T-bet regulates T-independent IgG2a class switching

International Immunology

Volumn 15, Issue 8, 2003, Pages 937-944

  Gerth, Andrea J ^a   Lin, Ling ^a   Peng, Stanford L ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antibody; B lymphocyte; Cellular activation; Rodent

Indexed keywords

CD40 ANTIGEN; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN G2A; LIPOPOLYSACCHARIDE; T BOX TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; CONTROLLED STUDY; GENE REARRANGEMENT; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; GERM LINE; HUMORAL IMMUNITY; IMMUNOSTIMULATION; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; WILD TYPE;

ANIMALS; ANTIGENS, CD40; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; ANTIGENS, T-INDEPENDENT; ENZYME-LINKED IMMUNOSORBENT ASSAY; FICOLL; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HAPTENS; IMMUNIZATION; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN G; IMMUNOGLOBULIN ISOTYPES; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; LYMPHOCYTE SUBSETS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPLEEN; T-BOX DOMAIN PROTEINS; TRANSCRIPTION FACTORS; TRINITROBENZENES;

EID: 0041522519     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/dxg093     Document Type: Article

References (25)

1. Snapper, C. M. and Finkelman, F. D. 1999. Immunoglobulin class switching. In Paul, W. E., ed., Fundamental Immunology, p. 831. Lippincott-Raven, Philadelphia, PA.
2. Snapper, C. M. and Paul, W. E. 1987. Interferon-γ and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236:944.
3. Snapper, C. M., McIntyre, T. M., Mandler, R., Pecanha, L. M., Finkelman, F. D., Lees, A. and Mond, J. J. 1992. Induction of IgG3 secretion by interferon gamma: a model for T cell-independent class switching in response to T cell-independent type 2 antigens. J. Exp. Med. 175:1367.
4. Gavalchin, J., Seder, R. A. and Datta, S. K. 1987. The NZB X SWR model of lupus nephritis. I. Cross-reactive idiotypes of monoclonal anti-DNA antibodies in relation to antigenic specificity, charge, and allotype. Identification of interconnected idiotype families inherited from the normal SWR and the autoimmune NZB parents. J. Immunol. 138:128.
5. Gyotoku, Y., Abdelmoula, M., Spertini, F., Izui, S. and Lambert, P. H. 1987. Cryoglobulinemia induced by monoclonal immunoglobulin G rheumatoid factors derived from autoimmune MRL/MpJ-/pr//pr mice. J. Immunol. 138:3785.
6. Haas, C., Ryffel, B. and Le Hir, M. 1997. IFN-γ is essential for the development of autoimmune glomerulonephritis in MRL//pr mice. J. Immunol. 158:5484.
7. Markine-Goriaynoff, D., van der Logt, J. T., Truyens, C., Nguyen, T. D., Heessen, F. W., Bigaignon, G., Carlier, Y. and Coutelier, J. P. 2000. IFN-γ-independent IgG2a production in mice infected with viruses and parasites. Int. Immunol. 12:223.
8. Peng, S. L., Szabo, S. J. and Glimcher, L. H. 2002. T-bet regulates IgG class switching and autoantibody production. Proc. Natl Acad. Sci. USA 99:5545.
9. h1 lineage commitment and IFN-γ production in CD4 and CD8 T cells. Science 295:338.
10. Peng, S. L., Madaio, M. P., Hughes, D. P., Crispe, I. N., Owen, M. J., Wen, L., Hayday, A. C. and Craft, J. 1996. Murine lupus in the absence of αβ T cells. J. Immunol. 156:4041.
11. Peng, S. L., Madaio, M. P., Hayday, A. C. and Craft, J. 1996. Propagation and regulation of systemic autoimmunity by γδ T cells. J. Immunol. 157:5689.
12. Peng, S. L. and Craft, J. 1996. PCR-RFLP genotyping of murine MHC haplotypes. Biotechniques 21:362.
13. Martin, R. M., Brady, J. L. and Lew, A. M. 1998, The need for IgG2c specific antiserum when isotyping antibodies from C57BL/6 and NOD mice. J. Immunol. Methods 212:187.
14. h1 marker in mice? Immunol. Today 19:49.
15. Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y. and Honjo, T. 2000. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102:553.
16. Kawabe, T., Naka, T., Yoshida, K., Tanaka, T., Fujiwara, H., Suematsu, S., Yoshida, N., Kishimoto, T. and Kikutani, H. 1994. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1:167.
17. Renshaw, B. R., Fanslow, W. C., III, Armitage, R. J., Campbell, K. A., Liggitt, D., Wright, B., Davison, B. L. and Maliszewski, C. R. 1994. Humoral immune responses in CD40 ligand-deficient mice. J. Exp. Med. 180:1889.
18. Xu, J., Foy, T. M., Laman, J. D., Elliott, E. A., Dunn, J. J., Waldschmidt, T. J., Elsemore, J., Noelle, R. J. and Flavell, R. A. 1994. Mice deficient for the CD40 ligand. Immunity 1:423.
19. Schubart, D. B., Rolink, A., Kosco-Vilbois, M. H., Botteri, F. and Matthias, P. 1996. B-cell-specific coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation. Nature 383:538.
20. Kontgen, F., Grumont, R. J., Strasser, A., Metcalf, D., Li, R., Tarlinton, D. and Gerondakis, S. 1995. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 9:1965.
21. Sha, W. C., Liou, H. C., Tuomanen, E. I. and Baltimore, D. 1995. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell 80:321.
22. Glimcher, L. H. and Singh, H. 1999. Transcription factors in lymphocyte development-T and B cells get together. Cell 96:13.
23. h1 lineage commitment. Cell 100:655.
24. Lighvani, A. A., Frucht, D. M., Jankovic, D., Yamane, H., Aliberti, J., Hissong, B. D., Nguyen, B. V., Gadina, M., Sher, A., Paul, W. E. and O'Shea, J. J. 2001. T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells. Proc. Natl Acad. Sci. USA 98:15137.
25. + T cells. Nat. Immunol. 3:549.