The Deacetylase Sirt6 Activates the Acetyltransferase GCN5 and Suppresses Hepatic Gluconeogenesis

Molecular Cell

Volumn 48, Issue 6, 2012, Pages 900-913

  Dominy Jr , John E ^a   Lee, Yoonjin ^a,b   Jedrychowski, Mark P ^a   Chim, Helen ^a   Jurczak, Michael J ^c   Camporez, Joao Paulo ^c   Ruan, Hai Bin ^c   Feldman, Jessica ^d   Pierce, Kerry ^e   Mostoslavsky, Raul ^a   Denu, John M ^d   Clish, Clary B ^e   Yang, Xiaoyong ^c   Shulman, Gerald I ^c   Gygi, Steven P ^a   Puigserver, Pere ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD UNIVERSITY   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

^e BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE 6 PHOSPHATASE; HISTONE ACETYLTRANSFERASE GCN5; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); SIRTUIN 6;

ACETYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE REPRESSION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; HEPATIC GLUCONEOGENESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; MALE; MOUSE; NONHUMAN; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

ACETYLATION; ANIMALS; BLOOD GLUCOSE; CELL LINE; ENZYME ACTIVATION; GENE EXPRESSION; GLUCONEOGENESIS; HEPATOCYTES; HUMANS; LIVER; MALE; MICE; MICE, INBRED BALB C; MICE, OBESE; P300-CBP TRANSCRIPTION FACTORS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIRTUIN 1; SIRTUINS; TRANS-ACTIVATORS;

ANIMALIA; MUS;

EID: 84871676013     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2012.09.030     Document Type: Article

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