BCMA Is Essential for the Survival of Long-lived Bone Marrow Plasma Cells

Journal of Experimental Medicine

Volumn 199, Issue 1, 2004, Pages 91-97

  O'Connor, Brian P ^a   Raman, Vanitha S ^a   Erickson, Loren D ^a   Cook, W James ^a   Weaver, Lehn K ^a   Ahonen, Cory ^a   Lin, Ling Li ^a   Mantchev, George T ^b   Bram, Richard J ^b   Noelle, Randolph J ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Antibody formation; B lymphocyte subsets; Cell differentiation; Cell lineage; Immunophenotyping

Indexed keywords

APRIL PROTEIN; B CELL MATURATION ANTIGEN; CYCLOPHILIN; GENE PRODUCT; IMMUNOGLOBULIN; INTERLEUKIN 6; LIGAND; PROTEIN BLYS; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; B LYMPHOCYTE; BONE MARROW; CELL LINEAGE; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; HUMORAL IMMUNITY; MOUSE; NONHUMAN; PLASMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; WILD TYPE;

ANIMALS; B-CELL ACTIVATING FACTOR; B-CELL MATURATION ANTIGEN; BASE SEQUENCE; BONE MARROW CELLS; CELL SURVIVAL; DNA PRIMERS; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; PLASMA CELLS; RECEPTORS, TUMOR NECROSIS FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0347285357     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20031330     Document Type: Article

References (34)

1. Calame, K.L. 2001. Plasma cells: finding new light at the end of B cell development. Nat. Immunol. 2:1103-1108.
2. Underhill, G.H., H.A. Minges Wols, J.L. Fornek, P.L. Witte, G.S. Kansas, and H.A. Minges-Wols. 2002. IgG plasma cells display a unique spectrum of leukocyte adhesion and homing molecules. Blood. 99:2905-2912.
3. Strasser, A., S. Whittingham, D.L. Vaux, M.L. Bath, J.M. Adams, S. Cory, and A.W. Harris. 1991. Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc. Natl. Acad. Sci. USA. 88: 8661-8665.
4. McDonnell, T.J., N. Deane, F.M. Platt, G. Nunez, U. Jaeger, J.P. McKearn, and S.J. Korsmeyer. 1989. bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell. 57:79-88.
5. Bouillet, P., D. Metcalf, D.C. Huang, D.M. Tarlinton, T.W. Kay, F. Kontgen, J.M. Adams, and A. Strasser. 1999. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science. 286:1735-1738.
6. Mackay, F., P. Schneider, P. Rennert, and J. Browning. 2003. BAFF AND APRIL: a tutorial on B cell survival. Annu. Rev. Immunol. 21:231-264.
7. Mackay, F., and J.L. Browning. 2002. BAFF: a fundamental survival factor for B cells. Nat. Rev. Immunol. 2:465-475.
8. Thompson, J.S., S.A. Bixler, F. Qian, K. Vora, M.L. Scott, T.G. Cachero, C. Hession, P. Schneider, I.D. Sizing, C. Mullen, et al. 2001. BAFF-R, a novel TNF receptor that specifically interacts with BAFF. Science. 293:2108-2111.
9. Schiemann, B., J.L. Gommerman, K. Vora, T.G. Cachero, S. Shulga-Morskaya, M. Dobles, E. Frew, and M.L. Scott. 2001. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science. 293:2111-2114.
10. Lentz, V.M., M.P. Cancro, F.E. Nashold, and C.E. Hayes. 1996. Bcmd governs recruitment of new B cells into the stable peripheral B cell pool in the A/WySnJ mouse. J. Immunol. 157:598-606.
11. von Bulow, G.U., J.M. van Deursen, and R.J. Bram. 2001. Regulation of the T-independent humoral response by TACI. Immunity. 14:573-582.
12. Seshasayee, D., P. Valdez, M. Yan, V.M. Dixit, D. Tumas, and I.S. Grewal. 2003. Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor. Immunity. 18:279-288.
13. Xu, S., and K.P. Lam. 2001. B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses. Mol. Cell. Biol. 21:4067-4074.
14. Do, R.K., E. Hatada, H. Lee, M.R. Tourigny, D. Hilbert, and S. Chen-Kiang. 2000. Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response. J. Exp. Med. 192:953-964.
15. Balazs, M., F. Martin, T. Zhou, and J. Kearney. 2002. Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses. Immunity. 17:341-352.
16. Nardelli, B., O. Belvedere, V. Roschke, P.A. Moore, H.S. Olsen, T.S. Migone, S. Sosnovtseva, J.A. Carrell, P. Feng, J.G. Giri, and D.M. Hilbert. 2001. Synthesis and release of B-lymphocyte stimulator from myeloid cells. Blood. 97:198-204.
17. Avery, D.T., S.L. Kalled, J.I. Ellyard, C. Ambrose, S.A. Bixler, M. Thien, R. Brink, F. Mackay, P.D. Hodgkin, and S.G. Tangye. 2003. BAFF selectively enhances the survival of plasmablasts generated from human memory B cells. J. Clin. Invest. 112:286-297.
18. Marsters, S.A., M. Yan, R.M. Pitti, P.E. Haas, V.M. Dixit, and A. Ashkenazi. 2000. Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. Curr. Biol. 10:785-788.
19. Gross, J.A., J. Johnston, S. Mudri, R. Enselman, S.R. Dillon, K. Madden, W. Xu, J. Parrish-Novak, D. Foster, C. Lofton-Day, et al. 2000. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature. 404:995-999.
20. Erickson, L.D, B.G. Durell, L.A. Vogel, B.P. O'Connor, M. Cascalho, T. Yasui, H. Kikutani, and R.J. Noelle. 2002. Short circuiting long-lived humoral immunity by heightened engagement of CD40. J. Clin. Invest. 109:613-620.
21. Slifka, M.K., R. Antia, J.K. Whitmire, and R. Ahmed. 1998. Humoral immunity due to long-lived plasma cells. Immunity. 8:363-372.
22. Manz, R.A., and A. Radbruch. 2002. Plasma cells for a lifetime? Eur. J. Immunol. 32:923-927.
23. O'Connor, B.P., M. Cascalho, and R.J. Noelle. 2002. Short-lived and long-lived bone marrow plasma cells are derived from a novel precursor population. J. Exp. Med. 195:737-745.
24. Claudio, J.O., E. Masih-Khan, H. Tang, J. Goncalves, M. Voralia, Z.H. Li, V. Nadeem, E. Cukerman, O. Francisco-Pabalan, C.C. Liew, et al. 2002. A molecular compendium of genes expressed in multiple myeloma. Blood. 100:2175-2186.
25. Mackay, F., S.A. Woodcock, P. Lawton, C. Ambrose, M. Baetscher, P. Schneider, J. Tschopp, and J.L. Browning. 1999. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J. Exp. Med. 190:1697-1710.
26. Spets, H., T. Stromberg, P. Georgii-Hemming, J. Siljason, K. Nilsson, and H. Jernberg-Wiklund. 2002. Expression of the bcl-2 family of pro- and anti-apoptotic genes in multiple myeloma and normal plasma cells: regulation during interleukin-6(IL-6)-induced growth and survival. Eur. J. Haematol. 69:76-89.
27. Altmeyer, A., R.C. Simmons, S. Krajewski, J.C. Reed, G.W. Bornkamm, and S. Chen-Kiang. 1997. Reversal of EBV immortalization precedes apoptosis in IL-6-induced human B cell terminal differentiation. Immunity. 7:667-677.
28. Tangye, S.G., D.T. Avery, E.K. Deenick, and P.D. Hodgkin. 2003. Intrinsic differences in the proliferation of naive and memory human B cells as a mechanism for enhanced secondary immune responses. J. Immunol. 170:686-694.
29. Stein, J.V., M. Lopez-Fraga, F.A. Elustondo, C.E. Carvalho-Pinto, D. Rodriguez, R. Gomez-Caro, J. De Jong, A.C. Martinez, J.P. Medema, and M. Hahne. 2002. APRIL modulates B and T cell immunity. J. Clin. Invest. 109:1587-1598.
30. Underhill, G.H., D. George, E.G. Bremer, and G.S. Kansas. 2003. Gene expression profiling reveals a highly specialized genetic program of plasma cells. Blood. 101:4013-4021.
31. Tarte, K., F. Zhan, J. De Vos, B. Klein, and J. Shaughnessy, Jr. 2003. Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B-cell differentiation. Blood. 102:592-600.
32. Novak, A.J., J.R. Darce, B.K. Arendt, B. Harder, K. Henderson, W. Kindsvogel, J.A. Gross, P.R. Greipp, and D.F. Jelinek. 2003. Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival. Blood. 10.1182/blood-2003-06-2043.
33. Karpusas, M., T.G. Cachero, F. Qian, A. Boriack-Sjodin, C. Mullen, K. Strauch, Y.M. Hsu, and S.L. Kalled. 2002. Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes. J. Mol. Biol. 315: 1145-1154.
34. Oren, D.A., Y. Li, Y. Volovik, T.S. Morris, C. Dharia, K. Das, O. Galperina, R. Gentz, and E. Arnold. 2002. Structural basis of BLyS receptor recognition. Nat. Struct. Biol. 9:288-292.