Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals

Journal of Experimental Medicine

Volumn 205, Issue 8, 2008, Pages 1797-1805

  Moir, Susan ^a   Ho, Jason ^a   Malaspina, Angela ^a   Wang, Wei ^a   DiPoto, Angela C ^a   O'Shea, Marie A ^a   Roby, Gregg ^a   Kottilil, Shyam ^a   Arthos, James ^a   Proschan, Michael A ^a   Chun, Tae Wook ^a   Fauci, Anthony S ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD20 ANTIGEN; CD27 ANTIGEN; COMPLEMENT COMPONENT C3D RECEPTOR;

ARTICLE; CELL DIVISION; CELL HOMING; CELL MIGRATION; CELL PROLIFERATION; CELL SUBPOPULATION; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; MEMORY CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIREMIA;

B-LYMPHOCYTE SUBSETS; CASE-CONTROL STUDIES; HIV ANTIBODIES; HIV INFECTIONS; HUMANS; IMMUNOLOGIC MEMORY; LYMPHOCYTE ACTIVATION; MODELS, IMMUNOLOGICAL; PHENOTYPE; RECEPTORS, FC; VIREMIA; VIRUS REPLICATION;

EID: 46049112339     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20072683     Document Type: Article

References (32)

1. Giri, M.S., M. Nebozhyn, L. Showe, and L.J. Montaner. 2006. Microarray data on gene modulation by HIV-1 in immune cells: 2000-2006. J. Leukoc. Biol. 80:1031-1043.
2. Grossman, Z., M. Meier-Schellersheim, W.E. Paul, and L.J. Picker. 2006. Pathogenesis of HIV infection: what the virus spares is as important as what it destroys. Nat. Med. 12:289-295.
3. Lawn, S.D., S.T. Butera, and T.M. Folks. 2001. Contribution of immune activation to the pathogenesis and transmission of human immunodeficiency virus type 1 infection. Clin. Microbiol. Rev. 14:753-777.
4. De Milito, A. 2004. B lymphocyte dysfunctions in HIV infection. Curr. HIV Res. 2:11-21.
5. Moir, S., A. Malaspina, K.M. Ogwaro, E.T. Donoghue, C.W. Hallahan, L.A. Ehler, S. Liu, J. Adelsberger, R. Lapointe, P. Hwu, et al. 2001. HIV-1 induces phenotypic and functional perturbations of B cells in chronically infected individuals. Proc. Natl. Acad. Sci. USA. 98:10362-10367.
6. Moir, S., A. Malaspina, O.K. Pickeral, E.T. Donoghue, J. Vasquez, N.J. Miller, S.R. Krishnan, M.A. Planta, J.F. Turney, J.S. Justement, et al. 2004. Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily. J. Exp. Med. 200:587-599.
7. Titanji, K., A. De Milito, A. Cagigi, R. Thorstensson, S. Grutzmeier, A. Atlas, B. Hejdeman, F.P. Kroon, L. Lopalco, A. Nilsson, and F. Chiodi. 2006. Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection. Blood . 108:1580-1587.
8. Malaspina, A., S. Moir, J. Ho, W. Wang, M.L. Howell, M.A. O'Shea, G.A. Roby, C.A. Rehm, J.M. Mican, T.W. Chun, and A.S. Fauci. 2006. Appearance of immature/transitional B cells in HIV-infected individuals with advanced disease: correlation with increased IL-7. Proc. Natl. Acad. Sci. USA. 103:2262-2267.
9. Malaspina, A., S. Moir, D.G. Chaitt, C.A. Rehm, S. Kottilil, J. Falloon, and A.S. Fauci. 2007. Idiopathic CD4+ T lymphocytopenia is associated with increases in immature/transitional B cells and serum levels of IL-7. Blood. 109:2086-2088.
10. Barber, D.L., E.J. Wherry, D. Masopust, B. Zhu, J.P. Allison, A.H. Sharpe, G.J. Freeman, and R. Ahmed. 2006. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature. 439:682-687.
11. Day, C.L., D.E. Kaufmann, P. Kiepiela, J.A. Brown, E.S. Moodley, S. Reddy, E.W. Mackey, J.D. Miller, A.J. Leslie, C. DePierres, et al. 2006. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature. 443:350-354.
12. Trautmann, L., L. Janbazian, N. Chomont, E.A. Said, S. Gimmig, B. Bessette, M.R. Boulassel, E. Delwart, H. Sepulveda, R.S. Balderas, et al. 2006. Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nat. Med. 12:1198-1202.
13. Wherry, E.J., S.J. Ha, S.M. Kaech, W.N. Haining, S. Sarkar, V. Kalia, S. Subramaniam, J.N. Blattman, D.L. Barber, and R. Ahmed. 2007. Molecular signature of CD8(+) T cell exhaustion during chronic viral infection. Immunity. 27:670-684.
14. Kaufmann, D.E., D.G. Kavanagh, F. Pereyra, J.J. Zaunders, E.W. Mackey, T. Miura, S. Palmer, M. Brockman, A. Rathod, A. Piechocka-Trocha, et al . 2007 . Upregulation of CTLA-4 by HIV-specific CD4(+) T cells correlates with disease progression and defines a reversible immune dysfunction. Nat. Immunol. 8:1246-1254.
15. Ehrhardt, G.R., J.T. Hsu, L. Gartland, C.M. Leu, S. Zhang, R.S. Davis, and M.D. Cooper. 2005 . Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells. J. Exp. Med. 202:783-791.
16. Montefiori, D., Q. Sattentau, J. Flores, J. Esparza, and J. Mascola. 2007. Antibody-based HIV-1 vaccines: recent developments and future directions. PLoS Med. 4:e348.
17. Nitschke, L. 2005. The role of CD22 and other inhibitory co-receptors in B-cell activation. Curr. Opin. Immunol. 17:290-297.
18. Ravetch, J.V., and L.L. Lanier. 2000. Immune inhibitory receptors. Science. 290:84-89.
19. Ehrhardt, G.R.A., A. Hijikata, H. Kitamura, O. Ohara, J.-Y. Wang, and M.D. Cooper. 2008. Discriminating gene expression profiles of memory B cell subpopulation. J. Exp. Med. 205:1807-1817.
20. Kunkel, E.J., and E.C. Butcher. 2003. Plasma-cell homing. Nat. Rev. Immunol. 3:822-829.
21. Ebert, L.M., P. Schaerli, and B. Moser . 2005 . Chemokine-mediated control of T cell traffic in lymphoid and peripheral tissues. Mol. Immunol. 42:799-809 .
22. Miyasaka, M., and T. Tanaka. 2004. Lymphocyte trafficking across high endothelial venules: dogmas and enigmas. Nat. Rev. Immunol. 4:360-370.
23. Allen, C.D., T. Okada, and J.G. Cyster. 2007. Germinal-center organization and cellular dynamics. Immunity . 27:190-202.
24. van Zelm, M.C., T. Szczepanski, M. van der Burg, and J.J. van Dongen. 2007. Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion. J. Exp. Med. 204:645-655.
25. Bonhomme, D., L. Hammarstrom, D. Webster, H. Chapel, O. Hermine, F. Le Deist, E. Lepage, P.H. Romeo, and Y. Levy. 2000. Impaired antibody affinity maturation process characterizes a subset of patients with common variable immunodeficiency. J. Immunol. 165:4725-4730.
26. Malaspina, A., S. Moir, A.C. DiPoto, J. Ho, W. Wang, G. Roby, M.A. O'Shea, and A.S. Fauci. 2008. CpG oligonucleotides enhance proliferative and effector responses of B cells in HIV-infected individuals. J. Immunol. 181:1199-1206.
27. Fecteau, J.F., G. Cote, and S. Neron. 2006. A new memory CD27-IgG+ B cell population in peripheral blood expressing VH genes with low frequency of somatic mutation. J. Immunol. 177:3728-3736.
28. Kacani, L., W.M. Prodinger, G.M. Sprinzl, M.G. Schwendinger, M. Spruth, H. Stoiber, S. Dopper, S. Steinhuber, F. Steindl, and M.P. Dierich. 2000. Detachment of human immunodeficiency virus type 1 from germinal centers by blocking complement receptor type 2. J. Virol. 74:7997-8002.
29. Moir, S., A. Malaspina, Y. Li, T.W. Chun, T. Lowe, J. Adelsberger, M. Baseler, L.A. Ehler, S. Liu, R.T. Davey Jr., et al. 2000. B cells of HIV-1-infected patients bind virions through CD21-complement interactions and transmit infectious virus to activated T cells. J. Exp. Med. 192:637-646.
30. Malaspina, A., S. Moir, S.M. Orsega, J. Vasquez, N.J. Miller, E.T. Donoghue, S. Kottilil, M. Gezmu, D. Follmann, G.M. Vodeiko, et al. 2005. Compromised B cell responses to influenza vaccination in HIV-infected individuals. J. Infect. Dis. 191:1442-1450.
31. Doria-Rose, N.A., G.H. Learn, A.G. Rodrigo, D.C. Nickle, F. Li, M. Mahalanabis, M.T. Hensel, S. McLaughlin, P.F. Edmonson, D. Montefiori, et al. 2005. Human immunodeficiency virus type 1 subtype B ancestral envelope protein is functional and elicits neutralizing antibodies in rabbits similar to those elicited by a circulating subtype B envelope. J. Virol. 79: 11214-11224.
32. Mossman, S.P., F. Bex, P. Berglund, J. Arthos, S.P. O'Neil, D. Riley, D.H. Maul, C. Bruck, P. Momin, A. Burny, et al. 1996. Protection against lethal simian immunodeficiency virus SIVsmmPBj14 disease by a recombinant Semliki Forest virus gp160 vaccine and by a gp120 subunit vaccine. J. Virol. 70:1953-1960.