메뉴 건너뛰기




Volumn 21, Issue 36, 2015, Pages 5212-5224

Nanoparticles in ocular drug delivery systems for topical administration: Promises and challenges

Author keywords

Chitosan; Colloidal dispersions; Eye drops; Lipids; Nanoparticles; Ocular; Polymers

Indexed keywords

EYE DROPS; NANOPARTICLE; POLYMER; DRUG; DRUG CARRIER; LIPID;

EID: 84947968734     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612821666150923095155     Document Type: Review
Times cited : (48)

References (224)
  • 1
    • 26644437438 scopus 로고    scopus 로고
    • The use of mucoadhesive polymers in ocular drug delivery
    • Ludwig A. The use of mucoadhesive polymers in ocular drug delivery. Adv Drug Deliv Rev 2005; 57: 1595-639.
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 1595-1639
    • Ludwig, A.1
  • 2
    • 12344249638 scopus 로고    scopus 로고
    • Studies on a new device for drug delivery to the eye
    • Pijls RT, Sonderkamp T, Daube GW, et al. Studies on a new device for drug delivery to the eye. Eur J Pharm Biopharm 2005; 59: 283- 8.
    • (2005) Eur J Pharm Biopharm , vol.59 , pp. 283-288
    • Pijls, R.T.1    Sonderkamp, T.2    Daube, G.W.3
  • 3
    • 84872287547 scopus 로고    scopus 로고
    • Nanotechnology in ophthalmic drug delivery systems: A survey of recent developments and patenting activity
    • Pignatello R, Puglisi G. Nanotechnology in ophthalmic drug delivery systems: a survey of recent developments and patenting activity. Recent Pat Nanomed 2011; 1: 42-54.
    • (2011) Recent Pat Nanomed , vol.1 , pp. 42-54
    • Pignatello, R.1    Puglisi, G.2
  • 4
    • 84899508220 scopus 로고    scopus 로고
    • In situ gelling systems: A strategy to improve the bioavailability of ophthalmic pharmaceutical formulations
    • Almeida H, Amaral MH, Lobão P, et al. In situ gelling systems: a strategy to improve the bioavailability of ophthalmic pharmaceutical formulations. Drug Discov Today 2014; 19: 400-12.
    • (2014) Drug Discov Today , vol.19 , pp. 400-412
    • Almeida, H.1    Amaral, M.H.2    Lobão, P.3
  • 5
    • 84919794342 scopus 로고    scopus 로고
    • Advances in ophthalmic drug delivery
    • Morrison PW, Khutoryanskiy VV. Advances in ophthalmic drug delivery. Ther Deliv 2014; 5: 1297-315.
    • (2014) Ther Deliv , vol.5 , pp. 1297-1315
    • Morrison, P.W.1    Khutoryanskiy, V.V.2
  • 6
    • 63949084823 scopus 로고    scopus 로고
    • Recent perspectives in ocular drug delivery
    • Gaudana R, Jwala J, Baddu SH. et al. Recent perspectives in ocular drug delivery. Pharm Res 2009; 26: 1197-216.
    • (2009) Pharm Res , vol.26 , pp. 1197-1216
    • Gaudana, R.1    Jwala, J.2    Baddu, S.H.3
  • 7
    • 84904559612 scopus 로고    scopus 로고
    • Applications of lipid and polymeric nanoparticles in ophthalmic pharmaceutical formulations: Present and futures considerations
    • Almeida H, Amaral MH, Lobão P, et al. Applications of lipid and polymeric nanoparticles in ophthalmic pharmaceutical formulations: present and futures considerations. J Pharm Pharm Sci 2014; 17: 278-93.
    • (2014) J Pharm Pharm Sci , vol.17 , pp. 278-293
    • Almeida, H.1    Amaral, M.H.2    Lobão, P.3
  • 8
    • 84884579982 scopus 로고    scopus 로고
    • Enhanced and sustained topical ocular delivery of cuclosporine A in thermosensitive hyaluronic acid based in situ forming microgels
    • Wu Y, You J, Zhou J, et al. Enhanced and sustained topical ocular delivery of cuclosporine A in thermosensitive hyaluronic acid based in situ forming microgels. Int J Nanomed 2013; 8: 3587-601.
    • (2013) Int J Nanomed , vol.8 , pp. 3587-3601
    • Wu, Y.1    You, J.2    Zhou, J.3
  • 9
    • 84882404475 scopus 로고    scopus 로고
    • Applications of poloxamers in ophthalmic pharmaceutical formulations: An overview
    • Almeida H, Amaral MH, Lobão P, et al. Applications of poloxamers in ophthalmic pharmaceutical formulations: an overview. Expet Opin Drug Deliv 2013; 10: 1223-37.
    • (2013) Expet Opin Drug Deliv , vol.10 , pp. 1223-1237
    • Almeida, H.1    Amaral, M.H.2    Lobão, P.3
  • 10
    • 84900547141 scopus 로고    scopus 로고
    • Drug delivery to the back of the eye following topical administration: An update on research and patenting activity
    • Boddu SH, Gupta H, Patel S. Drug delivery to the back of the eye following topical administration: an update on research and patenting activity. Recent Pat Drug Deliv Formul 2014; 8: 27-36.
    • (2014) Recent Pat Drug Deliv Formul , vol.8 , pp. 27-36
    • Boddu, S.H.1    Gupta, H.2    Patel, S.3
  • 11
    • 84944532516 scopus 로고    scopus 로고
    • Mucoadhesive polymers for enhancing retention in ocular drug delivery: A critical review
    • Khare A, Grover K, Pawar P, et al. Mucoadhesive polymers for enhancing retention in ocular drug delivery: a critical review. Rev Adhesion Adhesives 2014; 2: 467-502.
    • (2014) Rev Adhesion Adhesives , vol.2 , pp. 467-502
    • Khare, A.1    Grover, K.2    Pawar, P.3
  • 12
    • 84935020887 scopus 로고    scopus 로고
    • Gelatin-based particulate systems in ocular drug delivery
    • 8 January. [Epub ahead of print]
    • Hathout RM, Omran MK. Gelatin-based particulate systems in ocular drug delivery. Pharm Dev Technol Available online 8 January 2015; [Epub ahead of print].
    • (2015) Pharm Dev Technol
    • Hathout, R.M.1    Omran, M.K.2
  • 13
    • 0029757658 scopus 로고    scopus 로고
    • Delivery of drugs to the eye by topical application
    • Sasaki H, Yamamura K, Nishida K, et al. Delivery of drugs to the eye by topical application. Prog Ret Eye Res 1996; 15: 583-620.
    • (1996) Prog Ret Eye Res , vol.15 , pp. 583-620
    • Sasaki, H.1    Yamamura, K.2    Nishida, K.3
  • 14
    • 33845891058 scopus 로고    scopus 로고
    • Ocular drug delivery by liposome-chitosan nanoparticle complexes (LCS-NP)
    • Diebold Y, Jarrin M, Saez V, et al. Ocular drug delivery by liposome-chitosan nanoparticle complexes (LCS-NP). Biomaterials 2007; 28: 1553-64.
    • (2007) Biomaterials , vol.28 , pp. 1553-1564
    • Diebold, Y.1    Jarrin, M.2    Saez, V.3
  • 15
    • 39849100697 scopus 로고    scopus 로고
    • Chitosan-sodium alginate nanoparticles as submicroscopic reservoirs for ocular delivery: Formulation, optimisation and in vitro characterisation
    • Motwani SK, Chopra S, Talegaonkar S, et al. Chitosan-sodium alginate nanoparticles as submicroscopic reservoirs for ocular delivery: formulation, optimisation and in vitro characterisation. Eur J Pharm Biopharm 2008; 68: 513-25.
    • (2008) Eur J Pharm Biopharm , vol.68 , pp. 513-525
    • Motwani, S.K.1    Chopra, S.2    Talegaonkar, S.3
  • 16
    • 70749161866 scopus 로고    scopus 로고
    • Nanomedicines for ocular NSAIDs: Safety on drug delivery
    • Araújo J, Gonzalez E, Egea MA, et al. Nanomedicines for ocular NSAIDs: safety on drug delivery. Nanomedicine 2009; 5: 394-401.
    • (2009) Nanomedicine , vol.5 , pp. 394-401
    • Araújo, J.1    Gonzalez, E.2    Egea, M.A.3
  • 17
    • 77956161610 scopus 로고    scopus 로고
    • Solid lipid nanoparticles for ocular drug delivery
    • Seyfoddin A, Shaw J, Al-Kassas R. Solid lipid nanoparticles for ocular drug delivery. Drug Deliv 2010; 17: 467-89.
    • (2010) Drug Deliv , vol.17 , pp. 467-489
    • Seyfoddin, A.1    Shaw, J.2    Al-Kassas, R.3
  • 18
    • 77954735684 scopus 로고    scopus 로고
    • In-situ gel: New trends in controlled and sustained drug delivery system
    • Nirmal HB, Bakliwal SR, Pawar SP. In-situ gel: new trends in controlled and sustained drug delivery system. Int J PharmTech Res 2010; 2: 1398-408.
    • (2010) Int J PharmTech Res , vol.2 , pp. 1398-1408
    • Nirmal, H.B.1    Bakliwal, S.R.2    Pawar, S.P.3
  • 19
    • 84894511443 scopus 로고    scopus 로고
    • In-situ gel formation for ocular drug delivery system an overview
    • Agarwal KI, Mehta N, Namdev A, et al. In-situ gel formation for ocular drug delivery system an overview. Asia J Bio Pharm Sci 2011; 1: 1-7.
    • (2011) Asia J Bio Pharm Sci , vol.1 , pp. 1-7
    • Agarwal, K.I.1    Mehta, N.2    Namdev, A.3
  • 20
    • 78651485569 scopus 로고    scopus 로고
    • Preparation and evaluation of tubular micelles of pluronic lecithin organogel for transdermal delivery of sumatropin
    • Agrawal V, Gupta V, Ramteke S, et al. Preparation and evaluation of tubular micelles of pluronic lecithin organogel for transdermal delivery of sumatropin. AAPS Pharm SciTech 2010; 11: 1718-25.
    • (2010) AAPS Pharm SciTech , vol.11 , pp. 1718-1725
    • Agrawal, V.1    Gupta, V.2    Ramteke, S.3
  • 21
    • 84867706591 scopus 로고    scopus 로고
    • Current status of ophthalmic in-situ forming hydrogel
    • Champalal KD, Sushilkumar P. Current status of ophthalmic in-situ forming hydrogel. Int J Pharm Bio Sci 2012; 3: 372-88.
    • (2012) Int J Pharm Bio Sci , vol.3 , pp. 372-388
    • Champalal, K.D.1    Sushilkumar, P.2
  • 23
    • 84883870236 scopus 로고    scopus 로고
    • A potential carrier based on liquid crystal nanoparticles for ophthalmic delivery of pilocarpine nitrate
    • Li J, Wu L, Wu W, et al. A potential carrier based on liquid crystal nanoparticles for ophthalmic delivery of pilocarpine nitrate. Int J Pharm 2013; 455: 75-84.
    • (2013) Int J Pharm , vol.455 , pp. 75-84
    • Li, J.1    Wu, L.2    Wu, W.3
  • 24
    • 84875960642 scopus 로고    scopus 로고
    • Development and evaluation of fast forming nano-composite hydrogel for ocular delivery of diclofenac
    • Li X, Zhang Z, Chen H. Development and evaluation of fast forming nano-composite hydrogel for ocular delivery of diclofenac. Int J Pharm 2013, 448: 96-100.
    • (2013) Int J Pharm , vol.448 , pp. 96-100
    • Li, X.1    Zhang, Z.2    Chen, H.3
  • 25
    • 84926394128 scopus 로고    scopus 로고
    • Recent patents on ophthalmic nanoformulations and therapeutic implications
    • Ako-Adounvo AM, Nagarwal RC, Oliveira L, et al. Recent patents on ophthalmic nanoformulations and therapeutic implications. Recent Pat Drug Deliv Formul 2014; 8: 193-201.
    • (2014) Recent Pat Drug Deliv Formul , vol.8 , pp. 193-201
    • Ako-Adounvo, A.M.1    Nagarwal, R.C.2    Oliveira, L.3
  • 26
    • 84910676727 scopus 로고    scopus 로고
    • Thiolated poly(aspartic acid) as potential in situ gelling, ocular mucoadhesive drug delivery system
    • Horvát G, Gyarmati B, Berkó S, et al. Thiolated poly(aspartic acid) as potential in situ gelling, ocular mucoadhesive drug delivery system. Eur J Pharm Sci 2015; 67: 1-11.
    • (2015) Eur J Pharm Sci , vol.67 , pp. 1-11
    • Horvát, G.1    Gyarmati, B.2    Berkó, S.3
  • 27
    • 0029347460 scopus 로고
    • Liposome ocular delivery systems
    • Meisner D, Mezei M. Liposome ocular delivery systems. Adv Drug Deliv Rev 1995; 16: 75-93.
    • (1995) Adv Drug Deliv Rev , vol.16 , pp. 75-93
    • Meisner, D.1    Mezei, M.2
  • 28
    • 79952365177 scopus 로고    scopus 로고
    • Formulation and evaluation of pH-triggered in situ gelling system of levofloxacin
    • Mohanambal E, Arun k, Abdul Hasan Sathali A. Formulation and evaluation of pH-triggered in situ gelling system of levofloxacin. Indian J Pharm Educ Res 2011; 45: 58-64.
    • (2011) Indian J Pharm Educ Res , vol.45 , pp. 58-64
    • Mohanambal, E.1    Arun, K.2    Abdul Hasan Sathali, A.3
  • 29
    • 0029347475 scopus 로고
    • Microspheres and nanoparticles used in ocular delivery systems
    • Zimmer A, Kreuter J. Microspheres and nanoparticles used in ocular delivery systems. Adv Drug Deliv Rev 1995; 16: 61-73.
    • (1995) Adv Drug Deliv Rev , vol.16 , pp. 61-73
    • Zimmer, A.1    Kreuter, J.2
  • 30
    • 0029347478 scopus 로고
    • Topical semi-solid drug delivery: Kinetics and tolerance of ophthalmic hydrogels
    • Zignani M, Tabatabay C, Gurny R. Topical semi-solid drug delivery: kinetics and tolerance of ophthalmic hydrogels. Adv Drug Deliv Rev 1995; 16: 51-60.
    • (1995) Adv Drug Deliv Rev , vol.16 , pp. 51-60
    • Zignani, M.1    Tabatabay, C.2    Gurny, R.3
  • 32
    • 33751187547 scopus 로고    scopus 로고
    • Challenges and obstacles of ocular pharmacokinetics and drug delivery
    • Urtti A. Challenges and obstacles of ocular pharmacokinetics and drug delivery. Adv Drug Deliv Rev 2006; 58: 1131-5.
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 1131-1135
    • Urtti, A.1
  • 33
    • 68649088751 scopus 로고    scopus 로고
    • Liposome coated with low molecular weight chitosan and its potential use in ocular drug delivery
    • Li N, Zhuang C, Wang M, et al. Liposome coated with low molecular weight chitosan and its potential use in ocular drug delivery. Int J Pharm 2009; 379: 131-8.
    • (2009) Int J Pharm , vol.379 , pp. 131-138
    • Li, N.1    Zhuang, C.2    Wang, M.3
  • 34
    • 67649540150 scopus 로고    scopus 로고
    • Preparation and evaluation of ophthalmic thermosensitive in situ gels of penciclovir
    • Li G, Li M. Preparation and evaluation of ophthalmic thermosensitive in situ gels of penciclovir. J Chinese Pharm Sci 2007; 16: 90-5.
    • (2007) J Chinese Pharm Sci , vol.16 , pp. 90-95
    • Li, G.1    Li, M.2
  • 35
    • 67349194262 scopus 로고    scopus 로고
    • Effect of polymer viscosity on physicochemical properties and ocular tolerance of FB-loaded PLGA nanospheres
    • Araújo J, Veja E, Lopes C, et al. Effect of polymer viscosity on physicochemical properties and ocular tolerance of FB-loaded PLGA nanospheres. Colloids Surf B Biointerfaces 2009; 72: 48-56.
    • (2009) Colloids Surf B Biointerfaces , vol.72 , pp. 48-56
    • Araújo, J.1    Veja, E.2    Lopes, C.3
  • 36
    • 75149149000 scopus 로고    scopus 로고
    • Chitosan-based hydrogels for controlled, localized drug delivery
    • Bhattarai N, Gunn J, Zhang M. Chitosan-based hydrogels for controlled, localized drug delivery. Adv Drug Deliv Rev 2010; 62: 83- 99.
    • (2010) Adv Drug Deliv Rev , vol.62 , pp. 83-99
    • Bhattarai, N.1    Gunn, J.2    Zhang, M.3
  • 37
    • 78650582969 scopus 로고    scopus 로고
    • Applications of nanoparticles in ophthalmology
    • Diebold Y, Calonge M. Applications of nanoparticles in ophthalmology. Prog Retin Eye Res 2010; 29: 596-609.
    • (2010) Prog Retin Eye Res , vol.29 , pp. 596-609
    • Diebold, Y.1    Calonge, M.2
  • 38
    • 84874679837 scopus 로고    scopus 로고
    • Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers
    • Gan L, Wang J, Jiang M, et al. Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers. Drug Discov Today 2013; 18: 290-97.
    • (2013) Drug Discov Today , vol.18 , pp. 290-297
    • Gan, L.1    Wang, J.2    Jiang, M.3
  • 39
    • 84911874105 scopus 로고    scopus 로고
    • Cationic solid lipid nanoparticles enhance ocular hypotensive effect of melatonin in rabit
    • Leonardi A, Bucolo C, Drago F, et al. Cationic solid lipid nanoparticles enhance ocular hypotensive effect of melatonin in rabit. Int J Pharm 2015; 478: 180-6.
    • (2015) Int J Pharm , vol.478 , pp. 180-186
    • Leonardi, A.1    Bucolo, C.2    Drago, F.3
  • 40
    • 0345827826 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of the Gelrite gellan gum-based ocular delivery system for indomethacin
    • Balasubramaniam J, Kant S, Pandit JK. In vitro and in vivo evaluation of the Gelrite gellan gum-based ocular delivery system for indomethacin. Acta Pharm 2003; 53: 251-61.
    • (2003) Acta Pharm , vol.53 , pp. 251-261
    • Balasubramaniam, J.1    Kant, S.2    Pandit, J.K.3
  • 44
    • 78349311591 scopus 로고    scopus 로고
    • Thiolated nanostructured lipid carriers as a potential ocular delivery system for cyclosporine A: Improving in vivo ocular distribution
    • Shen J, Deng Y, Jin X, et al. Thiolated nanostructured lipid carriers as a potential ocular delivery system for cyclosporine A: improving in vivo ocular distribution. Int J Pharm 2010; 402: 248-53.
    • (2010) Int J Pharm , vol.402 , pp. 248-253
    • Shen, J.1    Deng, Y.2    Jin, X.3
  • 45
    • 67649101315 scopus 로고    scopus 로고
    • Mucoadhesive effect of thiolated PEG stearate and its modified NLC for ocular drug delivery
    • Shen J, Wang Y, Ping Q, et al. Mucoadhesive effect of thiolated PEG stearate and its modified NLC for ocular drug delivery. J Control Release 2009; 137: 217-23.
    • (2009) J Control Release , vol.137 , pp. 217-223
    • Shen, J.1    Wang, Y.2    Ping, Q.3
  • 46
    • 84911463961 scopus 로고    scopus 로고
    • Methazolamide-loaded solid lipid nanoparticles modified with low-molecular weight chitosan for the treatment of glaucoma: Vitro and vivo study
    • Wang F, Chen L, Zhang D, et al. Methazolamide-loaded solid lipid nanoparticles modified with low-molecular weight chitosan for the treatment of glaucoma: vitro and vivo study. J Drug Target 2014; 22: 849-56.
    • (2014) J Drug Target , vol.22 , pp. 849-856
    • Wang, F.1    Chen, L.2    Zhang, D.3
  • 47
    • 0035999781 scopus 로고    scopus 로고
    • Flurbiprofen-loaded acrylate polymer nanosuspensions for ophthalmic application
    • Pignatello R, Bucolo C, Spedalieri G, et al. Flurbiprofen-loaded acrylate polymer nanosuspensions for ophthalmic application. Biomaterials 2002; 23: 3247-55.
    • (2002) Biomaterials , vol.23 , pp. 3247-3255
    • Pignatello, R.1    Bucolo, C.2    Spedalieri, G.3
  • 48
    • 33847363962 scopus 로고    scopus 로고
    • Microparticle systems based on polymer drug interaction for ocular delivery of ciprofloxacin I. In vitro characterization
    • Bonferoni MC, Sandri G, Gavini E, et al. Microparticle systems based on polymer drug interaction for ocular delivery of ciprofloxacin I. In vitro characterization. J Drug Deliv Sci Tech 2007; 17: 57-62.
    • (2007) J Drug Deliv Sci Tech , vol.17 , pp. 57-62
    • Bonferoni, M.C.1    Sandri, G.2    Gavini, E.3
  • 49
    • 77955049646 scopus 로고    scopus 로고
    • Self-assembled liquid crystalline nanoparticles as a novel ophthalmic delivery system for dexamethasone: Improving preocular retention and ocular bioavailability
    • Gan L, Han S, Shen J, et al. Self-assembled liquid crystalline nanoparticles as a novel ophthalmic delivery system for dexamethasone: Improving preocular retention and ocular bioavailability. Int J Pharm 2010; 396: 179-87.
    • (2010) Int J Pharm , vol.396 , pp. 179-187
    • Gan, L.1    Han, S.2    Shen, J.3
  • 50
    • 79956102907 scopus 로고    scopus 로고
    • 20 years of lipid nanoparticles (SLN and NLC): Present state of development and industrial applications
    • Müller RH, Shegokar R, Keck CM 20 years of lipid nanoparticles (SLN and NLC): present state of development and industrial applications. Curr Drug Discov Technol 2011; 8: 207-27.
    • (2011) Curr Drug Discov Technol , vol.8 , pp. 207-227
    • Müller, R.H.1    Shegokar, R.2    Keck, C.M.3
  • 51
    • 84872812734 scopus 로고    scopus 로고
    • Dexamethasone eye drops containing γ-cyclodextrin-based nanogels
    • Moya-Ortega MD, Alves TFG, Alvarez-Lorenzo C, et al. Dexamethasone eye drops containing γ-cyclodextrin-based nanogels. Int J Pharm 2013; 41: 507-51.
    • (2013) Int J Pharm , vol.41 , pp. 507-551
    • Moya-Ortega, M.D.1    Alves, T.F.G.2    Alvarez-Lorenzo, C.3
  • 52
    • 84871134897 scopus 로고    scopus 로고
    • Poloxamine micellar solubilization of α-tocopherol for topical ocular treatment
    • Ribeiro A, Sandez-Macho I, Casas M, et al. Poloxamine micellar solubilization of α-tocopherol for topical ocular treatment. Colloids Surf B Biointerfaces 2013; 103: 550-7.
    • (2013) Colloids Surf B Biointerfaces , vol.103 , pp. 550-557
    • Ribeiro, A.1    Sandez-Macho, I.2    Casas, M.3
  • 53
    • 85039890392 scopus 로고    scopus 로고
    • Defining the properties of pH - sensitive polymeric micellar ocular delivery system of miconazole nitrate for the management of fungal endophthalmitis
    • Agrawal V, Kumar M, Pathak K. Defining the properties of pH - sensitive polymeric micellar ocular delivery system of miconazole nitrate for the management of fungal endophthalmitis. Pharm Nanotechnol 2014; 2: 157-66.
    • (2014) Pharm Nanotechnol , vol.2 , pp. 157-166
    • Agrawal, V.1    Kumar, M.2    Pathak, K.3
  • 54
    • 85039831523 scopus 로고    scopus 로고
    • Optimization and validationof a new method for the production of lipid nanoparticles for ophthalmic application
    • Pignatello R, Leonardi A, Cupri S. Optimization and validationof a new method for the production of lipid nanoparticles for ophthalmic application. Int J Med Nano Res 2014; 1: 1-6.
    • (2014) Int J Med Nano Res , vol.1 , pp. 1-6
    • Pignatello, R.1    Leonardi, A.2    Cupri, S.3
  • 55
    • 84947975032 scopus 로고    scopus 로고
    • Current nanotechnology approaches for the treatment and management of the diabetic retinopathy
    • [Epub ahead of print]
    • Fangueiro JF, Silva AM, Garcia ML et al. Current nanotechnology approaches for the treatment and management of the diabetic retinopathy. Eur J Pharm Biopharm 2014; [Epub ahead of print].
    • (2014) Eur J Pharm Biopharm
    • Fangueiro, J.F.1    Silva, A.M.2    Garcia, M.L.3
  • 56
    • 0033020812 scopus 로고    scopus 로고
    • Characterization and in-vivo ocular absorption of liposome-encapsulated acyclovir
    • Fresta M, Panico AM, Bucolo C, et al. Characterization and in-vivo ocular absorption of liposome-encapsulated acyclovir. J Pharm Pharmacol 1999; 51: 565-67.
    • (1999) J Pharm Pharmacol , vol.51 , pp. 565-567
    • Fresta, M.1    Panico, A.M.2    Bucolo, C.3
  • 58
    • 67349084376 scopus 로고    scopus 로고
    • Polymeric nanoparticulate system: A potential approach for ocular drug delivery
    • Nagarwal RC, Kant S, Singh PN, et al. Polymeric nanoparticulate system: A potential approach for ocular drug delivery. J Control Release 2009; 136: 2-13.
    • (2009) J Control Release , vol.136 , pp. 2-13
    • Nagarwal, R.C.1    Kant, S.2    Singh, P.N.3
  • 59
    • 84866499684 scopus 로고    scopus 로고
    • Chitosan coated sodium alginate- chitosan nanoparticles loaded with 5-FU for ocular delivery: In vitro characterization and in vivo study in rabbit eye
    • Nagarwal RC, Kumar R, Pandit JK. Chitosan coated sodium alginate- chitosan nanoparticles loaded with 5-FU for ocular delivery: in vitro characterization and in vivo study in rabbit eye. Eur J Pharm Sci 2012; 47: 678-85.
    • (2012) Eur J Pharm Sci , vol.47 , pp. 678-685
    • Nagarwal, R.C.1    Kumar, R.2    Pandit, J.K.3
  • 60
    • 84861600703 scopus 로고    scopus 로고
    • Mucoadhesive nanoparticles for prolonged ocular delivery of natamycin: In vitro and pharmacokinetics studies
    • Bhatta RS, Chandasana H, Chhonker YS, et al. Mucoadhesive nanoparticles for prolonged ocular delivery of natamycin: in vitro and pharmacokinetics studies. Int J Pharm 2012; 432: 105-12.
    • (2012) Int J Pharm , vol.432 , pp. 105-112
    • Bhatta, R.S.1    Chandasana, H.2    Chhonker, Y.S.3
  • 62
    • 0017742841 scopus 로고
    • The structural basis of the blood-ocular barriers
    • Raviola G. The structural basis of the blood-ocular barriers. Exp Eye Res 1977; 25: 27-63.
    • (1977) Exp Eye Res , vol.25 , pp. 27-63
    • Raviola, G.1
  • 63
    • 0035160002 scopus 로고    scopus 로고
    • The ocular surface and tear film and their dysfunction in dry eye disease
    • Rolando M, Zierhut M. The ocular surface and tear film and their dysfunction in dry eye disease. Surv Ophthalmol 2001; 45: S203- 10.
    • (2001) Surv Ophthalmol , vol.45 , pp. 203-210
    • Rolando, M.1    Zierhut, M.2
  • 64
    • 77957807681 scopus 로고    scopus 로고
    • Ocular anatomy and physiology relevant to anaesthesia
    • Presland A, Myatt J. Ocular anatomy and physiology relevant to anaesthesia. Anaesth Intens Care Med 2010; 11: 438-43.
    • (2010) Anaesth Intens Care Med , vol.11 , pp. 438-443
    • Presland, A.1    Myatt, J.2
  • 65
    • 79251528557 scopus 로고    scopus 로고
    • Ocular anatomy and crosssectional imaging of the eye
    • Malhotra A, Minja FJ, Crum A, et al. Ocular anatomy and crosssectional imaging of the eye. Semin Ultrasound CT MRI 2011; 32: 2-13.
    • (2011) Semin Ultrasound CT MRI , vol.32 , pp. 2-13
    • Malhotra, A.1    Minja, F.J.2    Crum, A.3
  • 66
    • 0031965225 scopus 로고    scopus 로고
    • Ophthalmic drug delivery systems: Recent advances
    • Bourlais CL, Acar L, Zia H, et al. Ophthalmic drug delivery systems: recent advances. Prog Retin Eye Res 1998; 17: 33-58.
    • (1998) Prog Retin Eye Res , vol.17 , pp. 33-58
    • Bourlais, C.L.1    Acar, L.2    Zia, H.3
  • 68
    • 0034508981 scopus 로고    scopus 로고
    • Anatomy of the eye and orbit
    • Smerdon D. Anatomy of the eye and orbit. Curr Anaesth Crit Care 2000; 11: 286-92.
    • (2000) Curr Anaesth Crit Care , vol.11 , pp. 286-292
    • Smerdon, D.1
  • 69
    • 75249101867 scopus 로고    scopus 로고
    • Chitosan-based nanostructures: A delivery platform for ocular therapeutics
    • De la Fuente, Raviña M, Paolicelli P, et al. Chitosan-based nanostructures: A delivery platform for ocular therapeutics. Adv Drug Deliv Rev 2010; 62: 100-17.
    • (2010) Adv Drug Deliv Rev , vol.62 , pp. 100-117
    • De la Fuente1    Raviña, M.2    Paolicelli, P.3
  • 70
    • 0037043105 scopus 로고    scopus 로고
    • In vitro an in vivo evaluation of Pluronic F127- based ocular delivery system for timolol maleate
    • El-Kamel AH. In vitro an in vivo evaluation of Pluronic F127- based ocular delivery system for timolol maleate. Int J Pharm 2002; 241: 47-55.
    • (2002) Int J Pharm , vol.241 , pp. 47-55
    • El-Kamel, A.H.1
  • 71
  • 72
    • 0030662662 scopus 로고    scopus 로고
    • Chemical and physical parameters of tears relevant for the design of ocular drug delivery formulations
    • Baeyens V, Gurny R. Chemical and physical parameters of tears relevant for the design of ocular drug delivery formulations. Pharm Acta Helv 1997; 72: 191-202.
    • (1997) Pharm Acta Helv , vol.72 , pp. 191-202
    • Baeyens, V.1    Gurny, R.2
  • 73
    • 41949139148 scopus 로고    scopus 로고
    • Polymeric hydrogels for novel contact lens-based ophthalmic drug delivery systems: A review
    • Xinming L, Yingde C, Lloyd AW, et al. Polymeric hydrogels for novel contact lens-based ophthalmic drug delivery systems: a review. Cont Lens Anterior Eye 2008; 31: 57-64.
    • (2008) Cont Lens Anterior Eye , vol.31 , pp. 57-64
    • Xinming, L.1    Yingde, C.2    Lloyd, A.W.3
  • 74
    • 84911493996 scopus 로고    scopus 로고
    • Nanocarriers for ocular delivery for possible benefits in the treatment of anterior uveitis: Focus on current paradigms and future directions
    • Suresh PK, Sah AK. Nanocarriers for ocular delivery for possible benefits in the treatment of anterior uveitis: focus on current paradigms and future directions. Expert Opin Drug Deliv 2014; 11: 1- 22.
    • (2014) Expert Opin Drug Deliv , vol.11 , pp. 1-22
    • Suresh, P.K.1    Sah, A.K.2
  • 76
    • 0028328729 scopus 로고
    • Ocular absorption and distribution of bendazac after topical administration to rabbits with different vehicles
    • Romanelli L, Valeri P, Morrone LA, et al. Ocular absorption and distribution of bendazac after topical administration to rabbits with different vehicles. Life Sci 1994; 54: 877-85.
    • (1994) Life Sci , vol.54 , pp. 877-885
    • Romanelli, L.1    Valeri, P.2    Morrone, L.A.3
  • 77
    • 84922575853 scopus 로고    scopus 로고
    • Sustained drug release by contact lenses for glaucoma treatment-A review
    • Carvalho IM, Marques CS, Oliveira RS, et al. Sustained drug release by contact lenses for glaucoma treatment-A review. J Control Release 2015; 202: 76-82.
    • (2015) J Control Release , vol.202 , pp. 76-82
    • Carvalho, I.M.1    Marques, C.S.2    Oliveira, R.S.3
  • 78
    • 0000883662 scopus 로고
    • Ocular drug delivery. Mechanism of corneal drug transport and mucoadhesive delivery systems
    • Robinson JR. Ocular drug delivery. Mechanism of corneal drug transport and mucoadhesive delivery systems. STP Pharma 1989; 5: 839-46.
    • (1989) STP Pharma , vol.5 , pp. 839-846
    • Robinson, J.R.1
  • 79
    • 0032055148 scopus 로고    scopus 로고
    • Rheological evaluation of poloxamer as an in situ gel for ophthalmic use
    • Edsman K, Carlfors J, Petersson R. Rheological evaluation of poloxamer as an in situ gel for ophthalmic use. Eur J Pharm Sci 1998; 6: 105-12.
    • (1998) Eur J Pharm Sci , vol.6 , pp. 105-112
    • Edsman, K.1    Carlfors, J.2    Petersson, R.3
  • 81
    • 0029347473 scopus 로고
    • Bioadhesive and phase-change polymers for ocular drug delivery
    • Robinson JR, Mlynek GM. Bioadhesive and phase-change polymers for ocular drug delivery. Adv Drug Deliv Rev 1995; 16: 45- 50.
    • (1995) Adv Drug Deliv Rev , vol.16 , pp. 45-50
    • Robinson, J.R.1    Mlynek, G.M.2
  • 82
    • 78751538795 scopus 로고    scopus 로고
    • Platelet lysate formulations based on mucoadhesive polymers for the treatment of corneal lesions
    • Sandri G, Bonferoni MC, Rossi S, et al. Platelet lysate formulations based on mucoadhesive polymers for the treatment of corneal lesions. J Pharm Pharmacol 2011; 63: 189-98.
    • (2011) J Pharm Pharmacol , vol.63 , pp. 189-198
    • Sandri, G.1    Bonferoni, M.C.2    Rossi, S.3
  • 83
    • 84876040790 scopus 로고    scopus 로고
    • Temperature triggered in situ gelling system for betaxolol in glaucoma
    • Geethalakshmia A, Karkib R, Sagib P, et al. Temperature triggered in situ gelling system for betaxolol in glaucoma. J App Pharm Sci 2013; 3: 153-9.
    • (2013) J App Pharm Sci , vol.3 , pp. 153-159
    • Geethalakshmia, A.1    Karkib, R.2    Sagib, P.3
  • 84
    • 84889032639 scopus 로고    scopus 로고
    • Recent patents on stimuli responsive hydrogels drug delivery systems
    • Patel GC, Dalwadi CA. Recent patents on stimuli responsive hydrogels drug delivery systems. Recent Pat Drug Deliv Formul 2013; 7: 206-15.
    • (2013) Recent Pat Drug Deliv Formul , vol.7 , pp. 206-215
    • Patel, G.C.1    Dalwadi, C.A.2
  • 85
    • 84925634644 scopus 로고    scopus 로고
    • Biomedical applications of hydrogels: A review of patents and commercial products
    • Caló E, Khutoryanskiy VV. Biomedical applications of hydrogels: A review of patents and commercial products. Eur Polym J 2015; 65: 252-67.
    • (2015) Eur Polym J , vol.65 , pp. 252-267
    • Caló, E.1    Khutoryanskiy, V.V.2
  • 86
    • 84857791283 scopus 로고    scopus 로고
    • Thermosensitive eyedrops containing platelet lysate for the treatment of corneal ulcers
    • Sandri G, Bonferoni MC, Rossi S, et al. Thermosensitive eyedrops containing platelet lysate for the treatment of corneal ulcers. Int J Pharm 2012; 426: 1-6.
    • (2012) Int J Pharm , vol.426 , pp. 1-6
    • Sandri, G.1    Bonferoni, M.C.2    Rossi, S.3
  • 87
    • 84893132069 scopus 로고    scopus 로고
    • Chitosan nanoparticles for ocular delivery of cyclosporine A
    • Başaran E, Yenilmez E, Berkman MS, et al. Chitosan nanoparticles for ocular delivery of cyclosporine A. J Microencapsul 2014; 31: 49-57.
    • (2014) J Microencapsul , vol.31 , pp. 49-57
    • Başaran, E.1    Yenilmez, E.2    Berkman, M.S.3
  • 88
    • 0842266330 scopus 로고    scopus 로고
    • Topical drug delivery in the eye
    • Wilson CG. Topical drug delivery in the eye. Exp Eye Res 2004; 78: 737-43.
    • (2004) Exp Eye Res , vol.78 , pp. 737-743
    • Wilson, C.G.1
  • 89
    • 33846141485 scopus 로고    scopus 로고
    • Preparation and evaluation of a Carbopol/ HPMC-based in situ gelling ophthalmic system for puerarin
    • Wu C, Qi H, Chen W, et al. Preparation and evaluation of a Carbopol/ HPMC-based in situ gelling ophthalmic system for puerarin. Yakugaku Zasshi 2007; 127: 183-91.
    • (2007) Yakugaku Zasshi , vol.127 , pp. 183-191
    • Wu, C.1    Qi, H.2    Chen, W.3
  • 90
    • 67349129109 scopus 로고    scopus 로고
    • Thixotropic property in pharmaceutical formulations
    • Lee CH, Moturi V, Lee Y. Thixotropic property in pharmaceutical formulations. J Control Release 2009; 136: 88-98.
    • (2009) J Control Release , vol.136 , pp. 88-98
    • Lee, C.H.1    Moturi, V.2    Lee, Y.3
  • 91
    • 78649361052 scopus 로고    scopus 로고
    • Bioresponsive matrices in drug delivery
    • You J, Almeda D, Ye GJC, et al. Bioresponsive matrices in drug delivery. J Biol Eng 2010; 4: 1-12.
    • (2010) J Biol Eng , vol.4 , pp. 1-12
    • You, J.1    Almeda, D.2    Ye, G.J.C.3
  • 92
    • 78649353750 scopus 로고    scopus 로고
    • Effect of gamma irradiation on pluronic gels for ocular delivery of ciprofloxacin: In vitro evaluation
    • El-Bagory IM, Bayomi MA, Mahrous GM, et al. Effect of gamma irradiation on pluronic gels for ocular delivery of ciprofloxacin: in vitro evaluation. Aust J of Basic Appl Sci 2010; 4: 4490-8.
    • (2010) Aust J of Basic Appl Sci , vol.4 , pp. 4490-4498
    • El-Bagory, I.M.1    Bayomi, M.A.2    Mahrous, G.M.3
  • 93
    • 79955959772 scopus 로고    scopus 로고
    • Comparison of ion-activated in situ gelling systems for ocular drug delivery. Part 1: Physicochemical characterisation and in vitro release
    • Rupenthal ID, Green CR, Alany RG. Comparison of ion-activated in situ gelling systems for ocular drug delivery. Part 1: physicochemical characterisation and in vitro release. Int J Pharm 2011; 411: 69-77.
    • (2011) Int J Pharm , vol.411 , pp. 69-77
    • Rupenthal, I.D.1    Green, C.R.2    Alany, R.G.3
  • 94
    • 84873988873 scopus 로고    scopus 로고
    • Promising ionsensitive in situ ocular nanoemulsion gels of terbinafine hydrochloride: Design, in vitro characterization and in vivo estimation of the ocular irritation and drug pharmacokinetics in the aqueous humor of rabbits
    • Tayel SA, El-Nabarawi MA, Tadros MI, et al. Promising ionsensitive in situ ocular nanoemulsion gels of terbinafine hydrochloride: Design, in vitro characterization and in vivo estimation of the ocular irritation and drug pharmacokinetics in the aqueous humor of rabbits. Int J Pharm 2013; 443: 293-305.
    • (2013) Int J Pharm , vol.443 , pp. 293-305
    • Tayel, S.A.1    El-Nabarawi, M.A.2    Tadros, M.I.3
  • 95
    • 84921762501 scopus 로고    scopus 로고
    • Liposome incorporated ion sensitive in situ gels for ophthalmic delivery of timolol maleate
    • Yu S, Wang Q, Wang X, et al. Liposome incorporated ion sensitive in situ gels for ophthalmic delivery of timolol maleate. Int J Pharm 2015; 480: 128-36.
    • (2015) Int J Pharm , vol.480 , pp. 128-136
    • Yu, S.1    Wang, Q.2    Wang, X.3
  • 96
    • 84879128919 scopus 로고    scopus 로고
    • Pluronic® F-127 and pluronic lecithin organogel (PLO): Main features and their applications in topical and transdermal administration of drugs
    • Almeida H, Amaral MH, Lobão P, et al. Pluronic® F-127 and pluronic lecithin organogel (PLO): main features and their applications in topical and transdermal administration of drugs. J Pharm Pharm Sci 2012; 15: 592-605.
    • (2012) J Pharm Pharm Sci , vol.15 , pp. 592-605
    • Almeida, H.1    Amaral, M.H.2    Lobão, P.3
  • 97
    • 28444451554 scopus 로고    scopus 로고
    • Ophthalmic delivery systems based on drug-polymer-polymer ionic ternary interaction: In vitro and in vivo characterization
    • Sandri G, Bonferoni MC, Chetoni P, et al. Ophthalmic delivery systems based on drug-polymer-polymer ionic ternary interaction: in vitro and in vivo characterization. Eur J Pharm Biopharm 2006; 62: 59-69.
    • (2006) Eur J Pharm Biopharm , vol.62 , pp. 59-69
    • Sandri, G.1    Bonferoni, M.C.2    Chetoni, P.3
  • 98
    • 67650699494 scopus 로고    scopus 로고
    • Stimuli-responsive polymers and their applications in drug delivery
    • Bawa P, Pillay V, Choonara YE, et al. Stimuli-responsive polymers and their applications in drug delivery. Biomed Mater 2009; 4: 1- 15.
    • (2009) Biomed Mater , vol.4 , pp. 1-15
    • Bawa, P.1    Pillay, V.2    Choonara, Y.E.3
  • 99
    • 0031667660 scopus 로고    scopus 로고
    • Evaluation of Pluronic F 127-based sustained- release ocular delivery systems for pilocarpine using the albino rabbit eye model
    • Desai SD, Blanchard J. Evaluation of Pluronic F 127-based sustained- release ocular delivery systems for pilocarpine using the albino rabbit eye model. J Pharm Sci 1998; 87: 1190-5.
    • (1998) J Pharm Sci , vol.87 , pp. 1190-1195
    • Desai, S.D.1    Blanchard, J.2
  • 100
    • 0035965508 scopus 로고    scopus 로고
    • In situ gelling xyloglucan formulations for sustained release ocular delivery of pilocarpine hydrochloride
    • Miyazaki S, Suzuki S, Kawasaki N, et al. In situ gelling xyloglucan formulations for sustained release ocular delivery of pilocarpine hydrochloride. Int J Pharm 2001; 229: 29-36.
    • (2001) Int J Pharm , vol.229 , pp. 29-36
    • Miyazaki, S.1    Suzuki, S.2    Kawasaki, N.3
  • 101
    • 0037130557 scopus 로고    scopus 로고
    • Thermosetting gels with modulated gelation temperature for ophthalmic use: The rheological and gamma scintigraphic studies
    • Wei G, Xu H, Ding PT, et al. Thermosetting gels with modulated gelation temperature for ophthalmic use: the rheological and gamma scintigraphic studies. J Control Release 2002; 83: 65-74.
    • (2002) J Control Release , vol.83 , pp. 65-74
    • Wei, G.1    Xu, H.2    Ding, P.T.3
  • 102
    • 33750705273 scopus 로고    scopus 로고
    • Optimization and physicochemical characterization of thermosensitive poloxamer gel containing puerarin for ophthalmic use
    • Qi H, Li L, Huang C, et al. Optimization and physicochemical characterization of thermosensitive poloxamer gel containing puerarin for ophthalmic use. Chem Pharm Bull 2006; 54: 1500-7.
    • (2006) Chem Pharm Bull , vol.54 , pp. 1500-1507
    • Qi, H.1    Li, L.2    Huang, C.3
  • 103
    • 34248571833 scopus 로고    scopus 로고
    • Development of a poloxamer analogs/carbopol-based in situ gelling and mucoadhesive ophthalmic delivery system for puerarin
    • Qi H, Chen W, Huang C, Li L, et al. Development of a poloxamer analogs/carbopol-based in situ gelling and mucoadhesive ophthalmic delivery system for puerarin. Int J Pharm 2007; 337: 178-87.
    • (2007) Int J Pharm , vol.337 , pp. 178-187
    • Qi, H.1    Chen, W.2    Huang, C.3    Li, L.4
  • 104
    • 46949093372 scopus 로고    scopus 로고
    • Ocular poloxamerbased ciprofloxacin hydrochloride in situ forming gels
    • Mansour M, Mansour S, Mortada ND, et al. Ocular poloxamerbased ciprofloxacin hydrochloride in situ forming gels. Drug Dev Ind Pharm 2008; 34: 744-52.
    • (2008) Drug Dev Ind Pharm , vol.34 , pp. 744-752
    • Mansour, M.1    Mansour, S.2    Mortada, N.D.3
  • 105
    • 50349102596 scopus 로고    scopus 로고
    • A novel poloxamers/ hyaluronic acid in situ forming hydrogel for drug delivery: Rheological, mucoadhesive and in vitro release properties
    • Mayol L, Quaglia F, Borzacchiello A, et al. A novel poloxamers/ hyaluronic acid in situ forming hydrogel for drug delivery: rheological, mucoadhesive and in vitro release properties. Eur J Pharm Biopharm 2008; 70: 199-206.
    • (2008) Eur J Pharm Biopharm , vol.70 , pp. 199-206
    • Mayol, L.1    Quaglia, F.2    Borzacchiello, A.3
  • 106
    • 78349298022 scopus 로고    scopus 로고
    • Designing of a thermoreversible chitosan/poloxamer in situ gel for ocular delivery of ciprofloxacin
    • Varshosaz J, Tabbakhian M, Salmani Z. Designing of a thermoreversible chitosan/poloxamer in situ gel for ocular delivery of ciprofloxacin. Open Drug Deliv J 2008; 2: 61-70.
    • (2008) Open Drug Deliv J , vol.2 , pp. 61-70
    • Varshosaz, J.1    Tabbakhian, M.2    Salmani, Z.3
  • 107
    • 78650089460 scopus 로고    scopus 로고
    • Preparation and evaluation of in-situ-gels for ocular drug delivery
    • Mohan EC, Kandukuri JM, Allenki V. Preparation and evaluation of in-situ-gels for ocular drug delivery. J Pharm Res 2009; 2: 1089- 94.
    • (2009) J Pharm Res , vol.2 , pp. 1089-1094
    • Mohan, E.C.1    Kandukuri, J.M.2    Allenki, V.3
  • 108
    • 78049390868 scopus 로고    scopus 로고
    • Studies on in situ hydrogel: A smart way for safe and sustained ocular drug delivery
    • Shastri DH, Patel LD, Parikh RK. Studies on in situ hydrogel: a smart way for safe and sustained ocular drug delivery. J Young Pharm 2010; 2: 116-20.
    • (2010) J Young Pharm , vol.2 , pp. 116-120
    • Shastri, D.H.1    Patel, L.D.2    Parikh, R.K.3
  • 109
    • 78650079930 scopus 로고    scopus 로고
    • Thermoreversible mucoadhesive ophthalmic in situ hydrogel: Design and optimization using a combination of polymers
    • Shastri DH, Prajapati ST, Patel LD. Thermoreversible mucoadhesive ophthalmic in situ hydrogel: design and optimization using a combination of polymers. Acta Pharm 2010; 60: 349-60.
    • (2010) Acta Pharm , vol.60 , pp. 349-360
    • Shastri, D.H.1    Prajapati, S.T.2    Patel, L.D.3
  • 110
    • 77950918063 scopus 로고    scopus 로고
    • Dual-drug delivery system based on in-situ gel-forming nanosuspension of forskolin to enhance antiglaucoma efficacy
    • Gupta S, Samanta MK, Raichur AM. Dual-drug delivery system based on in-situ gel-forming nanosuspension of forskolin to enhance antiglaucoma efficacy. AAPS PharmSciTech 2010; 11: 322- 35.
    • (2010) AAPS PharmSciTech , vol.11 , pp. 322-335
    • Gupta, S.1    Samanta, M.K.2    Raichur, A.M.3
  • 111
    • 84859959195 scopus 로고    scopus 로고
    • Development and evaluation of thermoreversible ocular gels of ketorolac tromethamine
    • Vodithala S, Khatry S, Shastri N, et al. Development and evaluation of thermoreversible ocular gels of ketorolac tromethamine. Int J Biopharm 2010; 1: 39-45.
    • (2010) Int J Biopharm , vol.1 , pp. 39-45
    • Vodithala, S.1    Khatry, S.2    Shastri, N.3
  • 112
    • 77956937545 scopus 로고    scopus 로고
    • Development of dorzolamide hydrochloride in situ gel nanoemulsion for ocular delivery
    • Ammar HO, Salama HA, Ghorab M, et al. Development of dorzolamide hydrochloride in situ gel nanoemulsion for ocular delivery. Drug Dev Ind Pharm 2010; 36: 1330-9.
    • (2010) Drug Dev Ind Pharm , vol.36 , pp. 1330-1339
    • Ammar, H.O.1    Salama, H.A.2    Ghorab, M.3
  • 113
    • 84881126379 scopus 로고    scopus 로고
    • Development and optimization of dorzolamide hydrochloride and timolol maleate in situ gel for glaucoma treatment
    • Darwhekar G, Jain P, Jain DK, et al. Development and optimization of dorzolamide hydrochloride and timolol maleate in situ gel for glaucoma treatment. Asian J Pharm Ana 2011; 1: 93-7.
    • (2011) Asian J Pharm Ana , vol.1 , pp. 93-97
    • Darwhekar, G.1    Jain, P.2    Jain, D.K.3
  • 114
    • 84878588191 scopus 로고    scopus 로고
    • Doxycycline and hydroxypropyl-bcyclodextrin complexin poloxamer thermal sensitive hydrogel for ophthalmic delivery
    • He Z, Wang Z, Zhang H, et al. Doxycycline and hydroxypropyl-bcyclodextrin complexin poloxamer thermal sensitive hydrogel for ophthalmic delivery. Acta Pharmaceut Sin B 2011; 1: 254-60.
    • (2011) Acta Pharmaceut Sin B , vol.1 , pp. 254-260
    • He, Z.1    Wang, Z.2    Zhang, H.3
  • 115
    • 77952957786 scopus 로고    scopus 로고
    • A poloxamer/chitosan in situ forming gel with prolonged retention time for ocular delivery
    • Gratieri T, Gelfuso GM, Rocha EM, et al. A poloxamer/chitosan in situ forming gel with prolonged retention time for ocular delivery. Eur J Pharm Biopharm 2010; 75: 186-93.
    • (2010) Eur J Pharm Biopharm , vol.75 , pp. 186-193
    • Gratieri, T.1    Gelfuso, G.M.2    Rocha, E.M.3
  • 116
    • 78650142775 scopus 로고    scopus 로고
    • Potential of ceragenin CSA- 13 and its mixture with pluronic F127 as treatment of topical bacterial infections
    • Leszczyńka K, Namiot A, Cruz K, et al. Potential of ceragenin CSA- 13 and its mixture with pluronic F127 as treatment of topical bacterial infections. J Appl Microbiol 2011; 110: 229-38.
    • (2011) J Appl Microbiol , vol.110 , pp. 229-238
    • Leszczyńka, K.1    Namiot, A.2    Cruz, K.3
  • 117
    • 84894509373 scopus 로고    scopus 로고
    • Thermoreversible in-situ ophthalmic gelling system of levofloxacin hemihydrate: Formulation and optimization by factorial design
    • Bankhele SC, Harale RB, Rao MRP, et al. Thermoreversible in-situ ophthalmic gelling system of levofloxacin hemihydrate: formulation and optimization by factorial design. Asian J Pharm Res 2012; 2: 100-6.
    • (2012) Asian J Pharm Res , vol.2 , pp. 100-106
    • Bankhele, S.C.1    Harale, R.B.2    Rao, M.R.P.3
  • 118
    • 84874142957 scopus 로고    scopus 로고
    • Evaluation of tropicamideloaded tamarind seed xyloglucan nanoaggregates for ophthalmic delivery
    • Dilbaghi N. Kaur H. Ahuja M. et al. Evaluation of tropicamideloaded tamarind seed xyloglucan nanoaggregates for ophthalmic delivery. Carbohydr Polym 2013; 94: 286-91.
    • (2013) Carbohydr Polym , vol.94 , pp. 286-291
    • Dilbaghi, N.1    Kaur, H.2    Ahuja, M.3
  • 119
    • 84903714320 scopus 로고    scopus 로고
    • Thermoresponsive polymers: Insights into decisive hydrogel characteristics, mechanisms of gelation, and promising biomedical applications
    • Matanović MR, Kristl J, Grabnar PA. Thermoresponsive polymers: Insights into decisive hydrogel characteristics, mechanisms of gelation, and promising biomedical applications. Int J Pharm 2014; 472: 262-75.
    • (2014) Int J Pharm , vol.472 , pp. 262-275
    • Matanović, M.R.1    Kristl, J.2    Grabnar, P.A.3
  • 120
    • 0030931036 scopus 로고    scopus 로고
    • Bioadhesive microspheres for ophthalmic administration of acyclovir
    • Genta I, Conti B, Perugini P, et al. Bioadhesive microspheres for ophthalmic administration of acyclovir. J Pharm Pharmacol 1997; 49: 737-42.
    • (1997) J Pharm Pharmacol , vol.49 , pp. 737-742
    • Genta, I.1    Conti, B.2    Perugini, P.3
  • 121
    • 0032964520 scopus 로고    scopus 로고
    • Topical use of chitosan in ophthalmology: Tolerance, assessment and evaluation of precorneal retention
    • Felt O, Furrer P, Mayer JM, et al. Topical use of chitosan in ophthalmology: tolerance, assessment and evaluation of precorneal retention. Int J Pharm 1999; 180: 185-93.
    • (1999) Int J Pharm , vol.180 , pp. 185-193
    • Felt, O.1    Furrer, P.2    Mayer, J.M.3
  • 122
    • 0035998953 scopus 로고    scopus 로고
    • Physical characterization of a chitosan-based hydrogel delivery system
    • Li J, Xu Z. Physical characterization of a chitosan-based hydrogel delivery system. J Pharm Sci 2002; 91: 1669-77.
    • (2002) J Pharm Sci , vol.91 , pp. 1669-1677
    • Li, J.1    Xu, Z.2
  • 123
    • 67549123418 scopus 로고    scopus 로고
    • Development and characterization of Tc-99m timolol maleate for evaluating efficacy of in situ ocular drug delivery system
    • Gupta H, Aqil M, Khar RK, et al. Development and characterization of Tc-99m timolol maleate for evaluating efficacy of in situ ocular drug delivery system. AAPS Pharm Sci Tech 2009; 10: 540- 6.
    • (2009) AAPS Pharm Sci Tech , vol.10 , pp. 540-546
    • Gupta, H.1    Aqil, M.2    Khar, R.K.3
  • 124
    • 0018198657 scopus 로고
    • Influence of highviscosity vehicles on miotic effect of pilocarpine
    • Schoenwald RD, Ward RL, DeSantis LM, et al. Influence of highviscosity vehicles on miotic effect of pilocarpine. J Pharm Sci 1978; 69: 1280-3.
    • (1978) J Pharm Sci , vol.69 , pp. 1280-1283
    • Schoenwald, R.D.1    Ward, R.L.2    DeSantis, L.M.3
  • 126
    • 0028960346 scopus 로고
    • Modification of in situ gelling behavior of carbopol solutions by hydroxypropyl methyl cellulose
    • Kumar S, Himmelstein KJ. Modification of in situ gelling behavior of carbopol solutions by hydroxypropyl methyl cellulose. J Pharm Sci 1995; 84: 344-8.
    • (1995) J Pharm Sci , vol.84 , pp. 344-348
    • Kumar, S.1    Himmelstein, K.J.2
  • 127
    • 0033007999 scopus 로고    scopus 로고
    • Polyacrylic acid/polyvinylpyrrolidone bipolymeric systems. I. Rheological and mucoadhesive properties of formulations potentially useful for the treatment of dry-eyesyndrome
    • Oechsner M, Keipert S. Polyacrylic acid/polyvinylpyrrolidone bipolymeric systems. I. Rheological and mucoadhesive properties of formulations potentially useful for the treatment of dry-eyesyndrome. Eur J Pharm Biopharm 1999; 47: 113-8.
    • (1999) Eur J Pharm Biopharm , vol.47 , pp. 113-118
    • Oechsner, M.1    Keipert, S.2
  • 128
    • 0034088257 scopus 로고    scopus 로고
    • Physico-chemical, in vitro and in vivo characterization of polymers for ocular use
    • Hartmann V, Keipert S. Physico-chemical, in vitro and in vivo characterization of polymers for ocular use. Pharmazie 2000; 55: 440-3.
    • (2000) Pharmazie , vol.55 , pp. 440-443
    • Hartmann, V.1    Keipert, S.2
  • 129
    • 0035850231 scopus 로고    scopus 로고
    • Sustained ophthalmic delivery of ofloxacin from a pH triggered in situ gelling system
    • Srividya B, Cardoza RM, Amin PD. Sustained ophthalmic delivery of ofloxacin from a pH triggered in situ gelling system. J Control Release 2001; 73: 205-11.
    • (2001) J Control Release , vol.73 , pp. 205-211
    • Srividya, B.1    Cardoza, R.M.2    Amin, P.D.3
  • 130
    • 9544254878 scopus 로고    scopus 로고
    • Stimuli-responsive polymers and their bioconjugates
    • Gil ES, Hudson SM. Stimuli-responsive polymers and their bioconjugates. Prog Polym Sci 2004; 29: 1173-222.
    • (2004) Prog Polym Sci , vol.29 , pp. 1173-1222
    • Gil, E.S.1    Hudson, S.M.2
  • 131
    • 79955643091 scopus 로고    scopus 로고
    • Design and evaluation of baicalincontaining in situ pH-triggered gelling system for sustained ophthalmic drug delivery
    • Wu H, Liu Z, Peng J, et al. Design and evaluation of baicalincontaining in situ pH-triggered gelling system for sustained ophthalmic drug delivery. Int J Pham 2011; 410: 31-40.
    • (2011) Int J Pham , vol.410 , pp. 31-40
    • Wu, H.1    Liu, Z.2    Peng, J.3
  • 132
    • 0026619898 scopus 로고
    • Pilocarpine bioavailability from a mucoadhesive liposomal ophthalmic drug delivery system
    • Durrani AM, Davies NM, Thomas M, et al. Pilocarpine bioavailability from a mucoadhesive liposomal ophthalmic drug delivery system. Int J Pharm 1992; 88: 409-15.
    • (1992) Int J Pharm , vol.88 , pp. 409-415
    • Durrani, A.M.1    Davies, N.M.2    Thomas, M.3
  • 133
    • 0028213925 scopus 로고
    • Improved ocular penetration of gentamicin by mucoadhesive polymer polycarbophil in the pigmented rabbit
    • Lehr CM, Yong HL, Lee VHL. Improved ocular penetration of gentamicin by mucoadhesive polymer polycarbophil in the pigmented rabbit. Invest Ophthalmol Vis Sci 1994; 35: 2809-14.
    • (1994) Invest Ophthalmol Vis Sci , vol.35 , pp. 2809-2814
    • Lehr, C.M.1    Yong, H.L.2    Lee, V.H.L.3
  • 134
    • 0032865395 scopus 로고    scopus 로고
    • Preparation of liposomal formulation of tropicamide for ocular delivery
    • Nagarsenker MS, Londhe VY, Nadkarni GD. Preparation of liposomal formulation of tropicamide for ocular delivery. Int J Pharm 1999; 190: 63-71.
    • (1999) Int J Pharm , vol.190 , pp. 63-71
    • Nagarsenker, M.S.1    Londhe, V.Y.2    Nadkarni, G.D.3
  • 135
    • 84942870719 scopus 로고    scopus 로고
    • Formulation and evaluation of Cyclosporin A emulgel for ocular delivery
    • Shen Y, Ling X, Jiang W, et al. Formulation and evaluation of Cyclosporin A emulgel for ocular delivery. Drug Deliv 2015; 22(7): 911-7.
    • (2015) Drug Deliv , vol.22 , Issue.7 , pp. 911-917
    • Shen, Y.1    Ling, X.2    Jiang, W.3
  • 136
    • 0022371077 scopus 로고
    • Ocular therapy with nanoparticulate systems for controlled drug delivery
    • Gurny R, Boye T, Ibrahim H. Ocular therapy with nanoparticulate systems for controlled drug delivery. J Control Release 1985; 2: 353-61.
    • (1985) J Control Release , vol.2 , pp. 353-361
    • Gurny, R.1    Boye, T.2    Ibrahim, H.3
  • 137
    • 0019399888 scopus 로고
    • Preliminary study of prolonged acting drug delivery systems for the treatment of glaucoma
    • Gurny R. Preliminary study of prolonged acting drug delivery systems for the treatment of glaucoma. Pharm Acta Helv 1981; 156: 130-2.
    • (1981) Pharm Acta Helv , vol.156 , pp. 130-132
    • Gurny, R.1
  • 138
    • 20244385516 scopus 로고    scopus 로고
    • Efficacite et tolerance du carteolol 1% liberation prolongee une fois par jour
    • Trinquand C, Romanet JP, Nordmann JP, et al. Efficacite et tolerance du carteolol 1% liberation prolongee une fois par jour. J Fr Ophthalmol 2003; 26: 131-6.
    • (2003) J Fr Ophthalmol , vol.26 , pp. 131-136
    • Trinquand, C.1    Romanet, J.P.2    Nordmann, J.P.3
  • 139
    • 79952644526 scopus 로고    scopus 로고
    • Formulation and evaluation of diclofenac sodium gel by using natural polymer
    • Ahuja N, Saini V, Bishnoi VK, et al. Formulation and evaluation of diclofenac sodium gel by using natural polymer. Rasayan J Chem 2008; 1: 564-6.
    • (2008) Rasayan J Chem , vol.1 , pp. 564-566
    • Ahuja, N.1    Saini, V.2    Bishnoi, V.K.3
  • 140
    • 0032055148 scopus 로고    scopus 로고
    • Rheological evaluation of Gelrite® in situ gels for ophthalmic use
    • Carlfors J, Edsman K, Petersson R, et al. Rheological evaluation of Gelrite® in situ gels for ophthalmic use. Eur J Pharm Sci 1998; 6: 105-12.
    • (1998) Eur J Pharm Sci , vol.6 , pp. 105-112
    • Carlfors, J.1    Edsman, K.2    Petersson, R.3
  • 141
    • 0344980091 scopus 로고    scopus 로고
    • Rheological studies of the gelation of deacetylated gellan gum (Gelrite®) in physiological conditions
    • Paulsson M, Hägerström H, Edsman K. Rheological studies of the gelation of deacetylated gellan gum (Gelrite®) in physiological conditions. Eur J Pharm Sci 1999; 9: 99-105.
    • (1999) Eur J Pharm Sci , vol.9 , pp. 99-105
    • Paulsson, M.1    Hägerström, H.2    Edsman, K.3
  • 142
    • 84939952207 scopus 로고    scopus 로고
    • Novel in situ gel systems based on P123/TPGS mixed micelles and gellan gum for ophthalmic delivery of curcumin
    • Duan Y, Cai X, Du H, et al. Novel in situ gel systems based on P123/TPGS mixed micelles and gellan gum for ophthalmic delivery of curcumin. Colloids and Surfaces B: Biointerfaces 2015; 128: 322-30.
    • (2015) Colloids and Surfaces B: Biointerfaces , vol.128 , pp. 322-330
    • Duan, Y.1    Cai, X.2    Du, H.3
  • 143
    • 84889072376 scopus 로고    scopus 로고
    • Influence of drug incorporation, temperature and storage time on the pH, textural and rheological properties of different poloxamer hydrogels
    • Almeida H, Amaral MH, Lobão P, et al. Influence of drug incorporation, temperature and storage time on the pH, textural and rheological properties of different poloxamer hydrogels. Curr Drug Deliv 2013; 10: 753-64.
    • (2013) Curr Drug Deliv , vol.10 , pp. 753-764
    • Almeida, H.1    Amaral, M.H.2    Lobão, P.3
  • 144
    • 0034602597 scopus 로고    scopus 로고
    • Carbopol/Pluronic phase change solutions for ophthalmic drug delivery
    • Lin HR, Sung KC. Carbopol/Pluronic phase change solutions for ophthalmic drug delivery. J Control Release 2000; 69: 379-88.
    • (2000) J Control Release , vol.69 , pp. 379-388
    • Lin, H.R.1    Sung, K.C.2
  • 145
    • 9744237249 scopus 로고    scopus 로고
    • In situ gelling of alginate/pluronic solutions for ophthalmic delivery of pilocarpine
    • Lin HR, Sung KC, Vong WJ. In situ gelling of alginate/pluronic solutions for ophthalmic delivery of pilocarpine. Biomacromolecules 2004; 5: 2358-65.
    • (2004) Biomacromolecules , vol.5 , pp. 2358-2365
    • Lin, H.R.1    Sung, K.C.2    Vong, W.J.3
  • 146
    • 36248934777 scopus 로고    scopus 로고
    • Sustained ocular drug delivery from a temperature and ph triggered novel in-situ gel system
    • Gupta H, Jain S, Mathur R, et al. Sustained ocular drug delivery from a temperature and ph triggered novel in-situ gel system. Drug Deliv 2007; 14: 507-15.
    • (2007) Drug Deliv , vol.14 , pp. 507-515
    • Gupta, H.1    Jain, S.2    Mathur, R.3
  • 147
    • 78650227405 scopus 로고    scopus 로고
    • Carbopol/chitosan based pH triggered in situ gelling system for ocular delivery of timolol maleate
    • Gupta S, Vyas SP. Carbopol/chitosan based pH triggered in situ gelling system for ocular delivery of timolol maleate. Sci Pharm 2010; 78: 959-76.
    • (2010) Sci Pharm , vol.78 , pp. 959-976
    • Gupta, S.1    Vyas, S.P.2
  • 148
    • 79955964137 scopus 로고    scopus 로고
    • Optimization and evaluation of thermoresponsive diclofenac sodium ophthalmic in situ gel
    • Asasutjarit R, Thanasanchokpibull S, Fuongfuchat A, et al. Optimization and evaluation of thermoresponsive diclofenac sodium ophthalmic in situ gel. Int J Pharm 2011; 411: 128-35.
    • (2011) Int J Pharm , vol.411 , pp. 128-135
    • Asasutjarit, R.1    Thanasanchokpibull, S.2    Fuongfuchat, A.3
  • 149
    • 79960966009 scopus 로고    scopus 로고
    • Thermosensitive in situ gel of Timolol Maleate for the treatment of open angle glaucoma
    • Yeole PG, Iyer D. Thermosensitive in situ gel of Timolol Maleate for the treatment of open angle glaucoma. Res J Pharm Biol Chem Sci 2011; 2: 1048-64.
    • (2011) Res J Pharm Biol Chem Sci , vol.2 , pp. 1048-1064
    • Yeole, P.G.1    Iyer, D.2
  • 150
    • 84894507519 scopus 로고    scopus 로고
    • Sustained ophthalmic delivery of atenolol for Glaucoma by in situ gelling system
    • Rathman G. Sustained ophthalmic delivery of atenolol for Glaucoma by in situ gelling system. Int J Pharm Res Dev 2012; 4: 291- 301.
    • (2012) Int J Pharm Res Dev , vol.4 , pp. 291-301
    • Rathman, G.1
  • 151
    • 84865071171 scopus 로고    scopus 로고
    • Formulation and evaluation of in situ gel drug delivery system of sesbania grandiflora flower extract for the treatment of bacterial conjunctivitis
    • Wagh VD, Deshmukh KH, Wagh KV. Formulation and evaluation of in situ gel drug delivery system of sesbania grandiflora flower extract for the treatment of bacterial conjunctivitis. J Pharm Sci Res 2012; 4: 1880-4.
    • (2012) J Pharm Sci Res , vol.4 , pp. 1880-1884
    • Wagh, V.D.1    Deshmukh, K.H.2    Wagh, K.V.3
  • 152
    • 84922010087 scopus 로고    scopus 로고
    • An alternative in situ gelformulation of levofloxacin eye drops for prolong ocular retention
    • Gupta H, Aquil M, Khar RK, et al. An alternative in situ gelformulation of levofloxacin eye drops for prolong ocular retention. J Pharm Bioallied Sci 2015; 7: 9-14.
    • (2015) J Pharm Bioallied Sci , vol.7 , pp. 9-14
    • Gupta, H.1    Aquil, M.2    Khar, R.K.3
  • 153
    • 0001604219 scopus 로고    scopus 로고
    • Characterization of a new ocular delivery system based on a dispersion of liposomes in a thermosensitive gel
    • Bochot A, Fattal E, Grossiord JL, et al. Characterization of a new ocular delivery system based on a dispersion of liposomes in a thermosensitive gel. Int J Pharm 1998; 162: 119-27.
    • (1998) Int J Pharm , vol.162 , pp. 119-127
    • Bochot, A.1    Fattal, E.2    Grossiord, J.L.3
  • 154
    • 2242472082 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations
    • Müller RH, Radtke M, Wissing SA. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv Drug Deliv Rev 2002; 54: S131- 55.
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 131-155
    • Müller, R.H.1    Radtke, M.2    Wissing, S.A.3
  • 155
    • 3042735591 scopus 로고    scopus 로고
    • Cytotoxicity studies of Dynasan 114 solid lipid nanoparticles (SLN) on RAW 264.7 macrophages- impact of phagocytosis on viability and cytokine production
    • Olbrich C, Scholer N, Tabatt K, et al. Cytotoxicity studies of Dynasan 114 solid lipid nanoparticles (SLN) on RAW 264.7 macrophages- impact of phagocytosis on viability and cytokine production. J Pharm Pharmacol 2004; 56: 883-91.
    • (2004) J Pharm Pharmacol , vol.56 , pp. 883-891
    • Olbrich, C.1    Scholer, N.2    Tabatt, K.3
  • 156
    • 0346787779 scopus 로고    scopus 로고
    • Vesicular systems in ocular drug delivery: An overview
    • Kaur IP, Garg A, Singla AK. et al. Vesicular systems in ocular drug delivery: an overview. Int J Pharm 2004; 269: 1-14.
    • (2004) Int J Pharm , vol.269 , pp. 1-14
    • Kaur, I.P.1    Garg, A.2    Singla, A.K.3
  • 157
    • 3843081845 scopus 로고    scopus 로고
    • Physicochemical characterization of colloidal drug delivery systems such as reverse micelles, vesicles, liquid crystals and nanoparticles for topical administration
    • Müller-Goymann CC. Physicochemical characterization of colloidal drug delivery systems such as reverse micelles, vesicles, liquid crystals and nanoparticles for topical administration. Eur J Pharm Biopharm 2004; 58: 343-56.
    • (2004) Eur J Pharm Biopharm , vol.58 , pp. 343-356
    • Müller-Goymann, C.C.1
  • 158
    • 33746480190 scopus 로고    scopus 로고
    • Investigation of the factors influencing the incorporation of clotrimazole in SLN and NLC prepared by hot high-pressure homogenization
    • Souto EB, Müller RH. Investigation of the factors influencing the incorporation of clotrimazole in SLN and NLC prepared by hot high-pressure homogenization. J Microencapsul 2006; 23: 377-88.
    • (2006) J Microencapsul , vol.23 , pp. 377-388
    • Souto, E.B.1    Müller, R.H.2
  • 159
    • 51349092516 scopus 로고    scopus 로고
    • Development and evaluation of lipid nanoparticles for camptothecin delivery: A comparison of solid lipid nanoparticles, nanostructured lipid carriers, and lipid emulsion
    • Huang ZR, Hua SC, Yang YL. et al. Development and evaluation of lipid nanoparticles for camptothecin delivery: a comparison of solid lipid nanoparticles, nanostructured lipid carriers, and lipid emulsion. Acta Pharmacol Sin 2008; 29: 1094-102.
    • (2008) Acta Pharmacol Sin , vol.29 , pp. 1094-1102
    • Huang, Z.R.1    Hua, S.C.2    Yang, Y.L.3
  • 160
    • 53949111819 scopus 로고    scopus 로고
    • Cyclosporine A loaded SLNs: Evaluation of cellular uptake and corneal cytotoxicity
    • Gokce EH, Sandri G, Bonferoni MC, et al. Cyclosporine A loaded SLNs: Evaluation of cellular uptake and corneal cytotoxicity. Int J Pharm 2008; 364: 76-86.
    • (2008) Int J Pharm , vol.364 , pp. 76-86
    • Gokce, E.H.1    Sandri, G.2    Bonferoni, M.C.3
  • 161
    • 70350714422 scopus 로고    scopus 로고
    • Lipid matrix nanoparticles. Pharmacokinetics and biopharmaceutics
    • Doktorovova S, Gokce E, Ozyazici M, et al. Lipid matrix nanoparticles. Pharmacokinetics and biopharmaceutics. Curr Nanosci 2009; 5: 358-71.
    • (2009) Curr Nanosci , vol.5 , pp. 358-371
    • Doktorovova, S.1    Gokce, E.2    Ozyazici, M.3
  • 162
    • 77953283407 scopus 로고    scopus 로고
    • Lipid nanoparticles: Effect on bioavailability and pharmacokinetic changes
    • Souto EB, Müller RH. Lipid nanoparticles: effect on bioavailability and pharmacokinetic changes. Handb Exp Pharmacol 2010; 197: 115-41.
    • (2010) Handb Exp Pharmacol , vol.197 , pp. 115-141
    • Souto, E.B.1    Müller, R.H.2
  • 163
    • 77953356716 scopus 로고    scopus 로고
    • Optimization and physicochemical characterization of a triamcinolone acetonideloaded NLC for ocular antiangiogenic applications
    • Araújo J, Gonzalez-Mira E, Egea MA, et al. Optimization and physicochemical characterization of a triamcinolone acetonideloaded NLC for ocular antiangiogenic applications. Int J Pharm 2010; 393: 167-75.
    • (2010) Int J Pharm , vol.393 , pp. 167-175
    • Araújo, J.1    Gonzalez-Mira, E.2    Egea, M.A.3
  • 164
    • 77954416176 scopus 로고    scopus 로고
    • Feasibility of Lipid Nanoparticles for Ocular Delivery of Anti-inflammatory Drugs
    • Souto EB, Doktorovova S, Gonzalez-Mira E, et al. Feasibility of Lipid Nanoparticles for Ocular Delivery of Anti-inflammatory Drugs. Curr Eye Res 2010; 35: 537-52.
    • (2010) Curr Eye Res , vol.35 , pp. 537-552
    • Souto, E.B.1    Doktorovova, S.2    Gonzalez-Mira, E.3
  • 165
    • 78650178421 scopus 로고    scopus 로고
    • Nanostructured lipid carrier (NLC) coated with Chitosan Oligosaccharides and its potential use in ocular drug delivery system
    • Luo Q, Zhao J, Zhang X, et al. Nanostructured lipid carrier (NLC) coated with Chitosan Oligosaccharides and its potential use in ocular drug delivery system. Int J Pharm 2011; 403: 185-91.
    • (2011) Int J Pharm , vol.403 , pp. 185-191
    • Luo, Q.1    Zhao, J.2    Zhang, X.3
  • 166
    • 78649442663 scopus 로고    scopus 로고
    • Microscopic and spectroscopic evaluation of novel PLGA-chitosan nanoplexes as an ocular delivery system
    • Jain GK, Pathan SA, Akhter S, et al. Microscopic and spectroscopic evaluation of novel PLGA-chitosan nanoplexes as an ocular delivery system. Colloids Surf B Biointerfaces 2011; 82: 397: 403.
    • (2011) Colloids Surf B Biointerfaces , vol.82 , Issue.397 , pp. 403
    • Jain, G.K.1    Pathan, S.A.2    Akhter, S.3
  • 167
    • 84857786575 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN)-based hydrogels as potential carriers for oral transmucosal delivery of risperidone: Preparation and characterization studies
    • Silva AC, Amaral MH, González-Mira E, et al. Solid lipid nanoparticles (SLN)-based hydrogels as potential carriers for oral transmucosal delivery of risperidone: preparation and characterization studies. Colloids Surf B Biointerfaces 2012; 93: 241-8.
    • (2012) Colloids Surf B Biointerfaces , vol.93 , pp. 241-248
    • Silva, A.C.1    Amaral, M.H.2    González-Mira, E.3
  • 170
    • 79955794727 scopus 로고    scopus 로고
    • Preparation, characterization and biocompatibility studies on risperidone-loaded solid lipid nanoparticles (SLN): High pressure homogenization versus ultrasound
    • Silva AC, González-Mira E, García ML, et al. Preparation, characterization and biocompatibility studies on risperidone-loaded solid lipid nanoparticles (SLN): High pressure homogenization versus ultrasound. Colloids Surf B Biointerfaces 2011; 86: 158-65.
    • (2011) Colloids Surf B Biointerfaces , vol.86 , pp. 158-165
    • Silva, A.C.1    González-Mira, E.2    García, M.L.3
  • 171
    • 77956650644 scopus 로고    scopus 로고
    • Design and ocular tolerance of flurbiprofen loaded ultrasound-engineered NLC
    • Gonzalez-Mira E, Egea MA, Garcia ML, et al. Design and ocular tolerance of flurbiprofen loaded ultrasound-engineered NLC. Colloids Surf B Biointerfaces 2010; 81: 412-21.
    • (2010) Colloids Surf B Biointerfaces , vol.81 , pp. 412-421
    • Gonzalez-Mira, E.1    Egea, M.A.2    Garcia, M.L.3
  • 172
    • 0035946615 scopus 로고    scopus 로고
    • Solid lipid nanoparticles: Production, characterization and applications
    • Mehnert W, Mäder K. Solid lipid nanoparticles: production, characterization and applications. Adv Drug Deliv Rev 2001; 47: 165- 96.
    • (2001) Adv Drug Deliv Rev , vol.47 , pp. 165-196
    • Mehnert, W.1    Mäder, K.2
  • 173
    • 84863226116 scopus 로고    scopus 로고
    • Experimental factorial design applied to mucoadhesive lipid nanoparticles via multiple emulsion process
    • Fangueiro JF, Andreani T, Egea MA, et al. Experimental factorial design applied to mucoadhesive lipid nanoparticles via multiple emulsion process. Colloids Surf B Biointerfaces 2012; 100: 84-9.
    • (2012) Colloids Surf B Biointerfaces , vol.100 , pp. 84-89
    • Fangueiro, J.F.1    Andreani, T.2    Egea, M.A.3
  • 174
    • 84889593525 scopus 로고    scopus 로고
    • Design of cationic lipid nanoparticles for ocular delivery: Development, characterization and cytotoxicity
    • Fangueiro JF, Andreani T, Egea MA, et al. Design of cationic lipid nanoparticles for ocular delivery: Development, characterization and cytotoxicity. Int J Pharm 2014; 461: 64-73.
    • (2014) Int J Pharm , vol.461 , pp. 64-73
    • Fangueiro, J.F.1    Andreani, T.2    Egea, M.A.3
  • 175
    • 84916208468 scopus 로고    scopus 로고
    • Physicochemical characterization of epigallocatechin gallate lipid nanoparticles (EGCG-LNs) for ocular instillation
    • Fangueiro JF, Andreani T, Fernandes L, et al. Physicochemical characterization of epigallocatechin gallate lipid nanoparticles (EGCG-LNs) for ocular instillation. Colloids Surf B Biointerfaces 2014; 123: 452-60.
    • (2014) Colloids Surf B Biointerfaces , vol.123 , pp. 452-460
    • Fangueiro, J.F.1    Andreani, T.2    Fernandes, L.3
  • 176
    • 1242338847 scopus 로고    scopus 로고
    • Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field flow fractionation and transmission electron microscopy
    • Jores K, Mehnert W, Drechsler M, et al. Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field flow fractionation and transmission electron microscopy. J Control Release 2004; 95: 217-27.
    • (2004) J Control Release , vol.95 , pp. 217-227
    • Jores, K.1    Mehnert, W.2    Drechsler, M.3
  • 177
    • 71549167988 scopus 로고    scopus 로고
    • Chapter 6 - solid lipid nanoparticle formulations: Pharmacokinetic and biopharmaceutical aspects in drug delivery
    • Souto EB, Doktorovova S. Chapter 6 - solid lipid nanoparticle formulations: pharmacokinetic and biopharmaceutical aspects in drug delivery. Methods Enzymol 2009; 464: 105-29.
    • (2009) Methods Enzymol , vol.464 , pp. 105-129
    • Souto, E.B.1    Doktorovova, S.2
  • 178
    • 0029844511 scopus 로고    scopus 로고
    • Phagocytic uptake and cytotoxicity of solid lipid nanoparticles (SLN) sterically stabilized with poloxamine 908 and poloxamer 407
    • Műller RH, Maassen S, Weyhers H, et al. Phagocytic uptake and cytotoxicity of solid lipid nanoparticles (SLN) sterically stabilized with poloxamine 908 and poloxamer 407. J Drug Target 1996; 4: 161-70.
    • (1996) J Drug Target , vol.4 , pp. 161-170
    • Műller, R.H.1    Maassen, S.2    Weyhers, H.3
  • 179
    • 0032126848 scopus 로고    scopus 로고
    • Effects of biodegradable polymer particles on rat marrow-derived stromal osteoblasts in vitro
    • Wake MC, Gerecht PD, Lu L, et al. Effects of biodegradable polymer particles on rat marrow-derived stromal osteoblasts in vitro. Biomaterials 1998; 19: 1255-68.
    • (1998) Biomaterials , vol.19 , pp. 1255-1268
    • Wake, M.C.1    Gerecht, P.D.2    Lu, L.3
  • 180
    • 0034182386 scopus 로고    scopus 로고
    • Nano and microparticles as controlled drug delivery devices
    • Ravi Kumar MNV, Nano and microparticles as controlled drug delivery devices. J Pharm Pharm Sci 2000; 3: 234-58.
    • (2000) J Pharm Pharm Sci , vol.3 , pp. 234-258
    • Ravi Kumar, M.N.V.1
  • 181
    • 3543046202 scopus 로고    scopus 로고
    • Chitosan nanoparticles as new ocular drug delivery systems: In vitro stability, in vivo fate, and cellular toxicity
    • De Campos AM, Diebold Y, Carvalho EL, et al. Chitosan nanoparticles as new ocular drug delivery systems: In vitro stability, in vivo fate, and cellular toxicity. Pharm Res 2004; 21: 803-10.
    • (2004) Pharm Res , vol.21 , pp. 803-810
    • De Campos, A.M.1    Diebold, Y.2    Carvalho, E.L.3
  • 182
    • 31544457644 scopus 로고    scopus 로고
    • Characterization of pilocarpineloaded chitosan/carbopol nanoparticles
    • Kao HJ, Lin HR, Lo YL, et al. Characterization of pilocarpineloaded chitosan/carbopol nanoparticles. J Pharm Pharmacol 2006; 58: 179-86.
    • (2006) J Pharm Pharmacol , vol.58 , pp. 179-186
    • Kao, H.J.1    Lin, H.R.2    Lo, Y.L.3
  • 183
    • 77949917853 scopus 로고    scopus 로고
    • Sparfloxacin-loaded PLGA nanoparticles for sustained ocular drug delivery
    • Gupta H, Aqil M, Khar RK, et al. Sparfloxacin-loaded PLGA nanoparticles for sustained ocular drug delivery. Nanomedicine 2010; 6: 324-33.
    • (2010) Nanomedicine , vol.6 , pp. 324-333
    • Gupta, H.1    Aqil, M.2    Khar, R.K.3
  • 184
    • 79958842065 scopus 로고    scopus 로고
    • Biodegradable levofloxacin nanoparticles for sustained ocular drug delivery
    • Gupta H, Aqil M, Khar RK, et al. Biodegradable levofloxacin nanoparticles for sustained ocular drug delivery. J Drug Target 2011; 19: 409-17.
    • (2011) J Drug Target , vol.19 , pp. 409-417
    • Gupta, H.1    Aqil, M.2    Khar, R.K.3
  • 185
    • 84878585634 scopus 로고    scopus 로고
    • Nanoparticles laden in situ gel for sustained ocular drug delivery
    • Gupta H, Aqil M, Khar RK, et al. Nanoparticles laden in situ gel for sustained ocular drug delivery. J Pharm Bioalled Sci 2013; 5: 162-5.
    • (2013) J Pharm Bioalled Sci , vol.5 , pp. 162-165
    • Gupta, H.1    Aqil, M.2    Khar, R.K.3
  • 186
    • 84884553126 scopus 로고    scopus 로고
    • Nanoparticles laden in situ gel of levofloxacin for enhanced ocular retention
    • Gupta H, Aqil M, Khar RK, et al. Nanoparticles laden in situ gel of levofloxacin for enhanced ocular retention. Drug Deliv 2013; 20: 306-9.
    • (2013) Drug Deliv , vol.20 , pp. 306-309
    • Gupta, H.1    Aqil, M.2    Khar, R.K.3
  • 187
    • 84942930709 scopus 로고    scopus 로고
    • Chitosan nanoparticles for daptomycin delivery in ocular treatment of bacterial endophthalmitis
    • Silva NC, Silva S, Sarmento B, et al. Chitosan nanoparticles for daptomycin delivery in ocular treatment of bacterial endophthalmitis. Drug Deliv 2015; 22(7): 885-93.
    • (2015) Drug Deliv , vol.22 , Issue.7 , pp. 885-893
    • Silva, N.C.1    Silva, S.2    Sarmento, B.3
  • 188
    • 84890941075 scopus 로고    scopus 로고
    • Current progresses on nanodelivery systems for the treatment of neuropsychiatric diseases: Alzheimer's and schizophrenia
    • Silva AC, González-Mira E, Lobo JM, et al. Current progresses on nanodelivery systems for the treatment of neuropsychiatric diseases: Alzheimer's and schizophrenia. Curr Pharm Des 2013; 19: 7185-95.
    • (2013) Curr Pharm Des , vol.19 , pp. 7185-7195
    • Silva, A.C.1    González-Mira, E.2    Lobo, J.M.3
  • 189
    • 84947931981 scopus 로고    scopus 로고
    • Chitosan nanoparticles as vehicle for prolonged ocular delivery of ofloxacin
    • Chockalingam V, Bandaru BR, Senthilkumar K. et al. Chitosan nanoparticles as vehicle for prolonged ocular delivery of ofloxacin. Pharm Nanotechnol 2014; 2: 149-56.
    • (2014) Pharm Nanotechnol , vol.2 , pp. 149-156
    • Chockalingam, V.1    Bandaru, B.R.2    Senthilkumar, K.3
  • 190
    • 79958014984 scopus 로고    scopus 로고
    • Chitosan/ sulfobutylether-β-cyclodextrin nanoparticles as a potential approach for ocular drug delivery
    • Mahmoud AA, El-Feky GS, Kamel R, et al. Chitosan/ sulfobutylether-β-cyclodextrin nanoparticles as a potential approach for ocular drug delivery. Int J Pharm 2011; 413: 229-36.
    • (2011) Int J Pharm , vol.413 , pp. 229-236
    • Mahmoud, A.A.1    El-Feky, G.S.2    Kamel, R.3
  • 191
    • 80052304918 scopus 로고    scopus 로고
    • In vitro and in vivo study of indomethacin loaded gelatin nanoparticles
    • Kumar R, Nagarwal RC, Dhanawat M, et al. In vitro and in vivo study of indomethacin loaded gelatin nanoparticles. J Biomed Nanotechnol 2011; 7: 325-33.
    • (2011) J Biomed Nanotechnol , vol.7 , pp. 325-333
    • Kumar, R.1    Nagarwal, R.C.2    Dhanawat, M.3
  • 192
    • 79955855088 scopus 로고    scopus 로고
    • Modified PLA nano in situ gel: A potential ophthalmic drug delivery system
    • Nagarwal RC, Kumar R, Dhanawat M, et al. Modified PLA nano in situ gel: a potential ophthalmic drug delivery system. Colloids Surf B Biointerfaces 2011; 86: 28-34.
    • (2011) Colloids Surf B Biointerfaces , vol.86 , pp. 28-34
    • Nagarwal, R.C.1    Kumar, R.2    Dhanawat, M.3
  • 193
    • 84863798254 scopus 로고    scopus 로고
    • Controlled release of bevacizumab through nanospheres for extended treatment of age-related macular degeneration
    • Li F, Hurley B, Liu Y, et al. Controlled release of bevacizumab through nanospheres for extended treatment of age-related macular degeneration. Open Ophthalmol J 2012; 6: 54-58.
    • (2012) Open Ophthalmol J , vol.6 , pp. 54-58
    • Li, F.1    Hurley, B.2    Liu, Y.3
  • 194
    • 84884512609 scopus 로고    scopus 로고
    • The protective effect of albumin on bevacizumab activity and stability in PLGA nanoparticles intended for retinal and choroidal neovascularization treatments
    • Varshochian R, Jeddi-Tehrani M, Mahmoudi AR, et al. The protective effect of albumin on bevacizumab activity and stability in PLGA nanoparticles intended for retinal and choroidal neovascularization treatments. Eur J Pharm Sci 2013; 50: 341-52.
    • (2013) Eur J Pharm Sci , vol.50 , pp. 341-352
    • Varshochian, R.1    Jeddi-Tehrani, M.2    Mahmoudi, A.R.3
  • 195
    • 0035859983 scopus 로고    scopus 로고
    • Chitosan nanoparticles: A new vehicle for the improvement of the delivery of drugs to the ocular surface. Application to cyclosporin A
    • De Campos AM, Sánchez A, Alonso MJ. Chitosan nanoparticles: a new vehicle for the improvement of the delivery of drugs to the ocular surface. Application to cyclosporin A. Int J Pharm 2001; 224: 159-68.
    • (2001) Int J Pharm , vol.224 , pp. 159-168
    • De Campos, A.M.1    Sánchez, A.2    Alonso, M.J.3
  • 196
    • 84943817780 scopus 로고    scopus 로고
    • Biopharmaceutical profile of pranoprofen-loaded PLGA nanoparticles containing hydrogels for ocular administration
    • [Epub ahead of print]
    • Abrego G, Alvarado H, Souto EB, et al. Biopharmaceutical profile of pranoprofen-loaded PLGA nanoparticles containing hydrogels for ocular administration. Eur J Pharm Biopharm 2015; [Epub ahead of print].
    • (2015) Eur J Pharm Biopharm
    • Abrego, G.1    Alvarado, H.2    Souto, E.B.3
  • 197
    • 66949117923 scopus 로고    scopus 로고
    • Nanostructured lipid carrier-based hidrogel formulations for drug delivery: A comprehensive review
    • Doktorovova S, Souto EB. Nanostructured lipid carrier-based hidrogel formulations for drug delivery: a comprehensive review. Expert Opin Drug Deliv 2009; 6: 165-75.
    • (2009) Expert Opin Drug Deliv , vol.6 , pp. 165-175
    • Doktorovova, S.1    Souto, E.B.2
  • 198
    • 0034595218 scopus 로고    scopus 로고
    • Vitamin A loaded solid lipid nanoparticles for topical use: Occlusive properties and drug targeting to the upper skin
    • Jenning V, Gysler A, Schafer-Korting M, et al. Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin. Eur J Pharm Biopharm 2000; 49: 211-8.
    • (2000) Eur J Pharm Biopharm , vol.49 , pp. 211-218
    • Jenning, V.1    Gysler, A.2    Schafer-Korting, M.3
  • 199
    • 17344391922 scopus 로고    scopus 로고
    • Vitamin A-loaded solid lipid nanoparticles for topical use: Active release properties
    • Jenning V, Schafer-Korting M, Gohla S. Vitamin A-loaded solid lipid nanoparticles for topical use: active release properties. J Control Release 2000; 66: 115-26.
    • (2000) J Control Release , vol.66 , pp. 115-126
    • Jenning, V.1    Schafer-Korting, M.2    Gohla, S.3
  • 200
    • 0038032150 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art
    • Müller RH, Mäder K, Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art. Eur J Pharm Biopharm 2000; 50: 161-77.
    • (2000) Eur J Pharm Biopharm , vol.50 , pp. 161-177
    • Müller, R.H.1    Mäder, K.2    Gohla, S.3
  • 201
    • 0037093721 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) as ocular delivery system for tobramycin
    • Cavalli R, Gasco MR, Chetoni P, et al. Solid lipid nanoparticles (SLN) as ocular delivery system for tobramycin. Int J Pharm 2002; 238: 241-5.
    • (2002) Int J Pharm , vol.238 , pp. 241-245
    • Cavalli, R.1    Gasco, M.R.2    Chetoni, P.3
  • 202
    • 0037173520 scopus 로고    scopus 로고
    • Incorporation of cyclosporin A in solid lipid nanoparticles (SLN)
    • Ugazio E, Cavalli R, Gasco MR. Incorporation of cyclosporin A in solid lipid nanoparticles (SLN). Int J Pharm 2002; 241: 341-4.
    • (2002) Int J Pharm , vol.241 , pp. 341-344
    • Ugazio, E.1    Cavalli, R.2    Gasco, M.R.3
  • 203
    • 41349106751 scopus 로고    scopus 로고
    • Diclofenac sodium delivery to the eye: In vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct
    • Attama AA, Reichl S, Műller-Goymann CC. Diclofenac sodium delivery to the eye: in vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct. Int J Pharm 2008; 355: 307-13.
    • (2008) Int J Pharm , vol.355 , pp. 307-313
    • Attama, A.A.1    Reichl, S.2    Műller-Goymann, C.C.3
  • 204
    • 51649130848 scopus 로고    scopus 로고
    • A controlled-release ocular delivery system for ibuprofen based on nanostructured lipid carriers
    • Li X, Nie SF, Kong J, et al. A controlled-release ocular delivery system for ibuprofen based on nanostructured lipid carriers. Int J Pharm 2008; 363: 177-82.
    • (2008) Int J Pharm , vol.363 , pp. 177-182
    • Li, X.1    Nie, S.F.2    Kong, J.3
  • 205
    • 77949419485 scopus 로고    scopus 로고
    • Preparation, characterization, and evaluation of gatifloxacin loaded solid lipid nanoparticles as colloidal ocular drug delivery system
    • Kalam MA, Sultana Y, Ali A, et al. Preparation, characterization, and evaluation of gatifloxacin loaded solid lipid nanoparticles as colloidal ocular drug delivery system. J Drug Target 2010; 18: 191- 204.
    • (2010) J Drug Target , vol.18 , pp. 191-204
    • Kalam, M.A.1    Sultana, Y.2    Ali, A.3
  • 206
    • 84865733382 scopus 로고    scopus 로고
    • Long-term stability, biocompatibility and oral delivery potential of risperidone-loaded solid lipid nanoparticles
    • Silva AC, Kumar A, Wild W, et al. Long-term stability, biocompatibility and oral delivery potential of risperidone-loaded solid lipid nanoparticles. Int J Pharm 2012; 436: 798-805.
    • (2012) Int J Pharm , vol.436 , pp. 798-805
    • Silva, A.C.1    Kumar, A.2    Wild, W.3
  • 207
    • 84865758788 scopus 로고    scopus 로고
    • Lipid-based Nanocarriers as an Alternative for Oral Delivery of Poorly Water- Soluble Drugs: Peroral and Mucosal Routes
    • Silva AC, Santos D, Ferreira D, et al. Lipid-based Nanocarriers as an Alternative for Oral Delivery of Poorly Water- Soluble Drugs: Peroral and Mucosal Routes. Curr Med Chem 2012; 19: 4495-510.
    • (2012) Curr Med Chem , vol.19 , pp. 4495-4510
    • Silva, A.C.1    Santos, D.2    Ferreira, D.3
  • 208
    • 80052103054 scopus 로고    scopus 로고
    • Nanostructured lipid carriers for triamcinolone acetonide delivery of the posterior segment of the eye
    • Araújo J, Nikolic S, Egea MA, et al. Nanostructured lipid carriers for triamcinolone acetonide delivery of the posterior segment of the eye. Colloids Surf B Biointerfaces 2011; 88: 150-7.
    • (2011) Colloids Surf B Biointerfaces , vol.88 , pp. 150-157
    • Araújo, J.1    Nikolic, S.2    Egea, M.A.3
  • 209
    • 84874502028 scopus 로고    scopus 로고
    • Development of solid lipid nanoparticles and nanostructured lipid carriers for improving ocular delivery of acyclovir
    • Seyfoddin A, Al-Kassas R. Development of solid lipid nanoparticles and nanostructured lipid carriers for improving ocular delivery of acyclovir. Drug Dev Ind Pharm 2012; 39: 508-19.
    • (2012) Drug Dev Ind Pharm , vol.39 , pp. 508-519
    • Seyfoddin, A.1    Al-Kassas, R.2
  • 210
    • 84866517859 scopus 로고    scopus 로고
    • Further investigation of nanostructured lipid carriers as an ocular delivery system: In vivo transcorneal mechanism and in vitro release study
    • Tian BC, Zhang WJ, Xu HM, et al. Further investigation of nanostructured lipid carriers as an ocular delivery system: in vivo transcorneal mechanism and in vitro release study. Colloids Surf B Biointerfaces 2013; 102: 251-6.
    • (2013) Colloids Surf B Biointerfaces , vol.102 , pp. 251-256
    • Tian, B.C.1    Zhang, W.J.2    Xu, H.M.3
  • 211
    • 84877716556 scopus 로고    scopus 로고
    • Controlling solid lipid nanoparticle adhesion by polyelectrolyte multilayer surface modifications
    • Finke JH, Schmolke H, Klages CP, et al. Controlling solid lipid nanoparticle adhesion by polyelectrolyte multilayer surface modifications. Int J Pharm 2013; 449: 59-71.
    • (2013) Int J Pharm , vol.449 , pp. 59-71
    • Finke, J.H.1    Schmolke, H.2    Klages, C.P.3
  • 212
    • 68349160715 scopus 로고    scopus 로고
    • Lipid-an emerging platform for oral delivery of drugs with poor bioavailability
    • Chakraborty S, Shukla D, Mishra B, Singh S. Lipid-an emerging platform for oral delivery of drugs with poor bioavailability. Eur J Pharm Biopharm 2009; 73: 1-15.
    • (2009) Eur J Pharm Biopharm , vol.73 , pp. 1-15
    • Chakraborty, S.1    Shukla, D.2    Mishra, B.3    Singh, S.4
  • 213
    • 84882791479 scopus 로고    scopus 로고
    • Miconazole-loaded nanostructured lipid carriers (NLC) for local delivery to the oral mucosa: Improving antifungal activity
    • Mendes AI, Silva AC, Catita JAM, et al. Miconazole-loaded nanostructured lipid carriers (NLC) for local delivery to the oral mucosa: Improving antifungal activity. Colloids Surf B Biointerfaces 2013; 111: 755-63.
    • (2013) Colloids Surf B Biointerfaces , vol.111 , pp. 755-763
    • Mendes, A.I.1    Silva, A.C.2    Catita, J.A.M.3
  • 214
    • 79953234715 scopus 로고    scopus 로고
    • Preparation and evaluation of solid lipid nanoparticles of baicalin for ocular drug delivery system in vitro and in vivo
    • Liu Z, Zhang X, Wu H, et al. Preparation and evaluation of solid lipid nanoparticles of baicalin for ocular drug delivery system in vitro and in vivo. Drug Dev Ind Pharm 2011; 37: 475-81.
    • (2011) Drug Dev Ind Pharm , vol.37 , pp. 475-481
    • Liu, Z.1    Zhang, X.2    Wu, H.3
  • 215
    • 84455205699 scopus 로고    scopus 로고
    • Improved and safe transcorneal delivery of flurbiprofen by NLC and NLC based hydrogels
    • Gonzalez-Mira E, Nikolic S, Calpena AC, et al. Improved and safe transcorneal delivery of flurbiprofen by NLC and NLC based hydrogels. J Pharm Sci 2012; 101: 707-25.
    • (2012) J Pharm Sci , vol.101 , pp. 707-725
    • Gonzalez-Mira, E.1    Nikolic, S.2    Calpena, A.C.3
  • 216
    • 84886867429 scopus 로고    scopus 로고
    • Fabrication of a composite system combining solid lipid nanoparticles and thermosensitive hydrogel for challenging ophthalmic drug delivery
    • Hao J, Wang X, Bi Y, et al. Fabrication of a composite system combining solid lipid nanoparticles and thermosensitive hydrogel for challenging ophthalmic drug delivery. Colloids Surf B Biointerfaces 2014; 114: 111-20.
    • (2014) Colloids Surf B Biointerfaces , vol.114 , pp. 111-120
    • Hao, J.1    Wang, X.2    Bi, Y.3
  • 217
    • 0346338109 scopus 로고    scopus 로고
    • Smart polymeric materials: Emerging biochemical applications
    • Roy I, Gupta MN. Smart polymeric materials: emerging biochemical applications. Chem Biol 2003; 10: 1161-71.
    • (2003) Chem Biol , vol.10 , pp. 1161-1171
    • Roy, I.1    Gupta, M.N.2
  • 218
    • 33748498943 scopus 로고    scopus 로고
    • Formulation and evaluation of Nanostructured lipid carrier (NLC)-based gel of Valdecoxib
    • Joshi M, Patravale V. Formulation and evaluation of Nanostructured lipid carrier (NLC)-based gel of Valdecoxib. Drug Dev Ind Pharm 2006; 32: 911-8.
    • (2006) Drug Dev Ind Pharm , vol.32 , pp. 911-918
    • Joshi, M.1    Patravale, V.2
  • 219
    • 36148968932 scopus 로고    scopus 로고
    • Nanostructured lipid carrier (NLC) based gel of celecoxib
    • Joshi M, Patravale V. Nanostructured lipid carrier (NLC) based gel of celecoxib. Int J Pharm 2008; 346: 124-32.
    • (2008) Int J Pharm , vol.346 , pp. 124-132
    • Joshi, M.1    Patravale, V.2
  • 220
    • 33749985938 scopus 로고    scopus 로고
    • Solid lipid nanoparticles incorporated in dextran hydrogels: A new drug delivery system for oral formulations
    • Casadei MA, Cerreto F, Cesa S, et al. Solid lipid nanoparticles incorporated in dextran hydrogels: a new drug delivery system for oral formulations. Int J Pharm 2006; 325: 140-6.
    • (2006) Int J Pharm , vol.325 , pp. 140-146
    • Casadei, M.A.1    Cerreto, F.2    Cesa, S.3
  • 221
    • 55849090299 scopus 로고    scopus 로고
    • Responsive polymers in controlled drug delivery
    • Bajpai AK, Shukla SK, Bhanu S, et al. Responsive polymers in controlled drug delivery. Prog Polym Sci 2008; 33: 1088-118.
    • (2008) Prog Polym Sci , vol.33 , pp. 1088-1118
    • Bajpai, A.K.1    Shukla, S.K.2    Bhanu, S.3
  • 222
    • 39049137795 scopus 로고    scopus 로고
    • Physicochemical characterization and in vitro release studies of ascorbyl palmitate- loaded semi-solid nanostructured lipid carriers (NLC gels)
    • Teeranachaideekul V, Souto EB, Muller RH, et al. Physicochemical characterization and in vitro release studies of ascorbyl palmitate- loaded semi-solid nanostructured lipid carriers (NLC gels). J Microencapsul 2008; 25: 111-20.
    • (2008) J Microencapsul , vol.25 , pp. 111-120
    • Teeranachaideekul, V.1    Souto, E.B.2    Muller, R.H.3
  • 223
    • 56749105731 scopus 로고    scopus 로고
    • Development of SLN and NLC enriched hydrogels for transdermal delivery of nitrendipine: In vitro and in vivo characteristics
    • Bhaskar K, Krishna MC, Lingam M, et al. Development of SLN and NLC enriched hydrogels for transdermal delivery of nitrendipine: in vitro and in vivo characteristics. Drug Dev Int Pharm 2009; 35: 98-113.
    • (2009) Drug Dev Int Pharm , vol.35 , pp. 98-113
    • Bhaskar, K.1    Krishna, M.C.2    Lingam, M.3
  • 224
    • 84931281534 scopus 로고    scopus 로고
    • Lipid nanocarriers (LNC) and their applications in ocular drug delivery
    • Puglia C, Offerta A, Carbone C, et al. Lipid nanocarriers (LNC) and their applications in ocular drug delivery. Curr Med Chem 2015; 22: 1-14.
    • (2015) Curr Med Chem , vol.22 , pp. 1-14
    • Puglia, C.1    Offerta, A.2    Carbone, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.