Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice

Science

Volumn 342, Issue 6158, 2013, Pages

  Peek, Clara Bien ^a,b   Affinati, Alison H ^a,b   Ramsey, Kathryn Moynihan ^a,b   Kuo, Hsin Yu ^b   Yu, Wei ^c   Sena, Laura A ^a   Ilkayeva, Olga ^d   Marcheva, Biliana ^a,b   Kobayashi, Yumiko ^a,b   Omura, Chiaki ^a,b   Levine, Daniel C ^a,b   Bacsik, David J ^a,b   Gius, David ^a   Newgard, Christopher B ^d   Goetzman, Eric ^e   Chandel, Navdeep S ^a   Denu, John M ^c   Mrksich, Milan ^b   Bass, Joseph ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

^e CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 PHOSPHOFRUCTOKINASE; ACYL COENZYME A DEHYDROGENASE; ADENOSINE TRIPHOSPHATE; ELECTRON TRANSFERRING FLAVOPROTEIN; MEDIUM CHAIN ACYL COENZYME A DEHYDROGENASE; MITOCHONDRIAL PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; ORNITHINE CARBAMOYLTRANSFERASE; OXIDOREDUCTASE; PROTEIN BMAL1; SELF ASSEMBLED MONOLAYER; TRIACYLGLYCEROL; ARNTL PROTEIN, MOUSE; SIRT3 PROTEIN, MOUSE; SIRTUIN 3; TRANSCRIPTION FACTOR ARNTL;

BIOAVAILABILITY; CIRCADIAN RHYTHM; FASTING; METABOLISM; MITOCHONDRION; OXYGEN CONSUMPTION; PROTEIN; RESPIRATION; SOLAR CYCLE;

ACETYLATION; AEROBIC METABOLISM; ARTICLE; BIOAVAILABILITY; BIOSYNTHESIS; CIRCADIAN RHYTHM; DEACETYLATION; ELECTROSPRAY MASS SPECTROMETRY; ENERGY YIELD; ENZYME ACTIVITY; FATTY ACID OXIDATION; FEEDBACK SYSTEM; GLUCOSE OXIDATION; IMMUNOBLOTTING; LIPID OXIDATION; LIVER; LIVER HOMOGENATE; LIVER MITOCHONDRION; MASS SPECTROMETRY; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOLECULAR DYNAMICS; MYOTUBE; NONHUMAN; OSCILLATION; OXYGEN CONSUMPTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METABOLISM; QUANTITATIVE ANALYSIS; WILD TYPE; ANIMAL; DIET RESTRICTION; ENERGY METABOLISM; GENETICS; KNOCKOUT MOUSE; LIPID METABOLISM; METABOLISM; MOUSE; OXIDATION REDUCTION REACTION; PHYSIOLOGY;

MUS;

ACETYLATION; ANIMALS; ARNTL TRANSCRIPTION FACTORS; CIRCADIAN CLOCKS; ENERGY METABOLISM; FASTING; LIPID METABOLISM; LIVER; MICE; MICE, KNOCKOUT; MITOCHONDRIA, LIVER; NAD; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; SIRTUIN 3;

EID: 84884248040     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1243417     Document Type: Article

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