Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

Neurobiology of Aging

Volumn 34, Issue 6, 2013, Pages 1581-1588

  Gong, Bing ^a   Pan, Yong ^a   Vempati, Prashant ^a   Zhao, Wei ^a   Knable, Lindsay ^a   Ho, Lap ^a   Wang, Jun ^a   Sastre, Magdalena ^c   Ono, Kenjiro ^a,e   Sauve, Anthony A ^d   Pasinetti, Giulio M ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e KANAZAWA UNIVERSITY   (Japan)

Author keywords

secretase (BACE1); Alzheimer's disease; Long term potentiation; Mitochondrial metabolism; Nicotinamide riboside; Promotes peroxisome proliferator activated receptor (PPAR) coactivator 1 (PGC) 1 ; Synaptic plasticity; Ubiquitin proteasome system

Indexed keywords

AMYLOID BETA PROTEIN; BETA SECRETASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE RIBOSIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; SHORT HAIRPIN RNA;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; COGNITION; CONTROLLED STUDY; DRUG EFFECT; EMBRYO; ENZYME DEGRADATION; FEMALE; GENE EXPRESSION; GENE SILENCING; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; LONG TERM POTENTIATION; MITOCHONDRIAL GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; UBIQUITINATION; UPREGULATION;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CELLS, CULTURED; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA; NIACINAMIDE; ORGAN CULTURE TECHNIQUES; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 84875245617     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2012.12.005     Document Type: Article

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