Substrate specificity and kinetic mechanism of the Sir2 family of NAD +-dependent histone/protein deacetylases

Biochemistry

Volumn 43, Issue 30, 2004, Pages 9877-9887

  Borra, Margie T ^a   Langer, Michael R ^b   Slama, James T ^c   Denu, John M ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLATION; ENZYME KINETICS; HYDROLYSIS; SUBSTRATES; YEAST;

HISTONES; SUBSTRATE SPECIFICITY;

ENZYMES;

ACETIC ACID DERIVATIVE; ADENOSINE DIPHOSPHATE RIBOSE; ADENOSINE DIPHOSPHATE RIBOSE ACETATE; HISTONE; HISTONE H3; HISTONE H4; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PROTEIN; PROTEIN DEACETYLASE; SILENT INFORMATION REGULATOR PROTEIN 2; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CATALYSIS; DEACETYLATION; ENZYME KINETICS; ENZYME SPECIFICITY; HYDROLYSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN TERTIARY STRUCTURE; STEADY STATE;

ACETYLATION; AMINO ACID SEQUENCE; CATALYSIS; DIALYSIS; ENZYME INHIBITORS; HISTONE DEACETYLASES; HISTONES; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; NAD; O-ACETYL-ADP-RIBOSE; PEPTIDE FRAGMENTS; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUINS; SUBSTRATE SPECIFICITY;

EID: 3343024449     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi049592e     Document Type: Article

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