681
    • (2004) J Immunol , vol.173 , pp. 673-681
    • Kang, I.1    Hong, M.S.2    Nolasco, H.3
  • 44
    • 49749119446 scopus 로고    scopus 로고
    • Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people
    • Koch S, Larbi A, Derhovanessian E, Ozcelik D, Naumova E, Pawelec G. Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people. Immun Ageing 2008; 5: 6.
    • (2008) Immun Ageing , vol.5 , pp. 6
    • Koch, S.1    Larbi, A.2    Derhovanessian, E.3    Ozcelik, D.4    Naumova, E.5    Pawelec, G.6
  • 45
    • 23944509562 scopus 로고    scopus 로고
    • B cell development and receptor diversity during aging
    • Allman D, Miller JP. B cell development and receptor diversity during aging. Curr Opin Immunol 2005; 17: 463-467
    • (2005) Curr Opin Immunol , vol.17 , pp. 463-467
    • Allman, D.1    Miller, J.P.2
  • 46
    • 4444320808 scopus 로고    scopus 로고
    • Ageing, autoimmunity and arthritis: Senescence of the B cell compartment - Implications for humoral immunity
    • Johnson SA, Cambier JC Ageing, autoimmunity and arthritis: senescence of the B cell compartment - implications for humoral immunity. Arthritis Res Ther 2004; 6: 131-139
    • (2004) Arthritis Res Ther , vol.6 , pp. 131-139
    • Johnson, S.A.1    Cambier, J.C.2
  • 47
    • 23044456776 scopus 로고    scopus 로고
    • Humoral immune response and B cell functions including immunoglobulin class switch are downregulated in aged mice and humans
    • Frasca D, Riley RL, Blomberg BB. Humoral immune response and B cell functions including immunoglobulin class switch are downregulated in aged mice and humans. Semin Immunol 2005; 17: 378-384
    • (2005) Semin Immunol , vol.17 , pp. 378-384
    • Frasca, D.1    Riley, R.L.2    Blomberg, B.B.3
  • 48
    • 20344375434 scopus 로고    scopus 로고
    • The effect of age on the cognate function of CD4+ T cells
    • Haynes L, Eaton SM. The effect of age on the cognate function of CD4+ T cells. Immunol Rev 2005; 205: 220-228
    • (2005) Immunol Rev , vol.205 , pp. 220-228
    • Haynes, L.1    Eaton, S.M.2
  • 49
    • 39649086079 scopus 로고    scopus 로고
    • Physical activity, inflammation, and muscle loss
    • Roubenoff R. Physical activity, inflammation, and muscle loss. Nutr Rev 2007; 65: S208-12.
    • (2007) Nutr Rev , vol.65
    • Roubenoff, R.1
  • 51
    • 0031012616 scopus 로고    scopus 로고
    • Age patterns of the life table aging rate for major causes of death in Japan, 1951-1990
    • Horiuchi S, Wilmoth JR. Age patterns of the life table aging rate for major causes of death in Japan, 1951-1990. J Gerontol A Biol Sci Med Sci 1997; 52: B67-77.
    • (1997) J Gerontol a Biol Sci Med Sci , vol.52
    • Horiuchi, S.1    Wilmoth, J.R.2
  • 55
    • 33846402146 scopus 로고    scopus 로고
    • Booster vaccination in the elderly: Their success depends on the vaccine type applied earlier in life as well as on pre-vaccination antibody titres
    • Kaml M, Weiskirchner I, Keller M et al. Booster vaccination in the elderly: their success depends on the vaccine type applied earlier in life as well as on pre-vaccination antibody titres. Vaccine 2006; 24: 6808-6811
    • (2006) Vaccine , vol.24 , pp. 6808-6811
    • Kaml, M.1    Weiskirchner, I.2    Keller, M.3
  • 58
    • 32044453088 scopus 로고    scopus 로고
    • Antibody response to influenza vaccination in the elderly: A quantitative review
    • Goodwin K, Viboud C, Simonsen L. Antibody response to influenza vaccination in the elderly: a quantitative review. Vaccine 2006; 24: 1159-1169
    • (2006) Vaccine , vol.24 , pp. 1159-1169
    • Goodwin, K.1    Viboud, C.2    Simonsen, L.3
  • 60
    • 33646014444 scopus 로고    scopus 로고
    • Phenotype of frailty: Characterization in the women's health and aging studies
    • Bandeen-Roche K, Xue QL, Ferrucci L et al. Phenotype of frailty: characterization in the women's health and aging studies. J Gerontol A Biol Sci Med Sci 2006; 61: M262-6.
    • (2006) J Gerontol a Biol Sci Med Sci , vol.61
    • Bandeen-Roche, K.1    Xue, Q.L.2    Ferrucci, L.3
  • 61
    • 0024414493 scopus 로고
    • Relation of chronic disease and immune response to influenza vaccine in the elderly
    • Gross PA, Quinnan GV, Weksler ME, Setia U, Douglas RG. Relation of chronic disease and immune response to influenza vaccine in the elderly. Vaccine 1989; 7: 303-308
    • (1989) Vaccine , vol.7 , pp. 303-308
    • Gross, P.A.1    Quinnan, G.V.2    Weksler, M.E.3    Setia, U.4    Douglas, R.G.5
  • 62
    • 0342281794 scopus 로고    scopus 로고
    • Relationship between the response to influenza vaccination and the nutritional status in institutionalized elderly subjects
    • Fülöp T, Wagner JR, Khalil A, Weber J, Trottier L, Payette H. Relationship between the response to influenza vaccination and the nutritional status in institutionalized elderly subjects. J Gerontol A Med Sci Biol Sci 1999; 54: M59-64.
    • (1999) J Gerontol a Med Sci Biol Sci , vol.54
    • Fülöp, T.1    Wagner, J.R.2    Khalil, A.3    Weber, J.4    Trottier, L.5    Payette, H.6
  • 63
    • 0002509156 scopus 로고    scopus 로고
    • Frailty and failure to thrive
    • Hazzard WR, Blass JP, Ettinger WH Jr, Halter JB, Ouslander J, eds. New York: McGraw Hill
    • Fried LP, Walston J. Frailty and failure to thrive. In Hazzard WR, Blass JP, Ettinger WH Jr, Halter JB, Ouslander J, eds. Principles of Geriatric Medicine and Gerontology. 4th ed. New York: McGraw Hill, 1998: 1387-1402
    • (1998) Principles of Geriatric Medicine and Gerontology. 4th Ed , pp. 1387-1402
    • Fried, L.P.1    Walston, J.2
  • 64
    • 18744371534 scopus 로고    scopus 로고
    • Effects of exercise training on frailty in community-dwelling older adults: Results of a randomized, controlled trial
    • Binder EF, Schechtman KB, Ehsani AA et al. Effects of exercise training on frailty in community-dwelling older adults: results of a randomized, controlled trial. J Am Geriatr Soc 2002; 50: 1921-1928
    • (2002) J Am Geriatr Soc , vol.50 , pp. 1921-1928
    • Binder, E.F.1    Schechtman, K.B.2    Ehsani, A.A.3
  • 65
    • 0037111615 scopus 로고    scopus 로고
    • Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: Results from the Cardiovascular Health Study
    • Walston J, McBurnie MA, Newman A et al. Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. Arch Intern Med 2002; 162: 2333-2341
    • (2002) Arch Intern Med , vol.162 , pp. 2333-2341
    • Walston, J.1    McBurnie, M.A.2    Newman, A.3
  • 66
    • 0037440670 scopus 로고    scopus 로고
    • Coagulation and activation of inflammatory pathways in the development of functional decline and mortality in the elderly
    • Cohen HJ, Harris T, Pieper CF. Coagulation and activation of inflammatory pathways in the development of functional decline and mortality in the elderly. Am J Med 2003; 114: 180-187
    • (2003) Am J Med , vol.114 , pp. 180-187
    • Cohen, H.J.1    Harris, T.2    Pieper, C.F.3
  • 68
    • 33845188426 scopus 로고    scopus 로고
    • Immunosenescence and vaccination
    • Pawelec G. Immunosenescence and vaccination. Immun Ageing 2005; 2: 16.
    • (2005) Immun Ageing , vol.2 , pp. 16
    • Pawelec, G.1
  • 70
    • 0037015543 scopus 로고    scopus 로고
    • A program to prevent functional decline in physically frail, elderly persons who live at home
    • Gill TM, Baker DI, Gottschalk M, Peduzzi PN, Allore H, Byers A. A program to prevent functional decline in physically frail, elderly persons who live at home. N Engl J Med 2002; 347: 1068-1074
    • (2002) N Engl J Med , vol.347 , pp. 1068-1074
    • Gill, T.M.1    Baker, D.I.2    Gottschalk, M.3    Peduzzi, P.N.4    Allore, H.5    Byers, A.6
  • 72
    • 0036172497 scopus 로고    scopus 로고
    • Influence of multinutrient supplement on immune responses and infection-related illness in 50-65 year old individuals
    • Chandra RK. Influence of multinutrient supplement on immune responses and infection-related illness in 50-65 year old individuals. Nutr Res 2002; 22: 5-11.
    • (2002) Nutr Res , vol.22 , pp. 5-11
    • Chandra, R.K.1
  • 73
    • 33847328456 scopus 로고    scopus 로고
    • Nutritional factors and immunological ageing
    • Lesourd B. Nutritional factors and immunological ageing. Proc Nutr Soc 2006; 65: 319-325
    • (2006) Proc Nutr Soc , vol.65 , pp. 319-325
    • Lesourd, B.1
  • 75
    • 12844251951 scopus 로고    scopus 로고
    • Immune response to influenza vaccine in healthy adults and the elderly: Associaton with nutritional status
    • Hara M, Tanaka K, Hirota Y. Immune response to influenza vaccine in healthy adults and the elderly: associaton with nutritional status. Vaccine 2005; 23: 1457-1463
    • (2005) Vaccine , vol.23 , pp. 1457-1463
    • Hara, M.1    Tanaka, K.2    Hirota, Y.3
  • 77
    • 0032951420 scopus 로고    scopus 로고
    • Antibody response to 1995-1996 influenza vaccine in institutionalized and non-institutionalized elderly women
    • Iorio AM, Alatri A, Camilloni B, Neri M, Baglio G, Donatelli I. Antibody response to 1995-1996 influenza vaccine in institutionalized and non-institutionalized elderly women. Gerontology 1999; 45: 31-38
    • (1999) Gerontology , vol.45 , pp. 31-38
    • Iorio, A.M.1    Alatri, A.2    Camilloni, B.3    Neri, M.4    Baglio, G.5    Donatelli, I.6
  • 78
    • 0037726810 scopus 로고    scopus 로고
    • The association between psychosocial factors and vaccine-induced cytokine production
    • Hayney MS, Love GD, Buck JM, Ryff CD, Singer B, Muller D. The association between psychosocial factors and vaccine-induced cytokine production. Vaccine 2003; 21: 2428-2432
    • (2003) Vaccine , vol.21 , pp. 2428-2432
    • Hayney, M.S.1    Love, G.D.2    Buck, J.M.3    Ryff, C.D.4    Singer, B.5    Muller, D.6
  • 79
    • 10744227364 scopus 로고    scopus 로고
    • Enhancement of antibody responses to influenza vaccination in the elderly following a cognitive-behavioural stress management intervention
    • Vedhara K, Bennett PD, Clark S et al. Enhancement of antibody responses to influenza vaccination in the elderly following a cognitive-behavioural stress management intervention. Psychother Psychosom 2003; 72: 245-252
    • (2003) Psychother Psychosom , vol.72 , pp. 245-252
    • Vedhara, K.1    Bennett, P.D.2    Clark, S.3
  • 80
    • 35048838041 scopus 로고    scopus 로고
    • Safety and immunogenicity of a high dosage trivalent influenza vaccine among elderly subjects
    • Couch RB, Winokur P, Brady R et al. Safety and immunogenicity of a high dosage trivalent influenza vaccine among elderly subjects. Vaccine 2007; 25: 7656-7663
    • (2007) Vaccine , vol.25 , pp. 7656-7663
    • Couch, R.B.1    Winokur, P.2    Brady, R.3
  • 81
    • 50949102312 scopus 로고    scopus 로고
    • Intradermal influenza vaccine administered using a new microinjection system produces superior immunogenicity in elderly adults: A randomized controlled trial
    • Holland D, Booy R, De Looze F et al. Intradermal influenza vaccine administered using a new microinjection system produces superior immunogenicity in elderly adults: a randomized controlled trial. J Infect Dis 2008; 198: 650-658
    • (2008) J Infect Dis , vol.198 , pp. 650-658
    • Holland, D.1    Booy, R.2    De Looze, F.3
  • 82
    • 36749096389 scopus 로고    scopus 로고
    • Antibody induction by virosomal, MF59-adjuvanted or conventional influenza vaccines in the elderly
    • de Brujin IA, Meyer I, Gerez L, Nauta J, Giezman K, Palache B. Antibody induction by virosomal, MF59-adjuvanted or conventional influenza vaccines in the elderly. Vaccine 2007; 26: 119-127
    • (2007) Vaccine , vol.26 , pp. 119-127
    • De Brujin, I.A.1    Meyer, I.2    Gerez, L.3    Nauta, J.4    Giezman, K.5    Palache, B.6
  • 83
    • 0035202615 scopus 로고    scopus 로고
    • Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals
    • Goronzy JJ, Fulbright JW, Crowson CS, Poland GA, O'Fallon WM, Weyana CM. Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. J Virol 2001; 75: 12182-12187
    • (2001) J Virol , vol.75 , pp. 12182-12187
    • Goronzy, J.J.1    Fulbright, J.W.2    Crowson, C.S.3    Poland, G.A.4    O'Fallon, W.M.5    Weyana, C.M.6
  • 84
    • 33646468500 scopus 로고    scopus 로고
    • T cell reponses are better correlates of vaccine protection in the elderly
    • McElhaney JE, Xie D, Hager WD et al. T cell reponses are better correlates of vaccine protection in the elderly. J Immunol 2006; 176: 6333-6339
    • (2006) J Immunol , vol.176 , pp. 6333-6339
    • McElhaney, J.E.1    Xie, D.2    Hager, W.D.3
  • 85
    • 58149301590 scopus 로고    scopus 로고
    • From bench to bedside and back: The SENIEUR Protocol and the efficacy of influenza vaccination in the elderly
    • Trzonkowski P, Mysliwska J, Pawelec G, Mysliwski A. From bench to bedside and back: the SENIEUR Protocol and the efficacy of influenza vaccination in the elderly. Biogerontology 2009: 10: 83-94.
    • (2009) Biogerontology , vol.10 , pp. 83-94
    • Trzonkowski, P.1    Mysliwska, J.2    Pawelec, G.3    Mysliwski, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.