-
1
-
-
84904872156
-
The growing landscape of lysine acetylation links metabolism and cell signalling
-
Choudhary, C., Weinert, B. T., Nishida, Y., Verdin, E., & Mann, M. The growing landscape of lysine acetylation links metabolism and cell signalling. Nat. Rev. Mol. Cell Biol. 15, 536-550 (2014
-
(2014)
Nat. Rev. Mol. Cell Biol
, vol.15
, pp. 536-550
-
-
Choudhary, C.1
Weinert, B.T.2
Nishida, Y.3
Verdin, E.4
Mann, M.5
-
2
-
-
84886717428
-
Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes
-
Canto, C., Sauve, A. A., & Bai, P. Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes. Mol. Aspects Med. 34, 1168-1201 (2013
-
(2013)
Mol. Aspects Med
, vol.34
, pp. 1168-1201
-
-
Canto, C.1
Sauve, A.A.2
Bai, P.3
-
3
-
-
4344574540
-
Large-scale characterization of HeLa cell nuclear phosphoproteins
-
Beausoleil, S. A., et al. Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc. Natl Acad. Sci. USA 101, 12130-12135 (2004
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 12130-12135
-
-
Beausoleil, S.A.1
-
4
-
-
84910679144
-
Proteome-wide post-Translational modification statistics: Frequency analysis and curation of the swiss-prot database
-
Khoury, G. A., Baliban, R. C., & Floudas, C. A. Proteome-wide post-Translational modification statistics: frequency analysis and curation of the swiss-prot database. Sci. Rep. 1, 90 (2011
-
(2011)
Sci. Rep
, vol.1
, pp. 90
-
-
Khoury, G.A.1
Baliban, R.C.2
Floudas, C.A.3
-
5
-
-
84859490749
-
Protein N terminal acetyltransferases: When the start matters
-
Starheim, K. K., Gevaert, K., & Arnesen, T. Protein N terminal acetyltransferases: when the start matters. Trends Biochem. Sci. 37, 152-161 (2012
-
(2012)
Trends Biochem. Sci
, vol.37
, pp. 152-161
-
-
Starheim, K.K.1
Gevaert, K.2
Arnesen, T.3
-
6
-
-
34547697009
-
Cytoskeleton and cellular signalling in the grip of protein N?-And O acetylation
-
Yang, X. J., & Gr?goire, S. Metabolism, cytoskeleton and cellular signalling in the grip of protein N?-And O acetylation. EMBO Rep. 8, 556-562 (2007
-
(2007)
EMBO Rep
, vol.8
, pp. 556-562
-
-
Yang, X.J.1
Metabolism, G.S.2
-
7
-
-
84875755814
-
Influence of metabolism on epigenetics and disease
-
Kaelin, W. G., & McKnight, S. L. Influence of metabolism on epigenetics and disease. Cell 153, 56-69 (2013
-
(2013)
Cell
, vol.153
, pp. 56-69
-
-
Kaelin, W.G.1
McKnight, S.L.2
-
8
-
-
0034912742
-
Histone acetyltransferases
-
Roth, S. Y., Denu, J. M., & Allis, C. D. Histone acetyltransferases. Annu. Rev. Biochem. 70, 81-120 (2001
-
(2001)
Annu. Rev. Biochem
, vol.70
, pp. 81-120
-
-
Roth, S.Y.1
Denu, J.M.2
Allis, C.D.3
-
9
-
-
84888327562
-
An acetylation rheostat for the control of muscle energy homeostasis
-
Menzies, K., & Auwerx, J. An acetylation rheostat for the control of muscle energy homeostasis. J. Mol. Endocrinol. 51, T101-T113 (2013
-
(2013)
J. Mol. Endocrinol
, vol.51
, pp. T101-T113
-
-
Menzies, K.1
Auwerx, J.2
-
10
-
-
33646145721
-
Circadian regulator CLOCK is a histone acetyltransferase
-
Doi, M., Hirayama, J., & Sassone-Corsi, P. Circadian regulator CLOCK is a histone acetyltransferase. Cell 125, 497-508 (2006
-
(2006)
Cell
, vol.125
, pp. 497-508
-
-
Doi, M.1
Hirayama, J.2
Sassone-Corsi, P.3
-
11
-
-
0016723918
-
Processing of newly synthesized histone molecules
-
Ruiz-Carrillo, A., Wangh, L. J., & Allfrey, V. G. Processing of newly synthesized histone molecules. Science 190, 117-128 (1975
-
(1975)
Science
, vol.190
, pp. 117-128
-
-
Ruiz-Carrillo, A.1
Wangh, L.J.2
Allfrey, V.G.3
-
12
-
-
57749170458
-
The many roles of histone deacetylases in development and physiology: Implications for disease and therapy
-
Haberland, M., Montgomery, R. L., & Olson, E. N. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat. Rev. Genet. 10, 32-42 (2009
-
(2009)
Nat. Rev. Genet
, vol.10
, pp. 32-42
-
-
Haberland, M.1
Montgomery, R.L.2
Olson, E.N.3
-
13
-
-
0038204415
-
The diverse functions of histone acetyltransferase complexes
-
Carrozza, M. J., Utley, R. T., Workman, J. L., & Cote, J. The diverse functions of histone acetyltransferase complexes. Trends Genet. 19, 321-329 (2003
-
(2003)
Trends Genet
, vol.19
, pp. 321-329
-
-
Carrozza, M.J.1
Utley, R.T.2
Workman, J.L.3
Cote, J.4
-
14
-
-
84858797950
-
Sirtuins as regulators of metabolism and healthspan
-
Houtkooper, R. H., Pirinen, E., & Auwerx, J. Sirtuins as regulators of metabolism and healthspan. Nat. Rev. Mol. Cell Biol. 13, 225-238 (2012
-
(2012)
Nat. Rev. Mol. Cell Biol
, vol.13
, pp. 225-238
-
-
Houtkooper, R.H.1
Pirinen, E.2
Auwerx, J.3
-
15
-
-
84900489549
-
Transcriptional repression by histone deacetylases in plants
-
Liu, X., et al. Transcriptional repression by histone deacetylases in plants. Mol. Plant 7, 764-772 (2014
-
(2014)
Mol. Plant
, vol.7
, pp. 764-772
-
-
Liu, X.1
-
16
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
Imai, S., Armstrong, C. M., Kaeberlein, M., & Guarente, L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403, 795-800 (2000
-
(2000)
Nature
, vol.403
, pp. 795-800
-
-
Imai, S.1
Armstrong, C.M.2
Kaeberlein, M.3
Guarente, L.4
-
17
-
-
0034703217
-
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
-
Lin, S. J., Defossez, P. A., & Guarente, L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-2128 (2000
-
(2000)
Science
, vol.289
, pp. 2126-2128
-
-
Lin, S.J.1
Defossez, P.A.2
Guarente, L.3
-
18
-
-
84874594425
-
The sirtuin family's role in aging and age-Associated pathologies
-
Hall, J. A., Dominy, J. E., Lee, Y., & Puigserver, P. The sirtuin family's role in aging and age-Associated pathologies. J. Clin. Invest. 123, 973-979 (2013
-
(2013)
J. Clin. Invest
, vol.123
, pp. 973-979
-
-
Hall, J.A.1
Dominy, J.E.2
Lee, Y.3
Puigserver, P.4
-
19
-
-
33845399894
-
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC 1α
-
Lagouge, M., et al Resveratrol Improves Mitochondrial Function and Protects Against Metabolic Disease by Activating SIRT1 and PGC 1α. Cell 127, 1109-1122 (2006
-
(2006)
Cell
, vol.127
, pp. 1109-1122
-
-
Lagouge, M.1
-
20
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC 1α and SIRT1
-
Rodgers, J T., et Al. Nutrient Control of Glucose Homeostasis Through A Complex of PGC 1α and SIRT1. Nature 434, 113-118 (2005
-
(2005)
Nature
, vol.434
, pp. 113-118
-
-
Rodgers, J.T.1
-
21
-
-
77249156847
-
Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle
-
Canto, C., et al. Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab. 11, 213-219 (2010
-
(2010)
Cell Metab
, vol.11
, pp. 213-219
-
-
Canto, C.1
-
22
-
-
1342264308
-
Mammalian SIRT1 represses forkhead transcription factors
-
Motta, M. C., et al. Mammalian SIRT1 represses forkhead transcription factors. Cell 116, 551-563 (2004
-
(2004)
Cell
, vol.116
, pp. 551-563
-
-
Motta, M.C.1
-
23
-
-
34948883324
-
SIRT1 deacetylates and positively regulates the nuclear receptor LXR
-
Li, X., et al. SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol. Cell 28, 91-106 (2007
-
(2007)
Mol. Cell
, vol.28
, pp. 91-106
-
-
Li, X.1
-
24
-
-
34547906123
-
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1
-
Rodgers, J. T., & Puigserver, P. Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc. Natl Acad. Sci. USA 104, 12861-12866 (2007
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 12861-12866
-
-
Rodgers, J.T.1
Puigserver, P.2
-
25
-
-
56249100986
-
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
-
Liu, Y., et al. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 456, 269-273 (2008
-
(2008)
Nature
, vol.456
, pp. 269-273
-
-
Liu, Y.1
-
26
-
-
84864615516
-
Brown remodeling of white adipose tissue by SirT1 dependent deacetylation of PPARγ
-
Qiang, L., et al. Brown remodeling of white adipose tissue by SirT1 dependent deacetylation of Pparγ. Cell 150, 620-632 (2012
-
(2012)
Cell
, vol.150
, pp. 620-632
-
-
Qiang, L.1
-
27
-
-
33745931074
-
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
-
Hallows, W. C., Lee, S., & Denu, J. M. Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc. Natl Acad. Sci. USA 103, 10230-10235 (2006
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 10230-10235
-
-
Hallows, W.C.1
Lee, S.2
Denu, J.M.3
-
28
-
-
84874925761
-
Sirtuin 1 mediated effects of exercise and resveratrol on mitochondrial biogenesis
-
Menzies, K. J., Singh, K., Saleem, A., & Hood, D. A. Sirtuin 1 mediated effects of exercise and resveratrol on mitochondrial biogenesis. J. Biol. Chem. 288, 6968-6979 (2013
-
(2013)
J. Biol. Chem
, vol.288
, pp. 6968-6979
-
-
Menzies, K.J.1
Singh, K.2
Saleem, A.3
Hood, D.A.4
-
29
-
-
84860477354
-
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
-
Price, N. L., et al. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab. 15, 675-690 (2012
-
(2012)
Cell Metab
, vol.15
, pp. 675-690
-
-
Price, N.L.1
-
30
-
-
67349276169
-
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
-
Canto, C., et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 458, 1056-1060 (2009
-
(2009)
Nature
, vol.458
, pp. 1056-1060
-
-
Canto, C.1
-
31
-
-
0032549811
-
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
-
Puigserver, P., et al. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829-839 (1998
-
(1998)
Cell
, vol.92
, pp. 829-839
-
-
Puigserver, P.1
-
32
-
-
0035855858
-
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC 1
-
Yoon, J C., et Al. Control of Hepatic Gluconeogenesis Through the Transcriptional Coactivator PGC 1. Nature 413, 131-138 (2001
-
(2001)
Nature
, vol.413
, pp. 131-138
-
-
Yoon, J.C.1
-
33
-
-
34247259630
-
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC 1α
-
Gerhart-Hines, Z., et al Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC 1α. EMBO J. 26, 1913-1923 (2007
-
(2007)
EMBO J.
, vol.26
, pp. 1913-1923
-
-
Gerhart-Hines, Z.1
-
34
-
-
83455206803
-
Targeting sirtuin 1 to improve metabolism: All you need is NAD+
-
Cantó, C., & Auwerx, J. Targeting sirtuin 1 to improve metabolism: all you need is NAD+? Pharmacol. Rev. 64, 166-187 (2012
-
(2012)
Pharmacol Rev
, vol.64
, pp. 166-187
-
-
Cantó, C.1
Auwerx, J.2
-
35
-
-
79953210362
-
Regulation of PGC 1α, a nodal regulator of mitochondrial biogenesis
-
Fernandez-Marcos, P. J., & Auwerx, J. Regulation of PGC 1α, a nodal regulator of mitochondrial biogenesis. Am. J. Clin. Nutr. 93, 884S-890S (2011
-
(2011)
Am. J. Clin. Nutr
, vol.93
, pp. 884S-890S
-
-
Fernandez-Marcos, P.J.1
Auwerx, J.2
-
36
-
-
84871676013
-
The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis
-
Dominy, J. E. Jr et al. The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis. Mol. Cell 48, 900-913 (2012
-
(2012)
Mol. Cell
, vol.48
, pp. 900-913
-
-
Dominy, J.E.1
-
37
-
-
74549142287
-
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1α
-
Zhong, L., et al The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1α. Cell 140, 280-293 (2010
-
(2010)
Cell
, vol.140
, pp. 280-293
-
-
Zhong, L.1
-
38
-
-
84905389924
-
Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism
-
Masri, S., et al. Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism. Cell 158, 659-672 (2014
-
(2014)
Cell
, vol.158
, pp. 659-672
-
-
Masri, S.1
-
39
-
-
84875881601
-
SIRT6 regulates TNF α secretion through hydrolysis of long-chain fatty acyl lysine
-
Jiang, H., et al. SIRT6 regulates TNF α secretion through hydrolysis of long-chain fatty acyl lysine. Nature 496, 110-113 (2013
-
(2013)
Nature
, vol.496
, pp. 110-113
-
-
Jiang, H.1
-
40
-
-
84886686038
-
Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins
-
Feldman, J. L., Baeza, J., & Denu, J. M. Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins. J. Biol. Chem. 288, 31350-31356 (2013
-
(2013)
J. Biol. Chem
, vol.288
, pp. 31350-31356
-
-
Feldman, J.L.1
Baeza, J.2
Denu, J.M.3
-
41
-
-
84897484512
-
SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway
-
Yoshizawa, T., et al. SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway. Cell Metab. 19, 712-721 (2014
-
(2014)
Cell Metab
, vol.19
, pp. 712-721
-
-
Yoshizawa, T.1
-
42
-
-
84910145057
-
A SIRT7 dependent acetylation switch of GABPβ1 controls mitochondrial function
-
Ryu, D., et al. A SIRT7 dependent acetylation switch of GABPβ1 controls mitochondrial function. Cell Metab. (2014
-
(2014)
Cell Metab
-
-
Ryu, D.1
-
43
-
-
84887613799
-
SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease
-
Shin, J., et al. SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. Cell Rep. 5, 654-665 (2013
-
(2013)
Cell Rep
, vol.5
, pp. 654-665
-
-
Shin, J.1
-
44
-
-
84925265469
-
A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging
-
Mohrin, M., et al. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging. Science 347, 1374-1377 (2015
-
(2015)
Science
, vol.347
, pp. 1374-1377
-
-
Mohrin, M.1
-
45
-
-
41449083867
-
Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice
-
Vakhrusheva, O., et al. Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ. Res. 102, 703-710 (2008
-
(2008)
Circ. Res
, vol.102
, pp. 703-710
-
-
Vakhrusheva, O.1
-
46
-
-
34547397081
-
SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation
-
Jing, E., Gesta, S., & Kahn, C. R. SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metab. 6, 105-114 (2007
-
(2007)
Cell Metab
, vol.6
, pp. 105-114
-
-
Jing, E.1
Gesta, S.2
Kahn, C.R.3
-
47
-
-
84882605310
-
Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth
-
Lin, R., et al. Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth. Mol. Cell 51, 506-518 (2013
-
(2013)
Mol. Cell
, vol.51
, pp. 506-518
-
-
Lin, R.1
-
48
-
-
79959906869
-
Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase
-
Jiang, W., et al. Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. Mol. Cell 43, 33-44 (2011
-
(2011)
Mol. Cell
, vol.43
, pp. 33-44
-
-
Jiang, W.1
-
49
-
-
84866529842
-
SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo
-
Bobrowska, A., Donmez, G., Weiss, A., Guarente, L., & Bates, G. SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo. PLoS ONE 7, e34805 (2012
-
(2012)
PLoS ONE
, vol.7
, pp. e34805
-
-
Bobrowska, A.1
Donmez, G.2
Weiss, A.3
Guarente, L.4
Bates, G.5
-
50
-
-
80055085172
-
Sir two homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par 3/atypical protein kinase C (aPKC) signaling
-
Beirowski, B., et al. Sir two homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par 3/atypical protein kinase C (aPKC) signaling. Proc. Natl Acad. Sci. USA 108, E952-E961 (2011
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. E952-E961
-
-
Beirowski, B.1
-
51
-
-
84875948762
-
Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS
-
Taes, I., et al. Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS. Hum. Mol. Genet. 22, 1783-1790 (2013
-
(2013)
Hum. Mol. Genet
, vol.22
, pp. 1783-1790
-
-
Taes, I.1
-
52
-
-
37549002891
-
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
-
Lombard, D. B., et al. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol. Cell Biol. 27, 8807-8814 (2007
-
(2007)
Mol. Cell Biol
, vol.27
, pp. 8807-8814
-
-
Lombard, D.B.1
-
53
-
-
77950806433
-
SIRT3 regulates mitochondrial fatty-Acid oxidation by reversible enzyme deacetylation
-
Hirschey, M. D., et al. SIRT3 regulates mitochondrial fatty-Acid oxidation by reversible enzyme deacetylation. Nature 464, 121-125 (2010
-
(2010)
Nature
, vol.464
, pp. 121-125
-
-
Hirschey, M.D.1
-
54
-
-
78649509214
-
SIRT3 deacetylates mitochondrial 3 hydroxy 3 methylglutaryl CoA synthase 2 and regulates ketone body production
-
Shimazu, T., et al. SIRT3 deacetylates mitochondrial 3 hydroxy 3 methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab. 12, 654-661 (2010
-
(2010)
Cell Metab
, vol.12
, pp. 654-661
-
-
Shimazu, T.1
-
55
-
-
78651468722
-
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
-
Someya, S., et al. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell 143, 802-812 (2010
-
(2010)
Cell
, vol.143
, pp. 802-812
-
-
Someya, S.1
-
56
-
-
55749084738
-
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
-
Ahn, B. H., et al. A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc. Natl Acad. Sci. USA 105, 14447-14452 (2008
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 14447-14452
-
-
Ahn, B.H.1
-
57
-
-
80052291180
-
Sirtuin 3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production
-
Jing, E., et al. Sirtuin 3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc. Natl Acad. Sci. USA 108, 14608-14613 (2011
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 14608-14613
-
-
Jing, E.1
-
58
-
-
84861589885
-
Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis
-
Fernandez-Marcos, P. J., et al. Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis. Sci. Rep. 2, 425 (2012
-
(2012)
Sci. Rep
, vol.2
, pp. 425
-
-
Fernandez-Marcos, P.J.1
-
59
-
-
84919933749
-
Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity
-
Mathias, R. A., et al. Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. Cell 159, 1615-1625 (2014
-
(2014)
Cell
, vol.159
, pp. 1615-1625
-
-
Mathias, R.A.1
-
60
-
-
33748316536
-
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic β cells
-
Haigis, M. C., et al. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic β cells. Cell 126, 941-954 (2006
-
(2006)
Cell
, vol.126
, pp. 941-954
-
-
Haigis, M.C.1
-
61
-
-
33748199578
-
Insulin secretion: SIRT4 gets in on the act
-
Argmann, C., & Auwerx, J. Insulin secretion: SIRT4 gets in on the act. Cell 126, 837-839 (2006
-
(2006)
Cell
, vol.126
, pp. 837-839
-
-
Argmann, C.1
Auwerx, J.2
-
62
-
-
84878891625
-
SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase
-
Laurent, G., et al. SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Mol. Cell 50, 686-698 (2013
-
(2013)
Mol. Cell
, vol.50
, pp. 686-698
-
-
Laurent, G.1
-
63
-
-
81055122671
-
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase
-
Du, J., et al. Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science 334, 806-809 (2011
-
(2011)
Science
, vol.334
, pp. 806-809
-
-
Du, J.1
-
64
-
-
84880791239
-
SIRT5 mediated lysine desuccinylation impacts diverse metabolic pathways
-
Park, J., et al. SIRT5 mediated lysine desuccinylation impacts diverse metabolic pathways. Mol. Cell 50, 919-930 (2013
-
(2013)
Mol. Cell
, vol.50
, pp. 919-930
-
-
Park, J.1
-
65
-
-
84889636259
-
SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks
-
Rardin, M. J., et al. SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab. 18, 920-933 (2013
-
(2013)
Cell Metab
, vol.18
, pp. 920-933
-
-
Rardin, M.J.1
-
66
-
-
84897565291
-
Lysine glutarylation is a protein posttranslational modification regulated by SIRT5
-
Tan, M., et al Lysine Glutarylation Is A Protein Posttranslational Modification Regulated by SIRT5. Cell Metab. 19, 605-617 (2014
-
(2014)
Cell Metab
, vol.19
, pp. 605-617
-
-
Tan, M.1
-
67
-
-
84885124677
-
Metabolic characterization of a Sirt5 deficient mouse model
-
Yu, J., et al. Metabolic characterization of a Sirt5 deficient mouse model. Sci. Rep. 3, 2806 (2013
-
(2013)
Sci. Rep
, vol.3
, pp. 2806
-
-
Yu, J.1
-
68
-
-
65249087389
-
SIRT5 deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
-
Nakagawa, T., Lomb, D. J., Haigis, M. C., & Guarente, L. SIRT5 deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell 137, 560-570 (2009
-
(2009)
Cell
, vol.137
, pp. 560-570
-
-
Nakagawa, T.1
Lomb, D.J.2
Haigis, M.C.3
Guarente, L.4
-
69
-
-
84937522438
-
NAD+ metabolism and the control of energy homeostasis: A balancing act between mitochondria and the nucleus
-
Canto, C., Menzies, K. J., & Auwerx, J. NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus. Cell Metab. 22, 31-53 (2015
-
(2015)
Cell Metab
, vol.22
, pp. 31-53
-
-
Canto, C.1
Menzies, K.J.2
Auwerx, J.3
-
70
-
-
84871650811
-
Metabolic reprogramming by class i and II histone deacetylases
-
Mihaylova, M. M., & Shaw, R. J. Metabolic reprogramming by class I and II histone deacetylases. Trends Endocrinol. Metab. 24, 48-57 (2013
-
(2013)
Trends Endocrinol. Metab
, vol.24
, pp. 48-57
-
-
Mihaylova, M.M.1
Shaw, R.J.2
-
71
-
-
77952002655
-
Redundant control of adipogenesis by histone deacetylases 1 and 2
-
Haberland, M., Carrer, M., Mokalled, M. H., Montgomery, R. L., & Olson, E. N. Redundant control of adipogenesis by histone deacetylases 1 and 2. J. Biol. Chem. 285, 14663-14670 (2010
-
(2010)
J. Biol. Chem
, vol.285
, pp. 14663-14670
-
-
Haberland, M.1
Carrer, M.2
Mokalled, M.H.3
Montgomery, R.L.4
Olson, E.N.5
-
72
-
-
84871650811
-
Metabolic reprogramming by class i and II histone deacetylases
-
Mihaylova, M. M., & Shaw, R. J. Metabolic reprogramming by class I and II histone deacetylases. Trends Endocrinol. Metab. 24, 48-57 (2013
-
(2013)
Trends Endocrinol. Metab
, vol.24
, pp. 48-57
-
-
Mihaylova, M.M.1
Shaw, R.J.2
-
73
-
-
80052992257
-
Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle
-
Sun, Z., et al. Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle. J. Biol. Chem. 286, 33301-33309 (2011
-
(2011)
J. Biol. Chem
, vol.286
, pp. 33301-33309
-
-
Sun, Z.1
-
74
-
-
0036900873
-
The retinoblastoma-histone deacetylase 3 complex inhibits PPARγ and adipocyte differentiation
-
Fajas, L., et al. The retinoblastoma-histone deacetylase 3 complex inhibits PPARγ and adipocyte differentiation. Dev. Cell 3, 903-910 (2002
-
(2002)
Dev. Cell
, vol.3
, pp. 903-910
-
-
Fajas, L.1
-
75
-
-
55849084700
-
Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice
-
Montgomery, R. L., et al. Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice. J. Clin. Invest. 118, 3588-3597 (2008
-
(2008)
J. Clin. Invest
, vol.118
, pp. 3588-3597
-
-
Montgomery, R.L.1
-
76
-
-
33846940901
-
Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2
-
Grégoire, S., et al. Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2. Mol. Cell. Biol. 27, 1280-1295 (2007
-
(2007)
Mol. Cell. Biol
, vol.27
, pp. 1280-1295
-
-
Grégoire, S.1
-
77
-
-
79952529158
-
A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism
-
Feng, D., et al. A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science 331, 1315-1319 (2011
-
(2011)
Science
, vol.331
, pp. 1315-1319
-
-
Feng, D.1
-
78
-
-
84862025421
-
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration
-
Sun, Z., et al. Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nat. Med. 18, 934-942 (2012
-
(2012)
Nat. Med
, vol.18
, pp. 934-942
-
-
Sun, Z.1
-
79
-
-
41949120723
-
Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks
-
Knutson, S. K., et al. Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. EMBO J. 27, 1017-1028 (2008
-
(2008)
EMBO J.
, vol.27
, pp. 1017-1028
-
-
Knutson, S.K.1
-
80
-
-
0037406061
-
Class II histone deacetylases: Versatile regulators
-
Verdin, E., Dequiedt, F., & Kasler, H. G. Class II histone deacetylases: versatile regulators. Trends Genet. 19, 286-293 (2003
-
(2003)
Trends Genet
, vol.19
, pp. 286-293
-
-
Verdin, E.1
Dequiedt, F.2
Kasler, H.G.3
-
81
-
-
34848858523
-
Histone deacetylase degradation and MEF2 activation promote the formation of slow-Twitch myofibers
-
Potthoff, M. J., et al. Histone deacetylase degradation and MEF2 activation promote the formation of slow-Twitch myofibers. J. Clin. Invest. 117, 2459-2467 (2007
-
(2007)
J. Clin. Invest
, vol.117
, pp. 2459-2467
-
-
Potthoff, M.J.1
-
82
-
-
81055125669
-
NCoR1 is a conserved physiological modulator of muscle mass and oxidative function
-
Yamamoto, H., et al. NCoR1 is a conserved physiological modulator of muscle mass and oxidative function. Cell 147, 827-839 (2011
-
(2011)
Cell
, vol.147
, pp. 827-839
-
-
Yamamoto, H.1
-
83
-
-
84945488022
-
Phosphorylation of the nuclear receptor co-repressor 1 by protein kinase B (PKB/Akt) switches its co-repressor targets in the liver
-
Jo, Y. S., et al. Phosphorylation of the nuclear receptor co-repressor 1 by protein kinase B (PKB/Akt) switches its co-repressor targets in the liver. Hepatology http://dx.doi.org/10.1002/hep.27907
-
Hepatology
-
-
Jo, Y.S.1
-
84
-
-
79955815135
-
Class IIa histone deacetylases are hormone-Activated regulators of FOXO and mammalian glucose homeostasis
-
Mihaylova, M. M., et al. Class IIa histone deacetylases are hormone-Activated regulators of FOXO and mammalian glucose homeostasis. Cell 145, 607-621 (2011
-
(2011)
Cell
, vol.145
, pp. 607-621
-
-
Mihaylova, M.M.1
-
85
-
-
84856541549
-
Histone deacetylase 6 (HDAC6) is an essential modifier of glucocorticoid-induced hepatic gluconeogenesis
-
Winkler, R., et al. Histone deacetylase 6 (HDAC6) is an essential modifier of glucocorticoid-induced hepatic gluconeogenesis. Diabetes 61, 513-523 (2012
-
(2012)
Diabetes
, vol.61
, pp. 513-523
-
-
Winkler, R.1
-
86
-
-
79954537130
-
Fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus
-
Funato, H., Oda, S., Yokofujita, J., Igarashi, H., & Kuroda, M. Fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus. PLoS ONE 6, e18950 (2011
-
(2011)
PLoS ONE
, vol.6
, pp. e18950
-
-
Funato, H.1
Oda, S.2
Yokofujita, J.3
Igarashi, H.4
Kuroda, M.5
-
87
-
-
78649321082
-
Lysine deacetylases are produced in pancreatic β cells and are differentially regulated by proinflammatory cytokines
-
Lundh, M., et al. Lysine deacetylases are produced in pancreatic β cells and are differentially regulated by proinflammatory cytokines. Diabetologia 53, 2569-2578 (2010
-
(2010)
Diabetologia
, vol.53
, pp. 2569-2578
-
-
Lundh, M.1
-
88
-
-
33744534726
-
GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC 1α
-
Lerin, C., et al GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC 1α. Cell Metab. 3, 429-438 (2006
-
(2006)
Cell Metab
, vol.3
, pp. 429-438
-
-
Lerin, C.1
-
89
-
-
84903521363
-
Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression
-
Lee, Y., et al. Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression. Nature 510, 547-551 (2014
-
(2014)
Nature
, vol.510
, pp. 547-551
-
-
Lee, Y.1
-
90
-
-
84859563667
-
CITED2 links hormonal signaling to PGC 1α acetylation in the regulation of gluconeogenesis
-
Sakai, M., et al. CITED2 links hormonal signaling to PGC 1α acetylation in the regulation of gluconeogenesis. Nat. Med. 18, 612-617 (2012
-
(2012)
Nat. Med
, vol.18
, pp. 612-617
-
-
Sakai, M.1
-
91
-
-
55949084664
-
The genetic ablation of SRC 3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC 1α
-
Coste, A., et al. The genetic ablation of SRC 3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC 1α. Proc. Natl Acad. Sci. USA 105, 17187-17192 (2008
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 17187-17192
-
-
Coste, A.1
-
92
-
-
84919841585
-
PCAF improves glucose homeostasis by suppressing the gluconeogenic activity of PGC 1α
-
Sun, C., et al PCAF improves glucose homeostasis by suppressing the gluconeogenic activity of PGC 1α. Cell Rep. 9, 2250-2262 (2014
-
(2014)
Cell Rep
, vol.9
, pp. 2250-2262
-
-
Sun, C.1
-
93
-
-
84885080311
-
Glucagon regulates gluconeogenesis through KAT2B-And WDR5 mediated epigenetic effects
-
Ravnskjaer, K., et al. Glucagon regulates gluconeogenesis through KAT2B-And WDR5 mediated epigenetic effects. J. Clin. Invest. 123, 4318-4328 (2013
-
(2013)
J. Clin. Invest
, vol.123
, pp. 4318-4328
-
-
Ravnskjaer, K.1
-
94
-
-
0033623238
-
Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development
-
Xu, W., et al. Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development. Nat. Genet. 26, 229-232 (2000
-
(2000)
Nat. Genet
, vol.26
, pp. 229-232
-
-
Xu, W.1
-
95
-
-
57049120143
-
Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: Implications for histone acetyltransferase evolution and function
-
Wang, L., Tang, Y., Cole, P. A., & Marmorstein, R. Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function. Curr. Opin. Struct. Biol. 18, 741-747 (2008
-
(2008)
Curr. Opin. Struct. Biol
, vol.18
, pp. 741-747
-
-
Wang, L.1
Tang, Y.2
Cole, P.A.3
Marmorstein, R.4
-
96
-
-
0036478904
-
Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice
-
Yamauchi, T., et al. Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice. Nat. Genet. 30, 221-226 (2002
-
(2002)
Nat. Genet
, vol.30
, pp. 221-226
-
-
Yamauchi, T.1
-
97
-
-
0037053361
-
Overexpression and ribozyme-mediated targeting of transcriptional coactivators CREB-binding protein and p300 revealed their indispensable roles in adipocyte differentiation through the regulation of peroxisome proliferator-Activated receptor γ
-
Takahashi, N., et al. Overexpression and ribozyme-mediated targeting of transcriptional coactivators CREB-binding protein and p300 revealed their indispensable roles in adipocyte differentiation through the regulation of peroxisome proliferator-Activated receptor γ. J. Biol. Chem. 277, 16906-16912 (2002
-
(2002)
J. Biol. Chem
, vol.277
, pp. 16906-16912
-
-
Takahashi, N.1
-
98
-
-
2942729543
-
Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein
-
Zhou, X. Y., et al. Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein. Nat. Med. 10, 633-637 (2004
-
(2004)
Nat. Med
, vol.10
, pp. 633-637
-
-
Zhou, X.Y.1
-
99
-
-
70350606061
-
FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states
-
Kemper, J. K., et al. FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states. Cell Metab. 10, 392-404 (2009
-
(2009)
Cell Metab
, vol.10
, pp. 392-404
-
-
Kemper, J.K.1
-
100
-
-
0033583023
-
P300 interacts with the N and C terminal part of PPARγ2 in a ligand-independent and-dependent manner, respectively
-
Gelman, L., et al. p300 interacts with the N and C terminal part of PPARγ2 in a ligand-independent and-dependent manner, respectively. J. Biol. Chem. 274, 7681-7688 (1999
-
(1999)
J. Biol. Chem
, vol.274
, pp. 7681-7688
-
-
Gelman, L.1
-
101
-
-
79953752384
-
PARP 1 inhibition increases mitochondrial metabolism through SIRT1 activation
-
Bai, P., et al. PARP 1 inhibition increases mitochondrial metabolism through SIRT1 activation. Cell Metab. 13, 461-468 (2011
-
(2011)
Cell Metab
, vol.13
, pp. 461-468
-
-
Bai, P.1
-
102
-
-
84862022077
-
The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity
-
Canto, C., et al. The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab. 15, 838-847 (2012
-
(2012)
Cell Metab
, vol.15
, pp. 838-847
-
-
Canto, C.1
-
103
-
-
2442624618
-
Poly(ADP-ribose) polymerase 1 mediated cell death in astrocytes requires NAD+ depletion and mitochondrial permeability transition
-
Alano, C. C., Ying, W., & Swanson, R. A. Poly(ADP-ribose) polymerase 1 mediated cell death in astrocytes requires NAD+ depletion and mitochondrial permeability transition. J. Biol. Chem. 279, 18895-18902 (2004
-
(2004)
J. Biol. Chem
, vol.279
, pp. 18895-18902
-
-
Alano, C.C.1
Ying, W.2
Swanson, R.A.3
-
104
-
-
10944270187
-
The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells
-
Revollo, J. R., Grimm, A. A., & Imai, S. The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J. Biol. Chem. 279, 50754-50763 (2004
-
(2004)
J. Biol. Chem
, vol.279
, pp. 50754-50763
-
-
Revollo, J.R.1
Grimm, A.A.2
Imai, S.3
-
105
-
-
77953631698
-
The secret life of NAD+: An old metabolite controlling new metabolic signaling pathways
-
Houtkooper, R. H., Canto, C., Wanders, R. J., & Auwerx, J. The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocr. Rev. 31, 194-223 (2010
-
(2010)
Endocr. Rev
, vol.31
, pp. 194-223
-
-
Houtkooper, R.H.1
Canto, C.2
Wanders, R.J.3
Auwerx, J.4
-
106
-
-
84865411082
-
The dynamic regulation of NAD metabolism in mitochondria
-
Stein, L. R., & Imai, S. The dynamic regulation of NAD metabolism in mitochondria. Trends Endocrinol. Metab. 23, 420-428 (2012
-
(2012)
Trends Endocrinol. Metab
, vol.23
, pp. 420-428
-
-
Stein, L.R.1
Imai, S.2
-
107
-
-
0029064219
-
The membrane of peroxisomes in Saccharomyces cerevisiae is impermeable to NAD(H) and acetyl-CoA under in vivo conditions
-
van Roermund, C. W., Elgersma, Y., Singh, N., Wanders, R. J., & Tabak, H. F. The membrane of peroxisomes in Saccharomyces cerevisiae is impermeable to NAD(H) and acetyl-CoA under in vivo conditions. EMBO J. 14, 3480-3486 (1995
-
(1995)
EMBO J.
, vol.14
, pp. 3480-3486
-
-
Van Roermund, C.W.1
Elgersma, Y.2
Singh, N.3
Wanders, R.J.4
Tabak, H.F.5
-
108
-
-
0029737904
-
Rat liver mitochondria can synthesize nicotinamide adenine dinucleotide from nicotinamide mononucleotide and ATP via a putative matrix nicotinamide mononucleotide adenylyltransferase
-
Barile, M., Passarella, S., Danese, G., & Quagliariello, E. Rat liver mitochondria can synthesize nicotinamide adenine dinucleotide from nicotinamide mononucleotide and ATP via a putative matrix nicotinamide mononucleotide adenylyltransferase. Biochem. Mol. Biol. Int. 38, 297-306 (1996
-
(1996)
Biochem. Mol. Biol. Int
, vol.38
, pp. 297-306
-
-
Barile, M.1
Passarella, S.2
Danese, G.3
Quagliariello, E.4
-
109
-
-
27744501798
-
Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms
-
Berger, F., Lau, C., Dahlmann, M., & Ziegler, M. Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms. J. Biol. Chem. 280, 36334-36341 (2005
-
(2005)
J. Biol. Chem
, vol.280
, pp. 36334-36341
-
-
Berger, F.1
Lau, C.2
Dahlmann, M.3
Ziegler, M.4
-
110
-
-
34548627517
-
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival
-
Yang, H., et al. Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell 130, 1095-1107 (2007
-
(2007)
Cell
, vol.130
, pp. 1095-1107
-
-
Yang, H.1
-
111
-
-
84859506559
-
Regulation of poly(ADP-ribose) polymerase 1 dependent gene expression through promoter-directed recruitment of a nuclear NAD+ synthase
-
Zhang, T., et al. Regulation of poly(ADP-ribose) polymerase 1 dependent gene expression through promoter-directed recruitment of a nuclear NAD+ synthase. J. Biol. Chem. 287, 12405-12416 (2012
-
(2012)
J. Biol. Chem
, vol.287
, pp. 12405-12416
-
-
Zhang, T.1
-
112
-
-
0035951823
-
Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart
-
Di Lisa, F., Menabo, R., Canton, M., Barile, M., & Bernardi, P. Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart. J. Biol. Chem. 276, 2571-2575 (2001
-
(2001)
J. Biol. Chem
, vol.276
, pp. 2571-2575
-
-
Di Lisa, F.1
Menabo, R.2
Canton, M.3
Barile, M.4
Bernardi, P.5
-
113
-
-
77958569431
-
Inhibition of nicotinamide phosphoribosyltransferase: Cellular bioenergetics reveals a mitochondrial insensitive NAD pool
-
Pittelli, M., et al. Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool. J. Biol. Chem. 285, 34106-34114 (2010
-
(2010)
J. Biol. Chem
, vol.285
, pp. 34106-34114
-
-
Pittelli, M.1
-
114
-
-
35848932089
-
Differences among cell types in NAD+ compartmentalization: A comparison of neurons, astrocytes, and cardiac myocytes
-
Alano, C. C., et al. Differences among cell types in NAD+ compartmentalization: a comparison of neurons, astrocytes, and cardiac myocytes. J. Neurosci. Res. 85, 3378-3385 (2007
-
(2007)
J. Neurosci. Res
, vol.85
, pp. 3378-3385
-
-
Alano, C.C.1
-
115
-
-
0017747012
-
Pyridine nucleotide distributions and enzyme mass action ratios in hepatocytes from fed and starved rats
-
Tischler, M. E., Friedrichs, D., Coll., K., & Williamson, J. R. Pyridine nucleotide distributions and enzyme mass action ratios in hepatocytes from fed and starved rats. Arch. Biochem. Biophys. 184, 222-236 (1977
-
(1977)
Arch. Biochem. Biophys
, vol.184
, pp. 222-236
-
-
Tischler, M.E.1
Friedrichs, D.2
Coll, K.3
Williamson, J.R.4
-
116
-
-
81555203042
-
Pharmacological effects of exogenous NAD on mitochondrial bioenergetics DNA repair, and apoptosis
-
Pittelli, M., et al. Pharmacological effects of exogenous NAD on mitochondrial bioenergetics, DNA repair, and apoptosis. Mol. Pharmacol. 80, 1136-1146 (2011
-
(2011)
Mol. Pharmacol
, vol.80
, pp. 1136-1146
-
-
Pittelli, M.1
-
117
-
-
50949120914
-
Nicotinic acid, nicotinamide, and nicotinamide riboside: A molecular evaluation of NAD+ precursor vitamins in human nutrition
-
Bogan, K. L., & Brenner, C. Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition. Annu. Rev. Nutr. 28, 115-130 (2008
-
(2008)
Annu. Rev. Nutr
, vol.28
, pp. 115-130
-
-
Bogan, K.L.1
Brenner, C.2
-
118
-
-
0037829279
-
Reconstructing eukaryotic NAD metabolism
-
Rongvaux, A., Andris, F., Van Gool, F., & Leo, O. Reconstructing eukaryotic NAD metabolism. Bioessays 25, 683-690 (2003
-
(2003)
Bioessays
, vol.25
, pp. 683-690
-
-
Rongvaux, A.1
Andris, F.2
Van Gool, F.3
Leo, O.4
-
119
-
-
84886398685
-
Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection
-
Chi, Y., & Sauve, A. A. Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection. Curr. Opin. Clin. Nutr. Metab. Care 16, 657-661 (2013
-
(2013)
Curr. Opin. Clin. Nutr. Metab. Care
, vol.16
, pp. 657-661
-
-
Chi, Y.1
Sauve, A.A.2
-
120
-
-
0020677595
-
Biochemistry of tryptophan in health and disease
-
Bender, D. A. Biochemistry of tryptophan in health and disease. Mol. Aspects Med. 6, 101-197 (1983
-
(1983)
Mol. Aspects Med
, vol.6
, pp. 101-197
-
-
Bender, D.A.1
-
121
-
-
0036856578
-
Pre B cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis
-
Rongvaux, A., et al. Pre B cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis. Eur. J. Immunol. 32, 3225-3234 (2002
-
(2002)
Eur. J. Immunol
, vol.32
, pp. 3225-3234
-
-
Rongvaux, A.1
-
122
-
-
0035808313
-
Molecular cloning, chromosomal localization, tissue mRNA levels, bacterial expression, and enzymatic properties of human NMN adenylyltransferase
-
Emanuelli, M., et al. Molecular cloning, chromosomal localization, tissue mRNA levels, bacterial expression, and enzymatic properties of human NMN adenylyltransferase. J. Biol. Chem. 276, 406-412 (2001
-
(2001)
J. Biol. Chem
, vol.276
, pp. 406-412
-
-
Emanuelli, M.1
-
123
-
-
0942279500
-
Characterization of human brain nicotinamide 5'-mononucleotide adenylyltransferase 2 and expression in human pancreas
-
Yalowitz, J. A., et al. Characterization of human brain nicotinamide 5'-mononucleotide adenylyltransferase 2 and expression in human pancreas. Biochem. J. 377, 317-326 (2004
-
(2004)
Biochem. J.
, vol.377
, pp. 317-326
-
-
Yalowitz, J.A.1
-
124
-
-
0038644836
-
Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis
-
Zhang, X., et al. Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis. J. Biol. Chem. 278, 13503-13511 (2003
-
(2003)
J. Biol. Chem
, vol.278
, pp. 13503-13511
-
-
Zhang, X.1
-
125
-
-
35549002189
-
Nampt/PBEF/Visfatin regulates insulin secretion in β cells as a systemic NAD biosynthetic enzyme
-
Revollo, J. R., et al. Nampt/PBEF/Visfatin regulates insulin secretion in β cells as a systemic NAD biosynthetic enzyme. Cell Metab. 6, 363-375 (2007
-
(2007)
Cell Metab
, vol.6
, pp. 363-375
-
-
Revollo, J.R.1
-
126
-
-
43049121395
-
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt
-
Fulco, M., et al. Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev. Cell 14, 661-673 (2008
-
(2008)
Dev. Cell
, vol.14
, pp. 661-673
-
-
Fulco, M.1
-
127
-
-
34249696938
-
Extension of human cell lifespan by nicotinamide phosphoribosyltransferase
-
van der Veer, E., et al. Extension of human cell lifespan by nicotinamide phosphoribosyltransferase. J. Biol. Chem. 282, 10841-10845 (2007
-
(2007)
J. Biol. Chem
, vol.282
, pp. 10841-10845
-
-
Van Der Veer, E.1
-
128
-
-
58149316660
-
Nicotinamide phosphoribosyl transferase/pre B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress
-
Rongvaux, A., et al. Nicotinamide phosphoribosyl transferase/pre B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress. J. Immunol. 181, 4685-4695 (2008
-
(2008)
J. Immunol
, vol.181
, pp. 4685-4695
-
-
Rongvaux, A.1
-
129
-
-
67650550813
-
Assimilation of endogenous nicotinamide riboside is essential for calorie restriction-mediated life span extension in Saccharomyces cerevisiae
-
Lu, S. P., Kato, M., & Lin, S. J. Assimilation of endogenous nicotinamide riboside is essential for calorie restriction-mediated life span extension in Saccharomyces cerevisiae. J. Biol. Chem. 284, 17110-17119 (2009
-
(2009)
J. Biol. Chem
, vol.284
, pp. 17110-17119
-
-
Lu, S.P.1
Kato, M.2
Lin, S.J.3
-
130
-
-
79957549799
-
Pathways and subcellular compartmentation of NAD biosynthesis in human cells: From entry of extracellular precursors to mitochondrial NAD generation
-
Nikiforov, A., Dolle, C., Niere, M., & Ziegler, M. Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation. J. Biol. Chem. 286, 21767-21778 (2011
-
(2011)
J. Biol. Chem
, vol.286
, pp. 21767-21778
-
-
Nikiforov, A.1
Dolle, C.2
Niere, M.3
Ziegler, M.4
-
131
-
-
34247502715
-
Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+
-
Belenky, P., et al Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+. Cell 129, 473-484 (2007
-
(2007)
Cell
, vol.129
, pp. 473-484
-
-
Belenky, P.1
-
132
-
-
2342550554
-
Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans
-
Bieganowski, P., & Brenner, C. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Cell 117, 495-502 (2004
-
(2004)
Cell
, vol.117
, pp. 495-502
-
-
Bieganowski, P.1
Brenner, C.2
-
133
-
-
84880517634
-
The NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling
-
Mouchiroud, L., et al. The NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling. Cell 154, 430-441 (2013
-
(2013)
Cell
, vol.154
, pp. 430-441
-
-
Mouchiroud, L.1
-
134
-
-
33748174151
-
Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy
-
Sasaki, Y., Araki, T., & Milbrandt, J. Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy. J. Neurosci. 26, 8484-8491 (2006
-
(2006)
J. Neurosci
, vol.26
, pp. 8484-8491
-
-
Sasaki, Y.1
Araki, T.2
Milbrandt, J.3
-
135
-
-
84901848955
-
Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3
-
Khan, N. A., et al. Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3. EMBO Mol. Med. 6, 721-731 (2014
-
(2014)
EMBO Mol. Med
, vol.6
, pp. 721-731
-
-
Khan, N.A.1
-
136
-
-
84902245774
-
NAD+-dependent activation of sirt1 corrects the phenotype in a mouse model of mitochondrial disease
-
Cerutti, R., et al. NAD+-dependent activation of sirt1 corrects the phenotype in a mouse model of mitochondrial disease. Cell Metab. 19, 1042-1049 (2014
-
(2014)
Cell Metab
, vol.19
, pp. 1042-1049
-
-
Cerutti, R.1
-
137
-
-
0021333746
-
Poly (ADP-Ribose) synthetase Separation and identification of three proteolytic fragments as the substrate-binding domain, the DNA-binding domain, and the automodification domain
-
Kameshita, I., Matsuda, Z., Taniguchi, T., & Shizuta, Y. Poly (ADP-Ribose) synthetase. Separation and identification of three proteolytic fragments as the substrate-binding domain, the DNA-binding domain, and the automodification domain. J. Biol. Chem. 259, 4770-4776 (1984
-
(1984)
J. Biol. Chem
, vol.259
, pp. 4770-4776
-
-
Kameshita, I.1
Matsuda, Z.2
Taniguchi, T.3
Shizuta, Y.4
-
138
-
-
78649901987
-
Identification of the aryl hydrocarbon receptor target gene TiPARP as a mediator of suppression of hepatic gluconeogenesis by 2 3 7, 8 tetrachlorodibenzo p-dioxin and of nicotinamide as a corrective agent for this effect
-
Diani-Moore, S., et al. Identification of the aryl hydrocarbon receptor target gene TiPARP as a mediator of suppression of hepatic gluconeogenesis by 2, 3, 7, 8 tetrachlorodibenzo p-dioxin and of nicotinamide as a corrective agent for this effect. J. Biol. Chem. 285, 38801-38810 (2010
-
(2010)
J. Biol. Chem
, vol.285
, pp. 38801-38810
-
-
Diani-Moore, S.1
-
139
-
-
33644755929
-
Generation and characterization of telomere length maintenance in tankyrase 2 deficient mice
-
Chiang, Y. J., et al. Generation and characterization of telomere length maintenance in tankyrase 2 deficient mice. Mol. Cell. Biol. 26, 2037-2043 (2006
-
(2006)
Mol. Cell. Biol
, vol.26
, pp. 2037-2043
-
-
Chiang, Y.J.1
-
140
-
-
77956627087
-
Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding
-
Asher, G., et al. Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding. Cell 142, 943-953 (2010
-
(2010)
Cell
, vol.142
, pp. 943-953
-
-
Asher, G.1
-
141
-
-
50349083286
-
Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology
-
Malavasi, F., et al. Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology. Physiol. Rev. 88, 841-886 (2008
-
(2008)
Physiol. Rev
, vol.88
, pp. 841-886
-
-
Malavasi, F.1
-
142
-
-
84902270555
-
PharmacologicaliInhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle
-
Pirinen, E., et al. PharmacologicaliInhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle. Cell Metab. 19, 1034-1041 (2014
-
(2014)
Cell Metab
, vol.19
, pp. 1034-1041
-
-
Pirinen, E.1
-
143
-
-
36049038217
-
The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity
-
Barbosa, M. T., et al. The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity. FASEB J. 21, 3629-3639 (2007
-
(2007)
FASEB J.
, vol.21
, pp. 3629-3639
-
-
Barbosa, M.T.1
-
144
-
-
33748309231
-
Regulation of SIRT 1 mediated NAD dependent deacetylation: A novel role for the multifunctional enzyme CD38
-
Aksoy, P., et al. Regulation of SIRT 1 mediated NAD dependent deacetylation: a novel role for the multifunctional enzyme CD38. Biochem. Biophys. Res. Commun. 349, 353-359 (2006
-
(2006)
Biochem. Biophys. Res. Commun
, vol.349
, pp. 353-359
-
-
Aksoy, P.1
-
145
-
-
33744509311
-
Regulation of intracellular levels of NAD: A novel role for CD38
-
Aksoy, P., White, T. A., Thompson, M., & Chini, E. N. Regulation of intracellular levels of NAD: a novel role for CD38. Biochem. Biophys. Res. Comm. 345, 1386-1392 (2006
-
(2006)
Biochem. Biophys. Res. Comm
, vol.345
, pp. 1386-1392
-
-
Aksoy, P.1
White, T.A.2
Thompson, M.3
Chini, E.N.4
-
146
-
-
84941124962
-
ARTD1 induced poly ADP ribose formation enhances PPARγ ligand binding and co-factor exchange
-
Lehmann, M., et al. ARTD1 induced poly ADP ribose formation enhances PPARγ ligand binding and co-factor exchange. Nucleic Acids Res. 43, 129-142 (2015
-
(2015)
Nucleic Acids Res
, vol.43
, pp. 129-142
-
-
Lehmann, M.1
-
147
-
-
46249100836
-
Tissue-specific regulation of SIRT1 by calorie restriction
-
Chen, D., et al. Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev. 22, 1753-1757 (2008
-
(2008)
Genes Dev
, vol.22
, pp. 1753-1757
-
-
Chen, D.1
-
148
-
-
73649133942
-
Skeletal muscle NAMPT is induced by exercise in humans
-
Costford, S. R., et al. Skeletal muscle NAMPT is induced by exercise in humans. Am. J. Physiol. Endocrinol. Metab. 298, E117-E126 (2010
-
(2010)
Am. J. Physiol. Endocrinol. Metab
, vol.298
, pp. E117-E126
-
-
Costford, S.R.1
-
149
-
-
0014082605
-
The redox state of free nicotinamide-Adenine dinucleotide in the cytoplasm and mitochondria of rat liver
-
Williamson, D. H., Lund, P., & Krebs, H. A. The redox state of free nicotinamide-Adenine dinucleotide in the cytoplasm and mitochondria of rat liver. Biochem. J. 103, 514-527 (1967
-
(1967)
Biochem. J.
, vol.103
, pp. 514-527
-
-
Williamson, D.H.1
Lund, P.2
Krebs, H.A.3
-
150
-
-
79953280488
-
Deletion or overexpression of mitochondrial NAD+ carriers in Saccharomyces cerevisiae alters cellular NAD and ATP contents and affects mitochondrial metabolism and the rate of glycolysis
-
Agrimi, G., et al. Deletion or overexpression of mitochondrial NAD+ carriers in Saccharomyces cerevisiae alters cellular NAD and ATP contents and affects mitochondrial metabolism and the rate of glycolysis. Appl. Environ. Microbiol. 77, 2239-2246 (2011
-
(2011)
Appl. Environ. Microbiol
, vol.77
, pp. 2239-2246
-
-
Agrimi, G.1
-
151
-
-
84872334045
-
Metabolism and the circadian clock converge
-
Eckel-Mahan, K., & Sassone-Corsi, P. Metabolism and the circadian clock converge. Physiol. Rev. 93, 107-135 (2013
-
(2013)
Physiol. Rev
, vol.93
, pp. 107-135
-
-
Eckel-Mahan, K.1
Sassone-Corsi, P.2
-
152
-
-
47549088250
-
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control
-
Nakahata, Y., et al. The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell 134, 329-340 (2008
-
(2008)
Cell
, vol.134
, pp. 329-340
-
-
Nakahata, Y.1
-
153
-
-
65549103855
-
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis
-
Ramsey, K. M., et al. Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science 324, 651-654 (2009
-
(2009)
Science
, vol.324
, pp. 651-654
-
-
Ramsey, K.M.1
-
154
-
-
84878562488
-
Endurance training ameliorates the metabolic and performance characteristics of circadian Clock mutant mice
-
Pastore, S., & Hood, D. A. Endurance training ameliorates the metabolic and performance characteristics of circadian Clock mutant mice. J. Appl. Physiol. (1985) 114, 1076-1084 (2013
-
(2013)
J. Appl. Physiol 1985)
, vol.114
, pp. 1076-1084
-
-
Pastore, S.1
Hood, D.A.2
-
155
-
-
65549118773
-
Circadian control of the NAD+ salvage pathway by CLOCK SIRT1
-
Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M., & Sassone-Corsi, P Circadian Control of the NAD+ Salvage Pathway by CLOCK SIRT1. Science 324, 654-657 (2009
-
(2009)
Science
, vol.324
, pp. 654-657
-
-
Nakahata, Y.1
Sahar, S.2
Astarita, G.3
Kaluzova, M.4
Sassone-Corsi, P.5
-
156
-
-
84884248040
-
Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice
-
Peek, C. B., et al. Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. Science 342, 1243417 (2013
-
(2013)
Science
, vol.342
, pp. 1243417
-
-
Peek, C.B.1
-
157
-
-
84879391795
-
SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging
-
Chang, H. C., & Guarente, L. SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging. Cell 153, 1448-1460 (2013
-
(2013)
Cell
, vol.153
, pp. 1448-1460
-
-
Chang, H.C.1
Guarente, L.2
-
158
-
-
47749140333
-
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
-
Asher, G., et al. SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 134, 317-328 (2008
-
(2008)
Cell
, vol.134
, pp. 317-328
-
-
Asher, G.1
-
159
-
-
0037160097
-
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1
-
Bitterman, K. J., Anderson, R. M., Cohen, H. Y., Latorre-Esteves, M., & Sinclair, D. A. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J. Biol. Chem. 277, 45099-45107 (2002
-
(2002)
J. Biol. Chem
, vol.277
, pp. 45099-45107
-
-
Bitterman, K.J.1
Anderson, R.M.2
Cohen, H.Y.3
Latorre-Esteves, M.4
Sinclair, D.A.5
-
160
-
-
3343024449
-
Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases
-
Borra, M. T., Langer, M. R., Slama, J. T., & Denu, J. M. Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases. Biochemistry 43, 9877-9887 (2004
-
(2004)
Biochemistry
, vol.43
, pp. 9877-9887
-
-
Borra, M.T.1
Langer, M.R.2
Slama, J.T.3
Denu, J.M.4
-
161
-
-
0038329323
-
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
-
Anderson, R. M., Bitterman, K. J., Wood, J. G., Medvedik, O., & Sinclair, D. A. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature 423, 181-185 (2003
-
(2003)
Nature
, vol.423
, pp. 181-185
-
-
Anderson, R.M.1
Bitterman, K.J.2
Wood, J.G.3
Medvedik, O.4
Sinclair, D.A.5
-
162
-
-
33746824192
-
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
-
Qin, W., et al. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J. Biol. Chem. 281, 21745-21754 (2006
-
(2006)
J. Biol. Chem
, vol.281
, pp. 21745-21754
-
-
Qin, W.1
-
163
-
-
84889594248
-
Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes
-
Yang, S. J., et al. Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes. J. Nutr. Biochem. 25, 66-72 (2014
-
(2014)
J. Nutr. Biochem
, vol.25
, pp. 66-72
-
-
Yang, S.J.1
-
164
-
-
0020505507
-
Metabolic effects of nicotinamide administration in rats
-
Kang-Lee, Y. A., et al. Metabolic effects of nicotinamide administration in rats. J. Nutr. 113, 215-221 (1983
-
(1983)
J. Nutr
, vol.113
, pp. 215-221
-
-
Kang-Lee, Y.A.1
-
165
-
-
80051970600
-
Metabolic regulation of protein N α acetylation by Bcl-xL promotes cell survival
-
Yi, C. H., et al. Metabolic regulation of protein N α acetylation by Bcl-xL promotes cell survival. Cell 146, 607-620 (2011
-
(2011)
Cell
, vol.146
, pp. 607-620
-
-
Yi, C.H.1
-
166
-
-
33745557847
-
Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription
-
Takahashi, H., McCaffery, J. M., Irizarry, R. A., & Boeke, J. D. Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription. Mol. Cell 23, 207-217 (2006
-
(2006)
Mol. Cell
, vol.23
, pp. 207-217
-
-
Takahashi, H.1
McCaffery, J.M.2
Irizarry, R.A.3
Boeke, J.D.4
-
167
-
-
67651183861
-
A glycolytic burst drives glucose induction of global histone acetylation by picNuA4 and SAGA
-
Friis, R. M., et al. A glycolytic burst drives glucose induction of global histone acetylation by picNuA4 and SAGA. Nucleic Acids Res. 37, 3969-3980 (2009
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 3969-3980
-
-
Friis, R.M.1
-
168
-
-
66249105703
-
ATP-citrate lyase links cellular metabolism to histone acetylation
-
Wellen, K. E., et al. ATP-citrate lyase links cellular metabolism to histone acetylation. Science 324, 1076-1080 (2009
-
(2009)
Science
, vol.324
, pp. 1076-1080
-
-
Wellen, K.E.1
-
169
-
-
79955960768
-
Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes
-
Cai, L., Sutter, B. M., Li, B., & Tu, B. P. Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes. Mol. Cell 42, 426-437 (2011
-
(2011)
Mol. Cell
, vol.42
, pp. 426-437
-
-
Cai, L.1
Sutter, B.M.2
Li, B.3
Tu, B.P.4
-
170
-
-
84891711763
-
The yeast AMPK homolog SNF1 regulates acetyl coenzyme A homeostasis and histone acetylation
-
Zhang, M., Galdieri, L., & Vancura, A. The yeast AMPK homolog SNF1 regulates acetyl coenzyme A homeostasis and histone acetylation. Mol. Cell Biol. 33, 4701-4717 (2013
-
(2013)
Mol. Cell Biol
, vol.33
, pp. 4701-4717
-
-
Zhang, M.1
Galdieri, L.2
Vancura, A.3
-
171
-
-
84885155285
-
Widespread and enzyme-independent N?-Acetylation and N?-succinylation of proteins in the chemical conditions of the mitochondrial matrix
-
Wagner, G. R., & Payne, R. M. Widespread and enzyme-independent N?-Acetylation and N?-succinylation of proteins in the chemical conditions of the mitochondrial matrix. J. Biol. Chem. 288, 29036-29045 (2013
-
(2013)
J. Biol. Chem
, vol.288
, pp. 29036-29045
-
-
Wagner, G.R.1
Payne, R.M.2
-
172
-
-
84898012537
-
Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae
-
Weinert, B. T., et al. Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae. Mol. Syst. Biol. 10, 716 (2014
-
(2014)
Mol. Syst. Biol
, vol.10
, pp. 716
-
-
Weinert, B.T.1
-
173
-
-
0014937061
-
Nonenzymatic acetylation of histones with acetyl-CoA
-
Paik, W. K., Pearson, D., Lee, H. W., & Kim, S. Nonenzymatic acetylation of histones with acetyl-CoA. Biochim. Biophys. Acta 213, 513-522 (1970
-
(1970)
Biochim. Biophys. Acta
, vol.213
, pp. 513-522
-
-
Paik, W.K.1
Pearson, D.2
Lee, H.W.3
Kim, S.4
-
174
-
-
0033603555
-
Catalytic mechanism and function of invariant glutamic acid 173 from the histone acetyltransferase GCN5 transcriptional coactivator
-
Tanner, K. G., et al. Catalytic mechanism and function of invariant glutamic acid 173 from the histone acetyltransferase GCN5 transcriptional coactivator. J. Biol. Chem. 274, 18157-18160 (1999
-
(1999)
J. Biol. Chem
, vol.274
, pp. 18157-18160
-
-
Tanner, K.G.1
-
175
-
-
0033178866
-
Getting across the nuclear pore complex
-
Talcott, B., & Moore, M. S. Getting across the nuclear pore complex. Trends Cell Biol. 9, 312-318 (1999
-
(1999)
Trends Cell Biol
, vol.9
, pp. 312-318
-
-
Talcott, B.1
Moore, M.S.2
-
177
-
-
82455212901
-
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome
-
Hirschey, M. D., et al. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol. Cell 44, 177-190 (2011
-
(2011)
Mol. Cell
, vol.44
, pp. 177-190
-
-
Hirschey, M.D.1
-
178
-
-
73949123433
-
Calorie restriction alters mitochondrial protein acetylation
-
Schwer, B., et al. Calorie restriction alters mitochondrial protein acetylation. Aging Cell 8, 604-606 (2009
-
(2009)
Aging Cell
, vol.8
, pp. 604-606
-
-
Schwer, B.1
-
179
-
-
84872276165
-
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome
-
Hebert, A. S., et al. Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Mol. Cell 49, 186-199 (2013
-
(2013)
Mol. Cell
, vol.49
, pp. 186-199
-
-
Hebert, A.S.1
-
180
-
-
84902331962
-
Mitochondrial protein acetylation is driven by acetyl-CoA from fatty acid oxidation
-
Pougovkina, O., et al. Mitochondrial protein acetylation is driven by acetyl-CoA from fatty acid oxidation. Hum. Mol. Genet. 23, 3513-3522 (2014
-
(2014)
Hum. Mol. Genet
, vol.23
, pp. 3513-3522
-
-
Pougovkina, O.1
-
181
-
-
0027062806
-
Cloning and disruption of a gene required for growth on acetate but not on ethanol: The acetyl-coenzyme A synthetase gene of Saccharomyces cerevisiae
-
De Virgilio, C., et al. Cloning and disruption of a gene required for growth on acetate but not on ethanol: the acetyl-coenzyme A synthetase gene of Saccharomyces cerevisiae. Yeast 8, 1043-1051 (1992
-
(1992)
Yeast
, vol.8
, pp. 1043-1051
-
-
De Virgilio, C.1
-
182
-
-
0037087575
-
Subcellular localization of the yeast proteome
-
Kumar, A., et al. Subcellular localization of the yeast proteome. Genes Dev. 16, 707-719 (2002
-
(2002)
Genes Dev
, vol.16
, pp. 707-719
-
-
Kumar, A.1
-
183
-
-
0142184341
-
Global analysis of protein localization in budding yeast
-
Huh, W. K., et al. Global analysis of protein localization in budding yeast. Nature 425, 686-691 (2003
-
(2003)
Nature
, vol.425
, pp. 686-691
-
-
Huh, W.K.1
-
184
-
-
0029802611
-
The two acetyl-coenzyme A synthetases of Saccharomyces cerevisiae differ with respect to kinetic properties and transcriptional regulation
-
van den Berg, M. A., et al. The two acetyl-coenzyme A synthetases of Saccharomyces cerevisiae differ with respect to kinetic properties and transcriptional regulation. J. Biol. Chem. 271, 28953-28959 (1996
-
(1996)
J. Biol. Chem
, vol.271
, pp. 28953-28959
-
-
Van Den Berg, M.A.1
-
185
-
-
0029118779
-
Carbon source-dependent regulation of the acetyl-coenzyme A synthetase-encoding gene ACS1 from Saccharomyces cerevisiae
-
Kratzer, S., & Schuller, H. J. Carbon source-dependent regulation of the acetyl-coenzyme A synthetase-encoding gene ACS1 from Saccharomyces cerevisiae. Gene 161, 75-79 (1995
-
(1995)
Gene
, vol.161
, pp. 75-79
-
-
Kratzer, S.1
Schuller, H.J.2
-
186
-
-
14544292885
-
YPL.db2: The yeast protein localization database, version 2.0
-
Kals, M., Natter, K., Thallinger, G G., Trajanoski, Z., & Kohlwein, S. D. YPL.db2: the Yeast Protein Localization database, version 2.0. Yeast 22, 213-218 (2005
-
(2005)
Yeast
, vol.22
, pp. 213-218
-
-
Kals, M.1
Natter, K.2
Thallinger, G.G.3
Trajanoski, Z.4
Kohlwein, S.D.5
-
187
-
-
0035815751
-
Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate
-
Fujino, T., Kondo, J., Ishikawa, M., Morikawa, K., & Yamamoto, T. T. Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate. J. Biol. Chem. 276, 11420-11426 (2001
-
(2001)
J. Biol. Chem
, vol.276
, pp. 11420-11426
-
-
Fujino, T.1
Kondo, J.2
Ishikawa, M.3
Morikawa, K.4
Yamamoto, T.T.5
-
188
-
-
0034714382
-
Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins
-
Luong, A., Hannah, V. C., Brown, M. S., & Goldstein, J. L. Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins. J. Biol. Chem. 275, 26458-26466 (2000
-
(2000)
J. Biol. Chem
, Issue.275
, pp. 26458-26466
-
-
Luong, A.1
Hannah, V.C.2
Brown, M.S.3
Goldstein, J.L.4
-
189
-
-
77953233003
-
Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase 1 in the rat brain
-
Ariyannur, P. S., et al. Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase 1 in the rat brain. J. Comp. Neurol. 518, 2952-2977 (2010
-
(2010)
J. Comp. Neurol
, vol.518
, pp. 2952-2977
-
-
Ariyannur, P.S.1
-
190
-
-
33745889628
-
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2
-
Schwer, B., Bunkenborg, J., Verdin, R. O., Andersen, J. S., & Verdin, E. Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc. Natl Acad. Sci. USA 103, 10224-10229 (2006
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 10224-10229
-
-
Schwer, B.1
Bunkenborg, J.2
Verdin, R.O.3
Andersen, J.S.4
Verdin, E.5
-
191
-
-
0037297590
-
Short-chain fatty acid activation by acyl-coenzyme A synthetases requires SIR2 protein function in Salmonella enterica and Saccharomyces cerevisiae
-
Starai, V. J., Takahashi, H., Boeke, J. D., & Escalante-Semerena, J. C. Short-chain fatty acid activation by acyl-coenzyme A synthetases requires SIR2 protein function in Salmonella enterica and Saccharomyces cerevisiae. Genetics 163, 545-555 (2003
-
(2003)
Genetics
, vol.163
, pp. 545-555
-
-
Starai, V.J.1
Takahashi, H.2
Boeke, J.D.3
Escalante-Semerena, J.C.4
-
192
-
-
0027473532
-
Molecular biology of carrier proteins
-
Kaplan, J. H. Molecular biology of carrier proteins. Cell 72, 13-18 (1993
-
(1993)
Cell
, vol.72
, pp. 13-18
-
-
Kaplan, J.H.1
-
193
-
-
84905816638
-
Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation
-
Lee, J. V., et al. Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation. Cell Metab. 20, 306-319 (2014
-
(2014)
Cell Metab
, vol.20
, pp. 306-319
-
-
Lee, J.V.1
-
194
-
-
77956191450
-
Acetate metabolism and aging: An emerging connection
-
Shimazu, T., Hirschey, M. D., Huang, J. Y., Ho, L. T. Y., & Verdin, E. Acetate metabolism and aging: an emerging connection. Mech. Ageing Dev. 131, 511-516 (2010
-
(2010)
Mech. Ageing Dev
, vol.131
, pp. 511-516
-
-
Shimazu, T.1
Hirschey, M.D.2
Huang, J.Y.3
Ho, L.T.Y.4
Verdin, E.5
-
195
-
-
84919936304
-
Acetate dependence of tumors
-
Comerford, S. A., et al. Acetate dependence of tumors. Cell 159, 1591-1602 (2014
-
(2014)
Cell
, vol.159
, pp. 1591-1602
-
-
Comerford, S.A.1
-
196
-
-
84919903877
-
Acetate is a bioenergetic substrate for human glioblastoma and brain metastases
-
Mashimo, T., et al. Acetate is a bioenergetic substrate for human glioblastoma and brain metastases. Cell 159, 1603-1614 (2014
-
(2014)
Cell
, vol.159
, pp. 1603-1614
-
-
Mashimo, T.1
-
197
-
-
0034283589
-
Characterization of rat liver malonyl-CoA decarboxylase and the study of its role in regulating fatty acid metabolism
-
Dyck, J. R., et al. Characterization of rat liver malonyl-CoA decarboxylase and the study of its role in regulating fatty acid metabolism. Biochem. J. 350, 599-608 (2000
-
(2000)
Biochem. J.
, vol.350
, pp. 599-608
-
-
Dyck, J.R.1
-
198
-
-
0033609919
-
MCD encodes peroxisomal and cytoplasmic forms of malonyl-CoA decarboxylase and is mutated in malonyl-CoA decarboxylase deficiency
-
Sacksteder, K. A., Morrell, J. C., Wanders, R. J., Matalon, R., & Gould, S. J. MCD encodes peroxisomal and cytoplasmic forms of malonyl-CoA decarboxylase and is mutated in malonyl-CoA decarboxylase deficiency. J. Biol. Chem. 274, 24461-24468 (1999
-
(1999)
J. Biol. Chem
, vol.274
, pp. 24461-24468
-
-
Sacksteder, K.A.1
Morrell, J.C.2
Wanders, R.J.3
Matalon, R.4
Gould, S.J.5
-
199
-
-
0033563243
-
Cloning and expression of rat pancreatic β-cell malonyl-CoA decarboxylase
-
Voilley, N., et al. Cloning and expression of rat pancreatic β-cell malonyl-CoA decarboxylase. Biochem. J. 340, 213-217 (1999
-
(1999)
Biochem. J.
, vol.340
, pp. 213-217
-
-
Voilley, N.1
-
200
-
-
0035008901
-
Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids
-
Young, M. E., et al. Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids. Am. J. Physiol. Endocrinol. Metab. 280, E471-E479 (2001
-
(2001)
Am. J. Physiol. Endocrinol. Metab
, vol.280
, pp. E471-E479
-
-
Young, M.E.1
-
201
-
-
0034010557
-
Contribution of malonyl-CoA decarboxylase to the high fatty acid oxidation rates seen in the diabetic heart
-
Sakamoto, J., Barr, R. L., Kavanagh, K. M., & Lopaschuk, G. D. Contribution of malonyl-CoA decarboxylase to the high fatty acid oxidation rates seen in the diabetic heart. Am. J. Physiol. Heart Circ. Physiol. 278, H1196-H1204(2000
-
(2000)
Am. J. Physiol. Heart Circ. Physiol
, vol.278
, pp. H1196-H1204
-
-
Sakamoto, J.1
Barr, R.L.2
Kavanagh, K.M.3
Lopaschuk, G.D.4
-
202
-
-
0033855904
-
Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle
-
Dean, D., et al. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. Diabetes 49, 1295-1300 (2000
-
(2000)
Diabetes
, vol.49
, pp. 1295-1300
-
-
Dean, D.1
-
203
-
-
84902306653
-
Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation
-
Chow, J. D., et al. Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation. Mol. Metab. 3, 419-431 (2014
-
(2014)
Mol. Metab
, vol.3
, pp. 419-431
-
-
Chow, J.D.1
-
204
-
-
84863613036
-
Acetyl-CoA carboxylase regulates global histone acetylation
-
Galdieri, L., & Vancura, A. Acetyl-CoA carboxylase regulates global histone acetylation. J. Biol. Chem. 287, 23865-23876 (2012
-
(2012)
J. Biol. Chem
, vol.287
, pp. 23865-23876
-
-
Galdieri, L.1
Vancura, A.2
-
205
-
-
84884755154
-
Yeast phospholipase C is required for normal acetyl-CoA homeostasis and global histone acetylation
-
Galdieri, L., Chang, J., Mehrotra, S., & Vancura, A. Yeast phospholipase C is required for normal acetyl-CoA homeostasis and global histone acetylation. J. Biol. Chem. 288, 27986-27998 (2013
-
(2013)
J. Biol. Chem
, vol.288
, pp. 27986-27998
-
-
Galdieri, L.1
Chang, J.2
Mehrotra, S.3
Vancura, A.4
-
206
-
-
0001262663
-
Redundant roles for the TFIID and SAGA complexes in global transcription
-
Lee, T. I., et al. Redundant roles for the TFIID and SAGA complexes in global transcription. Nature 405, 701-704 (2000
-
(2000)
Nature
, vol.405
, pp. 701-704
-
-
Lee, T.I.1
-
207
-
-
78651468707
-
Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction
-
Hallows, W. C., et al. Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Mol. Cell 41, 139-149 (2011
-
(2011)
Mol. Cell
, vol.41
, pp. 139-149
-
-
Hallows, W.C.1
-
208
-
-
5444240778
-
Hepatic gene expression profiles in a long-Term high-fat diet-induced obesity mouse model
-
Kim, S., et al. Hepatic gene expression profiles in a long-Term high-fat diet-induced obesity mouse model. Gene 340, 99-109 (2004
-
(2004)
Gene
, vol.340
, pp. 99-109
-
-
Kim, S.1
-
209
-
-
84863086273
-
SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism
-
Hirschey, M. D., Shimazu, T., Huang, J. Y., Schwer, B., & Verdin, E. SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism. Cold Spring Harb. Symp. Quant. Biol. 76, 267-277 (2011
-
(2011)
Cold Spring Harb. Symp. Quant. Biol
, vol.76
, pp. 267-277
-
-
Hirschey, M.D.1
Shimazu, T.2
Huang, J.Y.3
Schwer, B.4
Verdin, E.5
-
210
-
-
84903954689
-
A nuclear pyruvate dehydrogenase complex is important for the generation of acetyl-CoA and histone acetylation
-
Sutendra, G., et al. A nuclear pyruvate dehydrogenase complex is important for the generation of acetyl-CoA and histone acetylation. Cell 158, 84-97 (2014
-
(2014)
Cell
, vol.158
, pp. 84-97
-
-
Sutendra, G.1
-
211
-
-
0035224979
-
Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms
-
Roche, T. E., et al. Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms. Prog. Nucleic Acid Res. Mol. Biol. 70, 33-75 (2001
-
(2001)
Prog. Nucleic Acid Res. Mol. Biol
, vol.70
, pp. 33-75
-
-
Roche, T.E.1
-
212
-
-
0016343539
-
Regulation of heart muscle pyruvate dehydrogenase kinase
-
Cooper, R. H., Randle, P. J., & Denton, R. M. Regulation of heart muscle pyruvate dehydrogenase kinase. Biochem. J. 143, 625-641 (1974
-
(1974)
Biochem. J.
, vol.143
, pp. 625-641
-
-
Cooper, R.H.1
Randle, P.J.2
Denton, R.M.3
-
213
-
-
84891506172
-
Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation
-
Jing, E., et al. Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation. Diabetes 62, 3404-3417 (2013
-
(2013)
Diabetes
, vol.62
, pp. 3404-3417
-
-
Jing, E.1
-
214
-
-
84878441741
-
ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: A critical role of PDK4
-
Mori, J., et al. ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: a critical role of PDK4. Am. J. Physiol. Heart Circ. Physiol. 304, H1103-H1113 (2013
-
(2013)
Am. J. Physiol. Heart Circ. Physiol
, vol.304
, pp. H1103-H1113
-
-
Mori, J.1
-
215
-
-
84894263431
-
Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex
-
Fan, J., et al. Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex. Mol. Cell 53, 534-548 (2014
-
(2014)
Mol. Cell
, vol.53
, pp. 534-548
-
-
Fan, J.1
-
216
-
-
33846374117
-
Catalytic mechanism of a MYST family histone acetyltransferase
-
Berndsen, C. E., Albaugh, B. N., Tan, S., & Denu, J. M. Catalytic mechanism of a MYST family histone acetyltransferase. Biochemistry 46, 623-629 (2007
-
(2007)
Biochemistry
, vol.46
, pp. 623-629
-
-
Berndsen, C.E.1
Albaugh, B.N.2
Tan, S.3
Denu, J.M.4
-
217
-
-
0034698085
-
Kinetic mechanism of the histone acetyltransferase GCN5 from yeast
-
Tanner, K. G., Langer, M. R., Kim, Y., & Denu, J. M. Kinetic mechanism of the histone acetyltransferase GCN5 from yeast. J. Biol. Chem. 275, 22048-22055 (2000
-
(2000)
J. Biol. Chem
, vol.275
, pp. 22048-22055
-
-
Tanner, K.G.1
Langer, M.R.2
Kim, Y.3
Denu, J.M.4
-
218
-
-
39149109887
-
The structural basis of protein acetylation by the p300/CBP transcriptional coactivator
-
Liu, X., et al. The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature 451, 846-850 (2008
-
(2008)
Nature
, vol.451
, pp. 846-850
-
-
Liu, X.1
-
219
-
-
77955033193
-
Kinetic mechanism of the Rtt109-Vps75 histone acetyltransferase-chaperone complex
-
Albaugh, B. N., Kolonko, E. M., & Denu, J. M. Kinetic mechanism of the Rtt109-Vps75 histone acetyltransferase-chaperone complex. Biochemistry 49, 6375-6385 (2010
-
(2010)
Biochemistry
, vol.49
, pp. 6375-6385
-
-
Albaugh, B.N.1
Kolonko, E.M.2
Denu, J.M.3
-
220
-
-
34249989455
-
Simultaneous quantification of malonyl-CoA and several other short-chain acyl-CoAs in animal tissues by ion-pairing reversed-phase HPLC/MS
-
Gao, L., et al. Simultaneous quantification of malonyl-CoA and several other short-chain acyl-CoAs in animal tissues by ion-pairing reversed-phase HPLC/MS. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 853, 303-313 (2007
-
(2007)
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci
, vol.853
, pp. 303-313
-
-
Gao, L.1
-
221
-
-
80052460370
-
Zinc deprivation mediates alcohol-induced hepatocyte IL 8 analog expression in rodents via an epigenetic mechanism
-
Zhao, Y., et al. Zinc deprivation mediates alcohol-induced hepatocyte IL 8 analog expression in rodents via an epigenetic mechanism. Am. J. Pathol. 179, 693-702 (2011
-
(2011)
Am. J. Pathol
, vol.179
, pp. 693-702
-
-
Zhao, Y.1
-
222
-
-
0018894904
-
Zinc depletion in alcoholic liver diseases
-
Kiilerich, S., et al. Zinc depletion in alcoholic liver diseases. Scand. J. Gastroenterol. 15, 363-367 (1980
-
(1980)
Scand. J. Gastroenterol
, vol.15
, pp. 363-367
-
-
Kiilerich, S.1
-
223
-
-
0022903005
-
Zinc metabolism in alcoholic liver disease
-
McClain, C. J., Antonow, D. R., Cohen, D. A., & Shedlofsky, S. I. Zinc metabolism in alcoholic liver disease. Alcohol Clin. Exp. Res. 10, 582-589 (1986
-
(1986)
Alcohol Clin. Exp. Res
, vol.10
, pp. 582-589
-
-
McClain, C.J.1
Antonow, D.R.2
Cohen, D.A.3
Shedlofsky, S.I.4
-
224
-
-
85047692717
-
Alcohol-induced myocardial fibrosis in metallothionein-null mice: Prevention by zinc supplementation
-
Wang, L., Zhou, Z., Saari, J. T., & Kang, Y. J. Alcohol-induced myocardial fibrosis in metallothionein-null mice: prevention by zinc supplementation. Am. J. Pathol. 167, 337-344 (2005
-
(2005)
Am. J. Pathol
, vol.167
, pp. 337-344
-
-
Wang, L.1
Zhou, Z.2
Saari, J.T.3
Kang, Y.J.4
-
225
-
-
19544364689
-
Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress
-
Zhou, Z., et al. Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress. Am. J. Pathol. 166, 1681-1690 (2005
-
(2005)
Am. J. Pathol
, vol.166
, pp. 1681-1690
-
-
Zhou, Z.1
-
226
-
-
77955096525
-
Reversible binding of zinc in Plasmodium falciparum Sir2: Structure and activity of the apoenzyme
-
Chakrabarty, S. P., & Balaram, H. Reversible binding of zinc in Plasmodium falciparum Sir2: structure and activity of the apoenzyme. Biochim. Biophys. Acta 1804, 1743-1750 (2010
-
(2010)
Biochim. Biophys. Acta
, vol.1804
, pp. 1743-1750
-
-
Chakrabarty, S.P.1
Balaram, H.2
-
227
-
-
0035960636
-
Crystal structure and mechanism of catalysis of a pyrazinamidase from Pyrococcus horikoshii
-
Du, X., et al. Crystal structure and mechanism of catalysis of a pyrazinamidase from Pyrococcus horikoshii. Biochemistry 40, 14166-14172 (2001
-
(2001)
Biochemistry
, vol.40
, pp. 14166-14172
-
-
Du, X.1
-
228
-
-
84893263129
-
A QM/MM study of the catalytic mechanism of nicotinamidase
-
Sheng, X., & Liu, Y. A QM/MM study of the catalytic mechanism of nicotinamidase. Org. Biomol. Chem. 12, 1265-1277 (2014
-
(2014)
Org. Biomol. Chem
, vol.12
, pp. 1265-1277
-
-
Sheng, X.1
Liu, Y.2
-
229
-
-
84934295856
-
Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex
-
Nangle, S. N., et al. Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex. eLife 3, e03674 (2014
-
(2014)
ELife
, vol.3
, pp. e03674
-
-
Nangle, S.N.1
-
230
-
-
84901358563
-
Interaction of circadian clock proteins CRY1 and PER2 is modulated by zinc binding and disulfide bond formation
-
Schmalen, I., et al. Interaction of circadian clock proteins CRY1 and PER2 is modulated by zinc binding and disulfide bond formation. Cell 157, 1203-1215 (2014
-
(2014)
Cell
, vol.157
, pp. 1203-1215
-
-
Schmalen, I.1
-
231
-
-
0037117479
-
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor 1 α
-
Freedman, S. J., et al. Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor 1 α. Proc. Natl Acad. Sci. USA 99, 5367-5372 (2002
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 5367-5372
-
-
Freedman, S.J.1
-
232
-
-
0035097883
-
The histone H4 acetyltransferase MOF uses a C2HC zinc finger for substrate recognition
-
Akhtar, A., & Becker, P. B. The histone H4 acetyltransferase MOF uses a C2HC zinc finger for substrate recognition. EMBO Rep. 2, 113-118 (2001
-
(2001)
EMBO Rep
, vol.2
, pp. 113-118
-
-
Akhtar, A.1
Becker, P.B.2
-
233
-
-
2342599619
-
The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases
-
Yang, X. J. The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. Nucleic Acids Res. 32, 959-976 (2004
-
(2004)
Nucleic Acids Res
, vol.32
, pp. 959-976
-
-
Yang, X.J.1
-
234
-
-
78650579361
-
From the gut to the peripheral tissues: The multiple effects of butyrate
-
Guilloteau, P., et al. From the gut to the peripheral tissues: the multiple effects of butyrate. Nutr. Res. Rev. 23, 366-384 (2010
-
(2010)
Nutr. Res. Rev
, vol.23
, pp. 366-384
-
-
Guilloteau, P.1
-
235
-
-
0030764592
-
Time of day and glucose tolerance status affect serum short-chain fatty acid concentrations in humans
-
Wolever, T. M., Josse, R. G., Leiter, L. A., & Chiasson, J. L. Time of day and glucose tolerance status affect serum short-chain fatty acid concentrations in humans. Metabolism 46, 805-811 (1997
-
(1997)
Metabolism
, vol.46
, pp. 805-811
-
-
Wolever, T.M.1
Josse, R.G.2
Leiter, L.A.3
Chiasson, J.L.4
-
236
-
-
0038676409
-
Inhibition of histone deacetylase activity by butyrate
-
Davie, J. R. Inhibition of histone deacetylase activity by butyrate. J. Nutr. 133, 2485S-2493S (2003
-
(2003)
J. Nutr
, vol.133
, pp. 2485S-2493S
-
-
Davie, J.R.1
-
237
-
-
0017898940
-
Suppression of histone deacetylation in vivo and in vitro by sodium butyrate
-
Boffa, L. C., Vidali, G., Mann, R. S., & Allfrey, V. G. Suppression of histone deacetylation in vivo and in vitro by sodium butyrate. J. Biol. Chem. 253, 3364-3366 (1978
-
(1978)
J. Biol. Chem
, vol.253
, pp. 3364-3366
-
-
Boffa, L.C.1
Vidali, G.2
Mann, R.S.3
Allfrey, V.G.4
-
238
-
-
0017864644
-
The effect of sodium butyrate on histone modification
-
Sealy, L., & Chalkley, R. The effect of sodium butyrate on histone modification. Cell 14, 115-121 (1978
-
(1978)
Cell
, vol.14
, pp. 115-121
-
-
Sealy, L.1
Chalkley, R.2
-
239
-
-
0017886958
-
Sodium butyrate inhibits histone deacetylation in cultured cells
-
Candido, E. P., Reeves, R., & Davie, J. R. Sodium butyrate inhibits histone deacetylation in cultured cells. Cell 14, 105-113 (1978
-
(1978)
Cell
, vol.14
, pp. 105-113
-
-
Candido, E.P.1
Reeves, R.2
Davie, J.R.3
-
240
-
-
33750110683
-
Fuel metabolism in starvation
-
Cahill, G. F. Fuel metabolism in starvation. Annu. Rev. Nutr. 26, 1-22 (2006
-
(2006)
Annu. Rev. Nutr
, vol.26
, pp. 1-22
-
-
Cahill, G.F.1
-
241
-
-
0013964986
-
Hormone-fuel interrelationships during fasting
-
Cahill, G. F., et al. Hormone-fuel interrelationships during fasting. J. Clin. Invest. 45, 1751-1769 (1966
-
(1966)
J. Clin. Invest
, vol.45
, pp. 1751-1769
-
-
Cahill, G.F.1
-
242
-
-
0018876377
-
Physiological roles of ketone bodies as substrates and signals in mammalian tissues
-
Robinson, A. M., & Williamson, D. H. Physiological roles of ketone bodies as substrates and signals in mammalian tissues. Physiol. Rev. 60, 143-187 (1980
-
(1980)
Physiol. Rev
, vol.60
, pp. 143-187
-
-
Robinson, A.M.1
Williamson, D.H.2
-
243
-
-
84872166360
-
Suppression of oxidative stress by β hydroxybutyrate, an endogenous histone deacetylase inhibitor
-
Shimazu, T., et al. Suppression of oxidative stress by β hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science 339, 211-214 (2013
-
(2013)
Science
, vol.339
, pp. 211-214
-
-
Shimazu, T.1
-
244
-
-
84905908997
-
Contribution of defective mitophagy to the neurodegeneration in DNA repair-deficient disorders
-
Scheibye-Knudsen, M., Fang, E. F., Croteau, D. L., & Bohr, V. A. Contribution of defective mitophagy to the neurodegeneration in DNA repair-deficient disorders. Autophagy 10, 1468-1469 (2014
-
(2014)
Autophagy
, vol.10
, pp. 1468-1469
-
-
Scheibye-Knudsen, M.1
Fang, E.F.2
Croteau, D.L.3
Bohr, V.A.4
-
245
-
-
84910141322
-
Linking DNA damage nad+/sirt1 and aging
-
Guarente, L. Linking DNA damage, NAD+/SIRT1, and aging. Cell Metab. 20, 706-707 (2014
-
(2014)
Cell Metab
, vol.20
, pp. 706-707
-
-
Guarente, L.1
-
246
-
-
79955591489
-
Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats
-
Braidy, N., et al. Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats. PLoS ONE 6, e19194 (2011
-
(2011)
PLoS ONE
, vol.6
, pp. e19194
-
-
Braidy, N.1
-
247
-
-
84893442805
-
Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging
-
Gomes, A. P., et al. Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell 155, 1624-1638 (2013
-
(2013)
Cell
, vol.155
, pp. 1624-1638
-
-
Gomes, A.P.1
-
248
-
-
80053920774
-
Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet-And age-induced diabetes in mice
-
Yoshino, J., Mills, K. F., Yoon, M. J., & Imai, S. i. Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet-And age-induced diabetes in mice. Cell Metab. 14, 528-536 (2011
-
(2011)
Cell Metab
, vol.14
, pp. 528-536
-
-
Yoshino, J.1
Mills, K.F.2
Yoon, M.J.3
Imai, S.I.4
-
249
-
-
84864401965
-
Age-Associated changes in oxidative stress and NAD+ metabolism in human tissue
-
Massudi, H., et al. Age-Associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS ONE 7, e42357 (2012
-
(2012)
PLoS ONE
, vol.7
, pp. e42357
-
-
Massudi, H.1
-
250
-
-
84894143537
-
Partial reversal of skeletal muscle aging by restoration of normal NAD+ levels
-
Mendelsohn, A. R., & Larrick, J. W. Partial reversal of skeletal muscle aging by restoration of normal NAD+ levels. Rejuvenation Res. 17, 62-69 (2014
-
(2014)
Rejuvenation Res
, vol.17
, pp. 62-69
-
-
Mendelsohn, A.R.1
Larrick, J.W.2
-
251
-
-
38349112898
-
Age-Associated loss of Sirt1 mediated enhancement of glucose-stimulated insulin secretion in β cell-specific Sirt1 overexpressing (BESTO) mice
-
Ramsey, K. M., Mills, K. F., Satoh, A., & Imai, S. i. Age-Associated loss of Sirt1 mediated enhancement of glucose-stimulated insulin secretion in β cell-specific Sirt1 overexpressing (BESTO) mice. Aging Cell 7, 78-88 (2008
-
(2008)
Aging Cell
, vol.7
, pp. 78-88
-
-
Ramsey, K.M.1
Mills, K.F.2
Satoh, A.3
Imai, S.I.4
-
252
-
-
84900410413
-
Nicotinamide N methyltransferase knockdown protects against diet-induced obesity
-
Kraus, D., et al. Nicotinamide N methyltransferase knockdown protects against diet-induced obesity. Nature 508, 258-262 (2014
-
(2014)
Nature
, vol.508
, pp. 258-262
-
-
Kraus, D.1
-
253
-
-
84962030356
-
Evidence for a direct effect of the NAD+ precursor Acipimox on muscle mitochondrial function in humans
-
van de Weijer, T., et al. Evidence for a direct effect of the NAD+ precursor Acipimox on muscle mitochondrial function in humans. Diabetes 64, 1193-1201 (2014
-
(2014)
Diabetes
, vol.64
, pp. 1193-1201
-
-
Van De Weijer, T.1
-
254
-
-
4043165678
-
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
-
Araki, T., Sasaki, Y., & Milbrandt, J. Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 305, 1010-1013 (2004
-
(2004)
Science
, vol.305
, pp. 1010-1013
-
-
Araki, T.1
Sasaki, Y.2
Milbrandt, J.3
-
255
-
-
84875245617
-
Nicotinamide riboside restores cognition through an upregulation of proliferator-Activated receptor γ coactivator 1α regulated β secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models
-
Gong, B., et al. Nicotinamide riboside restores cognition through an upregulation of proliferator-Activated receptor γ coactivator 1α regulated β secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models. Neurobiol. Aging 34, 1581-1588 (2013
-
(2013)
Neurobiol. Aging
, vol.34
, pp. 1581-1588
-
-
Gong, B.1
-
256
-
-
84864452777
-
Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin
-
Benavente, C. A., Schnell, S. A., & Jacobson, E. L. Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin. PLoS ONE 7, e42276 (2012
-
(2012)
PLoS ONE
, vol.7
, pp. e42276
-
-
Benavente, C.A.1
Schnell, S.A.2
Jacobson, E.L.3
-
257
-
-
84919497464
-
Inhibition of de novo NAD+ synthesis by oncogenic URI causes liver tumorigenesis through DNA damage
-
Tummala, K. S., et al. Inhibition of de novo NAD+ synthesis by oncogenic URI causes liver tumorigenesis through DNA damage. Cancer Cell 26, 826-839 (2014
-
(2014)
Cancer Cell
, vol.26
, pp. 826-839
-
-
Tummala, K.S.1
-
258
-
-
84899494248
-
Poly (ADP-ribose) polymerase 1 is a key mediator of liver inflammation and fibrosis
-
Mukhopadhyay, P., et al. Poly (ADP-ribose) polymerase 1 is a key mediator of liver inflammation and fibrosis. Hepatology 59, 1998-2009 (2014
-
(2014)
Hepatology
, vol.59
, pp. 1998-2009
-
-
Mukhopadhyay, P.1
-
259
-
-
84875431269
-
Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: Implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome
-
Escande, C., et al. Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes 62, 1084-1093 (2013
-
(2013)
Diabetes
, vol.62
, pp. 1084-1093
-
-
Escande, C.1
-
260
-
-
84862205290
-
Effects of zinc supplementation on diabetes mellitus: A systematic review and meta-Analysis.Diabetol
-
Jayawardena, R., et al. Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-Analysis.Diabetol. Metab. Syndr. 4, 13 (2012
-
(2012)
Metab. Syndr
, vol.4
, pp. 13
-
-
Jayawardena, R.1
-
261
-
-
0018399737
-
Oxidation of cytosolic NADH formed during aerobic metabolism in mammalian cells
-
Dawson, A. G. Oxidation of cytosolic NADH formed during aerobic metabolism in mammalian cells. Trends Biochem. Sci. 4, 171-176
-
Trends Biochem. Sci
, vol.4
, pp. 171-176
-
-
Dawson, A.G.1
-
262
-
-
84921405747
-
Site-specific reactivity of nonenzymatic lysine acetylation
-
Baeza, J., Smallegan, M. J., & Denu, J. M. Site-specific reactivity of nonenzymatic lysine acetylation. ACS Chem. Biol. 10, 122-128 (2015
-
(2015)
ACS Chem. Biol
, vol.10
, pp. 122-128
-
-
Baeza, J.1
Smallegan, M.J.2
Denu, J.M.3
-
263
-
-
84942028125
-
Nonenzymatic protein acetylation detected by NAPPA protein arrays
-
Olia, A. S., et al. Nonenzymatic protein acetylation detected by NAPPA protein arrays. ACS Chem. Biol. 10, 2034-2047 (2015
-
(2015)
ACS Chem. Biol
, vol.10
, pp. 2034-2047
-
-
Olia, A.S.1
-
264
-
-
84880426255
-
Acetyl-phosphate is a critical determinant of lysine acetylation in E coli
-
Weinert, B. T., et al. Acetyl-phosphate is a critical determinant of lysine acetylation in E. coli. Mol. Cell 51, 265-272 (2013
-
(2013)
Mol. Cell
, vol.51
, pp. 265-272
-
-
Weinert, B.T.1
|