Resolution of three nonproliferate immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation

Journal of Immunology

Volumn 167, Issue 12, 2001, Pages 6834-6840

  Allman, D ^a   Lindsley, R C ^a   Demuth, W ^a   Rudd, K ^a   Shinton, S A ^a   Hardy, R R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CD23 ANTIGEN; IMMUNOGLOBULIN M; BTK PROTEIN; COMPLEMENT 1Q RECEPTOR; COMPLEMENT RECEPTOR; IMMUNOGLOBULIN E RECEPTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE P56(LYN); PROTEIN-TYROSINE KINASE P56(LYN); SRC FAMILY KINASES;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CELL LOSS; CELL MATURATION; CONTROLLED STUDY; CROSS LINKING; FEMALE; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; ANIMAL; CELL CULTURE; CELL LINEAGE; CHEMISTRY; CLASSIFICATION; GENETICS; IMMUNOLOGY; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE MUTANT; MOUSE STRAIN; MUTATION; SPLEEN; STEM CELL;

ANIMAL; B-LYMPHOCYTE SUBSETS; BROMODEOXYURIDINE; CELL LINEAGE; CELLS, CULTURED; FEMALE; IMMUNOGLOBULIN M; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MUTATION; PROTEIN-TYROSINE KINASE; RECEPTORS, COMPLEMENT; RECEPTORS, IGE; SPLEEN; SRC-FAMILY KINASES; STEM CELLS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0035892228     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.12.6834     Document Type: Article

References (29)

1. high splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells
2. high and exhibit unique signaling characteristics
3. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals
4. Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity
5. The transition from immature to mature B cells
6. Transitional B cells are the target of negative selection in the B cell compartment
7. Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire
8. Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death
9. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice
10. Self-tolerance checkpoints in B lymphocyte development
11. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes
12. Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter
13. Engagement of the antigen-receptor on immature murine B lymphocytes results in death by apoptosis
14. A B-cell receptor-specific selection step governs immature to mature B cell differentiation
15. Syk tyrosine kinase is required for the positive selection of immature B cells into the recirculating B cell pool
16. H recombination
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